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There are 11772 results for: content related to: Age-related modulation of γ-secretase activity in non-human primate brains

  1. You have full text access to this OnlineOpen article
    Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease

    EMBO Molecular Medicine

    Volume 4, Issue 4, April 2012, Pages: 344–352, Nobuto Kakuda, Mikio Shoji, Hiroyuki Arai, Katsutoshi Furukawa, Takeshi Ikeuchi, Kohei Akazawa, Mako Takami, Hiroyuki Hatsuta, Shigeo Murayama, Yasuhiro Hashimoto, Masakazu Miyajima, Hajime Arai, Yu Nagashima, Haruyasu Yamaguchi, Ryozo Kuwano, Kazuhiro Nagaike, Yasuo Ihara and the Japanese Alzheimer's Disease Neuroimaging Initiative

    Version of Record online : 21 FEB 2012, DOI: 10.1002/emmm.201200214

  2. β-Amyloid Therapeutic Strategies for Alzheimer's Disease

    Standard Article

    Burger's Medicinal Chemistry and Drug Discovery

    Bruno P. Imbimbo and Francesca Speroni

    Published Online : 14 OCT 2005, DOI: 10.1002/0471266949.bmc112

  3. You have full text access to this OnlineOpen article
    The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

    The EMBO Journal

    Volume 31, Issue 10, May 16, 2012, Pages: 2261–2274, Lucía Chávez-Gutiérrez, Leen Bammens, Iryna Benilova, Annelies Vandersteen, Manasi Benurwar, Marianne Borgers, Sam Lismont, Lujia Zhou, Simon Van Cleynenbreugel, Hermann Esselmann, Jens Wiltfang, Lutgarde Serneels, Eric Karran, Harrie Gijsen, Joost Schymkowitz, Frederic Rousseau, Kerensa Broersen and Bart De Strooper

    Version of Record online : 13 APR 2012, DOI: 10.1038/emboj.2012.79

  4. You have free access to this content
    Modulation of β-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures

    Journal of Neurochemistry

    Volume 88, Issue 2, January 2004, Pages: 337–348, Laura Gasparini, Laura Rusconi, Huaxi Xu, Piero Del Soldato and Ennio Ongini

    Version of Record online : 23 DEC 2003, DOI: 10.1111/j.1471-4159.2004.02154.x

  5. You have free access to this content
    A presenilin-independent aspartyl protease prefers the γ-42 site cleavage

    Journal of Neurochemistry

    Volume 96, Issue 1, January 2006, Pages: 118–125, Ming-Tain Lai, Ming-Chih Crouthamel, Jillian DiMuzio, Beth Lynn Pietrak, Dorit B. Donoviel, Alan Bernstein, Stephen J. Gardell, Yue-Ming Li and Daria Hazuda

    Version of Record online : 21 NOV 2005, DOI: 10.1111/j.1471-4159.2005.03528.x

  6. You have full text access to this Open Access content
    Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer’s disease

    Aging Cell

    Volume 11, Issue 4, August 2012, Pages: 559–568, A-Ryeong Gwon, Jong-Sung Park, Thiruma V. Arumugam, Yong-Kook Kwon, Sic L. Chan, Seol-Hee Kim, Sang-Ha Baik, Sunghee Yang, Young-Kwang Yun, Yuri Choi, Saerom Kim, Sung-Chun Tang, Dong-Hoon Hyun, Aiwu Cheng, Charles E. Dann III, Michel Bernier, Jaewon Lee, William R. Markesbery, Mark P. Mattson and Dong-Gyu Jo

    Version of Record online : 9 APR 2012, DOI: 10.1111/j.1474-9726.2012.00817.x

  7. You have full text access to this OnlineOpen article
    Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations

    FEBS Open Bio

    Volume 4, Issue 1, January 01, 2014, Pages: 393–406, Johanna Wanngren, Patricia Lara, Karin Öjemalm, Silvia Maioli, Nasim Moradi, Lu Chen, Lars O. Tjernberg, Johan Lundkvist, IngMarie Nilsson and Helena Karlström

    Version of Record online : 24 APR 2014, DOI: 10.1016/j.fob.2014.04.006

  8. You have free access to this content
    Inhibitors of Rho-kinase modulate amyloid-β (Aβ) secretion but lack selectivity for Aβ42

    Journal of Neurochemistry

    Volume 96, Issue 2, January 2006, Pages: 355–365, Stefanie Leuchtenberger, Markus P. Kummer, Thomas Kukar, Eva Czirr, Nicole Teusch, Sarah A. Sagi, Rebecca Berdeaux, Claus U. Pietrzik, Thomas B. Ladd, Todd E. Golde, Edward H. Koo and Sascha Weggen

    Version of Record online : 21 NOV 2005, DOI: 10.1111/j.1471-4159.2005.03553.x

  9. You have free access to this content
    Intracellular site of γ-secretase cleavage for Aβ42 generation in Neuro 2a cells harbouring a presenilin 1 mutation

    European Journal of Biochemistry

    Volume 267, Issue 7, April 2000, Pages: 2036–2045, Shinji Sudoh, 1, Gang Hua, 1 Yuuki Kawamura, 1 Kei Maruyama, 2 Hiroto Komano and 1 Katsuhiko Yanagisawa 1

    Version of Record online : 25 DEC 2001, DOI: 10.1046/j.1432-1327.2000.01206.x

  10. You have free access to this content
    Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease

    British Journal of Pharmacology

    Volume 163, Issue 2, May 2011, Pages: 375–389, B Van Broeck, J-M Chen, G Tréton, M Desmidt, C Hopf, N Ramsden, E Karran, M Mercken and A Rowley

    Version of Record online : 18 APR 2011, DOI: 10.1111/j.1476-5381.2011.01207.x

  11. You have free access to this content
    Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils

    Journal of Neurochemistry

    Volume 126, Issue 3, August 2013, Pages: 305–311, Lei Gu and Zhefeng Guo

    Version of Record online : 12 MAR 2013, DOI: 10.1111/jnc.12202

  12. You have free access to this content
    The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity

    The EMBO Journal

    Volume 34, Issue 12, 12 June 2015, Pages: 1674–1686, Hyo-Jin Park, Yong Ran, Joo In Jung, Oliver Holmes, Ashleigh R Price, Lisa Smithson, Carolina Ceballos-Diaz, Chul Han, Michael S Wolfe, Yehia Daaka, Andrey E Ryabinin, Seong-Hun Kim, Richard L Hauger, Todd E Golde and Kevin M Felsenstein

    Version of Record online : 11 MAY 2015, DOI: 10.15252/embj.201488795

  13. Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease

    Journal of Neuroscience Research

    Volume 88, Issue 16, December 2010, Pages: 3588–3597, Masashi Asai, Nobuhisa Iwata, Taisuke Tomita, Takeshi Iwatsubo, Shoichi Ishiura, Takaomi C. Saido and Kei Maruyama

    Version of Record online : 1 OCT 2010, DOI: 10.1002/jnr.22503

  14. You have free access to this content
    Cross-seeding between Aβ40 and Aβ42 in Alzheimer's disease

    FEBS Letters

    Volume 591, Issue 1, January 2017, Pages: 177–185, Joyce Tran, Dennis Chang, Frederick Hsu, Hongsu Wang and Zhefeng Guo

    Version of Record online : 29 DEC 2016, DOI: 10.1002/1873-3468.12526

  15. Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

    Histopathology

    Volume 38, Issue 2, February 2001, Pages: 120–134, M R D'Andrea, R G Nagele, H-Y Wang, P A Peterson and D H S Lee

    Version of Record online : 21 DEC 2001, DOI: 10.1046/j.1365-2559.2001.01082.x

  16. You have free access to this content
    GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42

    The EMBO Journal

    Volume 26, Issue 6, March 21, 2007, Pages: 1702–1712, Lisa-Marie Munter, Philipp Voigt, Anja Harmeier, Daniela Kaden, Kay E Gottschalk, Christoph Weise, Rüdiger Pipkorn, Michael Schaefer, Dieter Langosch and Gerd Multhaup

    Version of Record online : 1 MAR 2007, DOI: 10.1038/sj.emboj.7601616

  17. You have free access to this content
    Familial Alzheimer's disease mutations inhibit γ-secretase-mediated liberation of β-amyloid precursor protein carboxy-terminal fragment

    Journal of Neurochemistry

    Volume 94, Issue 5, September 2005, Pages: 1189–1201, Jesse C. Wiley, Mark Hudson, Kevin C. Kanning, Leslyanne C. Schecterson and Mark Bothwell

    Version of Record online : 30 JUN 2005, DOI: 10.1111/j.1471-4159.2005.03266.x

  18. You have free access to this content
    The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: The emerging role in the pathogenesis of Alzheimer's disease

    Geriatrics & Gerontology International

    Volume 10, Issue s1, July 2010, Pages: S169–S179, Kazuma Murakami, Yuichi Masuda, Takuji Shirasawa, Takahiko Shimizu and Kazuhiro Irie

    Version of Record online : 2 JUN 2010, DOI: 10.1111/j.1447-0594.2010.00598.x

  19. You have free access to this content
    When loss is gain: reduced presenilin proteolytic function leads to increased Aβ42/Aβ40

    EMBO reports

    Volume 8, Issue 2, February 2007, Pages: 136–140, Michael S Wolfe

    Version of Record online : 1 FEB 2007, DOI: 10.1038/sj.embor.7400896

  20. You have free access to this content
    Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1

    The EMBO Journal

    Volume 30, Issue 23, November 30, 2011, Pages: 4815–4824, Yu Ohki, Takuya Higo, Kengo Uemura, Naoaki Shimada, Satoko Osawa, Oksana Berezovska, Satoshi Yokoshima, Tohru Fukuyama, Taisuke Tomita and Takeshi Iwatsubo

    Version of Record online : 14 OCT 2011, DOI: 10.1038/emboj.2011.372