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There are 15877 results for: content related to: ICH E 14 Q & A ( R 1) document: perspectives on the updated recommendations on thorough QT studies

  1. You have free access to this content
    Moxifloxacin-induced QTc interval prolongations in healthy male Japanese and Caucasian volunteers: a direct comparison in a thorough QT study

    British Journal of Clinical Pharmacology

    Volume 80, Issue 3, September 2015, Pages: 446–459, Joel Morganroth, Yaning Wang, Michael Thorn, Yuji Kumagai, Stuart Harris, Norman Stockbridge, Robert Kleiman and Rashmi Shah

    Version of Record online : 2 JUL 2015, DOI: 10.1111/bcp.12684

  2. You have full text access to this OnlineOpen article
    Exenatide at therapeutic and supratherapeutic concentrations does not prolong the QTc interval in healthy subjects

    British Journal of Clinical Pharmacology

    Volume 75, Issue 4, April 2013, Pages: 979–989, Börje Darpö, Sager Philip, Leigh MacConell, Brenda Cirincione, Malcolm Mitchell, Jenny Han, Wenying Huang, Jaret Malloy, Christine Schulteis, Larry Shen and Lisa Porter

    Version of Record online : 15 MAR 2013, DOI: 10.1111/j.1365-2125.2012.04416.x

  3. You have free access to this content
    Insulin at normal physiological levels does not prolong QTc interval in thorough QT studies performed in healthy volunteers

    British Journal of Clinical Pharmacology

    Volume 75, Issue 2, February 2013, Pages: 392–403, Jorg Taubel, Ulrike Lorch, Georg Ferber, Jatinder Singh, Velislav N. Batchvarov, Irina Savelieva and A. John Camm

    Version of Record online : 10 JAN 2013, DOI: 10.1111/j.1365-2125.2012.04376.x

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    Drug-induced QT interval prolongation: does ethnicity of the thorough QT study population matter?

    British Journal of Clinical Pharmacology

    Volume 75, Issue 2, February 2013, Pages: 347–358, Rashmi R. Shah

    Version of Record online : 10 JAN 2013, DOI: 10.1111/j.1365-2125.2012.04415.x

  5. You have free access to this content
    The role of concentration−effect relationships in the assessment of QTc interval prolongation

    British Journal of Clinical Pharmacology

    Volume 79, Issue 1, January 2015, Pages: 117–131, Nicholas P. France and Oscar Della Pasqua

    Version of Record online : 19 DEC 2014, DOI: 10.1111/bcp.12443

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    Are women more susceptible than men to drug-induced QT prolongation? Concentration–QTc modelling in a phase 1 study with oral rac-sotalol

    British Journal of Clinical Pharmacology

    Volume 77, Issue 3, March 2014, Pages: 522–531, Borje Darpo, Dilip R. Karnad, Fabio Badilini, Jeff Florian, Christine E Garnett, Snehal Kothari, Gopi Krishna Panicker and Nenad Sarapa

    Version of Record online : 21 FEB 2014, DOI: 10.1111/bcp.12201

  7. You have free access to this content
    Thorough QT study of the effect of oral moxifloxacin on QTc interval in the fed and fasted state in healthy Japanese and Caucasian subjects

    British Journal of Clinical Pharmacology

    Volume 77, Issue 1, January 2014, Pages: 170–179, Jorg Taubel, Georg Ferber, Ulrike Lorch, Velislav Batchvarov, Irina Savelieva and A. John Camm

    Version of Record online : 20 DEC 2013, DOI: 10.1111/bcp.12168

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    Effects of atomoxetine on the QT interval in healthy CYP2D6 poor metabolizers

    British Journal of Clinical Pharmacology

    Volume 75, Issue 2, February 2013, Pages: 549–564, Corina Loghin, Harry Haber, Charles M. Beasley Jr, Prajakti A. Kothare, Lynnette Kauffman, John April, Ling Jin, Albert J. Allen and Malcolm I. Mitchell

    Version of Record online : 10 JAN 2013, DOI: 10.1111/j.1365-2125.2012.04382.x

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    ICH E14 Q&A(R2) document: commentary on the further updated recommendations on thorough QT studies

    British Journal of Clinical Pharmacology

    Volume 79, Issue 3, March 2015, Pages: 456–464, Rashmi R. Shah, Joel Morganroth and Robert B. Kleiman

    Version of Record online : 20 FEB 2015, DOI: 10.1111/bcp.12477

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    Use of selective serotonin re-uptake inhibitors and the heart rate corrected QT interval in a real-life setting: the population-based Rotterdam Study

    British Journal of Clinical Pharmacology

    Volume 80, Issue 4, October 2015, Pages: 698–705, Nevena M. Maljuric, Raymond Noordam, Nikkie Aarts, Maartje N. Niemeijer, Marten E. van den Berg, Albert Hofman, Jan A. Kors, Bruno H. Stricker and Loes E. Visser

    Version of Record online : 29 JUL 2015, DOI: 10.1111/bcp.12681

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    Identifying the translational gap in the evaluation of drug-induced QTc interval prolongation

    British Journal of Clinical Pharmacology

    Volume 76, Issue 5, November 2013, Pages: 708–724, Anne S.Y. Chain, Vincent F.S. Dubois, Meindert Danhof, Miriam C.J.M. Sturkenboom, Oscar Della Pasqua and on behalf of the Cardiovascular Safety Project Team, TI Pharma PKPD Platform

    Version of Record online : 21 OCT 2013, DOI: 10.1111/bcp.12082

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    Early QT assessment – how can our confidence in the data be improved?

    British Journal of Clinical Pharmacology

    Volume 76, Issue 5, November 2013, Pages: 642–648, Borje Darpo and Christine Garnett

    Version of Record online : 21 OCT 2013, DOI: 10.1111/bcp.12068

  13. You have free access to this content
    The effect of tafamidis on the QTc interval in healthy subjects

    British Journal of Clinical Pharmacology

    Volume 79, Issue 6, June 2015, Pages: 918–925, Karen J. Klamerus, Eric Watsky, Robert Moller, Ronnie Wang and Steve Riley

    Version of Record online : 22 MAY 2015, DOI: 10.1111/bcp.12561

  14. You have free access to this content
    Drug induced QT prolongation: the measurement and assessment of the QT interval in clinical practice

    British Journal of Clinical Pharmacology

    Volume 76, Issue 1, July 2013, Pages: 48–57, Geoffrey K. Isbister and Colin B. Page

    Version of Record online : 20 JUN 2013, DOI: 10.1111/bcp.12040

  15. You have full text access to this OnlineOpen article
    High dose droperidol and QT prolongation: analysis of continuous 12-lead recordings

    British Journal of Clinical Pharmacology

    Volume 77, Issue 5, May 2014, Pages: 880–886, Leonie Calver and Geoffrey K. Isbister

    Version of Record online : 22 APR 2014, DOI: 10.1111/bcp.12272

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    Replacing the thorough QT study: reflections of a baby in the bath water

    British Journal of Clinical Pharmacology

    Volume 78, Issue 2, August 2014, Pages: 195–201, Robert B. Kleiman, Rashmi R. Shah and Joel Morganroth

    Version of Record online : 21 JUL 2014, DOI: 10.1111/bcp.12296

  17. You have free access to this content
    The DPP-4 inhibitor linagliptin does not prolong the QT interval at therapeutic and supratherapeutic doses

    British Journal of Clinical Pharmacology

    Volume 72, Issue 1, July 2011, Pages: 39–50, Arne Ring, Andreas Port, E. Ulrike Graefe-Mody, Ivette Revollo, Mario Iovino and Klaus A. Dugi

    Version of Record online : 9 JUN 2011, DOI: 10.1111/j.1365-2125.2011.03931.x

  18. You have full text access to this OnlineOpen article
    Evaluation of the QT effect of a combination of piperaquine and a novel anti-malarial drug candidate OZ439, for the treatment of uncomplicated malaria

    British Journal of Clinical Pharmacology

    Volume 80, Issue 4, October 2015, Pages: 706–715, Borje Darpo, Georg Ferber, Peter Siegl, Bart Laurijssens, Fiona Macintyre, Stephen Toovey and Stephan Duparc

    Version of Record online : 14 JUL 2015, DOI: 10.1111/bcp.12680

  19. You have free access to this content
    Assessment of QTc-prolonging potential of BX471 in healthy volunteers. A ‘thorough QTc study’ following ICH E14 using various QT correction methods

    British Journal of Clinical Pharmacology

    Volume 68, Issue 3, September 2009, Pages: 435–446, Marc Vandemeulebroecke, Jürgen Lembcke, Herbert Wiesinger, Wolfgang Sittner and Stefanie Lindemann

    Version of Record online : 15 MAY 2009, DOI: 10.1111/j.1365-2125.2009.03460.x

  20. You have free access to this content
    Small doses of droperidol do not present relevant torsadogenic actions: a double-blind, ondansetron-controlled study

    British Journal of Clinical Pharmacology

    Volume 79, Issue 4, April 2015, Pages: 669–676, Krzysztof Tracz and Radosław Owczuk

    Version of Record online : 23 MAR 2015, DOI: 10.1111/bcp.12527