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There are 8425 results for: content related to: Asparaginyl endopeptidase cleaves TDP-43 in brain

  1. Review: Transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration

    Neuropathology and Applied Neurobiology

    Volume 36, Issue 2, April 2010, Pages: 97–112, T. F. Gendron, K. A. Josephs and L. Petrucelli

    Version of Record online : 23 MAR 2010, DOI: 10.1111/j.1365-2990.2010.01060.x

  2. RNA-binding proteins in neurodegenerative disease: TDP-43 and beyond

    Wiley Interdisciplinary Reviews: RNA

    Volume 3, Issue 2, March/April 2012, Pages: 265–285, Keith A. Hanson, Sang Hwa Kim and Randal S. Tibbetts

    Version of Record online : 25 OCT 2011, DOI: 10.1002/wrna.111

  3. You have free access to this content
    TDP-43 loss of function increases TFEB activity and blocks autophagosome–lysosome fusion

    The EMBO Journal

    Volume 35, Issue 2, 18 January 2016, Pages: 121–142, Qin Xia, Hongfeng Wang, Zongbing Hao, Cheng Fu, Qingsong Hu, Feng Gao, Haigang Ren, Dong Chen, Junhai Han, Zheng Ying and Guanghui Wang

    Version of Record online : 23 DEC 2015, DOI: 10.15252/embj.201591998

  4. Detection of TDP-43 oligomers in frontotemporal lobar degeneration–TDP

    Annals of Neurology

    Volume 78, Issue 2, August 2015, Pages: 211–221, Patricia F. Kao, Yun-Ru Chen, Xiao-Bo Liu, Charles DeCarli, William W. Seeley and Lee-Way Jin

    Version of Record online : 30 JUN 2015, DOI: 10.1002/ana.24431

  5. You have full text access to this OnlineOpen article
    Spliceosome integrity is defective in the motor neuron diseases ALS and SMA

    EMBO Molecular Medicine

    Volume 5, Issue 2, February 2013, Pages: 221–234, Hitomi Tsuiji, Yohei Iguchi, Asako Furuya, Ayane Kataoka, Hiroyuki Hatsuta, Naoki Atsuta, Fumiaki Tanaka, Yoshio Hashizume, Hiroyasu Akatsu, Shigeo Murayama, Gen Sobue and Koji Yamanaka

    Version of Record online : 25 JAN 2013, DOI: 10.1002/emmm.201202303

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    TDP-43: the relationship between protein aggregation and neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

    The FEBS Journal

    Volume 278, Issue 19, October 2011, Pages: 3539–3549, Robert H. Baloh

    Version of Record online : 24 AUG 2011, DOI: 10.1111/j.1742-4658.2011.08256.x

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    What is the key player in TDP-43 pathology in ALS: Disappearance from the nucleus or inclusion formation in the cytoplasm?

    Neurology and Clinical Neuroscience

    Volume 1, Issue 1, January 2013, Pages: 11–17, Osamu Onodera, Akihiro Sugai, Takuya Konno, Mari Tada, Akihide Koyama and Masatoyo Nishizawa

    Version of Record online : 31 JAN 2013, DOI: 10.1002/ncn3.9

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    Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

    The EMBO Journal

    Volume 31, Issue 5, March 7, 2012, Pages: 1241–1252, Todd J Cohen, Andrew W Hwang, Travis Unger, John Q Trojanowski and Virginia M Y Lee

    Version of Record online : 23 DEC 2011, DOI: 10.1038/emboj.2011.471

  9. CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration

    Annals of Neurology

    Volume 74, Issue 1, July 2013, Pages: 39–52, Nicole F. Liachko, Pamela J. McMillan, Chris R. Guthrie, Thomas D. Bird, James B. Leverenz and Brian C. Kraemer

    Version of Record online : 8 JUL 2013, DOI: 10.1002/ana.23870

  10. Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy

    Neuropathology

    Volume 30, Issue 2, April 2010, Pages: 170–181, Tetsuaki Arai, Masato Hasegawa, Takashi Nonoka, Fuyuki Kametani, Makiko Yamashita, Masato Hosokawa, Kazuhiro Niizato, Kuniaki Tsuchiya, Zen Kobayashi, Kenji Ikeda, Mari Yoshida, Mitsumoto Onaya, Hiroshige Fujishiro and Haruhiko Akiyama

    Version of Record online : 19 JAN 2010, DOI: 10.1111/j.1440-1789.2009.01089.x

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    TDP-43 and FUS/TLS: cellular functions and implications for neurodegeneration

    The FEBS Journal

    Volume 278, Issue 19, October 2011, Pages: 3550–3568, Fabienne C. Fiesel and Philipp J. Kahle

    Version of Record online : 24 AUG 2011, DOI: 10.1111/j.1742-4658.2011.08258.x

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    Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

    The EMBO Journal

    Volume 29, Issue 1, January 6, 2010, Pages: 209–221, Fabienne C Fiesel, Aaron Voigt, Stephanie S Weber, Chris Van den Haute, Andrea Waldenmaier, Karin Görner, Michael Walter, Marlene L Anderson, Jeannine V Kern, Tobias M Rasse, Thorsten Schmidt, Wolfdieter Springer, Roland Kirchner, Michael Bonin, Manuela Neumann, Veerle Baekelandt, Marianna Alunni-Fabbroni, Jörg B Schulz and Philipp J Kahle

    Version of Record online : 12 NOV 2009, DOI: 10.1038/emboj.2009.324

  13. You have full text access to this OnlineOpen article
    Review: Prion-like mechanisms of transactive response DNA binding protein of 43 kDa (TDP-43) in amyotrophic lateral sclerosis (ALS)

    Neuropathology and Applied Neurobiology

    Volume 41, Issue 5, August 2015, Pages: 578–597, Phillip Smethurst, Katie Claire Louise Sidle and John Hardy

    Version of Record online : 20 APR 2015, DOI: 10.1111/nan.12206

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    Significance and limitation of the pathological classification of TDP-43 proteinopathy

    Neuropathology

    Volume 34, Issue 6, December 2014, Pages: 578–588, Tetsuaki Arai

    Version of Record online : 8 SEP 2014, DOI: 10.1111/neup.12138

  15. TAR DNA-binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features

    Annals of Neurology

    Volume 78, Issue 5, November 2015, Pages: 697–709, Keith A. Josephs, Jennifer L. Whitwell, Nirubol Tosakulwong, Stephen D. Weigand, Melissa E. Murray, Amanda M. Liesinger, Leonard Petrucelli, Matthew L. Senjem, Robert J. Ivnik, Joseph E. Parisi, Ronald C. Petersen and Dennis W. Dickson

    Version of Record online : 16 SEP 2015, DOI: 10.1002/ana.24493

  16. Ubiquitinated, p62 immunopositive cerebellar cortical neuronal inclusions are evident across the spectrum of TDP-43 proteinopathies but are only rarely additionally immunopositive for phosphorylation-dependent TDP-43

    Neuropathology

    Volume 31, Issue 3, June 2011, Pages: 239–249, Andrew King, Satomi Maekawa, Istvan Bodi, Claire Troakes and Safa Al-Sarraj

    Version of Record online : 1 DEC 2010, DOI: 10.1111/j.1440-1789.2010.01171.x

  17. Tyrosine kinase inhibition reverses TDP-43 effects on synaptic protein expression, astrocytic function and amino acid dis-homeostasis

    Journal of Neurochemistry

    Volume 139, Issue 4, November 2016, Pages: 610–623, Lanier Heyburn, Michaeline L. Hebron, Jacqueline Smith, Charisse Winston, John Bechara, Zhaoxia Li, Irina Lonskaya, Mark P. Burns, Brent T. Harris and Charbel E.-H. Moussa

    Version of Record online : 27 SEP 2016, DOI: 10.1111/jnc.13763

  18. You have full text access to this OnlineOpen article
    TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons

    The EMBO Journal

    Volume 35, Issue 21, 2 November 2016, Pages: 2350–2370, Benjamin M Schwenk, Hannelore Hartmann, Alperen Serdaroglu, Martin H Schludi, Daniel Hornburg, Felix Meissner, Denise Orozco, Alessio Colombo, Sabina Tahirovic, Meike Michaelsen, Franziska Schreiber, Simone Haupt, Michael Peitz, Oliver Brüstle, Clemens Küpper, Thomas Klopstock, Markus Otto, Albert C Ludolph, Thomas Arzberger, Peer-Hendrik Kuhn and Dieter Edbauer

    Version of Record online : 12 SEP 2016, DOI: 10.15252/embj.201694221

  19. TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease

    Annals of Neurology

    Volume 61, Issue 5, May 2007, Pages: 435–445, Catalina Amador-Ortiz, Wen-Lang Lin, Zeshan Ahmed, David Personett, Peter Davies, Ranjan Duara, Neill R. Graff-Radford, Michael L. Hutton and Dennis W. Dickson

    Version of Record online : 27 APR 2007, DOI: 10.1002/ana.21154

  20. Rodent Models of Amyotrophic Lateral Sclerosis

    Unit

    Current Protocols in Pharmacology

    5:5.67.1–5.67.21

    Thomas Philips and Jeffrey D. Rothstein

    Published Online : 1 JUN 2015, DOI: 10.1002/0471141755.ph0567s69