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There are 623529 results for: content related to: Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

  1. β-Amyloid Therapeutic Strategies for Alzheimer's Disease

    Standard Article

    Burger's Medicinal Chemistry and Drug Discovery

    Bruno P. Imbimbo and Francesca Speroni

    Published Online : 14 OCT 2005, DOI: 10.1002/0471266949.bmc112

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    Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease

    British Journal of Pharmacology

    Volume 163, Issue 2, May 2011, Pages: 375–389, B Van Broeck, J-M Chen, G Tréton, M Desmidt, C Hopf, N Ramsden, E Karran, M Mercken and A Rowley

    Version of Record online : 18 APR 2011, DOI: 10.1111/j.1476-5381.2011.01207.x

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    A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

    EMBO reports

    Volume 3, Issue 7, July 2002, Pages: 688–694, Andrea Geling, Harald Steiner, Michael Willem, Laure Bally-Cuif and Christian Haass

    Version of Record online : 1 JUL 2002, DOI: 10.1093/embo-reports/kvf124

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    The same γ-secretase accounts for the multiple intramembrane cleavages of APP

    Journal of Neurochemistry

    Volume 100, Issue 5, March 2007, Pages: 1234–1246, Guojun Zhao, Jianxin Tan, Guozhang Mao, Mei-Zhen Cui and Xuemin Xu

    Version of Record online : 6 NOV 2006, DOI: 10.1111/j.1471-4159.2006.04302.x

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    Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics

    Journal of Neurochemistry

    Volume 97, Issue 6, June 2006, Pages: 1700–1725, Colin L. Masters, Roberto Cappai, Kevin J. Barnham and Victor L. Villemagne

    Version of Record online : 19 JUN 2006, DOI: 10.1111/j.1471-4159.2006.03989.x

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    In vivo manifestation of Notch related phenotypes in zebrafish treated with Alzheimer’s amyloid reducing γ-secretase inhibitors

    Journal of Neurochemistry

    Volume 113, Issue 5, June 2010, Pages: 1200–1209, Ting Yang, Dilyara Arslanova, Xiaoyin Xu, Yue-Ming Li and Weiming Xia

    Version of Record online : 12 MAR 2010, DOI: 10.1111/j.1471-4159.2010.06681.x

  7. γ-Secretase component presenilin is important for microglia β-amyloid clearance

    Annals of Neurology

    Volume 69, Issue 1, January 2011, Pages: 170–180, Dorit Farfara, Dorit Trudler, Niva Segev-Amzaleg, Ronit Galron, Reuven Stein and Dan Frenkel

    Version of Record online : 22 NOV 2010, DOI: 10.1002/ana.22191

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    Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing

    FEBS Open Bio

    Volume 5, Issue 1, January 01, 2015, Pages: 763–773, Marie Decock, Laetitia El Haylani, Serena Stanga, Ilse Dewachter, Jean-Noël Octave, Steven O. Smith, Stefan N. Constantinescu and Pascal Kienlen-Campard

    Version of Record online : 6 SEP 2015, DOI: 10.1016/j.fob.2015.09.002

  9. Lactacystin decreases amyloid-β peptide production by inhibiting β-secretase activity

    Journal of Neuroscience Research

    Volume 84, Issue 6, 1 November 2006, Pages: 1311–1322, Pascal Kienlen-Campard, Christine Feyt, Sandra Huysseune, Philippe de Diesbach, Francisca N'Kuli, Pierre J. Courtoy and Jean-Noël Octave

    Version of Record online : 28 AUG 2006, DOI: 10.1002/jnr.21025

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    Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling

    Journal of Neurochemistry

    Volume 107, Issue 1, October 2008, Pages: 279–290, Masamitsu Shimazawa, Yuta Inokuchi, Takashi Okuno, Yoshihiro Nakajima, Gaku Sakaguchi, Akira Kato, Hidehiro Oku, Tetsuya Sugiyama, Takashi Kudo, Tsunehiko Ikeda, Masatoshi Takeda and Hideaki Hara

    Version of Record online : 7 AUG 2008, DOI: 10.1111/j.1471-4159.2008.05606.x

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    REVIEW: γ-Secretase Inhibitors for the Treatment of Alzheimer's Disease: The Current State

    CNS Neuroscience & Therapeutics

    Volume 16, Issue 5, October 2010, Pages: 272–284, Francesco Panza, Vincenza Frisardi, Bruno P. Imbimbo, Cristiano Capurso, Giancarlo Logroscino, Daniele Sancarlo, Davide Seripa, Gianluigi Vendemiale, Alberto Pilotto and Vincenzo Solfrizzi

    Version of Record online : 16 JUN 2010, DOI: 10.1111/j.1755-5949.2010.00164.x

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    Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production

    Journal of Neurochemistry

    Volume 128, Issue 2, January 2014, Pages: 330–339, Marc Suárez-Calvet, Olivia Belbin, Marta Pera, Nahuai Badiola, Jordi Magrané, Cristina Guardia-Laguarta, Laia Muñoz, Martí Colom-Cadena, Jordi Clarimón and Alberto Lleó

    Version of Record online : 24 OCT 2013, DOI: 10.1111/jnc.12466

  13. Approaches to Amyloid Therapies for the Treatment of Alzheimer's Disease

    Standard Article

    Burger's Medicinal Chemistry and Drug Discovery

    Albert J. Robichaud, Ji-In Kim and J. Steven Jacobsen

    Published Online : 15 SEP 2010, DOI: 10.1002/0471266949.bmc249

  14. Alzheimer's Disease: From Pathology to Therapeutic Approaches

    Angewandte Chemie International Edition

    Volume 48, Issue 17, April 14, 2009, Pages: 3030–3059, Roland Jakob-Roetne and Helmut Jacobsen

    Version of Record online : 28 MAR 2009, DOI: 10.1002/anie.200802808

  15. Caspases-2 and -8 are involved in the presenilin1/γ-secretase-dependent cleavage of amyloid precursor protein after the induction of apoptosis

    Journal of Neuroscience Research

    Volume 88, Issue 9, July 2010, Pages: 1926–1933, San Sook Chae, Chul Bae Yoo, Chulman Jo, Sang-Moon Yun, Sangmee Ahn Jo and Young Ho Koh

    Version of Record online : 8 FEB 2010, DOI: 10.1002/jnr.22356

  16. Lipid membrane templates the ordering and induces the fibrillogenesis of Alzheimer's disease amyloid-β peptide

    Proteins: Structure, Function, and Bioinformatics

    Volume 72, Issue 1, July 2008, Pages: 1–24, Eva Y. Chi, Canay Ege, Amy Winans, Jaroslaw Majewski, Guohui Wu, Kristian Kjaer and Ka Yee C. Lee

    Version of Record online : 10 JAN 2008, DOI: 10.1002/prot.21887

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    Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity

    Journal of Neurochemistry

    Volume 123, Issue 5, December 2012, Pages: 856–865, Seok Soon Park, Hyun-Jung Jung, Yoon-Jeong Kim, Tae Kwan Park, Chaeyoung Kim, Heesun Choi, In Hee Mook-Jung, Edward H. Koo and Sun Ah Park

    Version of Record online : 25 OCT 2012, DOI: 10.1111/jnc.12032

  18. Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls

    Annals of Neurology

    Volume 73, Issue 1, January 2013, Pages: 104–119, Thomas J. Esparza, Hanzhi Zhao, John R. Cirrito, Nigel J. Cairns, Randall J. Bateman, David M. Holtzman and David L. Brody

    Version of Record online : 7 DEC 2012, DOI: 10.1002/ana.23748

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    APPε, the ε-secretase-derived N-terminal product of the β-amyloid precursor protein, behaves as a type I protein and undergoes α-, β-, and γ-secretase cleavages

    Journal of Neurochemistry

    Volume 97, Issue 3, May 2006, Pages: 807–817, Solveig Lefranc-Jullien, Claire Sunyach and Frédéric Checler

    Version of Record online : 8 MAR 2006, DOI: 10.1111/j.1471-4159.2006.03748.x

  20. Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Aβ levels in cellular models of Alzheimer's disease

    European Journal of Neuroscience

    Volume 26, Issue 4, August 2007, Pages: 882–889, Charlotte Sahlin, Frida Ekholm Pettersson, Lars N. G. Nilsson, Lars Lannfelt and Ann-Sofi Johansson

    Version of Record online : 15 AUG 2007, DOI: 10.1111/j.1460-9568.2007.05719.x