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There are 24516 results for: content related to: Pharmacokinetic/pharmacodynamic modeling of 5-fluorouracil by using a biomarker to predict tumor growth in a rat model of colorectal cancer

  1. A predictive biomarker for altered 5-fluorouracil pharmacokinetics following repeated administration in a rat model of colorectal cancer

    Biopharmaceutics & Drug Disposition

    Volume 34, Issue 7, October 2013, Pages: 365–376, Shinji Kobuchi, Shota Kuwano, Kazuki Imoto, Kae Okada, Asako Nishimura, Yukako Ito, Nobuhito Shibata and Kanji Takada

    Version of Record online : 12 AUG 2013, DOI: 10.1002/bdd.1851

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    Pretherapeutic uracil and dihydrouracil levels of colorectal cancer patients are associated with sex and toxic side effects during adjuvant 5-fluorouracil–based chemotherapy


    Volume 118, Issue 11, 1 June 2012, Pages: 2935–2943, Yvonne Wettergren, Göran Carlsson, Elisabeth Odin and Bengt Gustavsson

    Version of Record online : 21 OCT 2011, DOI: 10.1002/cncr.26595

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    Circadian rhythm of dihydrouracil/uracil ratios in biological fluids: a potential biomarker for dihydropyrimidine dehydrogenase levels

    British Journal of Pharmacology

    Volume 141, Issue 4, February 2004, Pages: 616–623, Hao Jiang, Jing Lu and Jiang Ji

    Version of Record online : 30 JAN 2009, DOI: 10.1038/sj.bjp.0705651

  4. Indirect assessment of dihydropyrimidine dehydrogenase activity in cats

    Veterinary and Comparative Oncology

    Volume 11, Issue 4, December 2013, Pages: 265–271, C. F. Saba, C. W. Schmiedt, K. G. Freeman and G. L. Edwards

    Version of Record online : 6 SEP 2013, DOI: 10.1111/vco.12064

  5. Simultaneous HPLC determination of 5-fluorouracil and its metabolites in plasma of cancer patients

    Biomedical Chromatography

    Volume 16, Issue 7, October 2002, Pages: 446–452, F. Casale, R. Canaparo, E. Muntoni, L. Serpe, G.P. Zara, C. Della Pepa, E. Berno, M. Costa and M. Eandi

    Version of Record online : 11 OCT 2002, DOI: 10.1002/bmc.181

  6. A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5′-deoxy-5-fluorocytidine, 5′-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma

    Biomedical Chromatography

    Volume 24, Issue 4, April 2010, Pages: 374–386, Liia D. Vainchtein, Hilde Rosing, Jan H.M. Schellens and Jos H. Beijnen

    Version of Record online : 2 AUG 2009, DOI: 10.1002/bmc.1302

  7. Quantitative analysis of 5-fluorouracil and 5,6-dihydrofluorouracil in plasma by gas chromatography mass spectrometry

    Biological Mass Spectrometry

    Volume 9, Issue 8, August 1982, Pages: 336–339, C. Aubert, J. P. Sommadossi, Ph. Coassolo, J. P. Cano and J. P. Rigault

    Version of Record online : 13 APR 2005, DOI: 10.1002/bms.1200090806

  8. A simple and rapid high-performance liquid chromatographic (HPLC) method for 5-fluorouracil (5-FU) assay in plasma and possible detection of patients with impaired dihydropyrimidine dehydrogenase (DPD) activity

    Journal of Clinical Pharmacy and Therapeutics

    Volume 29, Issue 4, August 2004, Pages: 307–315, J. Ciccolini, C. Mercier, M.-F. Blachon, R. Favre, A. Durand and B. Lacarelle

    Version of Record online : 20 JUL 2004, DOI: 10.1111/j.1365-2710.2004.00569.x

  9. Passage of 5'-dFUrd and its metabolites 5-FU and 5-FUH2 to CSF in a clinical Phase 1 study

    Acta Neurologica Scandinavica

    Volume 74, Issue 3, September 1986, Pages: 240–244, M. S. Heier, R. Heintz and S. D. Fosså

    Version of Record online : 29 JAN 2009, DOI: 10.1111/j.1600-0404.1986.tb07862.x

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    Beating the odds: efficacy and toxicity of dihydropyrimidine dehydrogenase-driven adaptive dosing of 5-FU in patients with digestive cancer

    British Journal of Clinical Pharmacology

    Volume 81, Issue 1, January 2016, Pages: 124–130, Manon Launay, Laetitia Dahan, Manon Duval, Anne Rodallec, Gérard Milano, Muriel Duluc, Bruno Lacarelle, Joseph Ciccolini and Jean-Francois Seitz

    Version of Record online : 28 NOV 2015, DOI: 10.1111/bcp.12790

  11. Synthesis of galactosylated chitosan/5-fluorouracil nanoparticles and its characteristics, in vitro and in vivo release studies

    Journal of Biomedical Materials Research Part B: Applied Biomaterials

    Volume 100B, Issue 8, November 2012, Pages: 2035–2043, Mingrong Cheng, Jiang Han, Qing Li, Bing He, Bingbing Zha, Jingbo Wu, Runjiao Zhou, Tao Ye, Wei Wang, Hongzhi Xu and Yiming Hou

    Version of Record online : 1 AUG 2012, DOI: 10.1002/jbm.b.32767

  12. 5-FU for genital warts in non-immunocompromised individuals

    Intervention Review

    The Cochrane Library

    Claudio S Batista, Álvaro N Atallah, Humberto Saconato and Edina MK da Silva

    Published Online : 14 APR 2010, DOI: 10.1002/14651858.CD006562.pub2

  13. Role of chemotherapy in the treatment of colorectal carcinoma

    Seminars in Surgical Oncology

    Volume 3, Issue 3, 1987, Pages: 190–214, Dr. Nancy Kemeny

    Version of Record online : 18 AUG 2006, DOI: 10.1002/ssu.2980030312

  14. 19F NMR monitoring of in vivo tumor metabolism after biochemical modulation of 5-fluorouracil by the uridine phosphorylase inhibitor 5-benzylacyclouridine

    Magnetic Resonance in Medicine

    Volume 38, Issue 6, December 1997, Pages: 907–916, Scott K. Holland, Andries M. Bergman, Yiming Zhao, Earle R. Adams and Giuseppe Pizzorno

    Version of Record online : 12 JAN 2006, DOI: 10.1002/mrm.1910380609

  15. 5-Fluorouracil efficiently enhanced apoptosis induced by adenovirus-mediated transfer of caspase-8 in DLD-1 colon cancer cells

    The Journal of Gene Medicine

    Volume 5, Issue 4, April 2003, Pages: 287–299, Hiroaki Uchida, Nobusada Shinoura, Joji Kitayama, Toshiaki Watanabe, Hirokazu Nagawa and Hirofumi Hamada

    Version of Record online : 4 NOV 2002, DOI: 10.1002/jgm.339

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    The combination therapy of α-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice

    International Journal of Cancer

    Volume 133, Issue 5, 1 September 2013, Pages: 1126–1134, Hiroshi Aketa, Tomohide Tatsumi, Keisuke Kohga, Hinako Tsunematsu, Satoshi Aono, Satoshi Shimizu, Takahiro Kodama, Takatoshi Nawa, Minoru Shigekawa, Hayato Hikita, Ryotaro Sakamori, Atsushi Hosui, Takuya Miyagi, Naoki Hiramatsu, Tatsuya Kanto, Norio Hayashi and Tetsuo Takehara

    Version of Record online : 13 MAR 2013, DOI: 10.1002/ijc.28118

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    Calpain regulates thymidylate synthase–5-fluoro-dUMP complex levels associated with response to 5-fluorouracil in gastric cancer cells

    Cancer Science

    Volume 102, Issue 8, August 2011, Pages: 1509–1515, Yoshihiro Nabeya, Takao Suzuki, Aki Furuya, Naoki Koide, Motohiro Ohkoshi, Masaki Takiguchi, Takenori Ochiai, Hisahiro Matsubara and Takaki Hiwasa

    Version of Record online : 23 JUN 2011, DOI: 10.1111/j.1349-7006.2011.01978.x

  18. 5-Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)-mediated apoptosis in hepatocellular carcinoma

    Clinical and Experimental Pharmacology and Physiology

    Volume 42, Issue 2, February 2015, Pages: 146–153, Xiao-Yun Hu, Ji-Yun Liang, Xue-Jun Guo, Li Liu and Ya-Bing Guo

    Version of Record online : 12 JAN 2015, DOI: 10.1111/1440-1681.12333

  19. Combined environmental risk assessment for 5-fluorouracil and capecitabine in Europe

    Integrated Environmental Assessment and Management

    Volume 6, Issue S1, July 2010, Pages: 540–566, Jürg Oliver Straub

    Version of Record online : 3 DEC 2009, DOI: 10.1897/IEAM_2009-073.1

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    Absence of large intragenic rearrangements in the DPYD gene in a large cohort of colorectal cancer patients treated with 5-FU-based chemotherapy

    British Journal of Clinical Pharmacology

    Volume 70, Issue 2, August 2010, Pages: 268–272, Laia Paré, David Paez, Juliana Salazar, Elisabeth Del Rio, Eduardo Tizzano, Eugenio Marcuello and Montserrat Baiget

    Version of Record online : 12 APR 2010, DOI: 10.1111/j.1365-2125.2010.03683.x