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There are 10950 results for: content related to: Safety, tolerability and pharmacokinetics of the histamine H 3 receptor antagonist, ABT -288, in healthy young adults and elderly volunteers

  1. You have free access to this content
    Effects of the TRPV1 antagonist ABT-102 on body temperature in healthy volunteers: pharmacokinetic/ pharmacodynamic analysis of three phase 1 trials

    British Journal of Clinical Pharmacology

    Volume 75, Issue 4, April 2013, Pages: 1029–1040, Ahmed A. Othman, Wolfram Nothaft, Walid M. Awni and Sandeep Dutta

    Article first published online : 15 MAR 2013, DOI: 10.1111/j.1365-2125.2012.04405.x

  2. You have free access to this content
    An oral TRPV1 antagonist attenuates laser radiant-heat-evoked potentials and pain ratings from UVB-inflamed and normal skin

    British Journal of Clinical Pharmacology

    Volume 75, Issue 2, February 2013, Pages: 404–414, Klaus Schaffler, Peter Reeh, W. Rachel Duan, Andrea E. Best, Ahmed A. Othman, Connie R. Faltynek, Charles Locke and Wolfram Nothaft

    Article first published online : 10 JAN 2013, DOI: 10.1111/j.1365-2125.2012.04377.x

  3. Single- and Multiple-Dose Pharmacokinetics, Safety, and Tolerability of the Selective α7 Neuronal Nicotinic Receptor Agonist, ABT-107, in Healthy Human Volunteers

    The Journal of Clinical Pharmacology

    Volume 51, Issue 4, April 2011, Pages: 512–526, Ahmed A. Othman, Robert A. Lenz, Jun Zhang, Jianling Li, Walid M. Awni and Sandeep Dutta

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270010370460

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    The H3 antagonist ABT-288 is tolerated at significantly higher exposures in subjects with schizophrenia than in healthy volunteers

    British Journal of Clinical Pharmacology

    Volume 77, Issue 6, June 2014, Pages: 965–974, Ahmed A. Othman, George Haig, Hana Florian, Charles Locke, Lev Gertsik and Sandeep Dutta

    Article first published online : 22 MAY 2014, DOI: 10.1111/bcp.12281

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    Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263

    International Journal of Cancer

    Volume 136, Issue 3, 1 February 2015, Pages: 688–698, Gernot Polier, Marco Giaisi, Rebecca Köhler, Wolfgang W. Müller, Christoph Lutz, Eike C. Buss, Peter H. Krammer and Min Li-Weber

    Article first published online : 13 JUN 2014, DOI: 10.1002/ijc.29009

  6. Clinical Safety, Pharmacokinetics, and Pharmacodynamics of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 in Healthy Volunteers and Elderly Adults

    Clinical Pharmacology in Drug Development

    Volume 2, Issue 2, April 2013, Pages: 133–151, Wei Liu, David A. Katz, Charles Locke, Dan Daszkowski, Yi Wang, Matthew J. Rieser, Walid Awni, Gerard J. Marek and Sandeep Dutta

    Article first published online : 21 FEB 2013, DOI: 10.1002/cpdd.5

  7. Population pharmacokinetics of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor ABT-384 in healthy volunteers following single and multiple dose regimens

    Biopharmaceutics & Drug Disposition

    Volume 35, Issue 7, October 2014, Pages: 417–429, Guohua An, Wei Liu, David A. Katz, Gerard J. Marek, Walid Awni and Sandeep Dutta

    Article first published online : 29 AUG 2014, DOI: 10.1002/bdd.1912

  8. Bcl-2 phosphorylation confers resistance on chronic lymphocytic leukaemia cells to the BH3 mimetics ABT-737, ABT-263 and ABT-199 by impeding direct binding

    British Journal of Pharmacology

    Volume 173, Issue 3, February 2016, Pages: 471–483, Ting Song, Gaobo Chai, Yubo Liu, Xiaoyan Yu, Ziqian Wang and Zhichao Zhang

    Article first published online : 16 JAN 2016, DOI: 10.1111/bph.13370

  9. Pharmacokinetics of the TRPV1 Antagonist ABT-102 in Healthy Human Volunteers: Population Analysis of Data From 3 Phase 1 Trials

    The Journal of Clinical Pharmacology

    Volume 52, Issue 7, July 2012, Pages: 1028–1041, Ahmed A. Othman, Wolfram Nothaft, Walid M. Awni and Sandeep Dutta

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270011407497

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    Activation and inhibition of rat neuronal nicotinic receptors by ABT-418

    British Journal of Pharmacology

    Volume 120, Issue 3, January 1997, Pages: 429–438, Roger L. Papke, Jeffrey S. Thinschmidt, Becky A. Moulton, Edwin M. Meyer and Amy Poirier

    Article first published online : 10 FEB 2009, DOI: 10.1038/sj.bjp.0700930

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    The BH3-mimetic ABT-737 inhibits allogeneic immune responses

    Transplant International

    Volume 24, Issue 7, July 2011, Pages: 722–732, Pietro E. Cippà, Anna K. Kraus, Ilka Edenhofer, Stephan Segerer, Jin Chen, Martin Hausmann, Yang Liu, Annick Guimezanes, Philip D. Bardwell, Rudolf P. Wüthrich and Thomas Fehr

    Article first published online : 25 MAY 2011, DOI: 10.1111/j.1432-2277.2011.01272.x

  12. Single-Dose Interaction Study of the Arginine Vasopressin Type 1B Receptor Antagonist ABT-436 and Alcohol in Moderate Alcohol Drinkers

    Alcoholism: Clinical and Experimental Research

    Volume 40, Issue 4, April 2016, Pages: 838–845, David A. Katz, Charles Locke, Wei Liu, Jun Zhang, Ramanuj Achari, Keith A. Wesnes and Katherine A. Tracy

    Article first published online : 10 MAR 2016, DOI: 10.1111/acer.12996

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    ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21(CIP1/WAF1) in human cancer cells

    British Journal of Pharmacology

    Volume 171, Issue 13, July 2014, Pages: 3182–3195, Jingru Li, Yicheng Chen, Jiali Wan, Xin Liu, Chunrong Yu and Wenhua Li

    Article first published online : 10 JUN 2014, DOI: 10.1111/bph.12659

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    Poster Session 4: Hepatitis C: New Agents (Not Approved)

    Hepatology

    Volume 60, Issue S1, October 2014, Pages: 1128A–1161A,

    Article first published online : 1 OCT 2014, DOI: 10.1002/hep.27533

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    Autologous blood transfusion in dogs with thoracic or abdominal hemorrhage: 25 cases (2007–2012)

    Journal of Veterinary Emergency and Critical Care

    Volume 25, Issue 6, November/December, Pages: 731–738, Veronica A. Higgs, Elke Rudloff, Rebecca Kirby and Andrew K.J. Linklater

    Article first published online : 20 JUL 2015, DOI: 10.1111/vec.12338

  16. Small-molecule compounds exhibiting target-mediated drug disposition — A case example of ABT-384

    The Journal of Clinical Pharmacology

    Volume 55, Issue 10, October 2015, Pages: 1079–1085, Guohua An, Wei Liu and Sandeep Dutta

    Article first published online : 16 JUN 2015, DOI: 10.1002/jcph.531

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    Preclinical Profiling and Safety Studies of ABT-769: A Compound with Potential for Broad-spectrum Antiepileptic Activity

    Epilepsia

    Volume 46, Issue 9, September 2005, Pages: 1349–1361, William J. Giardina, Michael J. Dart, Richard R. Harris, Robert S. Bitner, Richard J. Radek, Gerard B. Fox, Sanjay R. Chemburkar, Kennan C. Marsh, Jeffrey F. Waring, Julia Y Hui, Jinhua Chen, Peter Curzon, George K. Grayson, Victoria A. Komater, Yiyin Ku, Mark Lockwood, Holly M. Miner, Arthur L. Nikkel, Jia Bao Pan, Yu-Ming Pu, Lei Wang, Youssef Bennani, Niklaus Durmuller, Robert Jolly, Sylvain Roux, James P. Sullivan and Michael W. Decker

    Article first published online : 1 SEP 2005, DOI: 10.1111/j.1528-1167.2005.02905.x

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    Spanish consensus statement on alternatives to allogeneic transfusions: the ‘Seville document’

    Transfusion Alternatives in Transfusion Medicine

    Volume 8, Issue 4, December 2006, Pages: 178–202, RAMÓN LEAL-NOVAL, MANUEL MUÑOZ, JOSÉ A PÁRAMO and JOSÉ A GARCÍA-ERCE

    Article first published online : 12 JAN 2007, DOI: 10.1111/j.1778-428X.2006.00038.x

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    Combination treatments with ABT-263 and an immunotoxin produce synergistic killing of ABT-263-resistant small cell lung cancer cell lines

    International Journal of Cancer

    Volume 132, Issue 4, 15 February 2013, Pages: 978–987, Abid R. Mattoo and David J. Fitzgerald

    Article first published online : 16 AUG 2012, DOI: 10.1002/ijc.27732

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    The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib

    Hepatology

    Volume 52, Issue 4, October 2010, Pages: 1310–1321, Hayato Hikita, Tetsuo Takehara, Satoshi Shimizu, Takahiro Kodama, Minoru Shigekawa, Kyoko Iwase, Atsushi Hosui, Takuya Miyagi, Tomohide Tatsumi, Hisashi Ishida, Wei Li, Tatsuya Kanto, Naoki Hiramatsu and Norio Hayashi

    Article first published online : 16 JUL 2010, DOI: 10.1002/hep.23836