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There are 44170 results for: content related to: New central targets for the treatment of obesity

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    Temporal linear mode complexity as a surrogate measure of the effect of remifentanil on the central nervous system in healthy volunteers

    British Journal of Clinical Pharmacology

    Volume 71, Issue 6, June 2011, Pages: 871–885, Byung-Moon Choi, Da-Huin Shin, Moon-Ho Noh, Young-Hac Kim, Yong-Bo Jeong, Soo-Han Lee, Eun-Kyung Lee and Gyu-Jeong Noh

    Article first published online : 12 MAY 2011, DOI: 10.1111/j.1365-2125.2011.03904.x

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    A Bayesian approach for population pharmacokinetic modelling of sirolimus

    British Journal of Clinical Pharmacology

    Volume 62, Issue 4, October 2006, Pages: 420–434, Chantaratsamon Dansirikul, Raymond G. Morris, Susan E. Tett and Stephen B. Duffull

    Article first published online : 20 DEC 2005, DOI: 10.1111/j.1365-2125.2005.02533.x

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    Hormesis and medicine

    British Journal of Clinical Pharmacology

    Volume 66, Issue 5, November 2008, Pages: 594–617, Edward J. Calabrese

    Article first published online : 28 JUN 2008, DOI: 10.1111/j.1365-2125.2008.03243.x

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    Integrated analysis of preclinical data to support the design of the first in man study of LY2181308, a second generation antisense oligonucleotide

    British Journal of Clinical Pharmacology

    Volume 71, Issue 3, March 2011, Pages: 416–428, Sophie Callies, Valérie André, Bharvin Patel, David Waters, Paul Francis, Michael Burgess and Michael Lahn

    Article first published online : 1 FEB 2011, DOI: 10.1111/j.1365-2125.2010.03836.x

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    Population pharmacokinetic and pharmacodynamic modelling of the effects of nicorandil in the treatment of acute heart failure

    British Journal of Clinical Pharmacology

    Volume 66, Issue 3, September 2008, Pages: 352–365, Satofumi Iida, Haruki Kinoshita and Nicholas H. G. Holford

    Article first published online : 9 JUL 2008, DOI: 10.1111/j.1365-2125.2008.03257.x

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    A receptor theory-based semimechanistic PD model for the CCR5 noncompetitive antagonist maraviroc

    British Journal of Clinical Pharmacology

    Volume 65, Issue s1, April 2008, Pages: 95–106, Philippe Jacqmin, Lynn McFadyen and Janet R. Wade

    Article first published online : 10 MAR 2008, DOI: 10.1111/j.1365-2125.2008.03141.x

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    Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia

    British Journal of Clinical Pharmacology

    Volume 66, Issue 6, December 2008, Pages: 826–837, Ahmed F. Hawwa, Paul S. Collier, Jeff S. Millership, Anthony McCarthy, Sid Dempsey, Carole Cairns and James C. McElnay

    Article first published online : 15 AUG 2008, DOI: 10.1111/j.1365-2125.2008.03281.x

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    Pain relief model for a COX-2 inhibitor in patients with postoperative dental pain

    British Journal of Clinical Pharmacology

    Volume 66, Issue 1, July 2008, Pages: 60–70, Shashank Rohatagi, Helen Kastrissios, Kunihiro Sasahara, Kenneth Truitt, James B. Moberly, Russell Wada and Daniel E. Salazar

    Article first published online : 3 JUN 2008, DOI: 10.1111/j.1365-2125.2008.03175.x

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    The use of mechanistic DM-PK-PD modelling to assess the power of pharmacogenetic studies –CYP2C9 and warfarin as an example

    British Journal of Clinical Pharmacology

    Volume 64, Issue 1, July 2007, Pages: 14–26, Gemma L. Dickinson, Martin S. Lennard, Geoffrey T. Tucker and Amin Rostami-Hodjegan

    Article first published online : 12 FEB 2007, DOI: 10.1111/j.1365-2125.2007.02850.x

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    Population pharmacokinetics of darbepoetin alfa in healthy subjects

    British Journal of Clinical Pharmacology

    Volume 63, Issue 1, January 2007, Pages: 41–52, Balaji Agoram, Liviawati Sutjandra and John T. Sullivan

    Article first published online : 30 AUG 2006, DOI: 10.1111/j.1365-2125.2006.02752.x

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    Population pharmacokinetic analysis for nelfinavir and its metabolite M8 in virologically controlled HIV-infected patients on HAART

    British Journal of Clinical Pharmacology

    Volume 60, Issue 4, October 2005, Pages: 390–403, X. Panhard, C. Goujard, M. Legrand, A. M. Taburet, B. Diquet, F. Mentré and COPHAR 1-ANRS study group

    Article first published online : 19 JUL 2005, DOI: 10.1111/j.1365-2125.2005.02456.x

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    Population pharmacokinetic modelling for enterohepatic circulation of mycophenolic acid in healthy Chinese and the influence of polymorphisms in UGT1A9

    British Journal of Clinical Pharmacology

    Volume 65, Issue 6, June 2008, Pages: 893–907, Zheng Jiao, Jun-jie Ding, Jie Shen, Hui-qi Liang, Long-jin Zhong, Yi Wang, Ming-kang Zhong and Wei-yue Lu

    Article first published online : 15 FEB 2008, DOI: 10.1111/j.1365-2125.2008.03109.x

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    Is intent-to-treat analysis always (ever) enough?

    British Journal of Clinical Pharmacology

    Volume 54, Issue 2, August 2002, Pages: 203–211, Lewis B. Sheiner

    Article first published online : 4 SEP 2002, DOI: 10.1046/j.1365-2125.2002.01628.x

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    Pharmacokinetics of the antianginal agent perhexiline: relationship between metabolic ratio and steady-state dose

    British Journal of Clinical Pharmacology

    Volume 54, Issue 2, August 2002, Pages: 107–114, Benedetta C. Sallustio, Ian S. Westley and Raymond G. Morris

    Article first published online : 4 SEP 2002, DOI: 10.1046/j.1365-2125.2002.01618.x

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    Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects

    British Journal of Clinical Pharmacology

    Volume 59, Issue 5, May 2005, Pages: 495–510, G. J. H. Dumont, S. J. De Visser, A. F. Cohen and J. M. A. Van Gerven

    Article first published online : 19 APR 2005, DOI: 10.1111/j.1365-2125.2005.02342.x

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    Mechanism-based population modelling of the effects of vildagliptin on GLP-1, glucose and insulin in patients with type 2 diabetes

    British Journal of Clinical Pharmacology

    Volume 73, Issue 3, March 2012, Pages: 373–390, Cornelia B. Landersdorfer, Yan-Ling He and William J. Jusko

    Article first published online : 13 FEB 2012, DOI: 10.1111/j.1365-2125.2011.04109.x

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    Randomized exposure-controlled trials; impact of randomization and analysis strategies

    British Journal of Clinical Pharmacology

    Volume 64, Issue 3, September 2007, Pages: 266–277, Kristin E. Karlsson, Anders Grahnén, Mats O. Karlsson and E. Niclas Jonsson

    Article first published online : 10 APR 2007, DOI: 10.1111/j.1365-2125.2007.02887.x

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    Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers

    British Journal of Clinical Pharmacology

    Volume 70, Issue 1, July 2010, Pages: 65–77, Kathleen Butler and Renli Teng

    Article first published online : 22 MAR 2010, DOI: 10.1111/j.1365-2125.2010.03669.x

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    Desipramine, substrate for CYP2D6 activity: population pharmacokinetic model and design elements of drug–drug interaction trials

    British Journal of Clinical Pharmacology

    Volume 70, Issue 4, October 2010, Pages: 523–536, Ivelina Gueorguieva, Kimberley Jackson, Steven A. Wrighton, Vikram P. Sinha and Jenny Y. Chien

    Article first published online : 14 SEP 2010, DOI: 10.1111/j.1365-2125.2010.03731.x

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    Mechanistic pharmacokinetic modelling of ephedrine, norephedrine and caffeine in healthy subjects

    British Journal of Clinical Pharmacology

    Volume 59, Issue 3, March 2005, Pages: 335–345, C. Csajka, C. A. Haller, N. L. Benowitz and D. Verotta

    Article first published online : 9 FEB 2005, DOI: 10.1111/j.1365-2125.2005.02254.x