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There are 34330 results for: content related to: Application of optimal design methodologies in clinical pharmacology experiments

  1. You have free access to this content
    Methods and software tools for design evaluation in population pharmacokinetics–pharmacodynamics studies

    British Journal of Clinical Pharmacology

    Volume 79, Issue 1, January 2015, Pages: 6–17, Joakim Nyberg, Caroline Bazzoli, Kay Ogungbenro, Alexander Aliev, Sergei Leonov, Stephen Duffull, Andrew C. Hooker and France Mentré

    Version of Record online : 19 DEC 2014, DOI: 10.1111/bcp.12352

  2. Optimal design in pediatric pharmacokinetic and pharmacodynamic clinical studies

    Pediatric Anesthesia

    Volume 25, Issue 3, March 2015, Pages: 222–230, Jessica K. Roberts, Chris Stockmann, Alfred Balch, Tian Yu, Robert M. Ward, Michael G. Spigarelli and Catherine M. T. Sherwin

    Version of Record online : 9 JAN 2015, DOI: 10.1111/pan.12575

  3. Optimum blood sampling time windows for parameter estimation in population pharmacokinetic experiments

    Statistics in Medicine

    Volume 25, Issue 23, 15 December 2006, Pages: 4004–4019, Gordon Graham and Leon Aarons

    Version of Record online : 3 FEB 2006, DOI: 10.1002/sim.2512

  4. A general method to determine sampling windows for nonlinear mixed effects models with an application to population pharmacokinetic studies

    Pharmaceutical Statistics

    Volume 11, Issue 4, July/August 2012, Pages: 325–333, Lee Kien Foo, James McGree and Stephen Duffull

    Version of Record online : 12 MAR 2012, DOI: 10.1002/pst.1509

  5. Design optimisation for pharmacokinetic modeling of a cocktail of phenotyping drugs

    Pharmaceutical Statistics

    Volume 15, Issue 2, March/April 2016, Pages: 165–177, Thu Thuy Nguyen, Henri Bénech, Marcel Delaforge and Natacha Lenuzza

    Version of Record online : 22 DEC 2015, DOI: 10.1002/pst.1731

  6. You have full text access to this OnlineOpen article
    Current Use and Developments Needed for Optimal Design in Pharmacometrics: A Study Performed Among DDMoRe's European Federation of Pharmaceutical Industries and Associations Members

    CPT: Pharmacometrics & Systems Pharmacology

    Volume 2, Issue 6, June 2013, Pages: 1–2, F Mentré, M Chenel, E Comets, J Grevel, A Hooker, MO Karlsson, M Lavielle and I Gueorguieva

    Version of Record online : 5 JUN 2013, DOI: 10.1038/psp.2013.19

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    Optimal sampling of antipsychotic medicines: a pharmacometric approach for clinical practice

    British Journal of Clinical Pharmacology

    Volume 78, Issue 4, October 2014, Pages: 800–814, Vidya Perera, Robert R. Bies, Gary Mo, Michael J. Dolton, Vaughan J. Carr, Andrew J. McLachlan, Richard O. Day, Thomas M. Polasek and Alan Forrest

    Version of Record online : 19 SEP 2014, DOI: 10.1111/bcp.12410

  8. Application of the Optimal Design Approach to Improve a Pretransplant Drug Dose Finding Design for Ciclosporin

    The Journal of Clinical Pharmacology

    Volume 52, Issue 3, March 2012, Pages: 347–360, Dr Stefanie Hennig, Mr Joakim Nyberg, Dr Samuel Fanta, Dr Janne T. Backman, Dr Kalle Hoppu, Dr Andrew C. Hooker and Dr Mats O. Karlsson

    Version of Record online : 7 MAR 2013, DOI: 10.1177/0091270010397731

  9. You have free access to this content
    Optimal Design of Pharmacokinetic Studies

    Basic & Clinical Pharmacology & Toxicology

    Volume 106, Issue 3, March 2010, Pages: 250–255, Leon Aarons and Kayode Ogungbenro

    Version of Record online : 20 JAN 2010, DOI: 10.1111/j.1742-7843.2009.00533.x

  10. Fisher information matrix for nonlinear mixed effects multiple response models: Evaluation of the appropriateness of the first order linearization using a pharmacokinetic/pharmacodynamic model

    Statistics in Medicine

    Volume 28, Issue 14, 30 June 2009, Pages: 1940–1956, Caroline Bazzoli, Sylvie Retout and France Mentré

    Version of Record online : 5 MAR 2009, DOI: 10.1002/sim.3573

  11. Design in nonlinear mixed effects models: Optimization using the Fedorov–Wynn algorithm and power of the Wald test for binary covariates

    Statistics in Medicine

    Volume 26, Issue 28, 10 December 2007, Pages: 5162–5179, Sylvie Retout, Emmanuelle Comets, Adeline Samson and France Mentré

    Version of Record online : 8 MAY 2007, DOI: 10.1002/sim.2910

  12. Fisher information matrix for non-linear mixed-effects models: evaluation and application for optimal design of enoxaparin population pharmacokinetics

    Statistics in Medicine

    Volume 21, Issue 18, 30 September 2002, Pages: 2623–2639, Sylvie Retout, France Mentré and René Bruno

    Version of Record online : 12 JUL 2002, DOI: 10.1002/sim.1041

  13. Efficient Algorithms for Optimal Designs with Correlated Observations in Pharmacokinetics and Dose-Finding Studies

    Biometrics

    Volume 68, Issue 1, March 2012, Pages: 138–145, Tim Holland-Letz, Holger Dette and Didier Renard

    Version of Record online : 12 AUG 2011, DOI: 10.1111/j.1541-0420.2011.01657.x

  14. A Simultaneous D-Optimal Designed Study for Population Pharmacokinetic Analyses of Mycophenolic Acid and Tacrolimus Early After Renal Transplantation

    The Journal of Clinical Pharmacology

    Volume 52, Issue 12, December 2012, Pages: 1833–1843, Dr Flora Tshinanu Musuamba, Dr Michel Mourad, Dr Vincent Haufroid, Dr Martine Demeyer, Dr Arnaud Capron, Ms Isabelle K. Delattre, Mr Frederic Delaruelle, Dr Pierre Wallemacq and Dr Roger Karel Verbeeck

    Version of Record online : 7 MAR 2013, DOI: 10.1177/0091270011423661

  15. Optimal design of clinical trials with biologics using dose-time-response models

    Statistics in Medicine

    Volume 33, Issue 30, 30 December 2014, Pages: 5249–5264, Markus R. Lange and Heinz Schmidli

    Version of Record online : 10 SEP 2014, DOI: 10.1002/sim.6299

  16. You have free access to this content
    Population pharmacokinetics and optimal design of paediatric studies for famciclovir

    British Journal of Clinical Pharmacology

    Volume 68, Issue 4, October 2009, Pages: 546–560, Kayode Ogungbenro, Ivan Matthews, Michael Looby, Guenther Kaiser, Gordon Graham and Leon Aarons

    Version of Record online : 26 JUN 2009, DOI: 10.1111/j.1365-2125.2009.03479.x

  17. You have free access to this content
    A d-optimal designed population pharmacokinetic study of oral itraconazole in adult cystic fibrosis patients

    British Journal of Clinical Pharmacology

    Volume 63, Issue 4, April 2007, Pages: 438–450, Stefanie Hennig, Timothy H. Waterhouse, Scott C. Bell, Megan France, Claire E. Wainwright, Hugh Miller, Bruce G. Charles and Stephen B. Duffull

    Version of Record online : 30 OCT 2006, DOI: 10.1111/j.1365-2125.2006.02778.x

  18. Adaptive-Optimal Design in PET Occupancy Studies

    Clinical Pharmacology & Therapeutics

    Volume 87, Issue 5, May 2010, Pages: 563–571, S Zamuner, V L Di Iorio, J Nyberg, R N Gunn, V J Cunningham, R Gomeni and A C Hooker

    Version of Record online : 24 MAR 2010, DOI: 10.1038/clpt.2010.9

  19. Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models

    Statistics in Medicine

    Volume 31, Issue 11-12, 20-30 May 2012, Pages: 1043–1058, Thu Thuy Nguyen, Caroline Bazzoli and France Mentré

    Version of Record online : 3 OCT 2011, DOI: 10.1002/sim.4390

  20. Population pharmacometrics in support of analgesics studies

    Acta Anaesthesiologica Scandinavica

    Volume 58, Issue 2, February 2014, Pages: 143–156, P. VÄLITALO, V.-P. RANTA, A. C. HOOKER, M. KOKKI and H. KOKKI

    Version of Record online : 2 JAN 2014, DOI: 10.1111/aas.12253