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There are 6931 results for: content related to: Alpha-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential

  1. You have free access to this content
    ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

    The EMBO Journal

    Volume 29, Issue 17, September 1, 2010, Pages: 3020–3032, Peer-Hendrik Kuhn, Huanhuan Wang, Bastian Dislich, Alessio Colombo, Ulrike Zeitschel, Joachim W Ellwart, Elisabeth Kremmer, Steffen Roßner and Stefan F Lichtenthaler

    Version of Record online : 30 JUL 2010, DOI: 10.1038/emboj.2010.167

  2. You have free access to this content
    Identification and biology of α-secretase

    Journal of Neurochemistry

    Volume 120, Issue s1, January 2012, Pages: 34–45, Valérie Vingtdeux and Philippe Marambaud

    Version of Record online : 28 NOV 2011, DOI: 10.1111/j.1471-4159.2011.07477.x

  3. You have free access to this content
    ADAM10 and BACE1 are localized to synaptic vesicles

    Journal of Neurochemistry

    Volume 135, Issue 3, November 2015, Pages: 606–615, Jolanta L. Lundgren, Saheeb Ahmed, Sophia Schedin-Weiss, Gunnar K. Gouras, Bengt Winblad, Lars O. Tjernberg and Susanne Frykman

    Version of Record online : 17 SEP 2015, DOI: 10.1111/jnc.13287

  4. You have free access to this content
    α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation

    Journal of Neurochemistry

    Volume 111, Issue 6, December 2009, Pages: 1369–1382, Sebastian Jäger, Stefanie Leuchtenberger, Anne Martin, Eva Czirr, Johanna Wesselowski, Marco Dieckmann, Elaine Waldron, Carsten Korth, Edward H. Koo, Michael Heneka, Sascha Weggen and Claus U. Pietrzik

    Version of Record online : 5 OCT 2009, DOI: 10.1111/j.1471-4159.2009.06420.x

  5. You have free access to this content
    Activation of α-secretase cleavage

    Journal of Neurochemistry

    Volume 120, Issue s1, January 2012, Pages: 46–54, Rolf Postina

    Version of Record online : 28 NOV 2011, DOI: 10.1111/j.1471-4159.2011.07459.x

  6. You have free access to this content
    Regulated intramembrane proteolysis – lessons from amyloid precursor protein processing

    Journal of Neurochemistry

    Volume 117, Issue 5, June 2011, Pages: 779–796, Stefan F. Lichtenthaler, Christian Haass and Harald Steiner

    Version of Record online : 14 APR 2011, DOI: 10.1111/j.1471-4159.2011.07248.x

  7. ADAMs family members as amyloid precursor protein α-secretases

    Journal of Neuroscience Research

    Volume 74, Issue 3, 1 November 2003, Pages: 342–352, Tobias M.J. Allinson, Edward T. Parkin, Anthony J. Turner and Nigel M. Hooper

    Version of Record online : 28 OCT 2003, DOI: 10.1002/jnr.10737

  8. You have free access to this content
    The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein

    European Journal of Biochemistry

    Volume 271, Issue 12, June 2004, Pages: 2539–2547, Tobias M. J. Allinson, Edward T. Parkin, Thomas P. Condon, Sylva L. U. Schwager, Edward D. Sturrock, Anthony J. Turner and Nigel M. Hooper

    Version of Record online : 26 MAY 2004, DOI: 10.1111/j.1432-1033.2004.04184.x

  9. Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17

    Journal of Pineal Research

    Volume 58, Issue 2, March 2015, Pages: 151–165, Mayuri Shukla, Htut Htut Htoo, Phitchayapak Wintachai, Jean-Francois Hernandez, Claire Dubois, Rolf Postina, Huaxi Xu, Frédéric Checler, Duncan R. Smith, Piyarat Govitrapong and Bruno Vincent

    Version of Record online : 27 DEC 2014, DOI: 10.1111/jpi.12200

  10. You have full text access to this Open Access content
    Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers

    EMBO Molecular Medicine

    Volume 4, Issue 7, July 2012, Pages: 647–659, Daniela Kaden, Anja Harmeier, Christoph Weise, Lisa M. Munter, Veit Althoff, Benjamin R. Rost, Peter W. Hildebrand, Dietmar Schmitz, Michael Schaefer, Rudi Lurz, Sabine Skodda, Raina Yamamoto, Sönke Arlt, Ulrich Finckh and Gerd Multhaup

    Version of Record online : 19 APR 2012, DOI: 10.1002/emmm.201200239

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    Enhancement of α-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin

    Journal of Neurochemistry

    Volume 102, Issue 5, September 2007, Pages: 1595–1605, Yoshinori Hiraoka, Mikiko Ohno, Kazuhiro Yoshida, Katsuya Okawa, Hidekazu Tomimoto, Toru Kita and Eiichiro Nishi

    Version of Record online : 7 MAY 2007, DOI: 10.1111/j.1471-4159.2007.04685.x

  12. β-Amyloid Therapeutic Strategies for Alzheimer's Disease

    Standard Article

    Burger's Medicinal Chemistry and Drug Discovery

    Bruno P. Imbimbo and Francesca Speroni

    Published Online : 14 OCT 2005, DOI: 10.1002/0471266949.bmc112

  13. You have free access to this content
    Characterization of nectin processing mediated by presenilin-dependent gamma-secretase

    Journal of Neurochemistry

    Volume 119, Issue 5, December 2011, Pages: 945–956, Jinsook Kim, Allison Chang, Amanda Dudak, Howard J. Federoff and Seung T. Lim

    Version of Record online : 20 OCT 2011, DOI: 10.1111/j.1471-4159.2011.07479.x

  14. You have full text access to this Open Access content
    Alterations in phosphatidylethanolamine levels affect the generation of Aβ

    Aging Cell

    Volume 11, Issue 1, February 2012, Pages: 63–72, Iva Nesic, Francesc X. Guix, Krist’l Vennekens, Vasiliki Michaki, Paul P. Van Veldhoven, Fabian Feiguin, Bart De Strooper, Carlos G. Dotti and Tina Wahle

    Version of Record online : 28 NOV 2011, DOI: 10.1111/j.1474-9726.2011.00760.x

  15. You have free access to this content
    Upregulation of the α-secretase ADAM10 – risk or reason for hope?

    The FEBS Journal

    Volume 277, Issue 7, April 2010, Pages: 1585–1596, Kristina Endres and Falk Fahrenholz

    Version of Record online : 3 FEB 2010, DOI: 10.1111/j.1742-4658.2010.07566.x

  16. The Development of New Therapeutics for Alzheimer's Disease

    Clinical Pharmacology & Therapeutics

    Volume 88, Issue 4, October 2010, Pages: 475–486, M D Carter, G A Simms and D F Weaver

    Version of Record online : 1 SEP 2010, DOI: 10.1038/clpt.2010.165

  17. You have free access to this content
    Constitutive α-secretase cleavage of the β-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10

    Journal of Neurochemistry

    Volume 76, Issue 5, March 2001, Pages: 1532–1539, Elvira Lopez-Perez, Yue Zhang, Stuart J Frank, John Creemers, Nabil Seidah and Frédéric Checler

    Version of Record online : 20 DEC 2001, DOI: 10.1046/j.1471-4159.2001.00180.x

  18. You have free access to this content
    The Arctic Alzheimer mutation favors intracellular amyloid-β production by making amyloid precursor protein less available to α-secretase

    Journal of Neurochemistry

    Volume 101, Issue 3, May 2007, Pages: 854–862, Charlotte Sahlin, Anna Lord, Kristina Magnusson, Hillevi Englund, Claudia G. Almeida, Paul Greengard, Fred Nyberg, Gunnar K. Gouras, Lars Lannfelt and Lars N.G. Nilsson

    Version of Record online : 11 JAN 2007, DOI: 10.1111/j.1471-4159.2006.04443.x

  19. You have free access to this content
    Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases

    The FEBS Journal

    Volume 282, Issue 19, October 2015, Pages: 3693–3721, Mei-Kuang Chen and Mien-Chie Hung

    Version of Record online : 4 JUL 2015, DOI: 10.1111/febs.13342

  20. Short-term interleukin-1β increases the release of secreted APPα via MEK1/2-dependent and JNK-dependent α-secretase cleavage in neuroglioma U251 cells

    Journal of Neuroscience Research

    Volume 80, Issue 5, 1 June 2005, Pages: 683–692, Guozhao Ma, Shengdi Chen, Xijin Wang, Maowen Ba, Hui Yang and Guoqiang Lu

    Version of Record online : 3 MAY 2005, DOI: 10.1002/jnr.20515