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There are 7325 results for: content related to: Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

  1. Creation of Aggregation-Defective α-Synuclein Variants by Engineering the Sequence Connecting β-Strand-Forming Domains

    ChemBioChem

    Volume 12, Issue 17, November 25, 2011, Pages: 2630–2639, Michael Hernandez, Sofia Golbert, Li Guo Zhang and Prof. Jin Ryoun Kim

    Article first published online : 13 OCT 2011, DOI: 10.1002/cbic.201100430

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    α-Synuclein forms non-selective cation channels and stimulates ATP-sensitive potassium channels in hippocampal neurons

    The Journal of Physiology

    Volume 593, Issue 1, 1 January 2015, Pages: 145–159, Sergej L. Mironov

    Article first published online : 13 NOV 2014, DOI: 10.1113/jphysiol.2014.280974

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    Parathyroid hormone signaling via Gαs is selectively inhibited by an NH2-terminally truncated Gαs: Implications for pseudohypoparathyroidism

    Journal of Bone and Mineral Research

    Volume 26, Issue 10, October 2011, Pages: 2473–2485, Svetlana Puzhko, Cynthia Gates Goodyer, Mohammad Amin Kerachian, Lucie Canaff, Madhusmita Misra, Harald Jüppner, Murat Bastepe and Geoffrey N Hendy

    Article first published online : 21 SEP 2011, DOI: 10.1002/jbmr.461

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    Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

    The EMBO Journal

    Volume 29, Issue 20, October 20, 2010, Pages: 3571–3589, Frits Kamp, Nicole Exner, Anne Kathrin Lutz, Nora Wender, Jan Hegermann, Bettina Brunner, Brigitte Nuscher, Tim Bartels, Armin Giese, Klaus Beyer, Stefan Eimer, Konstanze F Winklhofer and Christian Haass

    Article first published online : 14 SEP 2010, DOI: 10.1038/emboj.2010.223

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    α-Synuclein and Polyunsaturated Fatty Acids Promote Clathrin-Mediated Endocytosis and Synaptic Vesicle Recycling

    Traffic

    Volume 10, Issue 2, February 2009, Pages: 218–234, Tziona Ben Gedalya, Virginie Loeb, Eitan Israeli, Yoram Altschuler, Dennis J. Selkoe and Ronit Sharon

    Article first published online : 31 OCT 2008, DOI: 10.1111/j.1600-0854.2008.00853.x

  6. Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity

    Journal of Neurochemistry

    Volume 134, Issue 5, September 2015, Pages: 943–955, Ryoichi Takahashi, Kenjiro Ono, Yusaku Takamura, Mineyuki Mizuguchi, Tokuhei Ikeda, Hisao Nishijo and Masahito Yamada

    Article first published online : 17 JUN 2015, DOI: 10.1111/jnc.13180

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    N-terminal region of α-synuclein is essential for the fatty acid-induced oligomerization of the molecules

    FEBS Letters

    Volume 582, Issue 25-26, October 29, 2008, Pages: 3693–3700, Hiroki Karube, Masahiro Sakamoto, Shigeki Arawaka, Susumu Hara, Hiroyasu Sato, Chang-Hong Ren, Saori Goto, Shingo Koyama, Manabu Wada, Toru Kawanami, Keiji Kurita and Takeo Kato

    Article first published online : 9 OCT 2008, DOI: 10.1016/j.febslet.2008.10.001

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    NMR determination of pKa values in α-synuclein

    Protein Science

    Volume 20, Issue 2, February 2011, Pages: 256–269, Robyn L. Croke, Sharadrao M. Patil, Jason Quevreaux, Debra A. Kendall and Andrei T. Alexandrescu

    Article first published online : 13 DEC 2010, DOI: 10.1002/pro.556

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    Hydrogen exchange of monomeric α-synuclein shows unfolded structure persists at physiological temperature and is independent of molecular crowding in Escherichia coli

    Protein Science

    Volume 17, Issue 8, August 2008, Pages: 1434–1445, Robyn L. Croke, Christine O. Sallum, Emma Watson, Eric D. Watt and Andrei T. Alexandrescu

    Article first published online : 2 JAN 2009, DOI: 10.1110/ps.033803.107

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    β-Synuclein occurs in vivo in lipid-associated oligomers and forms hetero-oligomers with α-synuclein

    Journal of Neurochemistry

    Volume 108, Issue 2, January 2009, Pages: 465–474, Eitan Israeli and Ronit Sharon

    Article first published online : 10 NOV 2008, DOI: 10.1111/j.1471-4159.2008.05776.x

  11. α-Synuclein abnormalities in mouse models of peroxisome biogenesis disorders

    Journal of Neuroscience Research

    Volume 88, Issue 4, March 2010, Pages: 866–876, Eugenia Yakunin, Ann Moser, Virginie Loeb, Ann Saada, Phyllis Faust, Denis I. Crane, Myriam Baes and Ronit Sharon

    Article first published online : 14 OCT 2009, DOI: 10.1002/jnr.22246

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    Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein

    Journal of Neurochemistry

    Volume 131, Issue 6, December 2014, Pages: 859–867, Nicola J. Rutherford, Brenda D. Moore, Todd E. Golde and Benoit I. Giasson

    Article first published online : 21 JUL 2014, DOI: 10.1111/jnc.12806

  13. Spin-Label EPR on α-Synuclein Reveals Differences in the Membrane Binding Affinity of the Two Antiparallel Helices

    ChemBioChem

    Volume 9, Issue 15, October 13, 2008, Pages: 2411–2416, Malte Drescher, Frans Godschalk, Gertjan Veldhuis, Bart D. van Rooijen, Vinod Subramaniam and Martina Huber

    Article first published online : 26 SEP 2008, DOI: 10.1002/cbic.200800238

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    The loss of inhibitory C-terminal conformations in disease associated P123H β-synuclein

    Protein Science

    Volume 25, Issue 1, January 2016, Pages: 286–294, Maria K. Janowska and Jean Baum

    Article first published online : 21 SEP 2015, DOI: 10.1002/pro.2798

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    Cross-seeding effects of amyloid β-protein and α-synuclein

    Journal of Neurochemistry

    Volume 122, Issue 5, September 2012, Pages: 883–890, Kenjiro Ono, Ryoichi Takahashi, Tokuhei Ikeda and Masahito Yamada

    Article first published online : 23 JUL 2012, DOI: 10.1111/j.1471-4159.2012.07847.x

  16. Effects of antiparkinsonian agents on β-amyloid and α-synuclein oligomer formation in vitro

    Journal of Neuroscience Research

    Volume 91, Issue 10, October 2013, Pages: 1371–1381, Kenjiro Ono, Jun-ichi Takasaki, Ryoichi Takahashi, Tokuhei Ikeda and Masahito Yamada

    Article first published online : 1 AUG 2013, DOI: 10.1002/jnr.23256

  17. Anti-fibrillogenic and fibril-destabilizing activities of anti-Parkinsonian agents for α-synuclein fibrils in vitro

    Journal of Neuroscience Research

    Volume 85, Issue 7, 15 May 2007, Pages: 1547–1557, Kenjiro Ono, Mie Hirohata and Masahito Yamada

    Article first published online : 23 MAR 2007, DOI: 10.1002/jnr.21271

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    Activation of Pyk2/RAFTK induces tyrosine phosphorylation of α-synuclein via Src-family kinases

    FEBS Letters

    Volume 521, Issue 1-3, June 19, 2002, Pages: 190–194, Takeshi Nakamura, Hiroshi Yamashita, Yoshito Nagano, Tetsuya Takahashi, Shalom Avraham, Hava Avraham, Masayasu Matsumoto and Shigenobu Nakamura

    Article first published online : 30 MAY 2002, DOI: 10.1016/S0014-5793(02)02861-2

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    Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death

    Journal of Neurochemistry

    Volume 98, Issue 1, July 2006, Pages: 45–56, Hiroshi Yamashita, Takeshi Nakamura, Tetsuya Takahashi, Yoshito Nagano, Masanori Hiji, Takahiro Hirabayashi, Taku Amano, Takeshi Yagi, Norio Sakai, Tatsuo Kohriyama and Masayasu Matsumoto

    Article first published online : 12 MAY 2006, DOI: 10.1111/j.1471-4159.2006.03815.x

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    Membrane interactions and fibrillization of α-synuclein play an essential role in membrane disruption

    FEBS Letters

    Volume 588, Issue 23, November 28, 2014, Pages: 4457–4463, Himanshu Chaudhary, Anja N.D. Stefanovic, Vinod Subramaniam and Mireille M.A.E. Claessens

    Article first published online : 25 OCT 2014, DOI: 10.1016/j.febslet.2014.10.016