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There are 14481 results for: content related to: The significance of QT interval in drug development

  1. QT and QTc Interval With Standard and Supratherapeutic Doses of Darifenacin, a Muscarinic M3 Selective Receptor Antagonist for the Treatment of Overactive Bladder

    The Journal of Clinical Pharmacology

    Volume 45, Issue 9, September 2005, Pages: 1038–1047, Denise B. Serra, Melton B. Affrime, Martin P. Bedigian, Gerard Greig, Slavica Milosavljev, Andrej Skerjanec and Yibin Wang

    Article first published online : 19 MAR 2013, DOI: 10.1177/0091270005279010

  2. Drug-induced prolongation of the QT interval: regulatory dilemmas and implications for approval and labelling of a new chemical entity

    Fundamental & Clinical Pharmacology

    Volume 16, Issue 2, April 2002, Pages: 147–156, Rashmi R. Shah

    Article first published online : 28 MAY 2002, DOI: 10.1046/j.1472-8206.2002.00083.x

  3. Proarrhythmic Safety of Repeat Doses of Mirabegron in Healthy Subjects: A Randomized, Double-Blind, Placebo-, and Active-Controlled Thorough QT Study

    Clinical Pharmacology & Therapeutics

    Volume 92, Issue 6, December 2012, Pages: 696–706, M Malik, E M van Gelderen, J H Lee, D L Kowalski, M Yen, R Goldwater, S K Mujais, M P Schaddelee, P de Koning, A Kaibara, S S Moy and J J Keirns

    Article first published online : 14 NOV 2012, DOI: 10.1038/clpt.2012.181

  4. In Vivo and In Vitro Electrophysiologic Effects of Terodiline on Dog Myocardium

    Journal of Cardiovascular Electrophysiology

    Volume 6, Issue 6, June 1995, Pages: 443–454, MILTON L. PRESSLER, MARGARET R. WARNER, MICHAEL RUBART, DAVID P. RARDON and DOUGLAS P. ZIPES

    Article first published online : 29 APR 2007, DOI: 10.1111/j.1540-8167.1995.tb00418.x

  5. Withdrawal of Terodiline: A Tale of Two Toxicities

    Pharmacovigilance, Second Edition

    Ronald D. Mann, Elizabeth B. Andrews, Pages: 109–136, 2007

    Published Online : 7 FEB 2007, DOI: 10.1002/9780470059210.ch10

  6. Stereoselective cardiotoxic effects of terodiline

    Clinical Pharmacology & Therapeutics

    Volume 60, Issue 1, July 1996, Pages: 89–98, Kenneth Hartigan-Go, D. Nicholas Bateman, Ann K. Daly and Simon H. L. Thomas

    Article first published online : 1 JUL 1996, DOI: 10.1016/S0009-9236(96)90171-X

  7. Withdrawal of Terodiline: A Tale of Two Toxicities

    Pharmacovigilance

    Ronald D. Mann, Elizabeth B. Andrews, Pages: 135–154, 2002

    Published Online : 31 OCT 2002, DOI: 10.1002/0470853093.ch11

  8. Drug-induced prolongation of the QT interval: why the regulatory concern?

    Fundamental & Clinical Pharmacology

    Volume 16, Issue 2, April 2002, Pages: 119–124, Rashmi R. Shah

    Article first published online : 28 MAY 2002, DOI: 10.1046/j.1472-8206.2002.00082.x

  9. PEM report number 2. Terodiline

    Pharmacoepidemiology and Drug Safety

    Volume 2, Issue 4-5, July - October 1993, Pages: 287–319, William Inman, Joan Clarke, Lynda Wilton, Gillian Pearce and Gerritt Jan Veldhuis

    Article first published online : 31 JAN 2006, DOI: 10.1002/pds.2630020405

  10. Actions of Terodiline, its Isomers and Main Metabolite on Isolated Detrusor Muscle from Rabbit and Man

    Pharmacology & Toxicology

    Volume 63, Issue 5, November 1988, Pages: 390–395, Karl-Erik Andersson, Björn Ekström and Anders Mattiasson

    Article first published online : 25 MAR 2009, DOI: 10.1111/j.1600-0773.1988.tb00974.x

  11. Concomitant Single-Dose and Multiple-Dose Pharmacokinetics of Terodiline in Man, with a Note on its Enantiomers and Major Metabolites

    Pharmacology & Toxicology

    Volume 76, Issue 3, March 1995, Pages: 171–177, Bengt Hallén, Johan Gabrielsson, Samuel Nyambati, Agneta Johansson, Eva Larsson and Olivier Guilbaud

    Article first published online : 25 MAR 2009, DOI: 10.1111/j.1600-0773.1995.tb00125.x

  12. Pharmacokinetics of Terodiline and a Major Metabolite in Dogs with a Correlation to a Pharmacodynamic Effect

    Pharmacology & Toxicology

    Volume 66, Issue 5, May 1990, Pages: 373–381, B. Hallén, M. Grälls, H. Brötell and S. Strömberg

    Article first published online : 25 MAR 2009, DOI: 10.1111/j.1600-0773.1990.tb00765.x

  13. Effects of three fluoroquinolones on QT interval in healthy adults after single doses

    Clinical Pharmacology & Therapeutics

    Volume 73, Issue 4, April 2003, Pages: 292–303, Gary J. Noel, Jaya Natarajan, Shuchean Chien, Thomas L. Hunt, Daniel B. Goodman and Robert Abels

    Article first published online : 25 APR 2003, DOI: 10.1016/S0009-9236(03)00009-2

  14. Antipsychotics and QT prolongation

    Acta Psychiatrica Scandinavica

    Volume 107, Issue 2, February 2003, Pages: 85–95, D. M. Taylor

    Article first published online : 17 JAN 2003, DOI: 10.1034/j.1600-0447.2003.02078.x

  15. Comparison of the Calcium–Antagonistic Effects of Terodiline, Nifedipine and Verapamil

    Acta Pharmacologica et Toxicologica

    Volume 57, Issue 1, July 1985, Pages: 8–17, Carin Larsson-Backström, Eva Arrhenius and Kristina Sagge

    Article first published online : 13 MAR 2009, DOI: 10.1111/j.1600-0773.1985.tb00002.x

  16. Single-dose pharmacokinetics of terodiline, including a stable isotope technique for improvement of statistical evaluations

    Biopharmaceutics & Drug Disposition

    Volume 9, Issue 3, May/June 1988, Pages: 229–250, Bengt Hallén, Olivier Guilbaud, Signhild Strömberg and Björn Lindeke

    Article first published online : 10 MAR 2006, DOI: 10.1002/bod.2510090302

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    Alterations in Corrected QT Interval Following Liver Transplant in Patients With End-Stage Liver Disease

    Clinical Cardiology

    Volume 33, Issue 11, November 2010, Pages: 672–677, Andrew O. Zurick III, Bret J. Spier, Thomas C. Teelin, Katelin R. Lorenze, Cesar Alberte, Steven Zacks, Mary J. Lindstrom, Patrick R. Pfau and Kimberly Selzman

    Article first published online : 18 NOV 2010, DOI: 10.1002/clc.20801

  18. Effects on Repolarization Using Dynamic QT Interval Monitoring in Long-QT Patients Following Left Cardiac Sympathetic Denervation

    Journal of Cardiovascular Electrophysiology

    CHRISTOPHER V. DESIMONE, J. MARTIJN BOS, KATY M. BOS, JACKSON J. LIANG, NIKHIL A. PATEL, DAVID O. HODGE, AMIT NOHERIA, SAMUEL J. ASIRVATHAM and MICHAEL J. ACKERMAN

    Article first published online : 8 FEB 2015, DOI: 10.1111/jce.12609

  19. Thorough QT Study With Recommended and Supratherapeutic Doses of Tolterodine

    Clinical Pharmacology & Therapeutics

    Volume 83, Issue 2, February 2008, Pages: 231–232, B Olshansky and DB Serra

    Article first published online : 8 AUG 2007, DOI: 10.1038/sj.clpt.6100328

  20. Preferred QT Correction Formula for the Assessment of Drug-Induced QT Interval Prolongation

    Journal of Cardiovascular Electrophysiology

    Volume 21, Issue 8, August 2010, Pages: 905–913, JOHN CHILADAKIS, ANDREAS KALOGEROPOULOS, PANAGIOTIS ARVANITIS, NIKOLAOS KOUTSOGIANNIS, FANI ZAGLI and DIMITRIOS ALEXOPOULOS

    Article first published online : 5 MAR 2010, DOI: 10.1111/j.1540-8167.2010.01738.x