Search Results

There are 77259 results for: content related to: Key multiplicity issues in clinical drug development

  1. You have free access to this content
    Traditional multiplicity adjustment methods in clinical trials

    Statistics in Medicine

    Volume 32, Issue 29, 20 December 2013, Pages: 5172–5218, Alex Dmitrienko and Ralph D'Agostino Sr

    Version of Record online : 30 SEP 2013, DOI: 10.1002/sim.5990

  2. Multiplicity in confirmatory clinical trials: a case study with discussion from a JSM panel

    Statistics in Medicine

    Volume 34, Issue 26, 20 November 2015, Pages: 3461–3480, Sue-Jane Wang, Frank Bretz, Alex Dmitrienko, Jason Hsu, H. M. James Hung, Gary Koch, Willi Maurer, Walt Offen and Robert O'Neill

    Version of Record online : 25 JUN 2015, DOI: 10.1002/sim.6561

  3. Superchain procedures in clinical trials with multiple objectives

    Statistics in Medicine

    Volume 32, Issue 3, 10 February 2013, Pages: 486–508, George Kordzakhia and Alex Dmitrienko

    Version of Record online : 17 AUG 2012, DOI: 10.1002/sim.5537

  4. You have free access to this content
    Advanced multiplicity adjustment methods in clinical trials

    Statistics in Medicine

    Volume 33, Issue 4, 20 February 2014, Pages: 693–713, Mohamed Alosh, Frank Bretz and Mohammad Huque

    Version of Record online : 16 SEP 2013, DOI: 10.1002/sim.5974

  5. On generalized fixed sequence procedures for controlling the FWER

    Statistics in Medicine

    Volume 34, Issue 30, 30 December 2015, Pages: 3968–3983, Zhiying Qiu, Wenge Guo and Gavin Lynch

    Version of Record online : 30 JUL 2015, DOI: 10.1002/sim.6603

  6. Biomarker driven population enrichment for adaptive oncology trials with time to event endpoints

    Statistics in Medicine

    Volume 33, Issue 26, 20 November 2014, Pages: 4515–4531, Cyrus Mehta, Helmut Schäfer, Hanna Daniel and Sebastian Irle

    Version of Record online : 30 JUL 2014, DOI: 10.1002/sim.6272

    Corrected by:

    Correction: Biomarker-driven population enrichment for adaptive oncology trials with time to event endpoints

    Vol. 35, Issue 28, 5320, Version of Record online: 3 AUG 2016

  7. Extension of adaptive alpha allocation methods for strong control of the family-wise error rate

    Statistics in Medicine

    Volume 32, Issue 2, 30 January 2013, Pages: 181–195, Haihong Li, Abdul J. Sankoh and Ralph B. D'Agostino Sr.

    Version of Record online : 16 JUL 2012, DOI: 10.1002/sim.5485

  8. Re-estimating sample size in cluster randomised trials with active recruitment within clusters

    Statistics in Medicine

    Volume 33, Issue 19, 30 August 2014, Pages: 3253–3268, S. van Schie and M. Moerbeek

    Version of Record online : 9 APR 2014, DOI: 10.1002/sim.6172

  9. Weighted multiple testing correction for correlated tests

    Statistics in Medicine

    Volume 31, Issue 4, 20 February 2012, Pages: 341–352, Changchun Xie

    Version of Record online : 23 NOV 2011, DOI: 10.1002/sim.4434

  10. Panel forum on multiple comparison procedures: A commentary from a complex trial design and analysis plan

    Biometrical Journal

    Volume 55, Issue 3, May 2013, Pages: 275–293, Sue-Jane Wang, Frank Bretz, Alex Dmitrienko, Jason Hsu, H. M. James Hung, Mohammad Huque and Gary Koch

    Version of Record online : 3 APR 2013, DOI: 10.1002/bimj.201200047

  11. Optimizing the order of hypotheses in serial testing of multiple endpoints in clinical trials

    Statistics in Medicine

    Volume 34, Issue 9, 30 April 2015, Pages: 1467–1482, Zhiwei Zhang, Chenguang Wang and James F. Troendle

    Version of Record online : 26 JAN 2015, DOI: 10.1002/sim.6425

  12. Adaptive seamless designs with interim treatment selection: a case study in oncology

    Statistics in Medicine

    Volume 34, Issue 8, 15 April 2015, Pages: 1317–1333, Máximo Carreras, Georg Gutjahr and Werner Brannath

    Version of Record online : 7 JAN 2015, DOI: 10.1002/sim.6407

  13. Memory and other properties of multiple test procedures generated by entangled graphs

    Statistics in Medicine

    Volume 32, Issue 10, 10 May 2013, Pages: 1739–1753, Willi Maurer and Frank Bretz

    Version of Record online : 28 DEC 2012, DOI: 10.1002/sim.5711

  14. You have free access to this content
    Tutorial in biostatistics: data-driven subgroup identification and analysis in clinical trials

    Statistics in Medicine

    Volume 36, Issue 1, 15 January 2017, Pages: 136–196, Ilya Lipkovich, Alex Dmitrienko and Ralph B. D'Agostino Sr.

    Version of Record online : 3 AUG 2016, DOI: 10.1002/sim.7064

  15. A new partition testing strategy for multiple endpoints

    Statistics in Medicine

    Volume 31, Issue 20, 10 September 2012, Pages: 2151–2168, Bushi Wang and Xinping Cui

    Version of Record online : 25 APR 2012, DOI: 10.1002/sim.5366

  16. You have full text access to this OnlineOpen article
    Fallback tests for co-primary endpoints

    Statistics in Medicine

    Volume 35, Issue 16, 20 July 2016, Pages: 2669–2686, Robin Ristl, Florian Frommlet, Armin Koch and Martin Posch

    Version of Record online : 25 FEB 2016, DOI: 10.1002/sim.6911

  17. You have free access to this content
    Multiple hypothesis testing in genomics

    Statistics in Medicine

    Volume 33, Issue 11, 20 May 2014, Pages: 1946–1978, Jelle J. Goeman and Aldo Solari

    Version of Record online : 8 JAN 2014, DOI: 10.1002/sim.6082

  18. A general multistage procedure for k-out-of-n gatekeeping

    Statistics in Medicine

    Volume 33, Issue 8, 15 April 2014, Pages: 1321–1335, Dong Xi and Ajit C. Tamhane

    Version of Record online : 17 OCT 2013, DOI: 10.1002/sim.6028

  19. Sensitivity analysis for unmeasured confounding in principal stratification settings with binary variables

    Statistics in Medicine

    Volume 31, Issue 10, 10 May 2012, Pages: 949–962, Scott Schwartz, Fan Li and Jerome P. Reiter

    Version of Record online : 24 FEB 2012, DOI: 10.1002/sim.4472

  20. Subgroup identification from randomized clinical trial data

    Statistics in Medicine

    Volume 30, Issue 24, 30 October 2011, Pages: 2867–2880, Jared C. Foster, Jeremy M.G. Taylor and Stephen J. Ruberg

    Version of Record online : 4 AUG 2011, DOI: 10.1002/sim.4322