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There are 48478 results for: content related to: Protein instability and immunogenicity: Roadblocks to clinical application of injectable protein delivery systems for sustained release

  1. Particles in therapeutic protein formulations, Part 1: Overview of analytical methods

    Journal of Pharmaceutical Sciences

    Volume 101, Issue 3, March 2012, Pages: 914–935, Sarah Zölls, Ruedeeporn Tantipolphan, Michael Wiggenhorn, Gerhard Winter, Wim Jiskoot, Wolfgang Friess and Andrea Hawe

    Version of Record online : 8 DEC 2011, DOI: 10.1002/jps.23001

  2. Characterization of Nanoparticle Tracking Analysis for Quantification and Sizing of Submicron Particles of Therapeutic Proteins

    Journal of Pharmaceutical Sciences

    Volume 104, Issue 8, August 2015, Pages: 2441–2450, Chen Zhou, Aaron B. Krueger, James G. Barnard, Wei Qi and John F. Carpenter

    Version of Record online : 27 MAY 2015, DOI: 10.1002/jps.24510

  3. Asymmetrical flow field-flow fractionation method for the analysis of submicron protein aggregates

    Journal of Pharmaceutical Sciences

    Volume 101, Issue 11, November 2012, Pages: 4129–4139, Andrea Hawe, Stefan Romeijn, Vasco Filipe and Wim Jiskoot

    Version of Record online : 21 AUG 2012, DOI: 10.1002/jps.23298

  4. Minimizing immunogenicity of biopharmaceuticals by controlling critical quality attributes of proteins

    Biotechnology Journal

    Volume 7, Issue 12, December 2012, Pages: 1473–1484, Dr. Miranda M. C. van Beers and Dr. Muriel Bardor

    Version of Record online : 2 OCT 2012, DOI: 10.1002/biot.201200065

  5. Immunogenicity of recombinant human interferon beta interacting with particles of glass, metal, and polystyrene

    Journal of Pharmaceutical Sciences

    Volume 101, Issue 1, January 2012, Pages: 187–199, Miranda M. C. Van Beers, Francesca Gilli, Huub Schellekens, Theodore W. Randolph and Wim Jiskoot

    Version of Record online : 14 SEP 2011, DOI: 10.1002/jps.22744

  6. Characterization of Submicron (0.1–1 μm) Particles in Therapeutic Proteins by Nanoparticle Tracking Analysis

    Journal of Pharmaceutical Sciences

    Volume 104, Issue 5, May 2015, Pages: 1622–1631, Rekha Vasudev, Sam Mathew and Nataliya Afonina

    Version of Record online : 3 MAR 2015, DOI: 10.1002/jps.24411

  7. The future of protein particle characterization and understanding its potential to diminish the immunogenicity of biopharmaceuticals: A shared perspective

    Journal of Pharmaceutical Sciences

    Volume 101, Issue 10, October 2012, Pages: 3580–3585, Jared S. Bee, Theresa J. Goletz and Jack A. Ragheb

    Version of Record online : 26 JUN 2012, DOI: 10.1002/jps.23247

  8. Aggregation and Immunogenicity of Therapeutic Proteins

    Aggregation of Therapeutic Proteins

    Vasco Filipe, Andrea Hawe, Huub Schellekens, Wim Jiskoot, Pages: 403–433, 2010

    Published Online : 5 AUG 2010, DOI: 10.1002/9780470769829.ch10

  9. Quality attributes of recombinant therapeutic proteins: An assessment of impact on safety and efficacy as part of a quality by design development approach

    Biotechnology Progress

    Volume 28, Issue 3, May/June 2012, Pages: 608–622, Alex Eon-Duval, Hervé Broly and Ralf Gleixner

    Version of Record online : 2 MAY 2012, DOI: 10.1002/btpr.1548

  10. You have free access to this content
    Impact of product-related factors on immunogenicity of biotherapeutics

    Journal of Pharmaceutical Sciences

    Volume 100, Issue 2, February 2011, Pages: 354–387, Satish Kumar Singh

    Version of Record online : 25 AUG 2010, DOI: 10.1002/jps.22276

  11. You have free access to this content
    Formulation and Stability of Cytokine Therapeutics

    Journal of Pharmaceutical Sciences

    Volume 104, Issue 2, February 2015, Pages: 307–326, Tiina Lipiäinen, Marikki Peltoniemi, Sanjay Sarkhel, Teijo Yrjönen, Heikki Vuorela, Arto Urtti and Anne Juppo

    Version of Record online : 9 DEC 2014, DOI: 10.1002/jps.24243

  12. Subvisible (2–100 μm) Particle Analysis During Biotherapeutic Drug Product Development: Part 1, Considerations and Strategy

    Journal of Pharmaceutical Sciences

    Volume 104, Issue 6, June 2015, Pages: 1899–1908, Linda O. Narhi, Vincent Corvari, Dean C. Ripple, Nataliya Afonina, Irene Cecchini, Michael R. Defelippis, Patrick Garidel, Andrea Herre, Atanas V. Koulov, Tony Lubiniecki, Hanns-Christian Mahler, Paolo Mangiagalli, Douglas Nesta, Bernardo Perez-Ramirez, Alla Polozova, Mara Rossi, Roland Schmidt, Robert Simler, Satish Singh, Thomas M. Spitznagel, Andrew Weiskopf and Klaus Wuchner

    Version of Record online : 1 APR 2015, DOI: 10.1002/jps.24437

  13. Probing bis-ANS binding sites of different affinity on aggregated IgG by steady-state fluorescence, time-resolved fluorescence and isothermal titration calorimetry

    Journal of Pharmaceutical Sciences

    Volume 100, Issue 4, April 2011, Pages: 1294–1305, Andrea Hawe, Theo Rispens, James N. Herron and Wim Jiskoot

    Version of Record online : 18 OCT 2010, DOI: 10.1002/jps.22368

  14. Protein particles: What we know and what we do not know

    Journal of Pharmaceutical Sciences

    Volume 101, Issue 10, October 2012, Pages: 3568–3579, Dean C. Ripple and Mariana N. Dimitrova

    Version of Record online : 26 JUN 2012, DOI: 10.1002/jps.23242

  15. Immunogenicity of Therapeutic Proteins and the Assessment of Risk

    Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials

    Huub Schellekens, Wim Jiskoot, Pages: 475–486, 2007

    Published Online : 14 NOV 2007, DOI: 10.1002/9780470292549.ch20

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    Relationship between potential aggregation-prone regions and HLA-DR-binding T-cell immune epitopes: Implications for rational design of novel and follow-on therapeutic antibodies

    Journal of Pharmaceutical Sciences

    Volume 101, Issue 8, August 2012, Pages: 2686–2701, Sandeep Kumar, Mark A. Mitchell, Bonita Rup and Satish K. Singh

    Version of Record online : 22 MAY 2012, DOI: 10.1002/jps.23169

  17. Development and in vitro Evaluation of Antigen-Loaded Poly(amidoamine) Nanoparticles for Respiratory Epithelium Applications

    ChemMedChem

    Volume 8, Issue 11, November 2013, Pages: 1787–1794, Dr. Grégory Coué, Dr. Iris Hermanns, Dr. Ronald E. Unger, Prof. C. James Kirkpatrick and Prof. Johan F. J. Engbersen

    Version of Record online : 5 SEP 2013, DOI: 10.1002/cmdc.201300307

  18. Transient molten globules and metastable aggregates induced by brief exposure of a monoclonal IgG to Low pH

    Journal of Pharmaceutical Sciences

    Volume 101, Issue 7, July 2012, Pages: 2327–2339, Vasco Filipe, BaşAk KüKrer, Andrea Hawe and Wim Jiskoot

    Version of Record online : 19 APR 2012, DOI: 10.1002/jps.23157

  19. Structural Characterization of IgG1 mAb Aggregates and Particles Generated Under Various Stress Conditions

    Journal of Pharmaceutical Sciences

    Volume 103, Issue 3, March 2014, Pages: 796–809, Srivalli N. Telikepalli, Ozan S. Kumru, Cavan Kalonia, Reza Esfandiary, Sangeeta B. Joshi, C. Russell Middaugh and David B. Volkin

    Version of Record online : 22 JAN 2014, DOI: 10.1002/jps.23839

  20. The use of flow cytometry for the detection of subvisible particles in therapeutic protein formulations

    Journal of Pharmaceutical Sciences

    Volume 100, Issue 5, May 2011, Pages: 1671–1678, Henryk Mach, Akhilesh Bhambhani, Brian K. Meyer, Steven Burek, Harrison Davis, Jeffrey T. Blue and Robert K. Evans

    Version of Record online : 13 DEC 2010, DOI: 10.1002/jps.22414