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There are 7540 results for: content related to: A novel splice site mutation in NCSTN underlies a Japanese family with hidradenitis suppurativa

  1. You have full text access to this Open Access content
    Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer’s disease

    Aging Cell

    Volume 11, Issue 4, August 2012, Pages: 559–568, A-Ryeong Gwon, Jong-Sung Park, Thiruma V. Arumugam, Yong-Kook Kwon, Sic L. Chan, Seol-Hee Kim, Sang-Ha Baik, Sunghee Yang, Young-Kwang Yun, Yuri Choi, Saerom Kim, Sung-Chun Tang, Dong-Hoon Hyun, Aiwu Cheng, Charles E. Dann III, Michel Bernier, Jaewon Lee, William R. Markesbery, Mark P. Mattson and Dong-Gyu Jo

    Article first published online : 9 APR 2012, DOI: 10.1111/j.1474-9726.2012.00817.x

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    Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and γ-secretase activity

    Journal of Neurochemistry

    Volume 94, Issue 5, September 2005, Pages: 1315–1328, A. L. Brunkan, M. Martinez, J. Wang, E. S. Walker, D. Beher, M. S. Shearman and A. M. Goate

    Article first published online : 7 JUL 2005, DOI: 10.1111/j.1471-4159.2005.03278.x

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    Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss

    Journal of Neurochemistry

    Volume 96, Issue 5, March 2006, Pages: 1423–1440, William A. Campbell, Hongwei Yang, Henrik Zetterberg, Stéphanie Baulac, Jacqueline A. Sears, Tianming Liu, Stephen T. C. Wong, Tao P. Zhong and Weiming Xia

    Article first published online : 8 FEB 2006, DOI: 10.1111/j.1471-4159.2006.03648.x

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    The levels of mature glycosylated nicastrin are regulated and correlate with γ-secretase processing of amyloid β-precursor protein

    Journal of Neurochemistry

    Volume 83, Issue 5, December 2002, Pages: 1065–1071, Shigeki Arawaka, Hiroshi Hasegawa, Anurag Tandon, Christopher Janus, Fusheng Chen, Gang Yu, Kenji Kikuchi, Shingo Koyama, Takeo Kato, Paul E. Fraser and Peter St George-Hyslop

    Article first published online : 19 NOV 2002, DOI: 10.1046/j.1471-4159.2002.01207.x

  5. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production

    Journal of Neurochemistry

    Volume 133, Issue 3, May 2015, Pages: 409–421, Alexandre Matz, Blanka Halamoda-Kenzaoui, Romain Hamelin, Sebastien Mosser, Jean-René Alattia, Mitko Dimitrov, Marc Moniatte and Patrick C. Fraering

    Article first published online : 24 FEB 2015, DOI: 10.1111/jnc.12996

  6. ADAM10 and BACE1 are localized to synaptic vesicles

    Journal of Neurochemistry

    Jolanta L. Lundgren, Saheeb Ahmed, Sophia Schedin-Weiss, Gunnar K. Gouras, Bengt Winblad, Lars O. Tjernberg and Susanne Frykman

    Article first published online : 17 SEP 2015, DOI: 10.1111/jnc.13287

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    Localization of presenilin–nicastrin complexes and γ-secretase activity to the trans-Golgi network

    Journal of Neurochemistry

    Volume 84, Issue 5, March 2003, Pages: 1143–1153, Robert Siman and Jamel Velji

    Article first published online : 18 FEB 2003, DOI: 10.1046/j.1471-4159.2003.01616.x

  8. Nicastrin, a key regulator of presenilin function, is expressed constitutively in human neural cell lines


    Volume 21, Issue 2, June 2001, Pages: 115–122, Jun-ichi Satoh and Yasuo Kuroda

    Article first published online : 21 DEC 2001, DOI: 10.1046/j.1440-1789.2001.00378.x

  9. Ethanol Inhibits γ-Secretase Proteolytic Activity in Vascular Smooth Muscle Cells

    Alcoholism: Clinical and Experimental Research

    Ekaterina Hatch, David Morrow, Weimin Liu, Paul A. Cahill and Eileen M. Redmond

    Article first published online : 7 OCT 2015, DOI: 10.1111/acer.12875

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    Alterations in phosphatidylethanolamine levels affect the generation of Aβ

    Aging Cell

    Volume 11, Issue 1, February 2012, Pages: 63–72, Iva Nesic, Francesc X. Guix, Krist’l Vennekens, Vasiliki Michaki, Paul P. Van Veldhoven, Fabian Feiguin, Bart De Strooper, Carlos G. Dotti and Tina Wahle

    Article first published online : 28 NOV 2011, DOI: 10.1111/j.1474-9726.2011.00760.x

  11. Haploinsufficiency caused by a nonsense mutation in NCSTN underlying hidradenitis suppurativa in a Chinese family

    Clinical and Experimental Dermatology

    J.-q. Yang, X.-j. Wu, T.-t. Dou, T. Jiao, X.-b. Chen, M. Min, S.-q. Cai and M. Zheng

    Article first published online : 30 JUL 2015, DOI: 10.1111/ced.12724

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    Caspase cleaved presenilin-1 is part of active γ-secretase complexes

    Journal of Neurochemistry

    Volume 97, Issue 2, April 2006, Pages: 356–364, Camilla A. Hansson, Bogdan O. Popescu, Hanna Laudon, Angel Cedazo-Minguez, Laurentiu M. Popescu, Bengt Winblad and Maria Ankarcrona

    Article first published online : 15 MAR 2006, DOI: 10.1111/j.1471-4159.2006.03735.x

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    Human brain proteins showing neuron-specific interactions with γ-secretase

    FEBS Journal

    Volume 282, Issue 14, July 2015, Pages: 2587–2599, Mitsuhiro Inoue, Ji-Yeun Hur, Takahiro Kihara, Yasuhiro Teranishi, Natsuko G. Yamamoto, Taizo Ishikawa, Birgitta Wiehager, Bengt Winblad, Lars O. Tjernberg and Sophia Schedin-Weiss

    Article first published online : 2 JUL 2015, DOI: 10.1111/febs.13303

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    In vivo manifestation of Notch related phenotypes in zebrafish treated with Alzheimer’s amyloid reducing γ-secretase inhibitors

    Journal of Neurochemistry

    Volume 113, Issue 5, June 2010, Pages: 1200–1209, Ting Yang, Dilyara Arslanova, Xiaoyin Xu, Yue-Ming Li and Weiming Xia

    Article first published online : 12 MAR 2010, DOI: 10.1111/j.1471-4159.2010.06681.x

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    Nicastrin controls aspects of photoreceptor neuron specification and differentiation in the Drosophila eye

    Developmental Dynamics

    Volume 234, Issue 3, November 2005, Pages: 590–601, Tianyi Zhang, Susan Tran, Christopher Clouser and Francesca Pignoni

    Article first published online : 6 SEP 2005, DOI: 10.1002/dvdy.20543

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    Aph-1 interacts at the cell surface with proteins in the active γ-secretase complex and membrane-tethered Notch

    Journal of Neurochemistry

    Volume 92, Issue 5, March 2005, Pages: 1010–1020, Emil M. Hansson, Kia Strömberg, Susanne Bergstedt, Gang Yu, Jan Näslund, Johan Lundkvist and Urban Lendahl

    Article first published online : 2 FEB 2005, DOI: 10.1111/j.1471-4159.2004.02926.x

  17. Functional reconstitution of γ-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2

    Journal of Neuroscience Research

    Volume 77, Issue 3, 1 August 2004, Pages: 309–322, Goran Periz and Mark E. Fortini

    Article first published online : 14 JUN 2004, DOI: 10.1002/jnr.20203

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    The role of protein glycosylation in Alzheimer disease

    FEBS Journal

    Volume 281, Issue 1, January 2014, Pages: 46–62, Sophia Schedin-Weiss, Bengt Winblad and Lars O. Tjernberg

    Article first published online : 26 NOV 2013, DOI: 10.1111/febs.12590

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    Familial Alzheimer's disease mutations inhibit γ-secretase-mediated liberation of β-amyloid precursor protein carboxy-terminal fragment

    Journal of Neurochemistry

    Volume 94, Issue 5, September 2005, Pages: 1189–1201, Jesse C. Wiley, Mark Hudson, Kevin C. Kanning, Leslyanne C. Schecterson and Mark Bothwell

    Article first published online : 30 JUN 2005, DOI: 10.1111/j.1471-4159.2005.03266.x

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    Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle

    Journal of Neurochemistry

    Volume 91, Issue 1, October 2004, Pages: 230–237, Nancy T. Ilaya, Geneviève Evin, Colin L. Masters and Janetta G. Culvenor

    Article first published online : 31 AUG 2004, DOI: 10.1111/j.1471-4159.2004.02718.x