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There are 13744 results for: content related to: Expanding the Number of ‘Druggable’ Targets: Non-Enzymes and Protein–Protein Interactions

  1. Druggability predictions: methods, limitations, and applications

    Wiley Interdisciplinary Reviews: Computational Molecular Science

    Volume 3, Issue 4, July/August 2013, Pages: 327–338, Xavier Barril

    Article first published online : 29 NOV 2012, DOI: 10.1002/wcms.1134

  2. You have full text access to this OnlineOpen article
    Identifying Druggable Targets by Protein Microenvironments Matching: Application to Transcription Factors

    CPT: Pharmacometrics & Systems Pharmacology

    Volume 3, Issue 1, January 2014, Pages: 1–9, T Liu and RB Altman

    Article first published online : 22 JAN 2014, DOI: 10.1038/psp.2013.66

  3. Binding cavities and druggability of intrinsically disordered proteins

    Protein Science

    Volume 24, Issue 5, May 2015, Pages: 688–705, Yugang Zhang, Huaiqing Cao and Zhirong Liu

    Article first published online : 24 FEB 2015, DOI: 10.1002/pro.2641

  4. You have full text access to this OnlineOpen article
    Open pipelines for integrated tumor genome profiles reveal differences between pancreatic cancer tumors and cell lines

    Cancer Medicine

    Volume 4, Issue 3, March 2015, Pages: 392–403, Jeremy Goecks, Bassel F. El-Rayes, Shishir K. Maithel, H. Jean Khoury, James Taylor and Michael R. Rossi

    Article first published online : 4 JAN 2015, DOI: 10.1002/cam4.360

  5. Thermodynamic analysis of water molecules at the surface of proteins and applications to binding site prediction and characterization

    Proteins: Structure, Function, and Bioinformatics

    Volume 80, Issue 3, March 2012, Pages: 871–883, Thijs Beuming, Ye Che, Robert Abel, Byungchan Kim, Veerabahu Shanmugasundaram and Woody Sherman

    Article first published online : 16 DEC 2011, DOI: 10.1002/prot.23244

  6. The Molecular Basis of Predicting Druggability

    Bioinformatics - From Genomes to Therapies

    Bissan Al-Lazikani, Anna Gaulton, Gaia Paolini, Jerry Lanfear, John Overington, Andrew Hopkins, Pages: 1315–1334, 2008

    Published Online : 5 FEB 2008, DOI: 10.1002/9783527619368.ch36

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    Structure of Class B GPCRs: new horizons for drug discovery

    British Journal of Pharmacology

    Volume 171, Issue 13, July 2014, Pages: 3132–3145, Andrea Bortolato, Andrew S Doré, Kaspar Hollenstein, Benjamin G Tehan, Jonathan S Mason and Fiona H Marshall

    Article first published online : 10 JUN 2014, DOI: 10.1111/bph.12689

  8. Targeting protein–protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?

    Immunological Reviews

    Volume 263, Issue 1, January 2015, Pages: 279–301, Tomasz Cierpicki and Jolanta Grembecka

    Article first published online : 15 DEC 2014, DOI: 10.1111/imr.12244

  9. Binding hotspots on K-ras: Consensus ligand binding sites and other reactive regions from probe-based molecular dynamics analysis

    Proteins: Structure, Function, and Bioinformatics

    Volume 83, Issue 5, May 2015, Pages: 898–909, Priyanka Prakash, John F. Hancock and Alemayehu A. Gorfe

    Article first published online : 25 MAR 2015, DOI: 10.1002/prot.24786

  10. Effects of Conformational Dynamics on Predicted Protein Druggability


    Volume 1, Issue 1, January 16, 2006, Pages: 70–72, Scott P. Brown and Philip J. Hajduk

    Article first published online : 5 JAN 2006, DOI: 10.1002/cmdc.200500013

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    Methylation-induced downregulation of TFPI-2 causes TMPRSS4 overexpression and contributes to oncogenesis in a subset of non-small-cell lung carcinoma

    Cancer Science

    Volume 106, Issue 1, January 2015, Pages: 34–42, Junko Hamamoto, Kenzo Soejima, Katsuhiko Naoki, Hiroyuki Yasuda, Yuichiro Hayashi, Satoshi Yoda, Sohei Nakayama, Ryosuke Satomi, Hideki Terai, Shinnosuke Ikemura, Takashi Sato, Daisuke Arai, Kota Ishioka, Keiko Ohgino and Tomoko Betsuyaku

    Article first published online : 8 DEC 2014, DOI: 10.1111/cas.12569

  12. The Molecular Basis of Predicting Druggability

    Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3

    Bissau Al-Lazikani, Anna Gaulton, Gaia Paolini, Jerry Lanfear, John Overington, Andrew Hopkins, Pages: 804–823, 2008

    Published Online : 21 APR 2008, DOI: 10.1002/9783527619375.ch14b

  13. You have full text access to this OnlineOpen article
    Drug-Like Protein[BOND]Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology

    Molecular Informatics

    Volume 33, Issue 6-7, June 2014, Pages: 414–437, Bruno O. Villoutreix, Melaine A. Kuenemann, Jean-Luc Poyet, Heriberto Bruzzoni-Giovanelli, Céline Labbé, David Lagorce, Olivier Sperandio and Maria A. Miteva

    Article first published online : 2 JUN 2014, DOI: 10.1002/minf.201400040

  14. Using chiral molecules as an approach to address low-druggability recognition sites

    Journal of Computational Chemistry

    Volume 35, Issue 29, November 5, 2014, Pages: 2114–2121, Xavier Lucas and Stefan Günther

    Article first published online : 16 SEP 2014, DOI: 10.1002/jcc.23726

  15. Saturation Screening of the Druggable Mammalian Genome

    Model Organisms in Drug Discovery

    Hector Beltrandelrio, Francis Kern, Thomas Lanthorn, Tamas Oravecz, James Piggott, David Powell, Ramiro Ramirez-Solis, Arthur T. Sands, Brian Zambrowicz, Pages: 251–278, 2005

    Published Online : 28 JAN 2005, DOI: 10.1002/0470014067.ch10

  16. Druggable Genome (Druggable Proteome)

    Standard Article

    Dictionary of Bioinformatics and Computational Biology

    Bissan Al-Lazikani

    Published Online : 7 APR 2014, DOI: 10.1002/9780471650126.dob0879

  17. Form follows function: Shape analysis of protein cavities for receptor-based drug design


    Volume 9, Issue 2, No. 2 January 2009, Pages: 451–459, Martin Weisel, Ewgenij Proschak, Jan M. Kriegl and Gisbert Schneider

    Article first published online : 13 JAN 2009, DOI: 10.1002/pmic.200800092

  18. You have full text access to this OnlineOpen article
    Single-cell analysis of population context advances RNAi screening at multiple levels

    Molecular Systems Biology

    Volume 8, Issue 1, 2012, Berend Snijder, Raphael Sacher, Pauli Rämö, Prisca Liberali, Karin Mench, Nina Wolfrum, Laura Burleigh, Cameron C Scott, Monique H Verheije, Jason Mercer, Stefan Moese, Thomas Heger, Kristina Theusner, Andreas Jurgeit, David Lamparter, Giuseppe Balistreri, Mario Schelhaas, Cornelis A M De Haan, Varpu Marjomäki, Timo Hyypiä, Peter J M Rottier, Beate Sodeik, Mark Marsh, Jean Gruenberg, Ali Amara, Urs Greber, Ari Helenius and Lucas Pelkmans

    Article first published online : 24 APR 2012, DOI: 10.1038/msb.2012.9

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    Dynamics of Plasmodium falciparum enoyl-ACP reductase and implications on drug discovery

    Protein Science

    Volume 21, Issue 11, November 2012, Pages: 1734–1745, Steffen Lindert and J. Andrew McCammon

    Article first published online : 9 OCT 2012, DOI: 10.1002/pro.2155

  20. From yeast to patient neurons and back again: Powerful new discovery platforms

    Movement Disorders

    Volume 29, Issue 10, September 2014, Pages: 1231–1240, Daniel F. Tardiff, Vikram Khurana, Chee Yeun Chung and Susan Lindquist

    Article first published online : 14 AUG 2014, DOI: 10.1002/mds.25989