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There are 232602 results for: content related to: Flexible design clinical trial methodology in regulatory applications

  1. A proportional hazards regression model for the subdistribution with right-censored and left-truncated competing risks data

    Statistics in Medicine

    Volume 30, Issue 16, 20 July 2011, Pages: 1933–1951, Xu Zhang,, Mei-Jie Zhang and Jason Fine

    Version of Record online : 9 MAY 2011, DOI: 10.1002/sim.4264

  2. Interval estimation of the over-dispersion parameter in the analysis of one-way layout of count data

    Statistics in Medicine

    Volume 30, Issue 1, 15 January 2011, Pages: 39–51, Krishna K. Saha

    Version of Record online : 13 SEP 2010, DOI: 10.1002/sim.4061

  3. Confidence intervals for random effects meta-analysis and robustness to publication bias

    Statistics in Medicine

    Volume 29, Issue 29, 20 December 2010, Pages: 2969–2983, Masayuki Henmi and John B. Copas

    Version of Record online : 20 OCT 2010, DOI: 10.1002/sim.4029

  4. A consistency approach to evaluation of bridging studies and multi-regional trials

    Statistics in Medicine

    Volume 30, Issue 17, 30 July 2011, Pages: 2171–2186, Hsiao-Hui Tsou, Tuan-Ying Chien, Jen-pei Liu and Chin-Fu Hsiao

    Version of Record online : 17 MAY 2011, DOI: 10.1002/sim.4251

  5. Log-linear, logistic model fitting and local score statistics for cluster detection with covariate adjustments

    Statistics in Medicine

    Volume 30, Issue 1, 15 January 2011, Pages: 91–100, Hock Peng Chan and I-Ping Tu

    Version of Record online : 20 OCT 2010, DOI: 10.1002/sim.4082

  6. Mendelian randomization analysis of case-control data using structural mean models

    Statistics in Medicine

    Volume 30, Issue 6, 15 March 2011, Pages: 678–694, Jack Bowden and Stijn Vansteelandt

    Version of Record online : 16 DEC 2010, DOI: 10.1002/sim.4138

  7. Frailty modelling for survival data from multi-centre clinical trials

    Statistics in Medicine

    Volume 30, Issue 17, 30 July 2011, Pages: 2144–2159, Il Do Ha, Richard Sylvester, Catherine Legrand and Gilbert MacKenzie

    Version of Record online : 12 MAY 2011, DOI: 10.1002/sim.4250

  8. Bounding the bias of unmeasured factors with confounding and effect-modifying potentials

    Statistics in Medicine

    Volume 30, Issue 9, 30 April 2011, Pages: 1007–1017, Wen-Chung Lee

    Version of Record online : 13 JAN 2011, DOI: 10.1002/sim.4151

  9. Flexible estimation of covariance function by penalized spline with application to longitudinal family data

    Statistics in Medicine

    Volume 30, Issue 15, 10 July 2011, Pages: 1883–1897, Yuanjia Wang

    Version of Record online : 13 APR 2011, DOI: 10.1002/sim.4236

  10. Hurdle models for multilevel zero-inflated data via h-likelihood

    Statistics in Medicine

    Volume 29, Issue 30, 30 December 2010, Pages: 3294–3310, Marek Molas and Emmanuel Lesaffre

    Version of Record online : 16 DEC 2010, DOI: 10.1002/sim.3852

  11. Joint modeling of longitudinal data and informative dropout time in the presence of multiple changepoints

    Statistics in Medicine

    Volume 30, Issue 6, 15 March 2011, Pages: 611–626, Pulak Ghosh, Kaushik Ghosh and Ram C. Tiwari

    Version of Record online : 30 NOV 2010, DOI: 10.1002/sim.4119

  12. Joint modeling of survival time and longitudinal data with subject-specific changepoints in the covariates

    Statistics in Medicine

    Volume 30, Issue 3, 10 February 2011, Pages: 232–249, Jean de Dieu Tapsoba, Shen-Ming Lee and C. Y. Wang

    Version of Record online : 5 NOV 2010, DOI: 10.1002/sim.4107

  13. Maximum inflation of the type 1 error rate when sample size and allocation rate are adapted in a pre-planned interim look

    Statistics in Medicine

    Volume 30, Issue 14, 30 June 2011, Pages: 1637–1647, Alexandra C. Graf and Peter Bauer

    Version of Record online : 15 APR 2011, DOI: 10.1002/sim.4230

  14. Two-stage instrumental variable methods for estimating the causal odds ratio: Analysis of bias

    Statistics in Medicine

    Volume 30, Issue 15, 10 July 2011, Pages: 1809–1824, Bing Cai, Dylan S. Small and Thomas R. Ten Have

    Version of Record online : 15 APR 2011, DOI: 10.1002/sim.4241

  15. A Bayesian semiparametric multivariate joint model for multiple longitudinal outcomes and a time-to-event

    Statistics in Medicine

    Volume 30, Issue 12, 30 May 2011, Pages: 1366–1380, Dimitris Rizopoulos and Pulak Ghosh

    Version of Record online : 21 FEB 2011, DOI: 10.1002/sim.4205

  16. Adaptive increase in sample size when interim results are promising: A practical guide with examples

    Statistics in Medicine

    Volume 30, Issue 28, 10 December 2011, Pages: 3267–3284, Cyrus R. Mehta and Stuart J. Pocock

    Version of Record online : 30 NOV 2010, DOI: 10.1002/sim.4102

  17. Regression-assisted deconvolution

    Statistics in Medicine

    Volume 30, Issue 14, 30 June 2011, Pages: 1722–1734, Julie McIntyre and Leonard A. Stefanski

    Version of Record online : 1 FEB 2011, DOI: 10.1002/sim.4186

  18. Exact logistic models for nested binary data

    Statistics in Medicine

    Volume 30, Issue 8, 15 April 2011, Pages: 866–876, Steven Troxler, Trent Lalonde and Jeffrey R. Wilson

    Version of Record online : 13 JAN 2011, DOI: 10.1002/sim.4157

  19. Assessing noninferiority in a three-arm trial using the Bayesian approach

    Statistics in Medicine

    Volume 30, Issue 15, 10 July 2011, Pages: 1795–1808, Pulak Ghosh, Farouk Nathoo,, Mithat Gönen and Ram C. Tiwari

    Version of Record online : 26 APR 2011, DOI: 10.1002/sim.4244

  20. Cutoff designs for community-based intervention studies

    Statistics in Medicine

    Volume 30, Issue 15, 10 July 2011, Pages: 1865–1882, Michael L. Pennell,, Erinn M. Hade,, David M. Murray and Dale A. Rhoda

    Version of Record online : 17 APR 2011, DOI: 10.1002/sim.4237

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    Correction: Correction

    Vol. 30, Issue 21, 2669, Version of Record online: 8 AUG 2011