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There are 13609 results for: content related to: Small molecular glucokinase activators: has another new anti-diabetic therapeutic lost favour?

  1. You have full text access to this OnlineOpen article
    Present status of clinical deployment of glucokinase activators

    Journal of Diabetes Investigation

    Volume 6, Issue 2, March 2015, Pages: 124–132, Akinobu Nakamura and Yasuo Terauchi

    Version of Record online : 10 NOV 2014, DOI: 10.1111/jdi.12294

  2. You have free access to this content
    Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia

    Human Mutation

    Volume 30, Issue 11, November 2009, Pages: 1512–1526, Kara K. Osbak, Kevin Colclough, Cecile Saint-Martin, Nicola L. Beer, Christine Bellanné-Chantelot, Sian Ellard and Anna L. Gloyn

    Version of Record online : 29 SEP 2009, DOI: 10.1002/humu.21110

  3. You have full text access to this Open Access content
    Effect of long-term treatment with a small-molecule glucokinase activator on glucose metabolism, lipid profiles and hepatic function

    Journal of Diabetes Investigation

    Volume 2, Issue 4, August 2011, Pages: 276–279, Akinobu Nakamura, Hiroko Shimazaki, Sumika Ohyama, Junichi Eiki and Yasuo Terauchi

    Version of Record online : 1 FEB 2011, DOI: 10.1111/j.2040-1124.2011.00104.x

  4. You have free access to this content
    Chronic glucokinase activator treatment at clinically translatable exposures gives durable glucose lowering in two animal models of type 2 diabetes

    British Journal of Pharmacology

    Volume 171, Issue 7, April 2014, Pages: 1642–1654, D J Baker, G P Wilkinson, A M Atkinson, H B Jones, M Coghlan, A D Charles and B Leighton

    Version of Record online : 18 MAR 2014, DOI: 10.1111/bph.12504

  5. Glucokinase diabetes in 103 families from a country-based study in the Czech Republic: geographically restricted distribution of two prevalent GCK mutations

    Pediatric Diabetes

    Volume 11, Issue 8, December 2010, Pages: 529–535, Stepanka Pruhova, Petra Dusatkova, Zdenek Sumnik, Stanislava Kolouskova, Oluf Pedersen, Torben Hansen, Ondrej Cinek and Jan Lebl

    Version of Record online : 10 MAR 2010, DOI: 10.1111/j.1399-5448.2010.00646.x

  6. You have full text access to this OnlineOpen article
    Familial adult onset hyperinsulinism due to an activating glucokinase mutation: implications for pharmacological glucokinase activation

    Clinical Endocrinology

    Volume 81, Issue 6, December 2014, Pages: 855–861, Benjamin G. Challis, Julie Harris, Alison Sleigh, Iona Isaac, Steve M. Orme, Nandini Seevaratnam, Ketan Dhatariya, Helen L. Simpson and Robert K. Semple

    Version of Record online : 2 JUL 2014, DOI: 10.1111/cen.12517

  7. Glucokinase (GCK) mutations in hyper- and hypoglycemia: Maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy

    Human Mutation

    Volume 22, Issue 5, November 2003, Pages: 353–362, Anna L. Gloyn

    Version of Record online : 18 SEP 2003, DOI: 10.1002/humu.10277

  8. Effect of high-fat diet on glucose homeostasis and gene expression in glucokinase knockout mice

    Diabetes, Obesity and Metabolism

    Volume 10, Issue 10, October 2008, Pages: 885–897, T. Gorman, D. C. D. Hope, R. Brownlie, A. Yu, D. Gill, J. Löfvenmark, M. Wedin, R. M. Mayers, M. R. Snaith and D. M. Smith

    Version of Record online : 22 NOV 2007, DOI: 10.1111/j.1463-1326.2007.00819.x

  9. You have free access to this content
    Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease

    Hepatology

    Volume 55, Issue 4, April 2012, Pages: 1083–1093, Lars P. Bechmann, Amalia Gastaldelli, Diana Vetter, Gillian L. Patman, Laura Pascoe, Rebekka A. Hannivoort, Ursula E. Lee, Isabel Fiel, Ursula Muñoz, Demetrio Ciociaro, Young-Min Lee, Emma Buzzigoli, Luca Miele, Kei Y. Hui, Elisabetta Bugianesi, Alastair D. Burt, Christopher P. Day, Andrea Mari, Loranne Agius, Mark Walker, Scott L. Friedman and Helen L. Reeves

    Version of Record online : 1 MAR 2012, DOI: 10.1002/hep.24793

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    Characterization of the heterozygous glucokinase knockout mouse as a translational disease model for glucose control in type 2 diabetes

    British Journal of Pharmacology

    Volume 171, Issue 7, April 2014, Pages: 1629–1641, D J Baker, A M Atkinson, G P Wilkinson, G J Coope, A D Charles and B Leighton

    Version of Record online : 18 MAR 2014, DOI: 10.1111/bph.12498

  11. You have free access to this content
    Liver glucokinase: An overview on the regulatorymechanisms of its activity

    IUBMB Life

    Volume 63, Issue 1, January 2011, Pages: 1–6, María L. Massa, Juan J. Gagliardino and Flavio Francini

    Version of Record online : 13 JAN 2011, DOI: 10.1002/iub.411

  12. Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry

    Pediatric Diabetes

    Volume 9, Issue 5, October 2008, Pages: 442–449, Jørn V Sagen, Lise Bjørkhaug, Janne Molnes, Helge Ræder, Louise Grevle, Oddmund Søvik, Anders Molven and Pål R Njølstad

    Version of Record online : 9 APR 2008, DOI: 10.1111/j.1399-5448.2008.00399.x

  13. Four novel cases of permanent neonatal diabetes mellitus caused by homozygous mutations in the glucokinase gene

    Pediatric Diabetes

    Volume 12, Issue 3pt1, May 2011, Pages: 192–196, Kate Bennett, Chela James, Angham Mutair, Hala Al-Shaikh, Aisha Sinani and Khalid Hussain

    Version of Record online : 6 SEP 2010, DOI: 10.1111/j.1399-5448.2010.00683.x

  14. Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus

    Pediatric Diabetes

    Volume 10, Issue 6, September 2009, Pages: 382–388, Ethel Codner, Ana Rocha, Liyong Deng, Alejandro Martínez-Aguayo, Claudia Godoy, Verónica Mericq and Wendy K Chung

    Version of Record online : 2 MAR 2009, DOI: 10.1111/j.1399-5448.2009.00499.x

  15. Glucokinase Gene Polymorphisms: a Genetic Marker for Glucose Intolerance in a Cohort of Elderly Finnish Men

    Diabetic Medicine

    Volume 11, Issue 2, March 1994, Pages: 198–204, Dr. M.I. McCarthy, G.A. Hitman, M. Hitchins, A. Riikonen, J. Stengård, A. Nissinen, E. Tuomilehto-Wolf and J. Tuomilehto

    Version of Record online : 30 JUL 2009, DOI: 10.1111/j.1464-5491.1994.tb02020.x

  16. The glucokinase mutation p.T206P is common among MODY patients of Jewish Ashkenazi descent

    Pediatric Diabetes

    Volume 13, Issue 6, September 2012, Pages: e14–e21, Yael Gozlan, Ariel Tenenbaum, Shlomit Shalitin, Yael Lebenthal, Tal Oron, Ohad Cohen, Moshe Phillip and Galia Gat-Yablonski

    Version of Record online : 7 OCT 2011, DOI: 10.1111/j.1399-5448.2011.00822.x

  17. Repair of diverse diabetic defects of β-cells in man and mouse by pharmacological glucokinase activation

    Diabetes, Obesity and Metabolism

    Volume 14, Issue s3, October 2012, Pages: 109–119, Nicolai M. Doliba, Deborah Fenner, Bogumil Zelent, Joseph Bass, Ramakanth Sarabu and Franz M. Matschinsky

    Version of Record online : 28 AUG 2012, DOI: 10.1111/j.1463-1326.2012.01652.x

  18. Molecular and biochemical analysis of the MODY syndromes

    Pediatric Diabetes

    Volume 1, Issue 2, June 2000, Pages: 88–117, William E. Winter

    Version of Record online : 25 DEC 2001, DOI: 10.1034/j.1399-5448.2000.010206.x

  19. You have free access to this content
    Role of connecting loop I in catalysis and allosteric regulation of human glucokinase

    Protein Science

    Volume 23, Issue 7, July 2014, Pages: 915–922, Juliana A. Martinez, Mioara Larion, Maria S. Conejo, Carol M. Porter and Brian G. Miller

    Version of Record online : 30 APR 2014, DOI: 10.1002/pro.2473

  20. Novel glucokinase mutations in patients with monogenic diabetes – clinical outline of GCK-MD and potential for founder effect in Slavic population

    Clinical Genetics

    Volume 81, Issue 3, March 2012, Pages: 278–283, M Borowiec, K Antosik, W Fendler, G Deja, P Jarosz-Chobot, M Mysliwiec, A Zmyslowska, M Malecki, A Szadkowska and W Mlynarski

    Version of Record online : 18 MAR 2011, DOI: 10.1111/j.1399-0004.2011.01656.x