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There are 4154 results for: content related to: Aggregation in protein-based biotherapeutics: Computational studies and tools to identify aggregation-prone regions

  1. Solubility and Early Assessment of Stability for Protein Therapeutics

    Biophysical Methods for Biotherapeutics: Discovery and Development Applications

    Sheng-Jiun Wu, Gary L. Gilliland, Yiqing Feng, Pages: 65–91, 2014

    Published Online : 14 MAR 2014, DOI: 10.1002/9781118354698.ch3

  2. Rational Design of Biobetters with Enhanced Stability

    Journal of Pharmaceutical Sciences

    Volume 104, Issue 8, August 2015, Pages: 2433–2440, Fabienne Courtois, Curtiss P. Schneider, Neeraj J. Agrawal and Bernhardt L. Trout

    Version of Record online : 10 JUN 2015, DOI: 10.1002/jps.24520

  3. You have free access to this content
    Impact of product-related factors on immunogenicity of biotherapeutics

    Journal of Pharmaceutical Sciences

    Volume 100, Issue 2, February 2011, Pages: 354–387, Satish Kumar Singh

    Version of Record online : 25 AUG 2010, DOI: 10.1002/jps.22276

  4. You have free access to this content
    Relationship between potential aggregation-prone regions and HLA-DR-binding T-cell immune epitopes: Implications for rational design of novel and follow-on therapeutic antibodies

    Journal of Pharmaceutical Sciences

    Volume 101, Issue 8, August 2012, Pages: 2686–2701, Sandeep Kumar, Mark A. Mitchell, Bonita Rup and Satish K. Singh

    Version of Record online : 22 MAY 2012, DOI: 10.1002/jps.23169

  5. Identification and Impact of Aggregation-Prone Regions in Proteins and Therapeutic Monoclonal Antibodies

    Aggregation of Therapeutic Proteins

    Sandeep Kumar, Xiaoling Wang, Satish K. Singh, Pages: 103–118, 2010

    Published Online : 5 AUG 2010, DOI: 10.1002/9780470769829.ch3

  6. Impact of deglycosylation and thermal stress on conformational stability of a full length murine igG2a monoclonal antibody: Observations from molecular dynamics simulations

    Proteins: Structure, Function, and Bioinformatics

    Volume 81, Issue 3, March 2013, Pages: 443–460, Xiaoling Wang, Sandeep Kumar, Patrick M. Buck and Satish K. Singh

    Version of Record online : 12 NOV 2012, DOI: 10.1002/prot.24202

  7. Developability Assessment During the Selection of Novel Therapeutic Antibodies

    Journal of Pharmaceutical Sciences

    Volume 104, Issue 6, June 2015, Pages: 1885–1898, Alexander Jarasch, Hans Koll, Joerg T. Regula, Martin Bader, Apollon Papadimitriou and Hubert Kettenberger

    Version of Record online : 26 MAR 2015, DOI: 10.1002/jps.24430

  8. Developability index: A rapid in silico tool for the screening of antibody aggregation propensity

    Journal of Pharmaceutical Sciences

    Volume 101, Issue 1, January 2012, Pages: 102–115, Timothy M. Lauer, Neeraj J. Agrawal, Naresh Chennamsetty, Kamal Egodage, Bernhard Helk and Bernhardt L. Trout

    Version of Record online : 20 SEP 2011, DOI: 10.1002/jps.22758

  9. Effect of biotherapeutics on cyclosporin-induced Clostridium difficile infection in mice

    Journal of Gastroenterology and Hepatology

    Volume 25, Issue 4, April 2010, Pages: 832–838, Sukhminderjit Kaur, Chetana Vaishnavi, Pallab Ray, Rakesh Kochhar and Kaushal Kishor Prasad

    Version of Record online : 14 JAN 2010, DOI: 10.1111/j.1440-1746.2009.06135.x

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    Large-scale production of pharmaceutical proteins in plant cell culture—the protalix experience

    Plant Biotechnology Journal

    Volume 13, Issue 8, October 2015, Pages: 1199–1208, Yoram Tekoah, Avidor Shulman, Tali Kizhner, Ilya Ruderfer, Liat Fux, Yakir Nataf, Daniel Bartfeld, Tami Ariel, Svetlana Gingis–Velitski, Uri Hanania and Yoseph Shaaltiel

    Version of Record online : 23 JUN 2015, DOI: 10.1111/pbi.12428

  11. Biophysical Methods Applied in Early Discovery of a Biotherapeutic: Case Study of an Egfr-Igf1R Bispecific Adnectin

    Biophysical Methods for Biotherapeutics: Discovery and Development Applications

    Michael L. Doyle, James W. Bryson, Virginie Lafont, Zheng Lin, Paul E. Morin, Lumelle A. Schneeweis, Aaron P. Yamniuk, Joseph Yanchunas, Pages: 1–24, 2014

    Published Online : 14 MAR 2014, DOI: 10.1002/9781118354698.ch1

  12. Nucleation, Aggregation, and Conformational Distortion

    Biophysical Methods for Biotherapeutics: Discovery and Development Applications

    Tapan K. Das, Pages: 125–149, 2014

    Published Online : 14 MAR 2014, DOI: 10.1002/9781118354698.ch5

  13. Qualitative and quantitative characterization of protein biotherapeutics with liquid chromatography mass spectrometry

    Mass Spectrometry Reviews

    Miao Qu, Bo An, Shichen Shen, Ming Zhang, Xiaomeng Shen, Xiaotao Duan, Joseph P. Balthasar and Jun Qu

    Version of Record online : 20 APR 2016, DOI: 10.1002/mas.21500

  14. How do thermophilic proteins resist aggregation?

    Proteins: Structure, Function, and Bioinformatics

    Volume 80, Issue 4, April 2012, Pages: 1003–1015, Anthony Mary Thangakani, Sandeep Kumar, Devadasan Velmurugan and Maria Siluvay Michael Gromiha

    Version of Record online : 4 JAN 2012, DOI: 10.1002/prot.24002

  15. Clinical Pharmacology in the Era of Biotherapeutics

    Clinical Pharmacology & Therapeutics

    Volume 84, Issue 5, November 2008, Pages: 533–536, RL Lalonde and P Honig

    Version of Record online : 17 SEP 2008, DOI: 10.1038/clpt.2008.182

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    Posters

    Journal of Thrombosis and Haemostasis

    Volume 7, Issue s2, July 2009, Pages: 317–1168,

    Version of Record online : 15 JUN 2009, DOI: 10.1111/j.1538-7836.2009.03473_2.x

  17. You have full text access to this Open Access content
    Commercial-scale biotherapeutics manufacturing facility for plant-made pharmaceuticals

    Plant Biotechnology Journal

    Volume 13, Issue 8, October 2015, Pages: 1180–1190, Barry R. Holtz, Brian R. Berquist, Lindsay D. Bennett, Vally J.M. Kommineni, Ranjith K. Munigunti, Earl L. White, Don C. Wilkerson, Kah-Yat I. Wong, Lan H. Ly and Sylvain Marcel

    Version of Record online : 21 SEP 2015, DOI: 10.1111/pbi.12469

  18. Target-Driven Pharmacokinetics of Biotherapeutics

    Standard Article

    Pharmaceutical Sciences Encyclopedia

    Guy M.L. Meno-Tetang

    Published Online : 30 DEC 2015, DOI: 10.1002/9780470571224.pse550

  19. Workshop on predictive science of the immunogenicity aspects of particles in biopharmaceutical products

    Journal of Pharmaceutical Sciences

    Volume 101, Issue 10, October 2012, Pages: 3555–3559, Ewa Marszal and Elizabeth Fowler

    Version of Record online : 26 JUN 2012, DOI: 10.1002/jps.23243

  20. Interaction with the Surrounding Water Plays a Key Role in Determining the Aggregation Propensity of Proteins

    Angewandte Chemie

    Volume 126, Issue 15, April 7, 2014, Pages: 4042–4045, Dr. Song-Ho Chong and Prof. Sihyun Ham

    Version of Record online : 24 FEB 2014, DOI: 10.1002/ange.201309317