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There are 29361 results for: content related to: Early termination of a two-stage study to develop and validate a panel of biomarkers

  1. Concordance measures in shared frailty models: application to clustered data in cancer prognosis

    Statistics in Medicine

    Volume 32, Issue 27, 30 November 2013, Pages: 4803–4820, Audrey Mauguen, Sandra Collette, Jean-Pierre Pignon and Virginie Rondeau

    Version of Record online : 3 JUN 2013, DOI: 10.1002/sim.5852

  2. Transforming the Model T: random effects meta-analysis with stable weights

    Statistics in Medicine

    Volume 32, Issue 11, 20 May 2013, Pages: 1842–1864, Michael J. Malloy, Luke A. Prendergast and Robert G. Staudte

    Version of Record online : 23 OCT 2012, DOI: 10.1002/sim.5666

  3. Considerations on covariates and endpoints in multi-arm multi-stage clinical trials selecting all promising treatments

    Statistics in Medicine

    Volume 32, Issue 7, 30 March 2013, Pages: 1150–1163, T. Jaki and D. Magirr

    Version of Record online : 30 OCT 2012, DOI: 10.1002/sim.5669

  4. A Bayesian adaptive dose selection procedure with an overdispersed count endpoint

    Statistics in Medicine

    Volume 32, Issue 28, 10 December 2013, Pages: 5008–5027, L. Pozzi, H. Schmidli, M. Gasparini and A. Racine-Poon

    Version of Record online : 11 SEP 2013, DOI: 10.1002/sim.5932

  5. Flexible bivariate phase II clinical trial design incorporating toxicity and response on different schedules

    Statistics in Medicine

    Volume 32, Issue 3, 10 February 2013, Pages: 470–485, Herman E. Ray and Shesh N. Rai

    Version of Record online : 12 NOV 2012, DOI: 10.1002/sim.5671

  6. Key multiplicity issues in clinical drug development

    Statistics in Medicine

    Volume 32, Issue 7, 30 March 2013, Pages: 1079–1111, Alex Dmitrienko, Ralph B. D'Agostino Sr. and Mohammad F. Huque

    Version of Record online : 9 OCT 2012, DOI: 10.1002/sim.5642

  7. Estimation of covariate effects in generalized linear mixed models with a misspecified distribution of random intercepts and slopes

    Statistics in Medicine

    Volume 32, Issue 14, 30 June 2013, Pages: 2419–2429, John M. Neuhaus, Charles E. McCulloch and Ross Boylan

    Version of Record online : 2 DEC 2012, DOI: 10.1002/sim.5682

  8. Conditional estimation after a two-stage diagnostic biomarker study that allows early termination for futility

    Statistics in Medicine

    Volume 31, Issue 5, 28 February 2012, Pages: 420–435, Joseph S. Koopmeiners, Ziding Feng and Margaret Sullivan Pepe

    Version of Record online : 12 JAN 2012, DOI: 10.1002/sim.4430

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    Methods for dealing with time-dependent confounding

    Statistics in Medicine

    Volume 32, Issue 9, 30 April 2013, Pages: 1584–1618, R.M. Daniel, S.N. Cousens, B.L. De Stavola, M. G. Kenward and J. A. C. Sterne

    Version of Record online : 3 DEC 2012, DOI: 10.1002/sim.5686

  10. Statistical considerations in biosimilar clinical efficacy trials with asymmetrical margins

    Statistics in Medicine

    Volume 32, Issue 3, 10 February 2013, Pages: 393–405, Yulan Li, Qing Liu, Patricia Wood and Anandhi Johri

    Version of Record online : 18 SEP 2012, DOI: 10.1002/sim.5612

  11. Time-varying coefficient proportional hazards model with missing covariates

    Statistics in Medicine

    Volume 32, Issue 12, 30 May 2013, Pages: 2013–2030, Xiao Song and Ching-Yun Wang

    Version of Record online : 9 OCT 2012, DOI: 10.1002/sim.5652

  12. Longitudinal measurement in health-related surveys. A Bayesian joint growth model for multivariate ordinal responses

    Statistics in Medicine

    Volume 32, Issue 17, 30 July 2013, Pages: 2988–3005, Josine Verhagen and Jean-Paul Fox

    Version of Record online : 5 DEC 2012, DOI: 10.1002/sim.5692

  13. Adaptive clinical trial designs with pre-specified rules for modifying the sample size: understanding efficient types of adaptation

    Statistics in Medicine

    Volume 32, Issue 8, 15 April 2013, Pages: 1259–1275, Gregory P. Levin, Sarah C. Emerson and Scott S. Emerson

    Version of Record online : 18 OCT 2012, DOI: 10.1002/sim.5662

  14. Sensitivity analysis for unmeasured confounding in principal stratification settings with binary variables

    Statistics in Medicine

    Volume 31, Issue 10, 10 May 2012, Pages: 949–962, Scott Schwartz, Fan Li and Jerome P. Reiter

    Version of Record online : 24 FEB 2012, DOI: 10.1002/sim.4472

  15. Empirical likelihood-based confidence intervals for length-biased data

    Statistics in Medicine

    Volume 32, Issue 13, 15 June 2013, Pages: 2278–2291, J. Ning, J. Qin, M. Asgharian and Y. Shen

    Version of Record online : 1 OCT 2012, DOI: 10.1002/sim.5637

  16. Level-adjusted funnel plots based on predicted marginal expectations: an application to prophylactic antibiotics in gallstone surgery

    Statistics in Medicine

    Volume 33, Issue 21, 20 September 2014, Pages: 3655–3675, Lars Lindhagen, Bahman Darkahi, Gabriel Sandblom and Lars Berglund

    Version of Record online : 26 JUN 2014, DOI: 10.1002/sim.5677

  17. Subgroup identification from randomized clinical trial data

    Statistics in Medicine

    Volume 30, Issue 24, 30 October 2011, Pages: 2867–2880, Jared C. Foster, Jeremy M.G. Taylor and Stephen J. Ruberg

    Version of Record online : 4 AUG 2011, DOI: 10.1002/sim.4322

  18. Estimation of controlled direct effects in time-varying treatments using structural nested mean models: application to a primary prevention trial for coronary events with pravastatin

    Statistics in Medicine

    Volume 33, Issue 18, 15 August 2014, Pages: 3214–3228, Tomohiro Shinozaki, Yutaka Matsuyama and Yasuo Ohashi

    Version of Record online : 3 APR 2014, DOI: 10.1002/sim.6162

  19. Time-varying effect moderation using the structural nested mean model: estimation using inverse-weighted regression with residuals

    Statistics in Medicine

    Volume 33, Issue 20, 10 September 2014, Pages: 3466–3487, Daniel Almirall, Beth Ann Griffin, Daniel F. McCaffrey, Rajeev Ramchand, Robert A. Yuen and Susan A. Murphy

    Version of Record online : 19 JUL 2013, DOI: 10.1002/sim.5892

  20. Repeated significance tests of linear combinations of sensitivity and specificity of a diagnostic biomarker

    Statistics in Medicine

    Volume 35, Issue 19, 30 August 2016, Pages: 3397–3412, Mixia Wu, Yu Shu, Zhaohai Li and Aiyi Liu

    Version of Record online : 7 MAR 2016, DOI: 10.1002/sim.6932