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There are 26389 results for: content related to: Reducing signs of aging and increasing lifespan by drug synergy

  1. You have full text access to this OnlineOpen article
    The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

    Aging Cell

    Yi Zhu, Tamara Tchkonia, Tamar Pirtskhalava, Adam C. Gower, Husheng Ding, Nino Giorgadze, Allyson K. Palmer, Yuji Ikeno, Gene B. Hubbard, Marc Lenburg, Steven P. O'Hara, Nicholas F. LaRusso, Jordan D. Miller, Carolyn M. Roos, Grace C. Verzosa, Nathan K. LeBrasseur, Jonathan D. Wren, Joshua N. Farr, Sundeep Khosla, Michael B. Stout, Sara J. McGowan, Heike Fuhrmann-Stroissnigg, Aditi U. Gurkar, Jing Zhao, Debora Colangelo, Akaitz Dorronsoro, Yuan Yuan Ling, Amira S. Barghouthy, Diana C. Navarro, Tokio Sano, Paul D. Robbins, Laura J. Niedernhofer and James L. Kirkland

    Article first published online : 22 APR 2015, DOI: 10.1111/acel.12344

  2. You have full text access to this OnlineOpen article
    Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging

    Aging Cell

    Volume 13, Issue 6, December 2014, Pages: 981–1000, Oge Arum, Ravneet K. Boparai, Jamal K. Saleh, Feiya Wang, Angela L. Dirks, Jeremy G. Turner, John J. Kopchick, Jun-Li Liu, Romesh K. Khardori and Andrzej Bartke

    Article first published online : 20 SEP 2014, DOI: 10.1111/acel.12262

  3. You have full text access to this OnlineOpen article
    Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors

    Aging Cell

    Volume 14, Issue 3, June 2015, Pages: 421–432, Talibah U. Metcalf, Rafael A. Cubas, Khader Ghneim, Michael J. Cartwright, Julien Van Grevenynghe, Justin M. Richner, David P. Olagnier, Peter A. Wilkinson, Mark J. Cameron, Byung S. Park, John B. Hiscott, Michael S. Diamond, Anne M. Wertheimer, Janko Nikolich-Zugich and Elias K. Haddad

    Article first published online : 27 FEB 2015, DOI: 10.1111/acel.12320

  4. You have full text access to this OnlineOpen article
    FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca2+/CREB pathway

    Aging Cell

    Volume 14, Issue 3, June 2015, Pages: 409–420, Xin-Mei Liu, Hsiao Chang Chan, Guo-Lian Ding, Jie Cai, Yang Song, Ting-Ting Wang, Dan Zhang, Hui Chen, Mei Kuen Yu, Yan-Ting Wu, Fan Qu, Ye Liu, Yong-Chao Lu, Eli Y. Adashi, Jian-Zhong Sheng and He-Feng Huang

    Article first published online : 6 MAR 2015, DOI: 10.1111/acel.12331

  5. You have full text access to this OnlineOpen article
    In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells

    Aging Cell

    Volume 14, Issue 3, June 2015, Pages: 382–390, Michelle Ratliff, Sarah Alter, Kelly McAvoy, Daniela Frasca, Jacqueline A. Wright, Sandra S. Zinkel, Wasif N. Khan, Bonnie B. Blomberg and Richard L. Riley

    Article first published online : 27 FEB 2015, DOI: 10.1111/acel.12302

  6. You have full text access to this OnlineOpen article
    Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake

    Aging Cell

    Adam P. Sharples, David C. Hughes, Colleen S. Deane, Amarjit Saini, Colin Selman and Claire E. Stewart

    Article first published online : 10 APR 2015, DOI: 10.1111/acel.12342

  7. You have full text access to this OnlineOpen article
    Accelerated microglial pathology is associated with Aβ plaques in mouse models of Alzheimer's disease

    Aging Cell

    Volume 13, Issue 4, August 2014, Pages: 584–595, Rona Baron, Alicia A. Babcock, Anna Nemirovsky, Bente Finsen and Alon Monsonego

    Article first published online : 18 MAR 2014, DOI: 10.1111/acel.12210

  8. You have full text access to this OnlineOpen article
    Modifications in stromal extracellular matrix of aged corneas can be induced by ultraviolet A irradiation

    Aging Cell

    Volume 14, Issue 3, June 2015, Pages: 433–442, Sébastien P. Gendron and Patrick J. Rochette

    Article first published online : 25 FEB 2015, DOI: 10.1111/acel.12324

  9. You have full text access to this OnlineOpen article
    Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae

    Aging Cell

    Volume 14, Issue 3, June 2015, Pages: 366–371, Alaattin Kaya, Alexei V. Lobanov and Vadim N. Gladyshev

    Article first published online : 22 FEB 2015, DOI: 10.1111/acel.12290

  10. You have full text access to this OnlineOpen article
    Essential role for the TRF2 telomere protein in adult skin homeostasis

    Aging Cell

    Volume 13, Issue 4, August 2014, Pages: 656–668, Paula Martínez, Iole Ferrara-Romeo, Juana M. Flores and Maria A. Blasco

    Article first published online : 14 APR 2014, DOI: 10.1111/acel.12221

  11. You have full text access to this OnlineOpen article
    CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase

    Aging Cell

    Amir Kumar Singh and Uttam Pati

    Article first published online : 13 MAR 2015, DOI: 10.1111/acel.12335

  12. You have full text access to this OnlineOpen article
    Aging and radiation: bad companions

    Aging Cell

    Volume 14, Issue 2, April 2015, Pages: 153–161, Laia Hernández, Mariona Terradas, Jordi Camps, Marta Martín, Laura Tusell and Anna Genescà

    Article first published online : 2 FEB 2015, DOI: 10.1111/acel.12306

  13. You have full text access to this OnlineOpen article
    Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

    Aging Cell

    Volume 13, Issue 3, June 2014, Pages: 529–539, Dao-Fu Dai, Pabalu P. Karunadharma, Ying A. Chiao, Nathan Basisty, David Crispin, Edward J. Hsieh, Tony Chen, Haiwei Gu, Danijel Djukovic, Daniel Raftery, Richard P. Beyer, Michael J. MacCoss and Peter S. Rabinovitch

    Article first published online : 25 FEB 2014, DOI: 10.1111/acel.12203

  14. You have full text access to this OnlineOpen article
    Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects

    Aging Cell

    Pabalu P. Karunadharma, Nathan Basisty, Dao-Fu Dai, Ying A. Chiao, Ellen K. Quarles, Edward J. Hsieh, David Crispin, Jason H. Bielas, Nolan G. Ericson, Richard P. Beyer, Vivian L. MacKay, Michael J. MacCoss and Peter S. Rabinovitch

    Article first published online : 23 MAR 2015, DOI: 10.1111/acel.12317

  15. You have full text access to this OnlineOpen article
    Gene expression defines natural changes in mammalian lifespan

    Aging Cell

    Volume 14, Issue 3, June 2015, Pages: 352–365, Alexey A. Fushan, Anton A. Turanov, Sang-Goo Lee, Eun Bae Kim, Alexei V. Lobanov, Sun Hee Yim, Rochelle Buffenstein, Sang-Rae Lee, Kyu-Tae Chang, Hwanseok Rhee, Jong-So Kim, Kap-Seok Yang and Vadim N. Gladyshev

    Article first published online : 9 FEB 2015, DOI: 10.1111/acel.12283

  16. You have full text access to this Open Access content
    Cryptochrome restores dampened circadian rhythms and promotes healthspan in aging Drosophila

    Aging Cell

    Volume 12, Issue 5, October 2013, Pages: 752–762, Kuntol Rakshit and Jadwiga M. Giebultowicz

    Article first published online : 25 JUN 2013, DOI: 10.1111/acel.12100

  17. You have full text access to this Open Access content
    Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans

    Aging Cell

    Volume 12, Issue 6, December 2013, Pages: 1073–1081, Keunhee Seo, Eunseok Choi, Dongyeop Lee, Dae-Eun Jeong, Sung Key Jang and Seung-Jae Lee

    Article first published online : 4 SEP 2013, DOI: 10.1111/acel.12140

  18. You have full text access to this OnlineOpen article
    Regulation of the p19Arf/p53 pathway by histone acetylation underlies neural stem cell behavior in senescence-prone SAMP8 mice

    Aging Cell

    Volume 14, Issue 3, June 2015, Pages: 453–462, Raúl Soriano-Cantón, Ana Perez-Villalba, José Manuel Morante-Redolat, María Ángeles Marqués-Torrejón, Mercé Pallás, Francisco Pérez-Sánchez and Isabel Fariñas

    Article first published online : 26 FEB 2015, DOI: 10.1111/acel.12328

  19. You have full text access to this OnlineOpen article
    Neuronal glycogen synthesis contributes to physiological aging

    Aging Cell

    Volume 13, Issue 5, October 2014, Pages: 935–945, Christopher Sinadinos, Jordi Valles-Ortega, Laura Boulan, Estel Solsona, Maria F. Tevy, Mercedes Marquez, Jordi Duran, Carmen Lopez-Iglesias, Joaquim Calbó, Ester Blasco, Marti Pumarola, Marco Milán and Joan J. Guinovart

    Article first published online : 25 JUL 2014, DOI: 10.1111/acel.12254

  20. You have full text access to this Open Access content
    Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging

    Aging Cell

    Volume 12, Issue 5, October 2013, Pages: 802–813, Eleni N. Tsakiri, Gerasimos P. Sykiotis, Issidora S. Papassideri, Evangelos Terpos, Meletios A. Dimopoulos, Vassilis G. Gorgoulis, Dirk Bohmann and Ioannis P. Trougakos

    Article first published online : 28 JUN 2013, DOI: 10.1111/acel.12111