Search Results

There are 12072 results for: content related to: Molecular dynamics simulations of the Hras-GTP complex and the Hras-GDP complex

  1. An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences

    American Journal of Medical Genetics Part A

    Volume 167, Issue 9, September 2015, Pages: 2085–2097, Karen W. Gripp, Katia Sol-Church, Patroula Smpokou, Gail E. Graham, David A. Stevenson, Heather Hanson, David H. Viskochil, Laura C. Baker, Bridget Russo, Nick Gardner, Deborah L. Stabley, Verena Kolbe and Georg Rosenberger

    Version of Record online : 25 APR 2015, DOI: 10.1002/ajmg.a.37128

  2. A novel HRAS substitution (c.266C>G; p.S89C) resulting in decreased downstream signaling suggests a new dimension of RAS pathway dysregulation in human development

    American Journal of Medical Genetics Part A

    Volume 158A, Issue 9, September 2012, Pages: 2106–2118, Karen W. Gripp, Eugenia Bifeld, Deborah L. Stabley, Elizabeth Hopkins, Stefanie Meien, Kathy Vinette, Katia Sol-Church and Georg Rosenberger

    Version of Record online : 20 JUL 2012, DOI: 10.1002/ajmg.a.35449

  3. Differential dynamics of RAS isoforms in GDP- and GTP-bound states

    Proteins: Structure, Function, and Bioinformatics

    Volume 83, Issue 6, June 2015, Pages: 1091–1106, Abhijeet Kapoor and Alex Travesset

    Version of Record online : 22 APR 2015, DOI: 10.1002/prot.24805

  4. You have full text access to this OnlineOpen article
    HRAS mutation prevalence and associated expression patterns in pheochromocytoma

    Genes, Chromosomes and Cancer

    Volume 55, Issue 5, May 2016, Pages: 452–459, Adam Stenman, Jenny Welander, Ida Gustavsson, Laurent Brunaud, Martin Bäckdahl, Peter Söderkvist, Oliver Gimm, C. Christofer Juhlin and Catharina Larsson

    Version of Record online : 23 FEB 2016, DOI: 10.1002/gcc.22347

  5. Molecular Genetics of Costello Syndrome

    Standard Article

    eLS

    Emma MM Burkitt Wright and Bronwyn Kerr

    Published Online : 15 SEP 2014, DOI: 10.1002/9780470015902.a0021471

  6. You have free access to this content
    Molecular aspects, clinical aspects and possible treatment modalities for Costello syndrome: Proceedings from the 1st International Costello Syndrome Research Symposium 2007

    American Journal of Medical Genetics Part A

    Volume 146A, Issue 9, 1 May 2008, Pages: 1205–1217, Katherine A. Rauen, Erin Hefner, Kristin Carrillo, Jill Taylor, Laure Messier, Yoko Aoki, Karen W. Gripp, Yoichi Matsubara, Virginia K. Proud, Peter Hammond, Judith E. Allanson, Marie-Ange Delrue, Marni E. Axelrad, Angela E. Lin, Daniel A. Doyle, Bronwyn Kerr, John C. Carey, Frank McCormick, Alcino J. Silva, Mark W. Kieran, Aleksander Hinek, Tan T. Nguyen and Lisa Schoyer

    Version of Record online : 15 APR 2008, DOI: 10.1002/ajmg.a.32276

  7. Frequent activating HRAS mutations in trichilemmoma

    British Journal of Dermatology

    Volume 171, Issue 5, November 2014, Pages: 1073–1077, J.-H. Tsai, W.-C. Huang, J.-Y. Jhuang, Y.-M. Jeng, M.-L. Cheng, H.-Y. Chiu, K.-T. Kuo and J.-Y. Liau

    Version of Record online : 30 SEP 2014, DOI: 10.1111/bjd.13143

  8. Mutant HrasG12V and KrasG12D have overlapping, but non-identical effects on hepatocyte growth and transformation frequency in transgenic mice

    Liver International

    Volume 32, Issue 4, April 2012, Pages: 582–591, Marxa L. Figueiredo, Timothy J. Stein, Adam Jochem and Eric P. Sandgren

    Version of Record online : 3 JAN 2012, DOI: 10.1111/j.1478-3231.2011.02732.x

  9. HRAS mutations and resistance to the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in head and neck squamous cell carcinoma cells

    Head & Neck

    Volume 36, Issue 11, November 2014, Pages: 1547–1554, J. Hun Hah, Mei Zhao, Curtis R. Pickering, Mitchell J. Frederick, Genevieve A. Andrews, Samar A. Jasser, David R. Fooshee, Zvonimir L. Milas, Chad Galer, Daisuke Sano, William N. William Jr, Edward Kim, John Heymach, Lauren A. Byers, Vali Papadimitrakopoulou and Jeffrey N. Myers

    Version of Record online : 20 MAR 2014, DOI: 10.1002/hed.23499

  10. You have free access to this content
    HRAS mutations in Costello syndrome: Detection of constitutional activating mutations in codon 12 and 13 and loss of wild-type allele in malignancy

    American Journal of Medical Genetics Part A

    Volume 140A, Issue 1, 1 January 2006, Pages: 8–16, Anne L. Estep, William E. Tidyman, Michael A. Teitell, Philip D. Cotter and Katherine A. Rauen

    Version of Record online : 13 DEC 2005, DOI: 10.1002/ajmg.a.31078

  11. Minimal cooperation between mutant Hras and c-myc or TGFα in the regulation of mouse hepatocyte growth or transformation in vivo

    Liver International

    Volume 31, Issue 9, October 2011, Pages: 1298–1305, Timothy J. Stein, Margaret Bowden and Eric P. Sandgren

    Version of Record online : 4 AUG 2011, DOI: 10.1111/j.1478-3231.2011.02596.x

  12. HRAS and the Costello syndrome

    Clinical Genetics

    Volume 71, Issue 2, February 2007, Pages: 101–108, KA Rauen

    Version of Record online : 23 JAN 2007, DOI: 10.1111/j.1399-0004.2007.00743.x

  13. You have free access to this content
    Inhibition of Ras oncogenic activity by Ras protooncogenes

    International Journal of Cancer

    Volume 113, Issue 2, 10 January 2005, Pages: 241–248, Roberto Diaz, Jeffrey Lue, Jeremy Mathews, Andrew Yoon, Daniel Ahn, Antonio Garcia-España, Peter Leonardi, Marcelo P. Vargas and Angel Pellicer

    Version of Record online : 13 SEP 2004, DOI: 10.1002/ijc.20563

  14. Left ventricular obstruction with restrictive inter-atrial communication leads to retardation in fetal lung maturation

    Prenatal Diagnosis

    Volume 35, Issue 5, May 2015, Pages: 463–470, Diane Goltz, Jean-Marc Lunkenheimer, Mojtaba Abedini, Ulrike Herberg, Christoph Berg, Ulrich Gembruch and Hans-Peter Fischer

    Version of Record online : 1 MAR 2015, DOI: 10.1002/pd.4559

  15. HRAS mutation analysis in Costello syndrome: Genotype and phenotype correlation

    American Journal of Medical Genetics Part A

    Volume 140A, Issue 1, 1 January 2006, Pages: 1–7, Karen W. Gripp, Angela E. Lin, Deborah L. Stabley, Linda Nicholson, Charles I. Scott Jr., Daniel Doyle, Yoko Aoki, Yoichi Matsubara, Elaine H. Zackai, Pablo Lapunzina, Antonio Gonzalez-Meneses, Jennifer Holbrook, Cynthia A. Agresta, Iris L. Gonzalez and Katia Sol-Church

    Version of Record online : 2 DEC 2005, DOI: 10.1002/ajmg.a.31047

  16. You have full text access to this OnlineOpen article
    Neonatal lethal Costello syndrome and unusual dinucleotide deletion/insertion mutations in HRAS predicting p.Gly12Val

    American Journal of Medical Genetics Part A

    Volume 158A, Issue 5, May 2012, Pages: 1102–1110, Emma M.M. Burkitt-Wright, Lisa Bradley, Jennifer Shorto, Vivienne P.M. McConnell, Caroline Gannon, Helen V. Firth, Soo-Mi Park, Angela D'Amore, Paul F. Munyard, Peter D. Turnpenny, Amanda Charlton, Meredith Wilson and Bronwyn Kerr

    Version of Record online : 11 APR 2012, DOI: 10.1002/ajmg.a.35296

  17. Recurrent duplication mutation in HRAS causing mild Costello syndrome in a Chinese patient

    Clinical and Experimental Dermatology

    Volume 40, Issue 4, June 2015, Pages: 404–407, F. Xu, H. J. Wang, Z. M. Lin and B. Yu

    Version of Record online : 10 FEB 2015, DOI: 10.1111/ced.12571

  18. Transmission of the rare HRAS mutation (c. 173C > T; p.T58I) further illustrates its attenuated phenotype

    American Journal of Medical Genetics Part A

    Volume 158A, Issue 5, May 2012, Pages: 1095–1101, Karen W. Gripp, Elizabeth Hopkins, Alvaro Serrano, Norma J. Leonard, Deborah L. Stabley and Katia Sol-Church

    Version of Record online : 9 APR 2012, DOI: 10.1002/ajmg.a.35294

  19. Costello syndrome associated with novel germline HRAS mutations: An attenuated phenotype?

    American Journal of Medical Genetics Part A

    Volume 146A, Issue 6, 15 March 2008, Pages: 683–690, Karen W. Gripp, A. Micheil Innes, Marni E. Axelrad, Tanya L. Gillan, Jillian S. Parboosingh, Christine Davies, Norma J. Leonard, Monique Lapointe, Daniel Doyle, Sarah Catalano, Linda Nicholson, Deborah L. Stabley and Katia Sol-Church

    Version of Record online : 4 FEB 2008, DOI: 10.1002/ajmg.a.32227

  20. You have free access to this content
    Paternal uniparental disomy 11p15.5 in the pancreatic nodule of an infant with Costello syndrome: Shared mechanism for hyperinsulinemic hypoglycemia in neonates with Costello and Beckwith–Wiedemann syndrome and somatic loss of heterozygosity in Costello syndrome driving clonal expansion

    American Journal of Medical Genetics Part A

    Volume 170, Issue 3, March 2016, Pages: 559–564, Karen W. Gripp, Katherine M. Robbins, Brandon S. Sheffield, Anna F. Lee, Millan S. Patel, Stephen Yip, Daniel Doyle, Deborah Stabley and Katia Sol-Church

    Version of Record online : 17 NOV 2015, DOI: 10.1002/ajmg.a.37471