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There are 42585 results for: content related to: An adaptive confirmatory trial with interim treatment selection: Practical experiences and unbalanced randomization

  1. Designing a seamless phase II/III clinical trial using early outcomes for treatment selection: An application in multiple sclerosis

    Statistics in Medicine

    Volume 30, Issue 13, 15 June 2011, Pages: 1528–1540, T. Friede, N. Parsons, N. Stallard, S. Todd, E. Valdes Marquez, J. Chataway and R. Nicholas

    Version of Record online : 22 FEB 2011, DOI: 10.1002/sim.4202

  2. Test and power considerations for multiple endpoint analyses using sequentially rejective graphical procedures

    Statistics in Medicine

    Volume 30, Issue 13, 15 June 2011, Pages: 1489–1501, Frank Bretz, Willi Maurer and Gerhard Hommel

    Version of Record online : 3 FEB 2011, DOI: 10.1002/sim.3988

  3. A recycling framework for the construction of Bonferroni-based multiple tests

    Statistics in Medicine

    Volume 28, Issue 5, 28 February 2009, Pages: 739–761, C.-F. Burman, C. Sonesson and O. Guilbaud

    Version of Record online : 13 JAN 2009, DOI: 10.1002/sim.3513

  4. You have full text access to this OnlineOpen article
    Optimizing the data combination rule for seamless phase II/III clinical trials

    Statistics in Medicine

    Volume 34, Issue 1, 15 January 2015, Pages: 39–58, Lisa V. Hampson and Christopher Jennison

    Version of Record online : 15 OCT 2014, DOI: 10.1002/sim.6316

  5. Adaptive seamless designs with interim treatment selection: a case study in oncology

    Statistics in Medicine

    Volume 34, Issue 8, 15 April 2015, Pages: 1317–1333, Máximo Carreras, Georg Gutjahr and Werner Brannath

    Version of Record online : 7 JAN 2015, DOI: 10.1002/sim.6407

  6. Dose selection in seamless phase II/III clinical trials based on efficacy and safety

    Statistics in Medicine

    Volume 28, Issue 6, 15 March 2009, Pages: 917–936, Peter K. Kimani, Nigel Stallard and Jane L. Hutton

    Version of Record online : 16 JAN 2009, DOI: 10.1002/sim.3522

  7. Partition testing in confirmatory adaptive designs with structured objectives

    Biometrical Journal

    Volume 55, Issue 3, May 2013, Pages: 341–359, Toshifumi Sugitani, Toshimitsu Hamasaki and Chikuma Hamada

    Version of Record online : 11 APR 2013, DOI: 10.1002/bimj.201200218

  8. On familywise type I error control for multiplicity in equivalence trials with three or more treatments

    Biometrical Journal

    Volume 53, Issue 6, November 2011, Pages: 914–926, Joachim Röhmel

    Version of Record online : 8 NOV 2011, DOI: 10.1002/bimj.201100073

  9. Two-stage instrumental variable methods for estimating the causal odds ratio: Analysis of bias

    Statistics in Medicine

    Volume 30, Issue 15, 10 July 2011, Pages: 1809–1824, Bing Cai, Dylan S. Small and Thomas R. Ten Have

    Version of Record online : 15 APR 2011, DOI: 10.1002/sim.4241

  10. Sample size and power determination in joint modeling of longitudinal and survival data

    Statistics in Medicine

    Volume 30, Issue 18, 15 August 2011, Pages: 2295–2309, Liddy M. Chen, Joseph G. Ibrahim and Haitao Chu

    Version of Record online : 17 MAY 2011, DOI: 10.1002/sim.4263

  11. Estimation of reliability in a three-factor model

    Statistics in Medicine

    Volume 30, Issue 11, 20 May 2011, Pages: 1254–1265, Luqiang Wang, Kevin John Keen and Burt Holland

    Version of Record online : 3 FEB 2011, DOI: 10.1002/sim.4182

  12. Defining and ranking effects of individual agents based on survival times of cancer patients treated with combination chemotherapies

    Statistics in Medicine

    Volume 30, Issue 15, 10 July 2011, Pages: 1777–1794, Peter F. Thall, Diane D. Liu, Su G. Berrak and Johannes E. Wolff

    Version of Record online : 17 MAY 2011, DOI: 10.1002/sim.4249

  13. Adaptive Dunnett tests for treatment selection

    Statistics in Medicine

    Volume 27, Issue 10, 10 May 2008, Pages: 1612–1625, Franz Koenig, Werner Brannath, Frank Bretz and Martin Posch

    Version of Record online : 17 SEP 2007, DOI: 10.1002/sim.3048

  14. You have free access to this content
    Testing multiple primary endpoints in clinical trials with sample size adaptation

    Pharmaceutical Statistics

    Volume 15, Issue 1, January/February 2016, Pages: 37–45, Yi Liu and Mingxiu Hu

    Version of Record online : 26 NOV 2015, DOI: 10.1002/pst.1724

  15. Multiplicity adjustments in testing for bioequivalence

    Statistics in Medicine

    Volume 34, Issue 2, 30 January 2015, Pages: 215–231, Steven Y. Hua, Siyan Xu and Ralph B. D'Agostino Sr.

    Version of Record online : 1 JUL 2014, DOI: 10.1002/sim.6247

  16. Optimized multi-stage designs controlling the false discovery or the family-wise error rate

    Statistics in Medicine

    Volume 27, Issue 21, 20 September 2008, Pages: 4145–4160, Sonja Zehetmayer, Peter Bauer and Martin Posch

    Version of Record online : 28 APR 2008, DOI: 10.1002/sim.3300

  17. Semiparametric regression models and sensitivity analysis of longitudinal data with non-random dropouts

    Statistica Neerlandica

    Volume 64, Issue 2, May 2010, Pages: 133–156, David Todem, KyungMann Kim, Jason Fine and Limin Peng

    Version of Record online : 18 NOV 2009, DOI: 10.1111/j.1467-9574.2009.00435.x

  18. Confirmatory Seamless Phase II/III Clinical Trials with Hypotheses Selection at Interim: General Concepts

    Biometrical Journal

    Volume 48, Issue 4, August 2006, Pages: 623–634, Frank Bretz, Heinz Schmidli, Franz König, Amy Racine and Willi Maurer

    Version of Record online : 25 JUL 2006, DOI: 10.1002/bimj.200510232

  19. Two contrasting spatial processes with a common variogram: inference about spatial models from higher-order statistics

    European Journal of Soil Science

    Volume 61, Issue 4, August 2010, Pages: 479–492, R. M. Lark

    Version of Record online : 1 JUL 2010, DOI: 10.1111/j.1365-2389.2010.01258.x

  20. Exploring the benefits of adaptive sequential designs in time-to-event endpoint settings

    Statistics in Medicine

    Volume 30, Issue 11, 20 May 2011, Pages: 1199–1217, Sarah C. Emerson, Kyle D. Rudser and Scott S. Emerson

    Version of Record online : 29 DEC 2010, DOI: 10.1002/sim.4156