Search Results

There are 32051 results for: content related to: Crystallographic Fragment-Based Drug Discovery: Use of a Brominated Fragment Library Targeting HIV Protease

  1. You have free access to this content
    Cantharidin-Based Small Molecules as Potential Therapeutic Agents

    Chemical Biology & Drug Design

    Volume 82, Issue 5, November 2013, Pages: 477–499, Carlos E. Puerto Galvis, Leonor Y. Vargas Méndez and Vladimir V. Kouznetsov

    Article first published online : 8 AUG 2013, DOI: 10.1111/cbdd.12180

  2. Homology Modeling, Docking Studies and Molecular Dynamic Simulations Using Graphical Processing Unit Architecture to Probe the Type-11 Phosphodiesterase Catalytic Site: A Computational Approach for the Rational Design of Selective Inhibitors

    Chemical Biology & Drug Design

    Volume 82, Issue 6, December 2013, Pages: 718–731, Elena Cichero, Pasqualina D'Ursi, Marco Moscatelli, Olga Bruno, Alessandro Orro, Chiara Rotolo, Luciano Milanesi and Paola Fossa

    Article first published online : 26 AUG 2013, DOI: 10.1111/cbdd.12193

  3. Triazole: A Promising Antitubercular Agent

    Chemical Biology & Drug Design

    Rangappa S. Keri, Siddappa A. Patil, Srinivasa Budagumpi and Bhari Mallanna Nagaraja

    Article first published online : 19 FEB 2015, DOI: 10.1111/cbdd.12527

  4. Further Insights Into the Pharmacology of the Human Trace Amine-Associated Receptors: Discovery of Novel Ligands for TAAR1 by a Virtual Screening Approach

    Chemical Biology & Drug Design

    Volume 84, Issue 6, December 2014, Pages: 712–720, Elena Cichero, Stefano Espinoza, Silvia Franchini, Sara Guariento, Livio Brasili, Raul R. Gainetdinov and Paola Fossa

    Article first published online : 29 JUN 2014, DOI: 10.1111/cbdd.12367

  5. Repurposing Human PDE4 Inhibitors for Neglected Tropical Diseases. Evaluation of Analogs of the Human PDE4 Inhibitor GSK-256066 as Inhibitors of PDEB1 of Trypanosoma brucei

    Chemical Biology & Drug Design

    Volume 85, Issue 5, May 2015, Pages: 549–564, Stefan O. Ochiana, Nicholas D. Bland, Luca Settimo, Robert K. Campbell and Michael P. Pollastri

    Article first published online : 18 NOV 2014, DOI: 10.1111/cbdd.12443

  6. In silico Characterization of an Atypical MAPK Phosphatase of Plasmodium falciparum as a Suitable Target for Drug Discovery

    Chemical Biology & Drug Design

    Volume 84, Issue 2, August 2014, Pages: 158–168, Christopher O. Campbell, Daniel N. Santiago, Wayne C. Guida, Roman Manetsch and John H. Adams

    Article first published online : 12 MAY 2014, DOI: 10.1111/cbdd.12315

  7. Theoretical Characterization of Galanin Receptor Type 3 (Gal3) and Its Interaction with Agonist (GALANIN) and Antagonists (SNAP 37889 and SNAP 398299): An In Silico Analysis

    Chemical Biology & Drug Design

    Volume 81, Issue 6, June 2013, Pages: 757–774, Gugan Kothandan, Changdev G. Gadhe and Seung J. Cho

    Article first published online : 17 APR 2013, DOI: 10.1111/cbdd.12128

  8. Targeting Influenza A Virus RNA Promoter

    Chemical Biology & Drug Design

    Angel Bottini, Surya K. De, Bainan Wu, Changyan Tang, Gabriele Varani and Maurizio Pellecchia

    Article first published online : 13 MAR 2015, DOI: 10.1111/cbdd.12534

  9. Isoenzyme- and Allozyme-Specific Inhibitors: 2,2′-Dihydroxybenzophenones and Their Carbonyl N-Analogues that Discriminate between Human Glutathione Transferase A1-1 and P1-1 Allozymes

    Chemical Biology & Drug Design

    Foteini M. Pouliou, Trias N. Thireou, Elias E. Eliopoulos, Petros G. Tsoungas, Nikolaos E. Labrou and Yannis D. Clonis

    Article first published online : 14 MAY 2015, DOI: 10.1111/cbdd.12574

  10. Synthesis, Antibacterial Activities, and 3D-QSAR of Sulfone Derivatives Containing 1, 3, 4-Oxadiazole Moiety

    Chemical Biology & Drug Design

    Volume 82, Issue 5, November 2013, Pages: 546–556, Pei Li, Juan Yin, Weiming Xu, Jian Wu, Ming He, Deyu Hu, Song Yang and Baoan Song

    Article first published online : 21 AUG 2013, DOI: 10.1111/cbdd.12181

  11. Potassium Channels: Structures, Diseases, and Modulators

    Chemical Biology & Drug Design

    Volume 83, Issue 1, January 2014, Pages: 1–26, Chuan Tian, Ruixin Zhu, Lixin Zhu, Tianyi Qiu, Zhiwei Cao and Tingguo Kang

    Article first published online : 23 DEC 2013, DOI: 10.1111/cbdd.12237

  12. In silico Target Fishing for the Potential Targets and Molecular Mechanisms of Baicalein as an Antiparkinsonian Agent: Discovery of the Protective Effects on NMDA Receptor-Mediated Neurotoxicity

    Chemical Biology & Drug Design

    Volume 81, Issue 6, June 2013, Pages: 675–687, Li Gao, Jian-Song Fang, Xiao-Yu Bai, Dan Zhou, Yi-Tao Wang, Ai-Lin Liu and Guan-Hua Du

    Article first published online : 25 MAY 2013, DOI: 10.1111/cbdd.12127

  13. Synthesis and 3D-QSAR Analysis of 2-Chloroquinoline Derivatives as H37RV MTB Inhibitors

    Chemical Biology & Drug Design

    Volume 82, Issue 6, December 2013, Pages: 669–684, Ranjan C. Khunt, Vijay M. Khedkar and Evans C. Coutinho

    Article first published online : 25 NOV 2013, DOI: 10.1111/cbdd.12178

  14. Synthesis and Evaluation of a New Series of 3,5-bis((5-bromo-6-methyl-2-t-aminopyrimidin-4-yl)thio)-4H-1,2,4-triazol-4-amines and their Cyclized Products ‘Pyrimidinylthio Pyrimidotriazolothiadiazines’ as 15- Lipo-Oxygenase Inhibitors

    Chemical Biology & Drug Design

    Volume 85, Issue 2, February 2015, Pages: 216–224, Tayebe Asghari, Mehdi Bakavoli, Mohammad Rahimizadeh, Hossein Eshghi, Sattar Saberi, Azam Karimian, Farzin Hadizadeh and Moreteza Ghandadi

    Article first published online : 10 JUL 2014, DOI: 10.1111/cbdd.12375

  15. Design, Synthesis and Biological Evaluation of Pazopanib Derivatives as Antitumor Agents

    Chemical Biology & Drug Design

    Volume 83, Issue 3, March 2014, Pages: 306–316, Yuping Jia, Jian Zhang, Jinhong Feng, Fuming Xu, Huili Pan and Wenfang Xu

    Article first published online : 1 FEB 2014, DOI: 10.1111/cbdd.12243

  16. Discovery and Structure Optimization of a Series of Isatin Derivatives as Mycobacterium tuberculosis Chorismate Mutase Inhibitors

    Chemical Biology & Drug Design

    Volume 83, Issue 4, April 2014, Pages: 498–506, Variam U. Jeankumar, Reshma Alokam, Jonnalagadda P. Sridevi, Priyanka Suryadevara, Siddharth S. Matikonda, Santosh Peddi, Seedarala Sahithi, Mallika Alvala, Perumal Yogeeswari and Dharmarajan Sriram

    Article first published online : 18 MAR 2014, DOI: 10.1111/cbdd.12265

  17. Insight into the Structural Features of Pyrazolopyrimidine- and Pyrazolopyridine-based B-RafV600E Kinase Inhibitors by Computational Explorations

    Chemical Biology & Drug Design

    Volume 83, Issue 6, June 2014, Pages: 643–655, Yan Li, Chunxiao Han, Jinghui Wang, Yinfeng Yang, Jingxiao Zhang, Shuwei Zhang and Ling Yang

    Article first published online : 20 MAR 2014, DOI: 10.1111/cbdd.12276

  18. Exploring the Ligand Recognition Properties of the Human Vasopressin V1a Receptor Using QSAR and Molecular Modeling Studies

    Chemical Biology & Drug Design

    Volume 83, Issue 2, February 2014, Pages: 207–223, Martha C. Contreras-Romo, Marlet Martínez-Archundia, Omar Deeb, Magdalena J. Ślusarz, Gema Ramírez-Salinas, Ramón Garduño-Juárez, Andrés Quintanar-Stephano, Guillermo Ramírez-Galicia and José Correa-Basurto

    Article first published online : 26 DEC 2013, DOI: 10.1111/cbdd.12229

  19. Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry

    Chemical Biology & Drug Design

    Rangappa S. Keri, Asha Hiremathad, Srinivasa Budagumpi and Bhari Mallanna Nagaraja

    Article first published online : 28 NOV 2014, DOI: 10.1111/cbdd.12462

  20. Design, Synthesis, and Preliminary Cardioprotective Effect Evaluation of Danshensu Derivatives

    Chemical Biology & Drug Design

    Volume 84, Issue 3, September 2014, Pages: 282–291, Qingbin Cui, Yonghong Chen, Mingjuan Zhang, Luchen Shan, Yewei Sun, Pei Yu, Gaoxiao Zhang, Dingyuan Wang, Zengchao Zhao, Qian Xu, Benhong Xu and Yuqiang Wang

    Article first published online : 1 JUL 2014, DOI: 10.1111/cbdd.12312