Search Results

There are 3426 results for: content related to: Screening for LRRK2 mutations in patients with Parkinson’s disease in Russia: identification of a novel LRRK2 variant

  1. Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER–Golgi export

    The EMBO Journal

    Volume 33, Issue 20, 16 October 2014, Pages: 2314–2331, Hyun Jin Cho, Jia Yu, Chengsong Xie, Parvathi Rudrabhatla, Xi Chen, Junbing Wu, Loukia Parisiadou, Guoxiang Liu, Lixin Sun, Bo Ma, Jinhui Ding, Zhihua Liu and Huaibin Cai

    Article first published online : 8 SEP 2014, DOI: 10.15252/embj.201487807

  2. You have full text access to this OnlineOpen article
    Ten Years and Counting: Moving Leucine-Rich RepeatKinase 2 Inhibitors to the Clinic

    Movement Disorders

    Andrew B. West

    Article first published online : 1 DEC 2014, DOI: 10.1002/mds.26075

  3. Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe

    Human Mutation

    Volume 33, Issue 7, July 2012, Pages: 1087–1098, Justin P. Rubio, Simon Topp, Liling Warren, Pamela L. St. Jean, Daniel Wegmann, Darren Kessner, John Novembre, Judong Shen, Dana Fraser, Jennifer Aponte, Keith Nangle, Lon R. Cardon, Margaret G. Ehm, Stephanie L. Chissoe, John C. Whittaker, Matthew R. Nelson and Vincent E. Mooser

    Article first published online : 4 APR 2012, DOI: 10.1002/humu.22075

  4. You have free access to this content
    LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles

    FEBS Journal

    Volume 276, Issue 22, November 2009, Pages: 6445–6454, Zhenyu Yue

    Article first published online : 5 OCT 2009, DOI: 10.1111/j.1742-4658.2009.07343.x

  5. Prediction of the Repeat Domain Structures and Impact of Parkinsonism-Associated Variations on Structure and Function of all Functional Domains of Leucine-Rich Repeat Kinase 2 (LRRK2)

    Human Mutation

    Volume 35, Issue 4, April 2014, Pages: 395–412, Ryan D. Mills, Terrence D. Mulhern, Fei Liu, Janetta G. Culvenor and Heung-Chin Cheng

    Article first published online : 24 FEB 2014, DOI: 10.1002/humu.22515

  6. You have free access to this content
    Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

    Journal of Neurochemistry

    Volume 122, Issue 3, August 2012, Pages: 650–658, Jingwen Niu, Mei Yu, Chunyan Wang and Zhiheng Xu

    Article first published online : 22 JUN 2012, DOI: 10.1111/j.1471-4159.2012.07809.x

  7. You have free access to this content
    Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

    Journal of Neurochemistry

    Volume 111, Issue 3, November 2009, Pages: 703–715, Christian L. Klein, Giorgio Rovelli, Wolfdieter Springer, Christoph Schall, Thomas Gasser and Philipp J. Kahle

    Article first published online : 27 AUG 2009, DOI: 10.1111/j.1471-4159.2009.06358.x

  8. LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson disease

    Movement Disorders

    Volume 25, Issue 15, 15 November 2010, Pages: 2536–2541, Rachel Saunders-Pullman, Matthew J. Barrett, Kaili M. Stanley, Marta San Luciano, Vicki Shanker, Lawrence Severt, Ann Hunt, Deborah Raymond, Laurie J. Ozelius and Susan B. Bressman

    Article first published online : 3 SEP 2010, DOI: 10.1002/mds.23314

  9. You have free access to this content
    Leucine-rich repeat kinase 2 (LRRK2): A key player in the pathogenesis of Parkinson's disease

    Journal of Neuroscience Research

    Volume 87, Issue 6, 1 May 2009, Pages: 1283–1295, Payal N. Gandhi, Shu G. Chen and Amy L. Wilson-Delfosse

    Article first published online : 21 NOV 2008, DOI: 10.1002/jnr.21949

  10. Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications

    Movement Disorders

    Volume 26, Issue 8, July 2011, Pages: 1386–1397, Zhenyu Yue and M. Lenard Lachenmayer

    Article first published online : 29 APR 2011, DOI: 10.1002/mds.23737

  11. Leucine-rich repeat kinase 2 and alternative splicing in Parkinson's disease

    Movement Disorders

    Volume 27, Issue 8, July 2012, Pages: 1004–1011, David A. Elliott, Woojin S. Kim, Sarsha Gorissen, Glenda M. Halliday and John B.J. Kwok

    Article first published online : 23 APR 2012, DOI: 10.1002/mds.25005

  12. You have free access to this content
    Poster Presentations

    Movement Disorders

    Volume 27, Issue S1, June 2012, Pages: S1–S523,

    Article first published online : 19 JUN 2012, DOI: 10.1002/mds.25051

  13. You have free access to this content
    Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β

    FEBS Journal

    Volume 281, Issue 1, January 2014, Pages: 3–13, Fumitaka Kawakami, Naoki Shimada, Etsuro Ohta, Go Kagiya, Rei Kawashima, Tatsunori Maekawa, Hiroko Maruyama and Takafumi Ichikawa

    Article first published online : 28 NOV 2013, DOI: 10.1111/febs.12579

  14. Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death

    Human Mutation

    Volume 32, Issue 12, December 2011, Pages: 1390–1397, Dario C. Angeles, Bong-Hwa Gan, Luisa Onstead, Yi Zhao, Kah-Leong Lim, Justus Dachsel, Heather Melrose, Matt Farrer, Zbigniew K. Wszolek, Dennis W. Dickson and Eng-King Tan

    Article first published online : 12 SEP 2011, DOI: 10.1002/humu.21582

  15. Striatal leucine-rich repeat kinase 2 mRNA is increased in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned common marmosets (Callithrix jacchus) with l-3, 4-dihydroxyphenylalanine methyl ester-induced dyskinesia

    European Journal of Neuroscience

    Volume 26, Issue 1, July 2007, Pages: 171–177, M. J. Hurley, P. H. Patel, M. J. Jackson, L. A. Smith, S. Rose and P. Jenner

    Article first published online : 3 JUL 2007, DOI: 10.1111/j.1460-9568.2007.05638.x

  16. LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study

    Neuropathology and Applied Neurobiology

    Volume 37, Issue 7, December 2011, Pages: 777–790, S. Sharma, R. Bandopadhyay, T. Lashley, A. E. M. Renton, A. E. Kingsbury, R. Kumaran, C. Kallis, C. Vilariño-Güell, S. S. O'Sullivan, A. J. Lees, T. Revesz, N. W. Wood and J. L. Holton

    Article first published online : 27 OCT 2011, DOI: 10.1111/j.1365-2990.2011.01187.x

  17. LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain

    European Journal of Neuroscience

    Volume 23, Issue 3, February 2006, Pages: 659–666, Javier Simón-Sánchez, Vicente Herranz-Pérez, Francisco Olucha-Bordonau and Jordi Pérez-Tur

    Article first published online : 16 FEB 2006, DOI: 10.1111/j.1460-9568.2006.04616.x

  18. Differential protein–protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

    Journal of Neurochemistry

    Volume 131, Issue 2, October 2014, Pages: 239–250, Lauran Reyniers, Maria Grazia Del Giudice, Laura Civiero, Elisa Belluzzi, Evy Lobbestael, Alexandra Beilina, Giorgio Arrigoni, Rita Derua, Etienne Waelkens, Yan Li, Claudia Crosio, Ciro Iaccarino, Mark R. Cookson, Veerle Baekelandt, Elisa Greggio and Jean-Marc Taymans

    Article first published online : 14 JUL 2014, DOI: 10.1111/jnc.12798

  19. Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

    Journal of Comparative Neurology

    Volume 522, Issue 11, 01 August 2014, Pages: 2465–2480, Andrew B. West, Rita M. Cowell, João P.L. Daher, Mark S. Moehle, Kelly M. Hinkle, Heather L. Melrose, David G. Standaert and Laura A. Volpicelli-Daley

    Article first published online : 12 APR 2014, DOI: 10.1002/cne.23583

  20. LRRK2 haplotype-sharing analysis in Parkinson's disease reveals a novel p.S1761R mutation

    Movement Disorders

    Volume 27, Issue 1, January 2012, Pages: 146–150, Oswaldo Lorenzo-Betancor, Lluís Samaranch, Mario Ezquerra, Eduardo Tolosa, Elena Lorenzo, Jaione Irigoyen, Carles Gaig, María A. Pastor, Alexandra I. Soto-Ortolaza, Owen A. Ross, María C. Rodríguez-Oroz, Francesc Valldeoriola, María J. Martí, María R. Luquin, Jordi Perez-Tur, Juan A. Burguera, José A. Obeso and Pau Pastor

    Article first published online : 28 OCT 2011, DOI: 10.1002/mds.23968