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There are 140871 results for: content related to: Cancer therapy based on oncogene addiction

  1. You have free access to this content
    Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

    The EMBO Journal

    Volume 21, Issue 21, November 1, 2002, Pages: 5611–5622, Tilman Brummer, Peter E. Shaw, Michael Reth and Yukiko Misawa

    Version of Record online : 1 NOV 2002, DOI: 10.1093/emboj/cdf588

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    Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling

    The EMBO Journal

    Volume 31, Issue 11, May 30, 2012, Pages: 2629–2647, Michael Röring, Ricarda Herr, Gina J Fiala, Katharina Heilmann, Sandra Braun, Anja E Eisenhardt, Sebastian Halbach, David Capper, Andreas von Deimling, Wolfgang W Schamel, Darren N Saunders and Tilman Brummer

    Version of Record online : 17 APR 2012, DOI: 10.1038/emboj.2012.100

  3. The tumour suppressor DiRas3 interacts with C-RAF and downregulates MEK activity to restrict cell migration

    Biology of the Cell

    Volume 105, Issue 2, February 2013, Pages: 91–107, Mirko Klingauf, Matthias Beck, Ulrich Berge, Yagmur Turgay, Stephan Heinzer, Peter Horvath and Ruth Kroschewski

    Version of Record online : 28 DEC 2012, DOI: 10.1111/boc.201200030

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    Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

    The EMBO Journal

    Volume 16, Issue 21, November 1, 1997, Pages: 6426–6438, Jeffrey A. Frost, Helge Steen, Paul Shapiro, Tim Lewis, Natalie Ahn, Peter E. Shaw and Melanie H. Cobb

    Version of Record online : 1 NOV 1997, DOI: 10.1093/emboj/16.21.6426

  5. Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways

    Journal of Cellular Physiology

    Volume 226, Issue 11, November 2011, Pages: 2762–2781, James A. McCubrey, Linda S. Steelman, C. Ruth Kempf, William H. Chappell, Stephen L. Abrams, Franca Stivala, Graziella Malaponte, Ferdinando Nicoletti, Massimo Libra, Jörg Bäsecke, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Giuseppe Montalto, Melchiorre Cervello, Lucio Cocco and Alberto M. Martelli

    Version of Record online : 24 AUG 2011, DOI: 10.1002/jcp.22647

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    Raf kinases: Oncogenesis and drug discovery

    International Journal of Cancer

    Volume 119, Issue 10, 15 November 2006, Pages: 2261–2271, Ralf Schreck and Ulf R. Rapp

    Version of Record online : 7 AUG 2006, DOI: 10.1002/ijc.22144

  7. Raf-1 and B-Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain

    European Journal of Neuroscience

    Volume 11, Issue 6, June 1999, Pages: 1995–2006, Cecile Morice, Fatiha Nothias, Sandra König, Philippe Vernier, Manuela Baccarini, Jean-Didier Vincent and Jean Vianney Barnier

    Version of Record online : 9 OCT 2008, DOI: 10.1046/j.1460-9568.1999.00609.x

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    Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601

    The EMBO Journal

    Volume 19, Issue 20, October 16, 2000, Pages: 5429–5439, Bao-Hong Zhang and Kun-Liang Guan

    Version of Record online : 16 OCT 2000, DOI: 10.1093/emboj/19.20.5429

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    MEK kinase activity is not necessary for Raf-1 function

    The EMBO Journal

    Volume 20, Issue 8, April 17, 2001, Pages: 1940–1951, Martin Hüser, Jeni Luckett, Antonio Chiloeches, Kathryn Mercer, Mabel Iwobi, Susan Giblett, Xiao-Ming Sun, Jane Brown, Richard Marais and Catrin Pritchard

    Version of Record online : 17 APR 2001, DOI: 10.1093/emboj/20.8.1940

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    Metastatic Melanoma: Insights Into the Evolution of the Treatments and Future Challenges

    Medicinal Research Reviews

    Volume 37, Issue 1, January 2017, Pages: 98–148, Antoine Millet, Anthony R. Martin, Cyril Ronco, Stéphane Rocchi and Rachid Benhida

    Version of Record online : 29 AUG 2016, DOI: 10.1002/med.21404

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    Nuclear Raf-1 kinase regulates the CXCR5 promoter by associating with NFATc3 to drive retinoic acid-induced leukemic cell differentiation

    The FEBS Journal

    Volume 281, Issue 4, February 2014, Pages: 1170–1180, Wendy M. Geil and Andrew Yen

    Version of Record online : 10 JAN 2014, DOI: 10.1111/febs.12693

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    Regulation of Raf-1 activation and signalling by dephosphorylation

    The EMBO Journal

    Volume 21, Issue 1-2, January 15, 2002, Pages: 64–71, Amardeep S. Dhillon, Sharon Meikle, Zihni Yazici, Manfred Eulitz and Walter Kolch

    Version of Record online : 15 JAN 2002, DOI: 10.1093/emboj/21.1.64

  13. Functional consequences of mutations in a putative Akt phosphorylation motif of B-raf in human cancers

    Molecular Carcinogenesis

    Volume 43, Issue 1, May 2005, Pages: 59–63, Tsuneo Ikenoue, Fumihiko Kanai, Yohko Hikiba, Yasuo Tanaka, Jun Imamura, Miki Ohta, Amarsanaa Jazag, Bayasi Guleng, Yoshinari Asaoka, Keisuke Tateishi, Takayuki Kawakami, Masayuki Matsumura, Takao Kawabe and Masao Omata

    Version of Record online : 24 MAR 2005, DOI: 10.1002/mc.20102

  14. You have free access to this content
    TCR ligand avidity determines the modeof B-Raf/Raf-1/ERK activation leading to the activationof human CD4+ T cell clone

    European Journal of Immunology

    Volume 36, Issue 7, July 2006, Pages: 1926–1937, Hirotake Tsukamoto, Atsushi Irie, Yu-Zhen Chen, Kumiko Takeshita, Jeong-Ran Kim and Yasuharu Nishimura

    Version of Record online : 22 JUN 2006, DOI: 10.1002/eji.200535803

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    Rafs constitute a nodal point in the regulation of embryonic endothelial progenitor cell growth and differentiation

    Journal of Cellular and Molecular Medicine

    Volume 11, Issue 6, November/December 2007, Pages: 1395–1407, Kiril Bidzhekov, Martina Hautmann, Matthias Semisch, Christian Weber, Bernd Engelmann and Antonis K. Hatzopoulos

    Version of Record online : 24 SEP 2007, DOI: 10.1111/j.1582-4934.2007.00123.x

  16. p21 activated kinase 5 activates Raf-1 and targets it to mitochondria

    Journal of Cellular Biochemistry

    Volume 105, Issue 1, 1 September 2008, Pages: 167–175, Xiaochong Wu, Heather S. Carr, Ippeita Dan, Peter P. Ruvolo and Jeffrey A. Frost

    Version of Record online : 8 MAY 2008, DOI: 10.1002/jcb.21809

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    The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf

    The EMBO Journal

    Volume 25, Issue 15, August 9, 2006, Pages: 3556–3564, Kenta Terai and Michiyuki Matsuda

    Version of Record online : 20 JUL 2006, DOI: 10.1038/sj.emboj.7601241

  18. You have full text access to this OnlineOpen article
    “RAF” neighborhood: Protein–protein interaction in the Raf/Mek/Erk pathway

    FEBS Letters

    Volume 588, Issue 15, August 01, 2014, Pages: 2398–2406, Botond Cseh, Eszter Doma and Manuela Baccarini

    Version of Record online : 14 JUN 2014, DOI: 10.1016/j.febslet.2014.06.025

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    Regulation of RKIP binding to the N-region of the Raf-1 kinase

    FEBS Letters

    Volume 580, Issue 27, November 27, 2006, Pages: 6405–6412, Sungdae Park, Oliver Rath, Sandy Beach, Xiaoqin Xiang, Sharon M. Kelly, Zhijun Luo, Walter Kolch and Kam C. Yeung

    Version of Record online : 3 NOV 2006, DOI: 10.1016/j.febslet.2006.10.054

  20. You have free access to this content
    The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila

    The EMBO Journal

    Volume 16, Issue 8, April 15, 1997, Pages: 1961–1969, Alexandra van der Straten, Christian Rommel, Barry Dickson and Ernst Hafen

    Version of Record online : 15 APR 1997, DOI: 10.1093/emboj/16.8.1961