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There are 2221 results for: content related to: PDE4 inhibitors: current status

  1. You have free access to this content
    Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets

    Oral Diseases

    Volume 21, Issue 1, January 2015, Pages: e25–e50, F Ahmad, T Murata, K Shimizu, E Degerman, D Maurice and V Manganiello

    Version of Record online : 12 SEP 2014, DOI: 10.1111/odi.12275

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    Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease

    British Journal of Pharmacology

    Volume 157, Issue 6, July 2009, Pages: 892–906, Katharine H Banner and Neil J Press

    Version of Record online : 5 JUN 2009, DOI: 10.1111/j.1476-5381.2009.00170.x

  3. The differential impact of PDE4 subtypes in human lung fibroblasts on cytokine-induced proliferation and myofibroblast conversion

    Journal of Cellular Physiology

    Volume 226, Issue 8, August 2011, Pages: 1970–1980, Jens Selige, Armin Hatzelmann and Torsten Dunkern

    Version of Record online : 25 APR 2011, DOI: 10.1002/jcp.22529

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    Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells

    British Journal of Pharmacology

    Volume 142, Issue 2, May 2004, Pages: 339–351, Malcolm C Shepherd, George S Baillie, David I Stirling and Miles D Houslay

    Version of Record online : 29 JAN 2009, DOI: 10.1038/sj.bjp.0705770

  5. Phosphodiesterase-4 inhibition as a therapeutic strategy for metabolic disorders

    Obesity Reviews

    Volume 17, Issue 5, May 2016, Pages: 429–441, C. Wu and S. Rajagopalan

    Version of Record online : 21 MAR 2016, DOI: 10.1111/obr.12385

  6. Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti-inflammatory therapeutics

    Allergology International

    Volume 53, Issue 2, June 2004, Pages: 101–110, Simon J MacKenzie

    Version of Record online : 28 JUN 2008, DOI: 10.1111/j.1323-8930.2004.00318.x

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    Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide

    British Journal of Pharmacology

    Volume 165, Issue 6, March 2012, Pages: 1877–1890, A Buenestado, S Grassin-Delyle, F Guitard, E Naline, C Faisy, D Israël-Biet, E Sage, JF Bellamy, H Tenor and P Devillier

    Version of Record online : 22 FEB 2012, DOI: 10.1111/j.1476-5381.2011.01667.x

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    Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

    British Journal of Pharmacology

    Volume 136, Issue 3, June 2002, Pages: 421–433, Simon J MacKenzie, George S Baillie, Ian McPhee, Carolynn MacKenzie, Rachael Seamons, Theresa McSorley, Jenni Millen, Matthew B Beard, Gino van Heeke and Miles D Houslay

    Version of Record online : 2 FEB 2009, DOI: 10.1038/sj.bjp.0704743

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    Dual PDE3/4 and PDE4 Inhibitors: Novel Treatments For COPD and Other Inflammatory Airway Diseases

    Basic & Clinical Pharmacology & Toxicology

    Volume 114, Issue 5, May 2014, Pages: 365–376, Katharine H. Abbott-Banner and Clive P. Page

    Version of Record online : 6 MAR 2014, DOI: 10.1111/bcpt.12209

  10. Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microglia in vitro and following CNS injury

    Glia

    Volume 60, Issue 12, December 2012, Pages: 1839–1859, Mousumi Ghosh, Daniela Garcia-Castillo, Vladimir Aguirre, Roozbeh Golshani, Coleen M. Atkins, Helen M. Bramlett, W. Dalton Dietrich and Damien D. Pearse

    Version of Record online : 2 AUG 2012, DOI: 10.1002/glia.22401

  11. An update view on the substrate recognition mechanism of phosphodiesterases: A computational study of PDE10 and PDE4 bound with cyclic nucleotides

    Biopolymers

    Volume 97, Issue 11, November 2012, Pages: 910–922, Justin Kai-Chi Lau and Yuen-Kit Cheng

    Version of Record online : 13 AUG 2012, DOI: 10.1002/bip.22104

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    Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism

    British Journal of Pharmacology

    Volume 143, Issue 2, September 2004, Pages: 257–268, Claire Jacob, Corinne Szilagyi, Janet M Allen, Claude Bertrand and Vincent Lagente

    Version of Record online : 17 FEB 2009, DOI: 10.1038/sj.bjp.0705927

  13. NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in human endothelial cells

    Journal of Cellular Physiology

    Volume 227, Issue 5, May 2012, Pages: 1941–1950, Saima Muzaffar, Jamie Y. Jeremy, Gianni D. Angelini and Nilima Shukla

    Version of Record online : 23 JAN 2012, DOI: 10.1002/jcp.22922

  14. Inhibitory effects of hesperetin derivatives on guinea pig phosphodiesterases and Their ratios between high- and low-affinity rolipram binding

    Journal of Pharmaceutical Sciences

    Volume 102, Issue 7, July 2013, Pages: 2120–2127, Hsin-Te Hsu, Wen-Hung Wang, Cheng-Ying Han, Chun-Nan Chen, Chi-Ming Chen and Wun-Chang Ko

    Version of Record online : 10 MAY 2013, DOI: 10.1002/jps.23591

  15. Development of Phosphodiesterase 4 Inhibitors for Allergic and Nonallergic Inflammatory Diseases of the Airways

    Standard Article

    Pharmaceutical Sciences Encyclopedia

    Mark A. Giembycz

    Published Online : 16 DEC 2011, DOI: 10.1002/9780470571224.pse471

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    Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro

    British Journal of Pharmacology

    Volume 166, Issue 8, August 2012, Pages: 2243–2262, J Milara, M Armengot, P Bañuls, H Tenor, Rolf Beume, E Artigues and J Cortijo

    Version of Record online : 24 JUL 2012, DOI: 10.1111/j.1476-5381.2012.01929.x

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    Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease

    British Journal of Pharmacology

    Volume 163, Issue 1, May 2011, Pages: 53–67, Klaus F. Rabe

    Version of Record online : 6 APR 2011, DOI: 10.1111/j.1476-5381.2011.01218.x

  18. PDE4B as a microglia target to reduce neuroinflammation

    Glia

    Volume 64, Issue 10, October 2016, Pages: 1698–1709, Damien D. Pearse and Zoë A. Hughes

    Version of Record online : 1 APR 2016, DOI: 10.1002/glia.22986

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    Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model

    British Journal of Pharmacology

    Volume 171, Issue 9, May 2014, Pages: 2385–2398, S D Boomkamp, M A McGrath, M D Houslay and S C Barnett

    Version of Record online : 11 APR 2014, DOI: 10.1111/bph.12588

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    A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo

    British Journal of Pharmacology

    Volume 126, Issue 8, April 1999, Pages: 1863–1871, Nicola Cooper, Mauro M Teixeira, Julie Warneck, Jadwiga M Miotla, Ruth E Wills, David M T Macari, Robert W Gristwood and Paul G Hellewell

    Version of Record online : 29 JAN 2009, DOI: 10.1038/sj.bjp.0702520