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There are 3228 results for: content related to: LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson disease

  1. You have free access to this content
    Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER–Golgi export

    The EMBO Journal

    Volume 33, Issue 20, 16 October 2014, Pages: 2314–2331, Hyun Jin Cho, Jia Yu, Chengsong Xie, Parvathi Rudrabhatla, Xi Chen, Junbing Wu, Loukia Parisiadou, Guoxiang Liu, Lixin Sun, Bo Ma, Jinhui Ding, Zhihua Liu and Huaibin Cai

    Article first published online : 8 SEP 2014, DOI: 10.15252/embj.201487807

  2. You have full text access to this OnlineOpen article
    Cellular processes associated with LRRK2 function and dysfunction

    The FEBS Journal

    Volume 282, Issue 15, August 2015, Pages: 2806–2826, Rebecca Wallings, Claudia Manzoni and Rina Bandopadhyay

    Article first published online : 9 MAY 2015, DOI: 10.1111/febs.13305

  3. You have full text access to this OnlineOpen article
    Ten Years and Counting: Moving Leucine-Rich RepeatKinase 2 Inhibitors to the Clinic

    Movement Disorders

    Volume 30, Issue 2, February 2015, Pages: 180–189, Andrew B. West

    Article first published online : 1 DEC 2014, DOI: 10.1002/mds.26075

  4. You have free access to this content
    Leucine-rich repeat kinase 2 (LRRK2): A key player in the pathogenesis of Parkinson's disease

    Journal of Neuroscience Research

    Volume 87, Issue 6, 1 May 2009, Pages: 1283–1295, Payal N. Gandhi, Shu G. Chen and Amy L. Wilson-Delfosse

    Article first published online : 21 NOV 2008, DOI: 10.1002/jnr.21949

  5. You have free access to this content
    LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles

    The FEBS Journal

    Volume 276, Issue 22, November 2009, Pages: 6445–6454, Zhenyu Yue

    Article first published online : 5 OCT 2009, DOI: 10.1111/j.1742-4658.2009.07343.x

  6. Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe

    Human Mutation

    Volume 33, Issue 7, July 2012, Pages: 1087–1098, Justin P. Rubio, Simon Topp, Liling Warren, Pamela L. St. Jean, Daniel Wegmann, Darren Kessner, John Novembre, Judong Shen, Dana Fraser, Jennifer Aponte, Keith Nangle, Lon R. Cardon, Margaret G. Ehm, Stephanie L. Chissoe, John C. Whittaker, Matthew R. Nelson and Vincent E. Mooser

    Article first published online : 4 APR 2012, DOI: 10.1002/humu.22075

  7. Prediction of the Repeat Domain Structures and Impact of Parkinsonism-Associated Variations on Structure and Function of all Functional Domains of Leucine-Rich Repeat Kinase 2 (LRRK2)

    Human Mutation

    Volume 35, Issue 4, April 2014, Pages: 395–412, Ryan D. Mills, Terrence D. Mulhern, Fei Liu, Janetta G. Culvenor and Heung-Chin Cheng

    Article first published online : 24 FEB 2014, DOI: 10.1002/humu.22515

  8. Motor and nonmotor heterogeneity of LRRK2-related and idiopathic Parkinson's disease

    Movement Disorders

    Connie Marras, Roy N. Alcalay, Chelsea Caspell-Garcia, Christopher Coffey, Piu Chan, John E. Duda, Maurizio F. Facheris, Rubén Fernández-Santiago, Javier Ruíz-Martínez, Tiago Mestre, Rachel Saunders-Pullman, Claustre Pont-Sunyer, Eduardo Tolosa, Bjorg Waro and the LRRK2 Cohort Consortium

    Article first published online : 19 APR 2016, DOI: 10.1002/mds.26614

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    Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

    Journal of Neurochemistry

    Volume 122, Issue 3, August 2012, Pages: 650–658, Jingwen Niu, Mei Yu, Chunyan Wang and Zhiheng Xu

    Article first published online : 22 JUN 2012, DOI: 10.1111/j.1471-4159.2012.07809.x

  10. You have full text access to this OnlineOpen article
    Novel recruitment strategy to enrich for LRRK2 mutation carriers

    Molecular Genetics & Genomic Medicine

    Volume 3, Issue 5, September 2015, Pages: 404–412, Tatiana Foroud, Danielle Smith, Jacqueline Jackson, Jennifer Verbrugge, Cheryl Halter, Leah Wetherill, Katherine Sims, Winnie Xin, Vanessa Arnedo, Shirley Lasch, Kenneth Marek and the Parkinson's Progression Markers Initiative

    Article first published online : 6 MAY 2015, DOI: 10.1002/mgg3.151

  11. Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications

    Movement Disorders

    Volume 26, Issue 8, July 2011, Pages: 1386–1397, Zhenyu Yue and M. Lenard Lachenmayer

    Article first published online : 29 APR 2011, DOI: 10.1002/mds.23737

  12. Striatal leucine-rich repeat kinase 2 mRNA is increased in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned common marmosets (Callithrix jacchus) with l-3, 4-dihydroxyphenylalanine methyl ester-induced dyskinesia

    European Journal of Neuroscience

    Volume 26, Issue 1, July 2007, Pages: 171–177, M. J. Hurley, P. H. Patel, M. J. Jackson, L. A. Smith, S. Rose and P. Jenner

    Article first published online : 3 JUL 2007, DOI: 10.1111/j.1460-9568.2007.05638.x

  13. You have free access to this content
    Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

    Journal of Neurochemistry

    Volume 111, Issue 3, November 2009, Pages: 703–715, Christian L. Klein, Giorgio Rovelli, Wolfdieter Springer, Christoph Schall, Thomas Gasser and Philipp J. Kahle

    Article first published online : 27 AUG 2009, DOI: 10.1111/j.1471-4159.2009.06358.x

  14. Cerebrospinal fluid biomarkers and clinical features in leucine-rich repeat kinase 2 (LRRK2) mutation carriers

    Movement Disorders

    Dolores Vilas, Leslie M. Shaw, Peggy Taylor, Daniela Berg, Kathrin Brockmann, Jan Aasly, Connie Marras, Claustre Pont-Sunyer, José Ríos, Ken Marek and Eduardo Tolosa

    Article first published online : 4 APR 2016, DOI: 10.1002/mds.26591

  15. Disclosure of research results in genetic studies of Parkinson's disease caused by LRRK2 mutations

    Movement Disorders

    Volume 30, Issue 7, June 2015, Pages: 904–908, Claustre Pont-Sunyer, Susan Bressman, Deborah Raymond, Amanda Glickman, Eduardo Tolosa and Rachel Saunders-Pullman

    Article first published online : 7 MAY 2015, DOI: 10.1002/mds.26250

  16. LRRK2 haplotype-sharing analysis in Parkinson's disease reveals a novel p.S1761R mutation

    Movement Disorders

    Volume 27, Issue 1, January 2012, Pages: 146–150, Oswaldo Lorenzo-Betancor, Lluís Samaranch, Mario Ezquerra, Eduardo Tolosa, Elena Lorenzo, Jaione Irigoyen, Carles Gaig, María A. Pastor, Alexandra I. Soto-Ortolaza, Owen A. Ross, María C. Rodríguez-Oroz, Francesc Valldeoriola, María J. Martí, María R. Luquin, Jordi Perez-Tur, Juan A. Burguera, José A. Obeso and Pau Pastor

    Article first published online : 28 OCT 2011, DOI: 10.1002/mds.23968

  17. You have free access to this content
    LRRK2 pathobiology in Parkinson's disease

    Journal of Neurochemistry

    Volume 131, Issue 5, December 2014, Pages: 554–565, Ian Martin, Jungwoo Wren Kim, Valina L. Dawson and Ted M. Dawson

    Article first published online : 10 OCT 2014, DOI: 10.1111/jnc.12949

  18. You have free access to this content
    Differential protein–protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

    Journal of Neurochemistry

    Volume 131, Issue 2, October 2014, Pages: 239–250, Lauran Reyniers, Maria Grazia Del Giudice, Laura Civiero, Elisa Belluzzi, Evy Lobbestael, Alexandra Beilina, Giorgio Arrigoni, Rita Derua, Etienne Waelkens, Yan Li, Claudia Crosio, Ciro Iaccarino, Mark R. Cookson, Veerle Baekelandt, Elisa Greggio and Jean-Marc Taymans

    Article first published online : 14 JUL 2014, DOI: 10.1111/jnc.12798

  19. You have free access to this content
    LRRK2 gene variation and its contribution to Parkinson disease

    Human Mutation

    Volume 30, Issue 8, August 2009, Pages: 1153–1160, Coro Paisán-Ruiz

    Article first published online : 21 APR 2009, DOI: 10.1002/humu.21038

  20. Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers

    Movement Disorders

    Nicolas Dzamko, Dominic B. Rowe and Glenda M. Halliday

    Article first published online : 25 FEB 2016, DOI: 10.1002/mds.26529