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There are 10174 results for: content related to: A Novel Missense Mutation Causing a G487R Substitution in the S2–S3 Loop of Human ether-à-go-go -Related Gene Channel

  1. Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

    Journal of Applied Toxicology

    Volume 29, Issue 3, April 2009, Pages: 183–206, Sebastian Polak, Barbara Wiśniowska and Jerzy Brandys

    Article first published online : 5 NOV 2008, DOI: 10.1002/jat.1395

  2. The EGFP/hERG fusion protein alter the electrophysiological properties of hERG channels in HEK293 cells

    Cell Biology International

    Volume 35, Issue 3, March 2011, Pages: 193–199, Na Huang, Jiang-Fang Lian, Jian-Hua Huo, Li-Ying Liu, Lei Ni, Xi Yang, Jian-Qing Zhou, Zong-Fang Li, Tu-Sheng Song and Chen Huang

    Article first published online : 2 JAN 2013, DOI: 10.1042/CBI20100022

  3. You have free access to this content
    The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels

    British Journal of Pharmacology

    Volume 155, Issue 3, October 2008, Pages: 365–373, Q Tang, Z-Q Li, W Li, J Guo, H-Y Sun, X-H Zhang, C-P Lau, H-F Tse, S Zhang and G-R Li

    Article first published online : 29 JAN 2009, DOI: 10.1038/bjp.2008.261

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    SYMPOSIUM REVIEW: Revealing the structural basis of action of hERG potassium channel activators and blockers

    The Journal of Physiology

    Volume 588, Issue 17, September 2010, Pages: 3157–3167, Matthew Perry, Michael Sanguinetti and John Mitcheson

    Article first published online : 31 AUG 2010, DOI: 10.1113/jphysiol.2010.194670

  5. You have free access to this content
    hERG subunit composition determines differential drug sensitivity

    British Journal of Pharmacology

    Volume 164, Issue 2b, September 2011, Pages: 419–432, N Abi-Gerges, H Holkham, EMC Jones, CE Pollard, J-P Valentin and GA Robertson

    Article first published online : 28 AUG 2011, DOI: 10.1111/j.1476-5381.2011.01378.x

  6. Partially Dominant Mutant Channel Defect Corresponding with Intermediate LQT2 Phenotype

    Pacing and Clinical Electrophysiology

    Volume 35, Issue 1, January 2012, Pages: 3–16, YAMINI KRISHNAN, RENJIAN ZHENG, CHRISTINE WALSH, YINGYING TANG and THOMAS V. McDONALD

    Article first published online : 25 SEP 2011, DOI: 10.1111/j.1540-8159.2011.03222.x

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    The antihistamine fexofenadine does not affect IKr currents in a case report of drug-induced cardiac arrhythmia

    British Journal of Pharmacology

    Volume 137, Issue 6, November 2002, Pages: 892–900, Constanze R Scherer, Christian Lerche, Niels Decher, Adrienne T Dennis, Patrick Maier, Eckhard Ficker, Andreas E Busch, Bernd Wollnik and Klaus Steinmeyer

    Article first published online : 2 FEB 2009, DOI: 10.1038/sj.bjp.0704873

  8. You have full text access to this OnlineOpen article
    Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition

    Physiological Reports

    Volume 1, Issue 6, November 2013, Chunyun Du, Aziza El Harchi, Henggui Zhang and Jules C. Hancox

    Article first published online : 29 NOV 2013, DOI: 10.1002/phy2.175

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    Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents

    British Journal of Pharmacology

    Volume 156, Issue 2, January 2009, Pages: 226–236, Daniel Scherer, David Hassel, Ramona Bloehs, Edgar Zitron, Katharina Von Löwenstern, Claudia Seyler, Dierk Thomas, Franziska Konrad, Heiner F. Bürgers, Gunnar Seemann, Wolfgang Rottbauer, Hugo A. Katus, Christoph A. Karle and Eberhard P. Scholz

    Article first published online : 19 JAN 2009, DOI: 10.1111/j.1476-5381.2008.00018.x

  10. Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity

    Journal of Applied Toxicology

    Volume 27, Issue 1, January/February 2007, Pages: 78–85, Kiyokazu Yunomae, Satoko Ichisaki, Junko Matsuo, Shinichi Nagayama, Koichiro Fukuzaki, Ryoichi Nagata and Go Kito

    Article first published online : 5 DEC 2006, DOI: 10.1002/jat.1201

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    Immunodetection of disease-associated mutant PrP, which accelerates disease in GSS transgenic mice

    The EMBO Journal

    Volume 24, Issue 13, July 6, 2005, Pages: 2472–2480, Karah E Nazor, Franziska Kuhn, Tanya Seward, Mike Green, Daniel Zwald, Mario Pürro, Jaqueline Schmid, Karin Biffiger, Aisling M Power, Bruno Oesch, Alex J Raeber and Glenn C Telling

    Article first published online : 16 JUN 2005, DOI: 10.1038/sj.emboj.7600717

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    N-linked glycosylation sites determine HERG channel surface membrane expression

    The Journal of Physiology

    Volume 515, Issue 1, February 1999, Pages: 41–48, Kevin Petrecca, Roxana Atanasiu, Armin Akhavan and Alvin Shrier

    Article first published online : 8 SEP 2004, DOI: 10.1111/j.1469-7793.1999.041ad.x

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    Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine

    British Journal of Pharmacology

    Volume 149, Issue 5, November 2006, Pages: 481–489, S Rajamani, L L Eckhardt, C R Valdivia, C A Klemens, B M Gillman, C L Anderson, K M Holzem, B P Delisle, B D Anson, J C Makielski and C T January

    Article first published online : 29 JAN 2009, DOI: 10.1038/sj.bjp.0706892

  14. Blockade of HERG K+ channel by an antihistamine drug brompheniramine requires the channel binding within the S6 residue Y652 and F656

    Journal of Applied Toxicology

    Volume 28, Issue 2, March 2008, Pages: 104–111, Sang-Joon Park, Ki-Suk Kim and Eun-Joo Kim

    Article first published online : 21 MAY 2007, DOI: 10.1002/jat.1252

  15. Modeling hERG and its Interactions with Drugs: Recent Advances in Light of Current Potassium Channel Simulations

    ChemMedChem

    Volume 3, Issue 4, April 14, 2008, Pages: 523–535, Maurizio Recanatini, Andrea Cavalli and Matteo Masetti

    Article first published online : 25 JAN 2008, DOI: 10.1002/cmdc.200700264

  16. Verapamil blocks HERG channel by the helix residue Y652 and F656 in the S6 transmembrane domain

    Acta Pharmacologica Sinica

    Volume 28, Issue 7, July 2007, Pages: 959–967, Jing-jing DUAN, Ji-hua MA, Pei-hua ZHANG, Xian-pei WANG, An-rou ZOU and Dan-na TU

    Article first published online : 3 JUL 2007, DOI: 10.1111/j.1745-7254.2007.00562.x

  17. You have free access to this content
    Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.

    The Journal of Physiology

    Volume 493, Issue 3, June 15, 1996, Pages: 635–642, R Schönherr and S H Heinemann

    Article first published online : 15 JUN 1996, DOI: 10.1113/jphysiol.1996.sp021410

  18. Examining Reactivity and Specificity of Cytochrome c Peroxidase by using Combinatorial Mutagenesis

    ChemBioChem

    Volume 3, Issue 11, November 4, 2002, Pages: 1097–1104, Martin Wilming, André Iffland, Petra Tafelmeyer, Claudio Arrivoli, Christophe Saudan and Kai Johnsson

    Article first published online : 28 OCT 2002, DOI: 10.1002/1439-7633(20021104)3:11<1097::AID-CBIC1097>3.0.CO;2-4

  19. HERG K+ Channels and β1 Integrins Interact through the Assembly of a Macromolecular Complex

    Annals of the New York Academy of Sciences

    Volume 973, Issue 1, November 2002, Pages: 559–561, A. CHERUBINI, S. PILLOZZI, G. HOFMANN, O. CROCIANI, L. GUASTI, E. LASTRAIOLI, S. POLVANI, A. MASI, A. BECCHETTI, E. WANKE, M. OLIVOTTO and A. ARCANGELI

    Article first published online : 24 JAN 2006, DOI: 10.1111/j.1749-6632.2002.tb04701.x

  20. Predicting Drug-Induced QT Prolongation and Torsades de Pointes: A Review of Preclinical Endpoint Measures

    Unit

    Current Protocols in Pharmacology

    10:10.16.1–10.16.19

    Claire Townsend and Barry S. Brown

    Published Online : 1 JUN 2013, DOI: 10.1002/0471141755.ph1016s61