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There are 18216 results for: content related to: Designing a seamless phase II/III clinical trial using early outcomes for treatment selection: An application in multiple sclerosis

  1. Correcting for misclassification for a monotone disease process with an application in dental research

    Statistics in Medicine

    Volume 29, Issue 30, 30 December 2010, Pages: 3103–3117, M. J. García-Zattera, T. Mutsvari, A. Jara, D. Declerck and E. Lesaffre

    Article first published online : 16 DEC 2010, DOI: 10.1002/sim.3906

  2. Defining and ranking effects of individual agents based on survival times of cancer patients treated with combination chemotherapies

    Statistics in Medicine

    Volume 30, Issue 15, 10 July 2011, Pages: 1777–1794, Peter F. Thall, Diane D. Liu, Su G. Berrak and Johannes E. Wolff

    Article first published online : 17 MAY 2011, DOI: 10.1002/sim.4249

  3. Discriminant analysis using a multivariate linear mixed model with a normal mixture in the random effects distribution

    Statistics in Medicine

    Volume 29, Issue 30, 30 December 2010, Pages: 3267–3283, Arnošt Komárek, Bettina E. Hansen, Edith M. M. Kuiper, Henk R. van Buuren and Emmanuel Lesaffre

    Article first published online : 16 DEC 2010, DOI: 10.1002/sim.3849

  4. You have full text access to this OnlineOpen article
    Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data

    Pharmaceutical Statistics

    Volume 13, Issue 4, July/August 2014, Pages: 238–246, Cornelia Ursula Kunz, Tim Friede, Nick Parsons, Susan Todd and Nigel Stallard

    Article first published online : 2 MAY 2014, DOI: 10.1002/pst.1619

  5. Maximum inflation of the type 1 error rate when sample size and allocation rate are adapted in a pre-planned interim look

    Statistics in Medicine

    Volume 30, Issue 14, 30 June 2011, Pages: 1637–1647, Alexandra C. Graf and Peter Bauer

    Article first published online : 15 APR 2011, DOI: 10.1002/sim.4230

  6. Two-stage instrumental variable methods for estimating the causal odds ratio: Analysis of bias

    Statistics in Medicine

    Volume 30, Issue 15, 10 July 2011, Pages: 1809–1824, Bing Cai, Dylan S. Small and Thomas R. Ten Have

    Article first published online : 15 APR 2011, DOI: 10.1002/sim.4241

  7. Sample size and power determination in joint modeling of longitudinal and survival data

    Statistics in Medicine

    Volume 30, Issue 18, 15 August 2011, Pages: 2295–2309, Liddy M. Chen, Joseph G. Ibrahim and Haitao Chu

    Article first published online : 17 MAY 2011, DOI: 10.1002/sim.4263

  8. A Bayesian semiparametric multivariate joint model for multiple longitudinal outcomes and a time-to-event

    Statistics in Medicine

    Volume 30, Issue 12, 30 May 2011, Pages: 1366–1380, Dimitris Rizopoulos and Pulak Ghosh

    Article first published online : 21 FEB 2011, DOI: 10.1002/sim.4205

  9. You have full text access to this OnlineOpen article
    Estimating cost-offsets of new medications: Use of new antipsychotics and mental health costs for schizophrenia

    Statistics in Medicine

    Volume 30, Issue 16, 20 July 2011, Pages: 1971–1988, A. James O'Malley, R. G. Frank and S.-L. T. Normand

    Article first published online : 26 APR 2011, DOI: 10.1002/sim.4245

  10. Simultaneous confidence bounds for relative risks in multiple comparisons to control

    Statistics in Medicine

    Volume 29, Issue 30, 30 December 2010, Pages: 3232–3244, B. Klingenberg

    Article first published online : 16 DEC 2010, DOI: 10.1002/sim.3924

  11. Timely detection of localized excess influenza activity in Northern California across patient care, prescription, and laboratory data

    Statistics in Medicine

    Volume 30, Issue 5, 28 February 2011, Pages: 549–559, Sharon K. Greene, Martin Kulldorff, Jie Huang, Richard J. Brand, Kenneth P. Kleinman, John Hsu and Richard Platt

    Article first published online : 10 FEB 2011, DOI: 10.1002/sim.3883

  12. Improving small-sample inference in group randomized trials with binary outcomes

    Statistics in Medicine

    Volume 30, Issue 3, 10 February 2011, Pages: 201–210, Philip M. Westgate and Thomas M. Braun

    Article first published online : 5 NOV 2010, DOI: 10.1002/sim.4101

  13. Multiple imputation based on restricted mean model for censored data

    Statistics in Medicine

    Volume 30, Issue 12, 30 May 2011, Pages: 1339–1350, Lyrica Xiaohong Liu, Susan Murray and Alex Tsodikov

    Article first published online : 11 JAN 2011, DOI: 10.1002/sim.4163

  14. Frailty modelling for survival data from multi-centre clinical trials

    Statistics in Medicine

    Volume 30, Issue 17, 30 July 2011, Pages: 2144–2159, Il Do Ha, Richard Sylvester, Catherine Legrand and Gilbert MacKenzie

    Article first published online : 12 MAY 2011, DOI: 10.1002/sim.4250

  15. An extension of the single threshold design for monitoring efficacy and safety in phase II clinical trials

    Statistics in Medicine

    Volume 30, Issue 14, 30 June 2011, Pages: 1648–1664, P. Brutti, S. Gubbiotti and V. Sambucini

    Article first published online : 26 APR 2011, DOI: 10.1002/sim.4229

  16. Test non-inferiority (and equivalence) based on the odds ratio under a simple crossover trial

    Statistics in Medicine

    Volume 30, Issue 11, 20 May 2011, Pages: 1230–1242, Kung-Jong Lui and Kuang-Chao Chang

    Article first published online : 12 JAN 2011, DOI: 10.1002/sim.4166

  17. Analysis of recurrent gap time data using the weighted risk-set method and the modified within-cluster resampling method

    Statistics in Medicine

    Volume 30, Issue 4, 20 February 2011, Pages: 301–311, Xianghua Luo and Chiung-Yu Huang

    Article first published online : 20 OCT 2010, DOI: 10.1002/sim.4074

  18. Estimating treatment difference for binary responses in the presence of surrogate endpoints

    Statistics in Medicine

    Volume 30, Issue 2, 30 January 2011, Pages: 186–196, Buddhananda Banerjee and Atanu Biswas

    Article first published online : 20 OCT 2010, DOI: 10.1002/sim.4089

  19. Marginal regression models with time-varying coefficients for recurrent event data

    Statistics in Medicine

    Volume 30, Issue 18, 15 August 2011, Pages: 2265–2277, Liuquan Sun, Xian Zhou and Shaojun Guo

    Article first published online : 17 MAY 2011, DOI: 10.1002/sim.4260

  20. A simulation study of predictive ability measures in a survival model I: Explained variation measures

    Statistics in Medicine

    Volume 31, Issue 23, 15 October 2012, Pages: 2627–2643, Babak Choodari-Oskooei, Patrick Royston and Mahesh K. B. Parmar

    Article first published online : 26 APR 2011, DOI: 10.1002/sim.4242