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There are 23192 results for: content related to: Simulation of the mutation F76del on the von Hippel–Lindau tumor suppressor protein: Mechanism of the disease and implications for drug development

  1. Regulation of E2F1 by the von Hippel–Lindau tumour suppressor protein predicts survival in renal cell cancer patients

    The Journal of Pathology

    Volume 231, Issue 1, September 2013, Pages: 117–129, Dorus A Mans, Joost S Vermaat, Bart G Weijts, Ellen van Rooijen, Jeroen van Reeuwijk, Karsten Boldt, Laura GM Daenen, Petra van der Groep, Benjamin D Rowland, Judith J Jans, Ronald Roepman, Emile E Voest, Paul J van Diest, Marianne C Verhaar, Alain de Bruin and Rachel H Giles

    Version of Record online : 6 AUG 2013, DOI: 10.1002/path.4219

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    The von Hippel–Lindau tumour suppressor interacts with microtubules through kinesin-2

    FEBS Letters

    Volume 581, Issue 24, October 02, 2007, Pages: 4571–4576, Martijn P. Lolkema, Dorus A. Mans, Cristel M. Snijckers, Mascha van Noort, Moniek van Beest, Emile E. Voest and Rachel H. Giles

    Version of Record online : 31 AUG 2007, DOI: 10.1016/j.febslet.2007.08.050

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    Adding structural information to the von Hippel–Lindau (VHL) tumor suppressor interaction network

    FEBS Letters

    Volume 583, Issue 22, November 19, 2009, Pages: 3704–3710, E. Leonardi, A. Murgia and S.C.E. Tosatto

    Version of Record online : 28 OCT 2009, DOI: 10.1016/j.febslet.2009.10.070

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    The multifaceted von Hippel–Lindau tumour suppressor protein

    FEBS Letters

    Volume 588, Issue 16, August 19, 2014, Pages: 2704–2711, Claire M. Robinson and Michael Ohh

    Version of Record online : 25 FEB 2014, DOI: 10.1016/j.febslet.2014.02.026

  5. Effects of point mutations in pVHL on the binding of HIF-1α

    Proteins: Structure, Function, and Bioinformatics

    Volume 80, Issue 3, March 2012, Pages: 733–746, Carmen Domene and Christopher J. R. Illingworth

    Version of Record online : 22 NOV 2011, DOI: 10.1002/prot.23230

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    Knockdown of von Hippel–Lindau protein decreases lung cancer cell proliferation and colonization

    FEBS Letters

    Volume 586, Issue 10, May 21, 2012, Pages: 1510–1515, Qiyuan Zhou, Tianji Chen, Joyce Christina F. Ibe, J. Usha Raj and Guofei Zhou

    Version of Record online : 20 APR 2012, DOI: 10.1016/j.febslet.2012.04.009

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    PKCζII is a target for degradation through the tumour suppressor protein pVHL

    FEBS Letters

    Volume 581, Issue 7, April 03, 2007, Pages: 1397–1402, Xavier Iturrioz and Peter J. Parker

    Version of Record online : 5 MAR 2007, DOI: 10.1016/j.febslet.2007.02.059

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    Identification and In Silico Analysis of Novel von Hippel-Lindau (VHL) Gene Variants from a Large Population

    Annals of Human Genetics

    Volume 75, Issue 4, July 2011, Pages: 483–496, Emanuela Leonardi, Maddalena Martella, Silvio C.E. Tosatto and Alessandra Murgia

    Version of Record online : 4 APR 2011, DOI: 10.1111/j.1469-1809.2011.00647.x

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    Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel—Lindau protein

    The EMBO Journal

    Volume 22, Issue 16, August 15, 2003, Pages: 4249–4259, Xi Na, Hai Ou Duan, Edward M. Messing, Susan R. Schoen, Charlotte K. Ryan, P.Anthony di Sant'Agnese, Erica A. Golemis and Guan Wu

    Version of Record online : 15 AUG 2003, DOI: 10.1093/emboj/cdg410

  10. pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma

    The Journal of Pathology

    Volume 214, Issue 4, March 2008, Pages: 464–471, K Struckmann, KD Mertz, S Steu, M Storz, P Staller, W Krek, P Schraml and H Moch

    Version of Record online : 11 DEC 2007, DOI: 10.1002/path.2310

  11. You have full text access to this OnlineOpen article
    Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice

    EMBO Molecular Medicine

    Volume 5, Issue 6, June 2013, Pages: 949–964, Joachim Albers, Michal Rajski, Désirée Schönenberger, Sabine Harlander, Peter Schraml, Adriana von Teichman, Strahil Georgiev, Peter J. Wild, Holger Moch, Wilhelm Krek and Ian J. Frew

    Version of Record online : 22 APR 2013, DOI: 10.1002/emmm.201202231

  12. The protein tyrosine phosphatase receptor type J is regulated by the pVHL–HIF axis in clear cell renal cell carcinoma

    The Journal of Pathology

    Volume 229, Issue 4, March 2013, Pages: 525–534, Silvia Casagrande, Melanie Ruf, Markus Rechsteiner, Laura Morra, Sonja Brun-Schmid, Adriana von Teichman, Wilhelm Krek, Peter Schraml and Holger Moch

    Version of Record online : 21 JAN 2013, DOI: 10.1002/path.4107

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    Ternary complex formation of pVHL, elongin B and elongin C visualized in living cells by a fluorescence resonance energy transfer–fluorescence lifetime imaging microscopy technique

    The FEBS Journal

    Volume 274, Issue 21, November 2007, Pages: 5567–5575, Koshi Kinoshita, Kenji Goryo, Mamiko Takada, Yosuke Tomokuni, Teijiro Aso, Heiwa Okuda, Taro Shuin, Hiroshi Fukumura and Kazuhiro Sogawa

    Version of Record online : 8 OCT 2007, DOI: 10.1111/j.1742-4658.2007.06075.x

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    The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1α transcriptional activity

    The EMBO Journal

    Volume 22, Issue 8, April 15, 2003, Pages: 1857–1867, Zaibo Li, Dakun Wang, Xi Na, Susan R. Schoen, Edward M. Messing and Guan Wu

    Version of Record online : 15 APR 2003, DOI: 10.1093/emboj/cdg173

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    In silico investigation of PHD-3 specific HIF1-α proline 567 hydroxylation: A new player in the VHL/HIF-1α interaction pathway?

    FEBS Letters

    Volume 587, Issue 18, September 17, 2013, Pages: 2996–3001, Giovanni Minervini, Alessandro Masiero, Stefano Moro and Silvio C.E. Tosatto

    Version of Record online : 22 JUL 2013, DOI: 10.1016/j.febslet.2013.07.019

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    von Hippel-Lindau tumor suppressor protein stimulation by thrombin involves RhoA activation

    International Journal of Cancer

    Volume 112, Issue 5, 10 December 2004, Pages: 777–786, Sandra Turcotte, Richard R. Desrosiers, Geneviève Brand and Richard Béliveau

    Version of Record online : 15 JUL 2004, DOI: 10.1002/ijc.20468

  17. You have full text access to this OnlineOpen article
    Clinical and functional properties of novel VHL mutation (X214L) consistent with Type 2A phenotype and low risk of renal cell carcinoma

    Clinical Genetics

    Volume 79, Issue 6, June 2011, Pages: 539–545, AD Sorrell, S Lee, C Stolle, J Ellenhorn, A Grix, WG Kaelin Jr and JN Weitzel

    Version of Record online : 13 MAY 2010, DOI: 10.1111/j.1399-0004.2010.01464.x

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    Failure to prolyl hydroxylate hypoxia-inducible factor α phenocopies VHL inactivation in vivo

    The EMBO Journal

    Volume 25, Issue 19, October 4, 2006, Pages: 4650–4662, William Y Kim, Michal Safran, Marshall RM Buckley, Benjamin L Ebert, Jonathan Glickman, Marcus Bosenberg, Meredith Regan and William G Kaelin Jr

    Version of Record online : 14 SEP 2006, DOI: 10.1038/sj.emboj.7601300

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    Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL

    Journal of Cellular and Molecular Medicine

    Volume 15, Issue 2, February 2011, Pages: 187–195, Mingqing Li and William Y. Kim

    Version of Record online : 24 FEB 2011, DOI: 10.1111/j.1582-4934.2010.01238.x

  20. VHL and HIF signalling in renal cell carcinogenesis

    The Journal of Pathology

    Volume 221, Issue 2, June 2010, Pages: 125–138, Marcella M Baldewijns, Iris JH van Vlodrop, Peter B Vermeulen, Patricia MMB Soetekouw, Manon van Engeland and Adriaan P de Bruïne

    Version of Record online : 19 JAN 2010, DOI: 10.1002/path.2689