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There are 2502 results for: content related to: Alpha-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential

  1. You have free access to this content
    ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

    The EMBO Journal

    Volume 29, Issue 17, September 1, 2010, Pages: 3020–3032, Peer-Hendrik Kuhn, Huanhuan Wang, Bastian Dislich, Alessio Colombo, Ulrike Zeitschel, Joachim W Ellwart, Elisabeth Kremmer, Steffen Roßner and Stefan F Lichtenthaler

    Article first published online : 30 JUL 2010, DOI: 10.1038/emboj.2010.167

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    Upregulation of the α-secretase ADAM10 – risk or reason for hope?

    FEBS Journal

    Volume 277, Issue 7, April 2010, Pages: 1585–1596, Kristina Endres and Falk Fahrenholz

    Article first published online : 3 FEB 2010, DOI: 10.1111/j.1742-4658.2010.07566.x

  3. You have free access to this content
    Identification and biology of α-secretase

    Journal of Neurochemistry

    Volume 120, Issue s1, January 2012, Pages: 34–45, Valérie Vingtdeux and Philippe Marambaud

    Article first published online : 28 NOV 2011, DOI: 10.1111/j.1471-4159.2011.07477.x

  4. You have free access to this content
    Activation of α-secretase cleavage

    Journal of Neurochemistry

    Volume 120, Issue s1, January 2012, Pages: 46–54, Rolf Postina

    Article first published online : 28 NOV 2011, DOI: 10.1111/j.1471-4159.2011.07459.x

  5. You have free access to this content
    Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases

    FEBS Journal

    Volume 272, Issue 22, November 2005, Pages: 5808–5820, Kristina Endres, Rolf Postina, Anja Schroeder, Ulrike Mueller and Falk Fahrenholz

    Article first published online : 31 OCT 2005, DOI: 10.1111/j.1742-4658.2005.04976.x

  6. You have free access to this content
    The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein

    European Journal of Biochemistry

    Volume 271, Issue 12, June 2004, Pages: 2539–2547, Tobias M. J. Allinson, Edward T. Parkin, Thomas P. Condon, Sylva L. U. Schwager, Edward D. Sturrock, Anthony J. Turner and Nigel M. Hooper

    Article first published online : 26 MAY 2004, DOI: 10.1111/j.1432-1033.2004.04184.x

  7. You have free access to this content
    α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation

    Journal of Neurochemistry

    Volume 111, Issue 6, December 2009, Pages: 1369–1382, Sebastian Jäger, Stefanie Leuchtenberger, Anne Martin, Eva Czirr, Johanna Wesselowski, Marco Dieckmann, Elaine Waldron, Carsten Korth, Edward H. Koo, Michael Heneka, Sascha Weggen and Claus U. Pietrzik

    Article first published online : 5 OCT 2009, DOI: 10.1111/j.1471-4159.2009.06420.x

  8. ADAMs family members as amyloid precursor protein α-secretases

    Journal of Neuroscience Research

    Volume 74, Issue 3, 1 November 2003, Pages: 342–352, Tobias M.J. Allinson, Edward T. Parkin, Anthony J. Turner and Nigel M. Hooper

    Article first published online : 28 OCT 2003, DOI: 10.1002/jnr.10737

  9. You have free access to this content
    The effects of α-secretase ADAM10 on the proteolysis of neuregulin-1

    FEBS Journal

    Volume 276, Issue 6, March 2009, Pages: 1568–1580, Christian Freese, Alistair N. Garratt, Falk Fahrenholz and Kristina Endres

    Article first published online : 13 FEB 2009, DOI: 10.1111/j.1742-4658.2009.06889.x

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    APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

    The EMBO Journal

    Volume 30, Issue 11, June 1, 2011, Pages: 2266–2280, Sascha W Weyer, Maja Klevanski, Andrea Delekate, Vootele Voikar, Dorothee Aydin, Meike Hick, Mikhail Filippov, Natalia Drost, Kristin L Schaller, Martina Saar, Miriam A Vogt, Peter Gass, Ayan Samanta, Andres Jäschke, Martin Korte, David P Wolfer, John H Caldwell and Ulrike C Müller

    Article first published online : 26 APR 2011, DOI: 10.1038/emboj.2011.119

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    Enhancement of α-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin

    Journal of Neurochemistry

    Volume 102, Issue 5, September 2007, Pages: 1595–1605, Yoshinori Hiraoka, Mikiko Ohno, Kazuhiro Yoshida, Katsuya Okawa, Hidekazu Tomimoto, Toru Kita and Eiichiro Nishi

    Article first published online : 7 MAY 2007, DOI: 10.1111/j.1471-4159.2007.04685.x

  12. You have free access to this content
    A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10

    Journal of Neurochemistry

    Volume 108, Issue 6, March 2009, Pages: 1464–1479, Edward Parkin and Benjamin Harris

    Article first published online : 22 JAN 2009, DOI: 10.1111/j.1471-4159.2009.05907.x

  13. You have full text access to this Open Access content
    Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers

    EMBO Molecular Medicine

    Volume 4, Issue 7, July 2012, Pages: 647–659, Daniela Kaden, Anja Harmeier, Christoph Weise, Lisa M. Munter, Veit Althoff, Benjamin R. Rost, Peter W. Hildebrand, Dietmar Schmitz, Michael Schaefer, Rudi Lurz, Sabine Skodda, Raina Yamamoto, Sönke Arlt, Ulrich Finckh and Gerd Multhaup

    Article first published online : 19 APR 2012, DOI: 10.1002/emmm.201200239

  14. You have free access to this content
    Tumor necrosis factor-α converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation

    European Journal of Biochemistry

    Volume 270, Issue 11, June 2003, Pages: 2386–2393, Kristina Endres, Andreas Anders, Elzbieta Kojro, Sandra Gilbert, Falk Fahrenholz and Rolf Postina

    Article first published online : 6 MAY 2003, DOI: 10.1046/j.1432-1033.2003.03606.x

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    Regulated intramembrane proteolysis – lessons from amyloid precursor protein processing

    Journal of Neurochemistry

    Volume 117, Issue 5, June 2011, Pages: 779–796, Stefan F. Lichtenthaler, Christian Haass and Harald Steiner

    Article first published online : 14 APR 2011, DOI: 10.1111/j.1471-4159.2011.07248.x

  16. You have free access to this content
    The Arctic Alzheimer mutation favors intracellular amyloid-β production by making amyloid precursor protein less available to α-secretase

    Journal of Neurochemistry

    Volume 101, Issue 3, May 2007, Pages: 854–862, Charlotte Sahlin, Anna Lord, Kristina Magnusson, Hillevi Englund, Claudia G. Almeida, Paul Greengard, Fred Nyberg, Gunnar K. Gouras, Lars Lannfelt and Lars N.G. Nilsson

    Article first published online : 11 JAN 2007, DOI: 10.1111/j.1471-4159.2006.04443.x

  17. You have full text access to this Open Access content
    Alterations in phosphatidylethanolamine levels affect the generation of Aβ

    Aging Cell

    Volume 11, Issue 1, February 2012, Pages: 63–72, Iva Nesic, Francesc X. Guix, Krist’l Vennekens, Vasiliki Michaki, Paul P. Van Veldhoven, Fabian Feiguin, Bart De Strooper, Carlos G. Dotti and Tina Wahle

    Article first published online : 28 NOV 2011, DOI: 10.1111/j.1474-9726.2011.00760.x

  18. You have free access to this content
    Constitutive α-secretase cleavage of the β-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10

    Journal of Neurochemistry

    Volume 76, Issue 5, March 2001, Pages: 1532–1539, Elvira Lopez-Perez, Yue Zhang, Stuart J Frank, John Creemers, Nabil Seidah and Frédéric Checler

    Article first published online : 20 DEC 2001, DOI: 10.1046/j.1471-4159.2001.00180.x

  19. You have full text access to this OnlineOpen article
    Thioredoxin-80 is a product of alpha-secretase cleavage that inhibits amyloid-beta aggregation and is decreased in Alzheimer's disease brain

    EMBO Molecular Medicine

    Volume 4, Issue 10, October 2012, Pages: 1097–1111, Francisco Gil-Bea, Susanne Akterin, Torbjörn Persson, Laura Mateos, Anna Sandebring, Javier Avila-Cariño, Angel Gutierrez-Rodriguez, Erik Sundström, Arne Holmgren, Bengt Winblad and Angel Cedazo-Minguez

    Article first published online : 30 AUG 2012, DOI: 10.1002/emmm.201201462

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    Size and sulfation are critical for the effect of heparin on APP processing and Aβ production

    Journal of Neurochemistry

    Volume 123, Issue 3, November 2012, Pages: 447–457, Hao Cui, Amos C. Hung, Craig Freeman, Christian Narkowicz, Glenn A. Jacobson and David H. Small

    Article first published online : 21 SEP 2012, DOI: 10.1111/j.1471-4159.2012.07929.x