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There are 34928 results for: content related to: Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

  1. You have full text access to this OnlineOpen article
    Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

    Aging Cell

    Volume 15, Issue 1, February 2016, Pages: 28–38, Sebastian I. Arriola Apelo, Joshua C. Neuman, Emma L. Baar, Faizan A. Syed, Nicole E. Cummings, Harpreet K. Brar, Cassidy P. Pumper, Michelle E. Kimple and Dudley W. Lamming

    Version of Record online : 13 OCT 2015, DOI: 10.1111/acel.12405

  2. You have full text access to this OnlineOpen article
    Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

    Aging Cell

    Volume 14, Issue 2, April 2015, Pages: 265–273, Katherine H. Schreiber, Denise Ortiz, Emmeline C. Academia, Arieanna C. Anies, Chen-Yu Liao and Brian K. Kennedy

    Version of Record online : 4 FEB 2015, DOI: 10.1111/acel.12313

  3. You have full text access to this OnlineOpen article
    TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast

    Aging Cell

    Volume 12, Issue 4, August 2013, Pages: 563–573, Charalampos Rallis, Sandra Codlin and Jürg Bähler

    Version of Record online : 2 MAY 2013, DOI: 10.1111/acel.12080

  4. You have full text access to this Open Access content
    Late-life rapamycin treatment reverses age-related heart dysfunction

    Aging Cell

    Volume 12, Issue 5, October 2013, Pages: 851–862, James M. Flynn, Monique N. O'Leary, Christopher A. Zambataro, Emmeline C. Academia, Michael P. Presley, Brittany J. Garrett, Artem Zykovich, Sean D. Mooney, Randy Strong, Clifford J. Rosen, Pankaj Kapahi, Michael D. Nelson, Brian K. Kennedy and Simon Melov

    Version of Record online : 7 JUL 2013, DOI: 10.1111/acel.12109

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    Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

    Aging Cell

    Volume 12, Issue 6, December 2013, Pages: 966–977, Chad Lerner, Alessandro Bitto, Daniel Pulliam, Timothy Nacarelli, Mina Konigsberg, Holly Van Remmen, Claudio Torres and Christian Sell

    Version of Record online : 30 JUL 2013, DOI: 10.1111/acel.12122

  6. You have full text access to this OnlineOpen article
    Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways

    Aging Cell

    Volume 16, Issue 1, February 2017, Pages: 17–26, Lisa A. Lesniewski, Douglas R. Seals, Ashley E. Walker, Grant D. Henson, Mark W. Blimline, Daniel W. Trott, Gary C. Bosshardt, Thomas J. LaRocca, Brooke R. Lawson, Melanie C. Zigler and Anthony J. Donato

    Version of Record online : 22 SEP 2016, DOI: 10.1111/acel.12524

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    Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive

    Aging Cell

    Volume 12, Issue 4, August 2013, Pages: 712–718, Dudley W. Lamming, Lan Ye, Clinton M. Astle, Joseph A. Baur, David M. Sabatini and David E. Harrison

    Version of Record online : 7 JUN 2013, DOI: 10.1111/acel.12097

  8. You have full text access to this OnlineOpen article
    Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism

    Aging Cell

    Volume 16, Issue 3, June 2017, Pages: 564–574, Rong Wang, Zhen Yu, Bharath Sunchu, James Shoaf, Ivana Dang, Stephanie Zhao, Kelsey Caples, Lynda Bradley, Laura M. Beaver, Emily Ho, Christiane V. Löhr and Viviana I. Perez

    Version of Record online : 31 MAR 2017, DOI: 10.1111/acel.12587

  9. You have full text access to this OnlineOpen article
    A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans

    Aging Cell

    Volume 15, Issue 2, April 2016, Pages: 256–266, Shaun Calvert, Robi Tacutu, Samim Sharifi, Rute Teixeira, Pratul Ghosh and João Pedro de Magalhães

    Version of Record online : 16 DEC 2015, DOI: 10.1111/acel.12432

  10. You have full text access to this OnlineOpen article
    Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice

    Aging Cell

    Volume 14, Issue 6, December 2015, Pages: 945–956, Vincent Hurez, Vinh Dao, Aijie Liu, Srilakshmi Pandeswara, Jonathan Gelfond, Lishi Sun, Molly Bergman, Carlos J. Orihuela, Veronica Galvan, Álvaro Padrón, Justin Drerup, Yang Liu, Paul Hasty, Zelton Dave Sharp and Tyler J. Curiel

    Version of Record online : 28 AUG 2015, DOI: 10.1111/acel.12380

  11. You have full text access to this OnlineOpen article
    A comprehensive approach to the molecular determinants of lifespan using a Boolean model of geroconversion

    Aging Cell

    Volume 15, Issue 6, December 2016, Pages: 1018–1026, Loic Verlingue, Aurélien Dugourd, Gautier Stoll, Emmanuel Barillot, Laurence Calzone and Arturo Londoño-Vallejo

    Version of Record online : 9 SEP 2016, DOI: 10.1111/acel.12504

  12. You have full text access to this OnlineOpen article
    Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake

    Aging Cell

    Volume 14, Issue 4, August 2015, Pages: 511–523, Adam P. Sharples, David C. Hughes, Colleen S. Deane, Amarjit Saini, Colin Selman and Claire E. Stewart

    Version of Record online : 10 APR 2015, DOI: 10.1111/acel.12342

  13. You have full text access to this OnlineOpen article
    Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction

    Aging Cell

    Volume 15, Issue 4, August 2016, Pages: 737–743, Michael Garratt, Shinichi Nakagawa and Mirre J. P. Simons

    Version of Record online : 3 MAY 2016, DOI: 10.1111/acel.12489

  14. You have full text access to this OnlineOpen article
    ATF4 activity: a common feature shared by many kinds of slow-aging mice

    Aging Cell

    Volume 13, Issue 6, December 2014, Pages: 1012–1018, Weiquan Li, Xinna Li and Richard A. Miller

    Version of Record online : 26 AUG 2014, DOI: 10.1111/acel.12264

  15. You have full text access to this OnlineOpen article
    Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet

    Aging Cell

    Volume 13, Issue 4, August 2014, Pages: 616–622, Olga V. Leontieva, Geraldine M. Paszkiewicz and Mikhail V. Blagosklonny

    Version of Record online : 22 MAR 2014, DOI: 10.1111/acel.12211

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    mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

    Aging Cell

    Volume 12, Issue 3, June 2013, Pages: 370–380, Antonella Caccamo, Andrea Magrì, David X. Medina, Elena V. Wisely, Manuel F. López-Aranda, Alcino J. Silva and Salvatore Oddo

    Version of Record online : 24 MAR 2013, DOI: 10.1111/acel.12057

  17. You have full text access to this OnlineOpen article
    Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

    Aging Cell

    Volume 13, Issue 3, June 2014, Pages: 529–539, Dao-Fu Dai, Pabalu P. Karunadharma, Ying A. Chiao, Nathan Basisty, David Crispin, Edward J. Hsieh, Tony Chen, Haiwei Gu, Danijel Djukovic, Daniel Raftery, Richard P. Beyer, Michael J. MacCoss and Peter S. Rabinovitch

    Version of Record online : 25 FEB 2014, DOI: 10.1111/acel.12203

  18. You have full text access to this OnlineOpen article
    mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice

    Aging Cell

    Volume 16, Issue 1, February 2017, Pages: 52–60, Graham Dominick, Jacqueline Bowman, Xinna Li, Richard A. Miller and Gonzalo G. Garcia

    Version of Record online : 13 SEP 2016, DOI: 10.1111/acel.12525

  19. You have full text access to this OnlineOpen article
    Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice

    Aging Cell

    Volume 15, Issue 1, February 2016, Pages: 155–166, Emma L. Baar, Kathryn A. Carbajal, Irene M. Ong and Dudley W. Lamming

    Version of Record online : 24 NOV 2015, DOI: 10.1111/acel.12425

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    Reducing signs of aging and increasing lifespan by drug synergy

    Aging Cell

    Volume 12, Issue 4, August 2013, Pages: 652–660, Xinhe Huang, Jun Liu, Bradley R. Withers, Aaron J. Samide, Markos Leggas and Robert C. Dickson

    Version of Record online : 15 MAY 2013, DOI: 10.1111/acel.12090