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There are 15066 results for: content related to: TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor

  1. Review: Transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration

    Neuropathology and Applied Neurobiology

    Volume 36, Issue 2, April 2010, Pages: 97–112, T. F. Gendron, K. A. Josephs and L. Petrucelli

    Article first published online : 23 MAR 2010, DOI: 10.1111/j.1365-2990.2010.01060.x

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    Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

    The EMBO Journal

    Volume 31, Issue 5, March 7, 2012, Pages: 1241–1252, Todd J Cohen, Andrew W Hwang, Travis Unger, John Q Trojanowski and Virginia M Y Lee

    Article first published online : 23 DEC 2011, DOI: 10.1038/emboj.2011.471

  3. RNA-binding proteins in neurodegenerative disease: TDP-43 and beyond

    Wiley Interdisciplinary Reviews: RNA

    Volume 3, Issue 2, March/April 2012, Pages: 265–285, Keith A. Hanson, Sang Hwa Kim and Randal S. Tibbetts

    Article first published online : 25 OCT 2011, DOI: 10.1002/wrna.111

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    Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

    The EMBO Journal

    Volume 29, Issue 1, January 6, 2010, Pages: 209–221, Fabienne C Fiesel, Aaron Voigt, Stephanie S Weber, Chris Van den Haute, Andrea Waldenmaier, Karin Görner, Michael Walter, Marlene L Anderson, Jeannine V Kern, Tobias M Rasse, Thorsten Schmidt, Wolfdieter Springer, Roland Kirchner, Michael Bonin, Manuela Neumann, Veerle Baekelandt, Marianna Alunni-Fabbroni, Jörg B Schulz and Philipp J Kahle

    Article first published online : 12 NOV 2009, DOI: 10.1038/emboj.2009.324

  5. Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43

    Journal of Neuroscience Research

    Volume 88, Issue 4, March 2010, Pages: 784–797, Makoto Urushitani, Takashi Sato, Hitoshi Bamba, Yasuo Hisa and Ikuo Tooyama

    Article first published online : 1 OCT 2009, DOI: 10.1002/jnr.22243

  6. You have full text access to this OnlineOpen article
    TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA

    The EMBO Journal

    Volume 33, Issue 24, 17 December 2014, Pages: 2947–2966, Tassa K Saldi, Peter EA Ash, Gavin Wilson, Patrick Gonzales, Alfonso Garrido-Lecca, Christine M Roberts, Vishantie Dostal, Tania F Gendron, Lincoln D Stein, Thomas Blumenthal, Leonard Petrucelli and Christopher D Link

    Article first published online : 12 NOV 2014, DOI: 10.15252/embj.201488740

  7. CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration

    Annals of Neurology

    Volume 74, Issue 1, July 2013, Pages: 39–52, Nicole F. Liachko, Pamela J. McMillan, Chris R. Guthrie, Thomas D. Bird, James B. Leverenz and Brian C. Kraemer

    Article first published online : 8 JUL 2013, DOI: 10.1002/ana.23870

  8. You have full text access to this OnlineOpen article
    Spliceosome integrity is defective in the motor neuron diseases ALS and SMA

    EMBO Molecular Medicine

    Volume 5, Issue 2, February 2013, Pages: 221–234, Hitomi Tsuiji, Yohei Iguchi, Asako Furuya, Ayane Kataoka, Hiroyuki Hatsuta, Naoki Atsuta, Fumiaki Tanaka, Yoshio Hashizume, Hiroyasu Akatsu, Shigeo Murayama, Gen Sobue and Koji Yamanaka

    Article first published online : 25 JAN 2013, DOI: 10.1002/emmm.201202303

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    Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

    Journal of Neurochemistry

    Volume 110, Issue 3, August 2009, Pages: 1082–1094, Dorothee Dormann, Anja Capell, Aaron M. Carlson, Sunita S. Shankaran, Ramona Rodde, Manuela Neumann, Elisabeth Kremmer, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihara and Christian Haass

    Article first published online : 9 JUN 2009, DOI: 10.1111/j.1471-4159.2009.06211.x

  10. Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy

    Neuropathology

    Volume 30, Issue 2, April 2010, Pages: 170–181, Tetsuaki Arai, Masato Hasegawa, Takashi Nonoka, Fuyuki Kametani, Makiko Yamashita, Masato Hosokawa, Kazuhiro Niizato, Kuniaki Tsuchiya, Zen Kobayashi, Kenji Ikeda, Mari Yoshida, Mitsumoto Onaya, Hiroshige Fujishiro and Haruhiko Akiyama

    Article first published online : 19 JAN 2010, DOI: 10.1111/j.1440-1789.2009.01089.x

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    TDP-43 regulates its mRNA levels through a negative feedback loop

    The EMBO Journal

    Volume 30, Issue 2, January 19, 2011, Pages: 277–288, Youhna M Ayala, Laura De Conti, S Eréndira Avendaño-Vázquez, Ashish Dhir, Maurizio Romano, Andrea D'Ambrogio, James Tollervey, Jernej Ule, Marco Baralle, Emanuele Buratti and Francisco E Baralle

    Article first published online : 3 DEC 2010, DOI: 10.1038/emboj.2010.310

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    TDP-43 and FUS/TLS: cellular functions and implications for neurodegeneration

    FEBS Journal

    Volume 278, Issue 19, October 2011, Pages: 3550–3568, Fabienne C. Fiesel and Philipp J. Kahle

    Article first published online : 24 AUG 2011, DOI: 10.1111/j.1742-4658.2011.08258.x

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    Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay

    The EMBO Journal

    Volume 31, Issue 23, November 28, 2012, Pages: 4415–4427, Xuefeng Liu, Dan Li, Weimin Zhang, Mingzhou Guo and Qimin Zhan

    Article first published online : 26 OCT 2012, DOI: 10.1038/emboj.2012.292

  14. Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis

    Journal of Neurochemistry

    Volume 129, Issue 2, April 2014, Pages: 350–361, Michaeline Hebron, Wenqiang Chen, Matthew J. Miessau, Irina Lonskaya and Charbel E.-H. Moussa

    Article first published online : 19 DEC 2013, DOI: 10.1111/jnc.12630

  15. p62/sequestosome 1 binds to TDP-43 in brains with frontotemporal lobar degeneration with TDP-43 inclusions

    Journal of Neuroscience Research

    Volume 90, Issue 10, October 2012, Pages: 2034–2042, Kunikazu Tanji, Hai-Xin Zhang, Fumiaki Mori, Akiyoshi Kakita, Hitoshi Takahashi and Koichi Wakabayashi

    Article first published online : 5 JUN 2012, DOI: 10.1002/jnr.23081

  16. Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's disease

    Neuropathology

    Volume 30, Issue 4, August 2010, Pages: 408–419, Andrew King, Fiona Sweeney, Istvan Bodi, Claire Troakes, Satomi Maekawa and Safa Al-Sarraj

    Article first published online : 19 JAN 2010, DOI: 10.1111/j.1440-1789.2009.01085.x

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    Biochemical and histopathological alterations in TAR DNA-binding protein-43 after acute ischemic stroke in rats

    Journal of Neurochemistry

    Volume 116, Issue 6, March 2011, Pages: 957–965, Masato Kanazawa, Akiyoshi Kakita, Hironaka Igarashi, Tetsuya Takahashi, Kunio Kawamura, Hitoshi Takahashi, Tsutomu Nakada, Masatoyo Nishizawa and Takayoshi Shimohata

    Article first published online : 14 JUN 2010, DOI: 10.1111/j.1471-4159.2010.06860.x

  18. Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis

    Muscle & Nerve

    Volume 40, Issue 1, July 2009, Pages: 19–31, Mohammad Salajegheh, Jack L. Pinkus, J.Paul Taylor, Anthony A. Amato, Remedios Nazareno, Robert H. Baloh and Steven A. Greenberg

    Article first published online : 16 JUN 2009, DOI: 10.1002/mus.21386

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    TDP-43: the relationship between protein aggregation and neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

    FEBS Journal

    Volume 278, Issue 19, October 2011, Pages: 3539–3549, Robert H. Baloh

    Article first published online : 24 AUG 2011, DOI: 10.1111/j.1742-4658.2011.08256.x

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    What is the key player in TDP-43 pathology in ALS: Disappearance from the nucleus or inclusion formation in the cytoplasm?

    Neurology and Clinical Neuroscience

    Volume 1, Issue 1, January 2013, Pages: 11–17, Osamu Onodera, Akihiro Sugai, Takuya Konno, Mari Tada, Akihide Koyama and Masatoyo Nishizawa

    Article first published online : 31 JAN 2013, DOI: 10.1002/ncn3.9