Search Results

There are 3499 results for: content related to: Double-blind, randomized, placebo-controlled study of safety, tolerability, pharmacokinetics and pharmacodynamics of TAK -683, an investigational metastin analogue in healthy men

  1. You have free access to this content
    Clinical pharmacology of AMG 181, a gut-specific human anti-α4β7 monoclonal antibody, for treating inflammatory bowel diseases

    British Journal of Clinical Pharmacology

    Volume 78, Issue 6, December 2014, Pages: 1315–1333, Wei-Jian Pan, Kathleen Köck, William A. Rees, Barbara A. Sullivan, Christine M. Evangelista, Mark Yen, Jane M. Andrews, Graham L. Radford-Smith, Peter J. Prince, Kaz O. Reynhardt, David R. Doherty, Sonal K. Patel, Christine D. Krill, Kefei Zhou, Jing Shen, Lynn E. Smith, Jason M. Gow, Jonathan Lee, Anthony M. Treacy, Zhigang Yu, Virginia M. Platt and Dominic C. Borie

    Article first published online : 20 NOV 2014, DOI: 10.1111/bcp.12418

  2. You have free access to this content
    Early stage development of the glycine-1 re-uptake inhibitor SCH 900435: central nervous system effects compared with placebo in healthy men

    British Journal of Clinical Pharmacology

    Volume 75, Issue 6, June 2013, Pages: 1455–1467, Marieke Liem-Moolenaar, Pierre Peeters, Ingrid M. C. Kamerling, Chris Hogg, Graham Holder, Huub Jan Kleijn, Edwin Spaans, Joanna Udo De Haes, Marieke L. de Kam, Kari L. Franson, Adam F. Cohen and Joop M. A. van Gerven

    Article first published online : 20 MAY 2013, DOI: 10.1111/bcp.12015

  3. You have free access to this content
    Model-based evaluation of drug-induced QTc prolongation for compounds in early development

    British Journal of Clinical Pharmacology

    Volume 79, Issue 1, January 2015, Pages: 148–161, Vincent F. S. Dubois, Huixin Yu, Meindert Danhof, Oscar Della Pasqua and on behalf of the Cardiovascular Safety Project Team and TI Pharma PKPD Platform

    Article first published online : 19 DEC 2014, DOI: 10.1111/bcp.12482

  4. You have free access to this content
    Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-activating protein inhibitor

    British Journal of Clinical Pharmacology

    Volume 75, Issue 3, March 2013, Pages: 779–790, Gretchen Bain, Christopher D. King, Kevin Schaab, Melissa Rewolinski, Virginia Norris, Claire Ambery, Jane Bentley, Masanori Yamada, Angelina M. Santini, Jeroen van de Wetering de Rooij, Nicholas Stock, Jasmine Zunic, John H. Hutchinson and Jilly F. Evans

    Article first published online : 5 FEB 2013, DOI: 10.1111/j.1365-2125.2012.04386.x

  5. Pharmacokinetics and pharmacodynamics of liposomal mifamurtide in adult volunteers with mild or moderate hepatic impairment

    British Journal of Clinical Pharmacology

    Volume 77, Issue 6, June 2014, Pages: 998–1010, Karthik Venkatakrishnan, Yi Liu, Dennis Noe, Jaime Mertz, Michael Bargfrede, Thomas Marbury, Kambiz Farbakhsh, Cristina Oliva and Ashley Milton

    Article first published online : 22 MAY 2014, DOI: 10.1111/bcp.12261

  6. You have free access to this content
    Odanacatib, a selective cathepsin K inhibitor to treat osteoporosis: safety, tolerability, pharmacokinetics and pharmacodynamics – results from single oral dose studies in healthy volunteers

    British Journal of Clinical Pharmacology

    Volume 75, Issue 5, May 2013, Pages: 1240–1254, S. Aubrey Stoch, Stefan Zajic, Julie A. Stone, Deborah L. Miller, Lucas van Bortel, Kenneth C. Lasseter, Barnali Pramanik, Caroline Cilissen, Qi Liu, Lida Liu, Boyd B. Scott, Deborah Panebianco, Yu Ding, Keith Gottesdiener and John A. Wagner

    Article first published online : 8 APR 2013, DOI: 10.1111/j.1365-2125.2012.04471.x

  7. Pharmacokinetics and pharmacodynamics of liposomal mifamurtide in adult volunteers with mild or moderate renal impairment

    British Journal of Clinical Pharmacology

    Volume 77, Issue 6, June 2014, Pages: 986–997, Karthik Venkatakrishnan, Yi Liu, Dennis Noe, Jaime Mertz, Michael Bargfrede, Thomas Marbury, Kambiz Farbakhsh, Cristina Oliva and Ashley Milton

    Article first published online : 22 MAY 2014, DOI: 10.1111/bcp.12260

  8. You have free access to this content
    Pharmacokinetics and central nervous system effects of the novel dual NK1/NK3 receptor antagonist GSK1144814 in alcohol-intoxicated volunteers

    British Journal of Clinical Pharmacology

    Volume 75, Issue 5, May 2013, Pages: 1328–1339, Erik T. te Beek, Justin L. Hay, Jonathan N. Bullman, Clare Burgess, Kimberly J. Nahon, Erica S. Klaassen, Frank A. Gray and Joop M. A. van Gerven

    Article first published online : 8 APR 2013, DOI: 10.1111/bcp.12004

  9. The evolution of Reference Drug Lists and Clinical Practice Guidelines in the public health system of a middle-income country

    British Journal of Clinical Pharmacology

    Volume 78, Issue 2, August 2014, Pages: 410–421, Israel Rico-Alba and Albert Figueras

    Article first published online : 21 JUL 2014, DOI: 10.1111/bcp.12337

  10. You have free access to this content
    Pharmacokinetic–pharmacodynamic studies of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor MK-0916 in healthy subjects

    British Journal of Clinical Pharmacology

    Volume 76, Issue 6, December 2013, Pages: 917–931, D. Hamish Wright, Julie A. Stone, Tami M. Crumley, Larissa Wenning, Wei Zheng, Kerri Yan, Amy Yifan Yang, Li Sun, Caroline Cilissen, Steven Ramael, Anne Hermanowski-Vosatka, Ronald B. Langdon, Keith M. Gottesdiener, John A. Wagner and Eseng Lai

    Article first published online : 20 NOV 2013, DOI: 10.1111/bcp.12131

  11. You have free access to this content
    Modelling the time course of antimalarial parasite killing: a tour of animal and human models, translation and challenges

    British Journal of Clinical Pharmacology

    Volume 79, Issue 1, January 2015, Pages: 97–107, Kashyap Patel, Julie A. Simpson, Kevin T. Batty, Sophie Zaloumis and Carl M. Kirkpatrick

    Article first published online : 19 DEC 2014, DOI: 10.1111/bcp.12288

  12. Pharmacokinetics and pharmacodynamics of the cathepsin S inhibitor, LY3000328, in healthy subjects

    British Journal of Clinical Pharmacology

    Volume 78, Issue 6, December 2014, Pages: 1334–1342, Christopher D. Payne, Mark A. Deeg, Melanie Chan, Lai Hock Tan, Elizabeth Smith LaBell, Tong Shen and David J. DeBrota

    Article first published online : 20 NOV 2014, DOI: 10.1111/bcp.12470

  13. Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers

    British Journal of Clinical Pharmacology

    Volume 78, Issue 3, September 2014, Pages: 556–564, Tae-Eun Kim, Howard Lee, Kyoung Soo Lim, SeungHwan Lee, Seo-Hyun Yoon, Kyung-Mi Park, Hyesun Han, Sang-Goo Shin, In-Jin Jang, Kyung-Sang Yu and Joo-Youn Cho

    Article first published online : 21 AUG 2014, DOI: 10.1111/bcp.12368

  14. You have free access to this content
    The influence of kidney function on dapagliflozin exposure, metabolism and pharmacodynamics in healthy subjects and in patients with type 2 diabetes mellitus

    British Journal of Clinical Pharmacology

    Volume 76, Issue 3, September 2013, Pages: 432–444, Sreeneeranj Kasichayanula, Xiaoni Liu, Melanie Pe Benito, Ming Yao, Marc Pfister, Frank P. LaCreta, William Griffith Humphreys and David W. Boulton

    Article first published online : 20 AUG 2013, DOI: 10.1111/bcp.12056

  15. Corticosteroid insensitive alveolar macrophages from asthma patients; synergistic interaction with a p38 mitogen-activated protein kinase (MAPK) inhibitor

    British Journal of Clinical Pharmacology

    Volume 79, Issue 5, May 2015, Pages: 756–766, Simon Lea, Chris Harbron, Naimat Khan, George Booth, Jane Armstrong and Dave Singh

    Article first published online : 22 APR 2015, DOI: 10.1111/bcp.12536

  16. You have free access to this content
    Pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1 receptor modulator, in the first-in-human study

    British Journal of Clinical Pharmacology

    Volume 76, Issue 6, December 2013, Pages: 888–896, Patrick Brossard, Hartmut Derendorf, Jian Xu, Haidar Maatouk, Atef Halabi and Jasper Dingemanse

    Article first published online : 20 NOV 2013, DOI: 10.1111/bcp.12129

  17. Switching from body surface area-based to fixed dosing for the investigational proteasome inhibitor ixazomib: a population pharmacokinetic analysis

    British Journal of Clinical Pharmacology

    Volume 79, Issue 5, May 2015, Pages: 789–800, Neeraj Gupta, Yuan Zhao, Ai-Min Hui, Dixie-Lee Esseltine and Karthik Venkatakrishnan

    Article first published online : 22 APR 2015, DOI: 10.1111/bcp.12542

  18. You have full text access to this OnlineOpen article
    Monitoring vigabatrin in head injury patients by cerebral microdialysis: obtaining pharmacokinetic measurements in a neurocritical care setting

    British Journal of Clinical Pharmacology

    Volume 78, Issue 5, November 2014, Pages: 981–995, Richard J. Shannon, Ivan Timofeev, Jürgens Nortje, Peter J. Hutchinson and Keri L. H. Carpenter

    Article first published online : 20 OCT 2014, DOI: 10.1111/bcp.12414

  19. You have full text access to this OnlineOpen article
    Pharmacokinetics and pharmacodynamics of intravenous and inhaled fluticasone furoate in healthy Caucasian and East Asian subjects

    British Journal of Clinical Pharmacology

    Volume 77, Issue 5, May 2014, Pages: 808–820, Ann Allen, Joanne Bal, Anne Cheesbrough, Melanie Hamilton and Rodger Kempsford

    Article first published online : 22 APR 2014, DOI: 10.1111/bcp.12263

  20. Pitavastatin is a more sensitive and selective organic anion-transporting polypeptide 1B clinical probe than rosuvastatin

    British Journal of Clinical Pharmacology

    Volume 78, Issue 3, September 2014, Pages: 587–598, Thomayant Prueksaritanont, Xiaoyan Chu, Raymond Evers, Stephanie O. Klopfer, Luzelena Caro, Prajakti A. Kothare, Cynthia Dempsey, Scott Rasmussen, Robert Houle, Grace Chan, Xiaoxin Cai, Robert Valesky, Iain P. Fraser and S. Aubrey Stoch

    Article first published online : 21 AUG 2014, DOI: 10.1111/bcp.12377