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There are 900 results for: content related to: Apixaban, an oral, direct factor X a inhibitor: single dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects

  1. You have free access to this content
    Evaluation of the effect of naproxen on the pharmacokinetics and pharmacodynamics of apixaban

    British Journal of Clinical Pharmacology

    Volume 78, Issue 4, October 2014, Pages: 877–885, Charles Frost, Andrew Shenker, Mohit D. Gandhi, Janice Pursley, Yu Chen Barrett, Jessie Wang, Donglu Zhang, Wonkyung Byon, Rebecca A. Boyd and Frank LaCreta

    Article first published online : 19 SEP 2014, DOI: 10.1111/bcp.12393

  2. You have free access to this content
    Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies

    Journal of Thrombosis and Haemostasis

    Volume 6, Issue 5, May 2008, Pages: 820–829, P. C. WONG, E. J. CRAIN, B. XIN, R. R. WEXLER, P. Y. S. LAM, D. J. PINTO, J. M. LUETTGEN and R. M. KNABB

    Article first published online : 26 FEB 2008, DOI: 10.1111/j.1538-7836.2008.02939.x

  3. You have full text access to this OnlineOpen article
    Development of apixaban: a novel anticoagulant for prevention of stroke in patients with atrial fibrillation

    Annals of the New York Academy of Sciences

    Volume 1329, Issue 1, November 2014, Pages: 93–106, Michael S. Hanna, Puneet Mohan, Robert Knabb, Elora Gupta, Charles Frost and John H. Lawrence

    Article first published online : 5 NOV 2014, DOI: 10.1111/nyas.12567

  4. Randomized, blinded, placebo- and positive-controlled crossover study to determine the effect of multiple doses of apixaban on the QTc interval

    The Journal of Clinical Pharmacology

    Volume 55, Issue 5, May 2015, Pages: 549–555, Charles Frost, Sunil Nepal, Wonkyung Byon, Kenneth Moore, Richard A. Reeves, Rebecca Boyd and Frank LaCreta

    Article first published online : 14 JAN 2015, DOI: 10.1002/jcph.447

  5. You have full text access to this OnlineOpen article
    Safety, pharmacokinetics and pharmacodynamics of multiple oral doses of apixaban, a factor Xa inhibitor, in healthy subjects

    British Journal of Clinical Pharmacology

    Volume 76, Issue 5, November 2013, Pages: 776–786, Charles Frost, Sunil Nepal, Jessie Wang, Alan Schuster, Wonkyung Byon, Rebecca A. Boyd, Zhigang Yu, Andrew Shenker, Yu Chen Barrett, Rogelio Mosqueda-Garcia and Frank LaCreta

    Article first published online : 21 OCT 2013, DOI: 10.1111/bcp.12106

  6. Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor

    British Journal of Clinical Pharmacology

    Volume 79, Issue 5, May 2015, Pages: 838–846, Charles E. Frost, Wonkyung Byon, Yan Song, Jessie Wang, Alan E. Schuster, Rebecca A. Boyd, Donglu Zhang, Zhigang Yu, Clapton Dias, Andrew Shenker and Frank LaCreta

    Article first published online : 22 APR 2015, DOI: 10.1111/bcp.12541

  7. Pharmacokinetics, pharmacodynamics, and safety of apixaban in subjects with end-stage renal disease on hemodialysis

    The Journal of Clinical Pharmacology

    Xiaoli Wang, Giridhar Tirucherai, Thomas C. Marbury, Jessie Wang, Ming Chang, Donglu Zhang, Yan Song, Janice Pursley, Rebecca A. Boyd and Charles Frost

    Article first published online : 22 DEC 2015, DOI: 10.1002/jcph.628

  8. You have full text access to this OnlineOpen article
    Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects

    British Journal of Clinical Pharmacology

    Volume 76, Issue 6, December 2013, Pages: 908–916, Vijay V. Upreti, Jessie Wang, Yu Chen Barrett, Wonkyung Byon, Rebecca A. Boyd, Janice Pursley, Frank P. LaCreta and Charles E. Frost

    Article first published online : 20 NOV 2013, DOI: 10.1111/bcp.12114

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    Arterial antithrombotic and bleeding time effects of apixaban, a direct factor Xa inhibitor, in combination with antiplatelet therapy in rabbits

    Journal of Thrombosis and Haemostasis

    Volume 6, Issue 10, October 2008, Pages: 1736–1741, P. C. WONG, C. A. WATSON and E. J. CRAIN

    Article first published online : 19 JUL 2008, DOI: 10.1111/j.1538-7836.2008.03092.x

  10. Quantification of Apixaban's Therapeutic Utility in Prevention of Venous Thromboembolism: Selection of Phase III Trial Dose

    Clinical Pharmacology & Therapeutics

    Volume 88, Issue 3, September 2010, Pages: 375–382, T A Leil, Y Feng, L Zhang, A Paccaly, P Mohan and M Pfister

    Article first published online : 4 AUG 2010, DOI: 10.1038/clpt.2010.106

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    Effects of the oral, direct factor Xa inhibitor apixaban on routine coagulation assays and anti-FXa assays

    Journal of Thrombosis and Haemostasis

    Volume 12, Issue 9, September 2014, Pages: 1545–1553, A. Hillarp, K. M. Gustafsson, L. Faxälv, K. Strandberg, F. Baghaei, I. Fagerberg Blixter, M. Berndtsson and T. L. Lindahl

    Article first published online : 23 JUL 2014, DOI: 10.1111/jth.12649

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    Non-vitamin K antagonist oral anticoagulants in cardiovascular disease management: evidence and unanswered questions

    Journal of Clinical Pharmacy and Therapeutics

    Volume 39, Issue 2, April 2014, Pages: 118–135, J. W. Cheng and G. Barillari

    Article first published online : 3 JAN 2014, DOI: 10.1111/jcpt.12122

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    Consideration of clinical variables for choosing new anticoagulant alternatives to warfarin for the management of non-valvular atrial fibrillation

    Journal of Clinical Pharmacy and Therapeutics

    Volume 39, Issue 6, December 2014, Pages: 628–636, Y. Lu, R. Branstad, R. M. Karim and R. W. Asinger

    Article first published online : 24 SEP 2014, DOI: 10.1111/jcpt.12207

  14. Multimodal assessment of non-specific hemostatic agents for apixaban reversal

    Journal of Thrombosis and Haemostasis

    Volume 13, Issue 3, March 2015, Pages: 426–436, A.-C. Martin, I. Gouin-Thibault, V. Siguret, A. Mordohay, C.-M. Samama, P. Gaussem, B. Le Bonniec and A. Godier

    Article first published online : 5 FEB 2015, DOI: 10.1111/jth.12830

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    Favorable therapeutic index of the direct factor Xa inhibitors, apixaban and rivaroxaban, compared with the thrombin inhibitor dabigatran in rabbits

    Journal of Thrombosis and Haemostasis

    Volume 7, Issue 8, August 2009, Pages: 1313–1320, P. C. WONG, E. J. CRAIN, C. A. WATSON and B. XIN

    Article first published online : 3 JUN 2009, DOI: 10.1111/j.1538-7836.2009.03503.x

  16. You have free access to this content
    Practical Considerations for Using Novel Oral Anticoagulants in Patients With Atrial Fibrillation

    Clinical Cardiology

    Volume 37, Issue 1, January 2014, Pages: 32–47, Irene Savelieva and A. John Camm

    Article first published online : 19 NOV 2013, DOI: 10.1002/clc.22204

  17. You have full text access to this OnlineOpen article
    Preclinical and translational evaluation of coagulation factor IXa as a novel therapeutic target

    Pharmacology Research & Perspectives

    Volume 4, Issue 1, February 2016, Wendy Ankrom, Harold B. Wood, Jiayi Xu, Wayne Geissler, Tom Bateman, Manash S. Chatterjee, Kung-I Feng, Joseph M. Metzger, Walter R. Strapps, Marija Tadin-Strapps, Dietmar Seiffert and Patrick Andre

    Article first published online : 15 JAN 2016, DOI: 10.1002/prp2.207

  18. Effect of renal impairment on the pharmacokinetics, pharmacodynamics, and safety of apixaban

    The Journal of Clinical Pharmacology

    Ming Chang, Zhigang Yu, Andrew Shenker, Jessie Wang, Janice Pursley, Wonkyung Byon, Rebecca A. Boyd, Frank LaCreta and Charles E. Frost

    Article first published online : 4 DEC 2015, DOI: 10.1002/jcph.633

  19. You have full text access to this OnlineOpen article
    Model-Based Exposure–Response Analysis of Apixaban to Quantify Bleeding Risk in Special Populations of Subjects Undergoing Orthopedic Surgery

    CPT: Pharmacometrics & Systems Pharmacology

    Volume 3, Issue 9, September 2014, Pages: 1–9, TA Leil, C Frost, X Wang, M Pfister and F LaCreta

    Article first published online : 17 SEP 2014, DOI: 10.1038/psp.2014.34

  20. You have free access to this content
    A randomized phase II trial of apixaban for the prevention of thromboembolism in patients with metastatic cancer

    Journal of Thrombosis and Haemostasis

    Volume 10, Issue 5, May 2012, Pages: 807–814, M. N. LEVINE, C. GU, H. A. LIEBMAN, C. P. ESCALANTE, S. SOLYMOSS, D. DEITCHMAN, L. RAMIREZ and J. JULIAN

    Article first published online : 2 MAY 2012, DOI: 10.1111/j.1538-7836.2012.04693.x