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There are 3585 results for: content related to: MEK-ERK Signaling Dictates DNA-Repair Gene MGMT Expression and Temozolomide Resistance of Stem-Like Glioblastoma Cells via the MDM2-p53 Axis

  1. You have free access to this content
    Aggressive pituitary tumours: the role of temozolomide and the assessment of MGMT status

    European Journal of Clinical Investigation

    Volume 41, Issue 10, October 2011, Pages: 1133–1148, Ann I. McCormack, John A. H. Wass and Ashley B. Grossman

    Article first published online : 18 APR 2011, DOI: 10.1111/j.1365-2362.2011.02520.x

  2. Anti-O6-Methylguanine-Methyltransferase (MGMT) Immunohistochemistry in Glioblastoma Multiforme: Observer Variability and Lack of Association with Patient Survival Impede Its Use as Clinical Biomarker

    Brain Pathology

    Volume 18, Issue 4, October 2008, Pages: 520–532, Matthias Preusser, Robert Charles Janzer, Jörg Felsberg, Guido Reifenberger, Marie-France Hamou, Annie-Claire Diserens, Roger Stupp, Thierry Gorlia, Christine Marosi, Harald Heinzl, Johannes A Hainfellner and Monika Hegi

    Article first published online : 8 APR 2008, DOI: 10.1111/j.1750-3639.2008.00153.x

  3. Low O6-methylguanine-DNA methyltransferase (MGMT) expression and response to temozolomide in aggressive pituitary tumours

    Clinical Endocrinology

    Volume 71, Issue 2, August 2009, Pages: 226–233, Ann I. McCormack, Kerrie L. McDonald, Anthony J. Gill, Susan J. Clark, Morton G. Burt, Kirsten A. Campbell, Wilton J. Braund, Nicholas S. Little, Raymond J. Cook, Ashley B. Grossman, Bruce G. Robinson and Roderick J. Clifton-Bligh

    Article first published online : 3 DEC 2008, DOI: 10.1111/j.1365-2265.2008.03487.x

  4. You have free access to this content
    O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and low MGMT-encoded protein expression as prognostic markers in glioblastoma patients treated with biodegradable carmustine wafer implants after initial surgery followed by radiotherapy with concomitant and adjuvant temozolomide


    Volume 118, Issue 18, 15 September 2012, Pages: 4545–4554, Emmanuèle Lechapt-Zalcman, Guénaëlle Levallet, Audrey Emmanuelle Dugué, Anne Vital, Marie-Danièle Diebold, Philippe Menei, Philippe Colin, Philippe Peruzzy, Evelyne Emery, Myriam Bernaudin, Françoise Chapon and Jean-Sébastien Guillamo

    Article first published online : 22 FEB 2012, DOI: 10.1002/cncr.27441

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    Treatment of pituitary neoplasms with temozolomide


    Volume 117, Issue 3, 1 February 2011, Pages: 454–462, Luis V. Syro, Leon D. Ortiz, Bernd W. Scheithauer, Ricardo Lloyd, Queenie Lau, Ricardo Gonzalez, Humberto Uribe, Michael Cusimano, Kalman Kovacs and Eva Horvath

    Article first published online : 15 SEP 2010, DOI: 10.1002/cncr.25413

  6. You have free access to this content
    O6-methylguanine DNA methyltransferase immunoexpression in nonfunctioning pituitary adenomas


    Volume 115, Issue 5, 1 March 2009, Pages: 1070–1080, Georg Widhalm, Stefan Wolfsberger, Matthias Preusser, Adelheid Woehrer, Mark R. Kotter, Thomas Czech, Christine Marosi and Engelbert Knosp

    Article first published online : 20 JAN 2009, DOI: 10.1002/cncr.24053

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    MGMT in primary and recurrent human glioblastomas after radiation and chemotherapy and comparison with p53 status and clinical outcome

    International Journal of Cancer

    Volume 122, Issue 6, 15 March 2008, Pages: 1391–1399, Dorothee Wiewrodt, Georg Nagel, Nadine Dreimüller, Thomas Hundsberger, Axel Perneczky and Bernd Kaina

    Article first published online : 13 NOV 2007, DOI: 10.1002/ijc.23219

  8. The expression of O6-methylguanine-DNA methyltransferase in human oral keratinocytes stimulated with arecoline

    Journal of Oral Pathology & Medicine

    Volume 42, Issue 8, September 2013, Pages: 600–605, Shiuan-Shinn Lee, Chung-Hung Tsai, Cheng-Chia Yu, Yung-Chuan Ho, Hsin-I Hsu and Yu-Chao Chang

    Article first published online : 21 DEC 2012, DOI: 10.1111/jop.12037

  9. You have free access to this content
    Pituitary carcinomas and aggressive pituitary tumours: merits and pitfalls of temozolomide treatment

    Clinical Endocrinology

    Volume 76, Issue 6, June 2012, Pages: 769–775, Gérald Raverot, Frédéric Castinetti, Emmanuel Jouanneau, Isabelle Morange, Dominique Figarella-Branger, Henry Dufour, Jacqueline Trouillas and Thierry Brue

    Article first published online : 23 APR 2012, DOI: 10.1111/j.1365-2265.2012.04381.x

  10. Inactivation of O6-methyguanine-DNA methyltransferase by promoter hypermethylation: Association of epithelial ovarian carcinogenesis in specific histological types

    Journal of Obstetrics and Gynaecology Research

    Volume 37, Issue 7, July 2011, Pages: 851–860, Hyun-Jin Roh, Dong-Soo Suh, Kyung-Un Choi, Hang-Jo Yoo, Won-Deok Joo and Man-Soo Yoon

    Article first published online : 31 MAR 2011, DOI: 10.1111/j.1447-0756.2010.01452.x

  11. Phase II study of targeted therapy with temozolomide in acute myeloid leukaemia and high-risk myelodysplastic syndrome patients pre-screened for low O6-methylguanine DNA methyltransferase expression

    British Journal of Haematology

    Volume 167, Issue 5, December 2014, Pages: 664–670, Joseph M. Brandwein, Jeannine Kassis, Brian Leber, Donna Hogge, Kang Howson-Jan, Mark D. Minden, André Galarneau and Jean-François Pouliot

    Article first published online : 27 AUG 2014, DOI: 10.1111/bjh.13094

  12. MGMT as a potential stratification marker in relapsed high-grade glioma of children: The HIT-GBM experience

    Pediatric Blood & Cancer

    Volume 54, Issue 2, February 2010, Pages: 228–237, Sabrina Schlosser, Sabine Wagner, Jörg Mühlisch, Martin Hasselblatt, Joachim Gerß, Johannes E.A. Wolff and Michael C. Frühwald

    Article first published online : 23 OCT 2009, DOI: 10.1002/pbc.22323

  13. Immunohistochemical evaluation of O6-methylguanine DNA methyltransferase (MGMT) expression in 117 cases of glioblastoma


    Volume 34, Issue 3, June 2014, Pages: 268–276, Masaya Miyazaki, Hiroshi Nishihara, Shunsuke Terasaka, Hiroyuki Kobayashi, Shigeru Yamaguchi, Tamio Ito, Yuuta Kamoshima, Shin Fujimoto, Sadao Kaneko, Masahito Katoh, Nobuaki Ishii, Hiromi Mohri, Mishie Tanino, Taichi Kimura and Shinya Tanaka

    Article first published online : 7 JAN 2014, DOI: 10.1111/neup.12091

  14. SDHB mutations are associated with response to temozolomide in patients with metastatic pheochromocytoma or paraganglioma

    International Journal of Cancer

    Volume 135, Issue 11, 1 December 2014, Pages: 2711–2720, Julien Hadoux, Judith Favier, Jean-Yves Scoazec, Sophie Leboulleux, Abir Al Ghuzlan, Caroline Caramella, Désirée Déandreis, Isabelle Borget, Céline Loriot, Cécile Chougnet, Eric Letouzé, Jacques Young, Laurence Amar, Jérome Bertherat, Rosella Libé, Frédéric Dumont, Frédéric Deschamps, Martin Schlumberger, Anne Paule Gimenez-Roqueplo and Eric Baudin

    Article first published online : 5 MAY 2014, DOI: 10.1002/ijc.28913

  15. Alteration of O6-methylguanine-DNA methyltransferase in colorectal neoplasms in sporadic and familial adenomatous polyposis patients

    Molecular Carcinogenesis

    Volume 37, Issue 1, May 2003, Pages: 32–38, Sun Hee Kim, Soo In Bae, Hye Seung Lee and Woo Ho Kim

    Article first published online : 23 APR 2003, DOI: 10.1002/mc.10116

  16. You have free access to this content
    Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol

    International Journal of Cancer

    Volume 118, Issue 3, 1 February 2006, Pages: 527–531, Rana Abdel-Fattah, Adam Glick, Ishtiaq Rehman, Patrick Maiberger and Henry Hennings

    Article first published online : 10 AUG 2005, DOI: 10.1002/ijc.21316

  17. Aberrant methylation and loss of expression of O6-methylguanine-DNA methyltransferase in pulmonary squamous cell carcinoma and adenocarcinoma

    Pathology International

    Volume 55, Issue 6, June 2005, Pages: 303–309, Osamu Furonaka, Yukio Takeshima, Hirokazu Awaya, Kei Kushitani, Nobuoki Kohno and Kouki Inai

    Article first published online : 9 JUN 2005, DOI: 10.1111/j.1440-1827.2005.01830.x

  18. You have free access to this content
    Activity of O6-methylguanine-DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer

    International Journal of Cancer

    Volume 84, Issue 4, 20 August 1999, Pages: 388–395, Jan G. Hengstler, Berno Tanner, Lars Möller, Rolf Meinert and Bernd Kaina

    Article first published online : 10 NOV 1999, DOI: 10.1002/(SICI)1097-0215(19990820)84:4<388::AID-IJC10>3.0.CO;2-3

  19. You have free access to this content
    MGMT activity, promoter methylation and immunohistochemistry of pretreatment and recurrent malignant gliomas: a comparative study on astrocytoma and glioblastoma

    International Journal of Cancer

    Volume 127, Issue 9, 1 November 2010, Pages: 2106–2118, Markus Christmann, Georg Nagel, Sigrid Horn, Ulrike Krahn, Dorothee Wiewrodt, Clemens Sommer and Bernd Kaina

    Article first published online : 3 FEB 2010, DOI: 10.1002/ijc.25229

  20. MGMT promoter methylation is associated with temozolomide response and prolonged progression-free survival in disseminated cutaneous melanoma

    International Journal of Cancer

    Rainer Tuominen, Rosalyn Jewell, Joost J. van den Oord, Pascal Wolter, Ulrika Stierner, Christer Lindholm, Carolina Hertzman Johansson, Diana Lindén, Hemming Johansson, Marianne Frostvik Stolt, Christy Walker, Helen Snowden, Julia Newton-Bishop, Johan Hansson and Suzanne Egyházi Brage

    Article first published online : 24 NOV 2014, DOI: 10.1002/ijc.29332