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There are 3977 results for: content related to: Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications

  1. You have full text access to this OnlineOpen article
    Cellular processes associated with LRRK2 function and dysfunction

    The FEBS Journal

    Volume 282, Issue 15, August 2015, Pages: 2806–2826, Rebecca Wallings, Claudia Manzoni and Rina Bandopadhyay

    Version of Record online : 9 MAY 2015, DOI: 10.1111/febs.13305

  2. Prediction of the Repeat Domain Structures and Impact of Parkinsonism-Associated Variations on Structure and Function of all Functional Domains of Leucine-Rich Repeat Kinase 2 (LRRK2)

    Human Mutation

    Volume 35, Issue 4, April 2014, Pages: 395–412, Ryan D. Mills, Terrence D. Mulhern, Fei Liu, Janetta G. Culvenor and Heung-Chin Cheng

    Version of Record online : 24 FEB 2014, DOI: 10.1002/humu.22515

  3. You have free access to this content
    LRRK2 pathobiology in Parkinson's disease

    Journal of Neurochemistry

    Volume 131, Issue 5, December 2014, Pages: 554–565, Ian Martin, Jungwoo Wren Kim, Valina L. Dawson and Ted M. Dawson

    Version of Record online : 10 OCT 2014, DOI: 10.1111/jnc.12949

  4. You have free access to this content
    Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER–Golgi export

    The EMBO Journal

    Volume 33, Issue 20, 16 October 2014, Pages: 2314–2331, Hyun Jin Cho, Jia Yu, Chengsong Xie, Parvathi Rudrabhatla, Xi Chen, Junbing Wu, Loukia Parisiadou, Guoxiang Liu, Lixin Sun, Bo Ma, Jinhui Ding, Zhihua Liu and Huaibin Cai

    Version of Record online : 8 SEP 2014, DOI: 10.15252/embj.201487807

  5. You have free access to this content
    Differential protein–protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

    Journal of Neurochemistry

    Volume 131, Issue 2, October 2014, Pages: 239–250, Lauran Reyniers, Maria Grazia Del Giudice, Laura Civiero, Elisa Belluzzi, Evy Lobbestael, Alexandra Beilina, Giorgio Arrigoni, Rita Derua, Etienne Waelkens, Yan Li, Claudia Crosio, Ciro Iaccarino, Mark R. Cookson, Veerle Baekelandt, Elisa Greggio and Jean-Marc Taymans

    Version of Record online : 14 JUL 2014, DOI: 10.1111/jnc.12798

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    Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

    Journal of Neurochemistry

    Volume 122, Issue 3, August 2012, Pages: 650–658, Jingwen Niu, Mei Yu, Chunyan Wang and Zhiheng Xu

    Version of Record online : 22 JUN 2012, DOI: 10.1111/j.1471-4159.2012.07809.x

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    Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β

    The FEBS Journal

    Volume 281, Issue 1, January 2014, Pages: 3–13, Fumitaka Kawakami, Naoki Shimada, Etsuro Ohta, Go Kagiya, Rei Kawashima, Tatsunori Maekawa, Hiroko Maruyama and Takafumi Ichikawa

    Version of Record online : 28 NOV 2013, DOI: 10.1111/febs.12579

  8. You have full text access to this OnlineOpen article
    Ten Years and Counting: Moving Leucine-Rich RepeatKinase 2 Inhibitors to the Clinic

    Movement Disorders

    Volume 30, Issue 2, February 2015, Pages: 180–189, Andrew B. West

    Version of Record online : 1 DEC 2014, DOI: 10.1002/mds.26075

  9. You have free access to this content
    LRRK2 in Parkinson’s disease: function in cells and neurodegeneration

    The FEBS Journal

    Volume 276, Issue 22, November 2009, Pages: 6436–6444, Philip J. Webber and Andrew B. West

    Version of Record online : 5 OCT 2009, DOI: 10.1111/j.1742-4658.2009.07342.x

  10. LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation

    Journal of Neuroscience Research

    Volume 94, Issue 8, August 2016, Pages: 717–735, Shubhangi Prabhudesai, Fatima Zahra Bensabeur, Rashed Abdullah, Indranil Basak, Solange Baez, Guido Alves, Nathalia G. Holtzman, Jan Petter Larsen and Simon Geir Møller

    Version of Record online : 5 JUN 2016, DOI: 10.1002/jnr.23754

  11. You have free access to this content
    Investigation of leucine-rich repeat kinase 2

    The FEBS Journal

    Volume 276, Issue 2, January 2009, Pages: 466–478, Vasanti S. Anand, Laurie J. Reichling, Kerri Lipinski, Wayne Stochaj, Weili Duan, Kerry Kelleher, Pooja Pungaliya, Eugene L. Brown, Peter H. Reinhart, Richard Somberg, Warren D. Hirst, Steven M. Riddle and Steven P. Braithwaite

    Version of Record online : 8 DEC 2008, DOI: 10.1111/j.1742-4658.2008.06789.x

  12. Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2

    Journal of Neuroscience Research

    Volume 93, Issue 10, October 2015, Pages: 1567–1580, Matthew Hamm, Rachel Bailey, Gerry Shaw, Shu-Hui Yen, Jada Lewis and Benoit I. Giasson

    Version of Record online : 30 JUN 2015, DOI: 10.1002/jnr.23614

  13. Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

    Journal of Comparative Neurology

    Volume 522, Issue 11, 01 August 2014, Pages: 2465–2480, Andrew B. West, Rita M. Cowell, João P.L. Daher, Mark S. Moehle, Kelly M. Hinkle, Heather L. Melrose, David G. Standaert and Laura A. Volpicelli-Daley

    Version of Record online : 12 APR 2014, DOI: 10.1002/cne.23583

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    Leucine-rich repeat kinase 2 (LRRK2): A key player in the pathogenesis of Parkinson's disease

    Journal of Neuroscience Research

    Volume 87, Issue 6, 1 May 2009, Pages: 1283–1295, Payal N. Gandhi, Shu G. Chen and Amy L. Wilson-Delfosse

    Version of Record online : 21 NOV 2008, DOI: 10.1002/jnr.21949

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    MKK6 binds and regulates expression of Parkinson’s disease-related protein LRRK2

    Journal of Neurochemistry

    Volume 112, Issue 6, March 2010, Pages: 1593–1604, Cindy H. Hsu, Diane Chan, Elisa Greggio, Shamol Saha, Maria D. Guillily, Andrew Ferree, Kesav Raghavan, Grace C. Shen, Lilach Segal, Hoon Ryu, Mark R. Cookson and Benjamin Wolozin

    Version of Record online : 7 JAN 2010, DOI: 10.1111/j.1471-4159.2010.06568.x

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    LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles

    The FEBS Journal

    Volume 276, Issue 22, November 2009, Pages: 6445–6454, Zhenyu Yue

    Version of Record online : 5 OCT 2009, DOI: 10.1111/j.1742-4658.2009.07343.x

  17. You have free access to this content
    Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

    Journal of Neurochemistry

    Volume 111, Issue 3, November 2009, Pages: 703–715, Christian L. Klein, Giorgio Rovelli, Wolfdieter Springer, Christoph Schall, Thomas Gasser and Philipp J. Kahle

    Version of Record online : 27 AUG 2009, DOI: 10.1111/j.1471-4159.2009.06358.x

  18. You have free access to this content
    Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1

    Journal of Neurochemistry

    Volume 128, Issue 4, February 2014, Pages: 561–576, Gregory C. Luerman, Chuong Nguyen, Harry Samaroo, Paula Loos, Hualin Xi, Andres Hurtado-Lorenzo, Elie Needle, G. Stephen Noell, Paul Galatsis, John Dunlop, Kieran F. Geoghegan and Warren D. Hirst

    Version of Record online : 11 NOV 2013, DOI: 10.1111/jnc.12483

  19. You have free access to this content
    LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: Impairment of the kinase activity by Parkinson's disease-associated mutations

    FEBS Letters

    Volume 585, Issue 14, July 21, 2011, Pages: 2165–2170, Etsuro Ohta, Fumitaka Kawakami, Makoto Kubo and Fumiya Obata

    Version of Record online : 2 JUN 2011, DOI: 10.1016/j.febslet.2011.05.044

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    Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson’s disease mutations and LRRK2 pharmacological inhibition

    Journal of Neurochemistry

    Volume 120, Issue 1, January 2012, Pages: 37–45, Elizabeth A. Doggett, Jing Zhao, Christina N. Mork, Dongmei Hu and R. Jeremy Nichols

    Version of Record online : 11 NOV 2011, DOI: 10.1111/j.1471-4159.2011.07537.x