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There are 810771 results for: content related to: Patient-control association study of the Leucine-Rich repeat kinase 2 (LRRK2) gene in South African Parkinson's disease patients

  1. You have free access to this content
    Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β

    The FEBS Journal

    Volume 281, Issue 1, January 2014, Pages: 3–13, Fumitaka Kawakami, Naoki Shimada, Etsuro Ohta, Go Kagiya, Rei Kawashima, Tatsunori Maekawa, Hiroko Maruyama and Takafumi Ichikawa

    Article first published online : 28 NOV 2013, DOI: 10.1111/febs.12579

  2. You have free access to this content
    Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1

    Journal of Neurochemistry

    Volume 128, Issue 4, February 2014, Pages: 561–576, Gregory C. Luerman, Chuong Nguyen, Harry Samaroo, Paula Loos, Hualin Xi, Andres Hurtado-Lorenzo, Elie Needle, G. Stephen Noell, Paul Galatsis, John Dunlop, Kieran F. Geoghegan and Warren D. Hirst

    Article first published online : 11 NOV 2013, DOI: 10.1111/jnc.12483

  3. Prediction of the Repeat Domain Structures and Impact of Parkinsonism-Associated Variations on Structure and Function of all Functional Domains of Leucine-Rich Repeat Kinase 2 (LRRK2)

    Human Mutation

    Volume 35, Issue 4, April 2014, Pages: 395–412, Ryan D. Mills, Terrence D. Mulhern, Fei Liu, Janetta G. Culvenor and Heung-Chin Cheng

    Article first published online : 24 FEB 2014, DOI: 10.1002/humu.22515

  4. You have full text access to this OnlineOpen article
    Cellular processes associated with LRRK2 function and dysfunction

    The FEBS Journal

    Volume 282, Issue 15, August 2015, Pages: 2806–2826, Rebecca Wallings, Claudia Manzoni and Rina Bandopadhyay

    Article first published online : 9 MAY 2015, DOI: 10.1111/febs.13305

  5. You have free access to this content
    LRRK2 pathobiology in Parkinson's disease

    Journal of Neurochemistry

    Volume 131, Issue 5, December 2014, Pages: 554–565, Ian Martin, Jungwoo Wren Kim, Valina L. Dawson and Ted M. Dawson

    Article first published online : 10 OCT 2014, DOI: 10.1111/jnc.12949

  6. Parkinson disease phenotype in Ashkenazi jews with and without LRRK2 G2019S mutations

    Movement Disorders

    Volume 28, Issue 14, December 2013, Pages: 1966–1971, Roy N. Alcalay, Anat Mirelman, Rachel Saunders-Pullman, Ming-X Tang, Helen Mejia Santana, Deborah Raymond, Ernest Roos, Martha Orbe-Reilly, Tanya Gurevich, Anat Bar Shira, Mali Gana Weisz, Kira Yasinovsky, Maayan Zalis, Avner Thaler, Andres Deik, Matthew James Barrett, Jose Cabassa, Mark Groves, Ann L. Hunt, Naomi Lubarr, Marta San Luciano, Joan Miravite, Christina Palmese, Rivka Sachdev, Harini Sarva, Lawrence Severt, Vicki Shanker, Matthew Carrington Swan, Jeannie Soto-Valencia, Brooke Johannes, Robert Ortega, Stanley Fahn, Lucien Cote, Cheryl Waters, Pietro Mazzoni, Blair Ford, Elan Louis, Oren Levy, Llency Rosado, Diana Ruiz, Tsvyatko Dorovski, Michael Pauciulo, William Nichols, Avi Orr-Urtreger, Laurie Ozelius, Lorraine Clark, Nir Giladi, Susan Bressman and Karen S. Marder

    Article first published online : 15 OCT 2013, DOI: 10.1002/mds.25647

  7. Evidence that the LRRK2 ROC domain Parkinson's disease-associated mutants A1442P and R1441C exhibit increased intracellular degradation

    Journal of Neuroscience Research

    Volume 92, Issue 4, April 2014, Pages: 506–516, Izabella D. Greene, Francis Mastaglia, Bruno P. Meloni, Kristin A. West, Joanne Chieng, Chris J. Mitchell, Wei-Ping Gai and Sherif Boulos

    Article first published online : 24 DEC 2013, DOI: 10.1002/jnr.23331

  8. You have full text access to this OnlineOpen article
    Ten Years and Counting: Moving Leucine-Rich RepeatKinase 2 Inhibitors to the Clinic

    Movement Disorders

    Volume 30, Issue 2, February 2015, Pages: 180–189, Andrew B. West

    Article first published online : 1 DEC 2014, DOI: 10.1002/mds.26075

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    Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER–Golgi export

    The EMBO Journal

    Volume 33, Issue 20, 16 October 2014, Pages: 2314–2331, Hyun Jin Cho, Jia Yu, Chengsong Xie, Parvathi Rudrabhatla, Xi Chen, Junbing Wu, Loukia Parisiadou, Guoxiang Liu, Lixin Sun, Bo Ma, Jinhui Ding, Zhihua Liu and Huaibin Cai

    Article first published online : 8 SEP 2014, DOI: 10.15252/embj.201487807

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    Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

    Journal of Neurochemistry

    Volume 122, Issue 3, August 2012, Pages: 650–658, Jingwen Niu, Mei Yu, Chunyan Wang and Zhiheng Xu

    Article first published online : 22 JUN 2012, DOI: 10.1111/j.1471-4159.2012.07809.x

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    Differential protein–protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

    Journal of Neurochemistry

    Volume 131, Issue 2, October 2014, Pages: 239–250, Lauran Reyniers, Maria Grazia Del Giudice, Laura Civiero, Elisa Belluzzi, Evy Lobbestael, Alexandra Beilina, Giorgio Arrigoni, Rita Derua, Etienne Waelkens, Yan Li, Claudia Crosio, Ciro Iaccarino, Mark R. Cookson, Veerle Baekelandt, Elisa Greggio and Jean-Marc Taymans

    Article first published online : 14 JUL 2014, DOI: 10.1111/jnc.12798

  12. Pathogenic LRRK2 mutations in nuclear ageing—A new organelle to study in Parkinson's disease

    Movement Disorders

    Volume 28, Issue 10, September 2013, Pages: 1344–1345, John McKinley, Alan McCarthy and Timothy Lynch

    Article first published online : 23 SEP 2013, DOI: 10.1002/mds.25595

  13. Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2

    Journal of Neuroscience Research

    Volume 93, Issue 10, October 2015, Pages: 1567–1580, Matthew Hamm, Rachel Bailey, Gerry Shaw, Shu-Hui Yen, Jada Lewis and Benoit I. Giasson

    Article first published online : 30 JUN 2015, DOI: 10.1002/jnr.23614

  14. Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

    Journal of Comparative Neurology

    Volume 522, Issue 11, 01 August 2014, Pages: 2465–2480, Andrew B. West, Rita M. Cowell, João P.L. Daher, Mark S. Moehle, Kelly M. Hinkle, Heather L. Melrose, David G. Standaert and Laura A. Volpicelli-Daley

    Article first published online : 12 APR 2014, DOI: 10.1002/cne.23583

  15. Prevalence of cancer in Parkinson's disease related to R1441G and G2019S mutations in LRRK2

    Movement Disorders

    Volume 29, Issue 6, May 2014, Pages: 750–755, Javier Ruiz-Martínez, Patricia de la Riva, Maria C. Rodríguez-Oroz, Elisabet Mondragón Rezola, Alberto Bergareche, Ana Gorostidi, Belen Gago, Ainara Estanga, Nerea Larrañaga, Cristina Sarasqueta, Adolfo López de Munain and José F. Martí Massó

    Article first published online : 19 DEC 2013, DOI: 10.1002/mds.25778

  16. Fall risk and gait in Parkinson's disease: The role of the LRRK2 G2019S mutation

    Movement Disorders

    Volume 28, Issue 12, October 2013, Pages: 1683–1690, Anat Mirelman, Talia Heman, Kira Yasinovsky, Avner Thaler, Tanya Gurevich, Karen Marder, Susan Bressman, Anat Bar-Shira, Avi Orr-Urtreger, Nir Giladi, Jeffrey M. Hausdorff and on behalf of the LRRK2 Ashkenazi Jewish Consortium

    Article first published online : 7 OCT 2013, DOI: 10.1002/mds.25587

  17. You have full text access to this Open Access content
    Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease

    EMBO Molecular Medicine

    Volume 4, Issue 5, May 2012, Pages: 380–395, Adriana Sánchez-Danés, Yvonne Richaud-Patin, Iria Carballo-Carbajal, Senda Jiménez-Delgado, Carles Caig, Sergio Mora, Claudia Di Guglielmo, Mario Ezquerra, Bindiben Patel, Albert Giralt, Josep M. Canals, Maurizio Memo, Jordi Alberch, José López-Barneo, Miquel Vila, Ana Maria Cuervo, Eduard Tolosa, Antonella Consiglio and Angel Raya

    Article first published online : 8 MAR 2012, DOI: 10.1002/emmm.201200215

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    LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles

    The FEBS Journal

    Volume 276, Issue 22, November 2009, Pages: 6445–6454, Zhenyu Yue

    Article first published online : 5 OCT 2009, DOI: 10.1111/j.1742-4658.2009.07343.x

  19. Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe

    Human Mutation

    Volume 33, Issue 7, July 2012, Pages: 1087–1098, Justin P. Rubio, Simon Topp, Liling Warren, Pamela L. St. Jean, Daniel Wegmann, Darren Kessner, John Novembre, Judong Shen, Dana Fraser, Jennifer Aponte, Keith Nangle, Lon R. Cardon, Margaret G. Ehm, Stephanie L. Chissoe, John C. Whittaker, Matthew R. Nelson and Vincent E. Mooser

    Article first published online : 4 APR 2012, DOI: 10.1002/humu.22075

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    Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

    Journal of Neurochemistry

    Volume 111, Issue 3, November 2009, Pages: 703–715, Christian L. Klein, Giorgio Rovelli, Wolfdieter Springer, Christoph Schall, Thomas Gasser and Philipp J. Kahle

    Article first published online : 27 AUG 2009, DOI: 10.1111/j.1471-4159.2009.06358.x