Search Results

There are 1196 results for: content related to: Knocking out salicylate biosynthesis genes in Mycobacterium smegmatis induces hypersensitivity to p -aminosalicylate (PAS)

  1. Structural analysis of dihydrofolate reductases enables rationalization of antifolate binding affinities and suggests repurposing possibilities

    The FEBS Journal

    Volume 283, Issue 6, March 2016, Pages: 1139–1167, Amrisha Bhosle and Nagasuma Chandra

    Version of Record online : 25 FEB 2016, DOI: 10.1111/febs.13662

  2. You have free access to this content
    Loss of folylpoly-γ-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines

    International Journal of Cancer

    Volume 103, Issue 5, 20 February 2003, Pages: 587–599, Esti Liani, Lilah Rothem, Marlene A. Bunni, Clyde A. Smith, Gerrit Jansen and Yehuda G. Assaraf

    Version of Record online : 25 NOV 2002, DOI: 10.1002/ijc.10829

  3. Isolation and characterisation of an antifolate insensitive (afi1) mutant of Arabidopsis thaliana

    Plant Biology

    Volume 15, Issue 1, January 2013, Pages: 37–44, O. Navarrete, J. Van Daele, C. Stove, W. Lambert, S. Storozhenko and D. Van Der Straeten

    Version of Record online : 5 JUN 2012, DOI: 10.1111/j.1438-8677.2012.00602.x

  4. Selectively weakened binding of methotrexate by human dihydrofolate reductase allows rapid ex vivo selection of mammalian cells

    Journal of Molecular Recognition

    Volume 24, Issue 2, March/April 2011, Pages: 188–198, Jordan P. Volpato, Nadine Mayotte, Elena Fossati, Vanessa Guerrero, Guy Sauvageau and Joelle N. Pelletier

    Version of Record online : 14 MAY 2010, DOI: 10.1002/jmr.1037

  5. Screening and In Vitro Testing of Antifolate Inhibitors of Human Cytosolic Serine Hydroxymethyltransferase


    Volume 10, Issue 3, March 2015, Pages: 490–497, Dr. Alessandro Paiardini, Dr. Alessio Fiascarelli, Dr. Serena Rinaldo, Dr. Frederick Daidone, Dr. Giorgio Giardina, Dr. David R. Koes, Dr. Alessia Parroni, Dr. Giulia Montini, Dr. Marina Marani, Dr. Alessio Paone, Prof. Lee A. McDermott, Prof. Roberto Contestabile and Prof. Francesca Cutruzzolà

    Version of Record online : 10 FEB 2015, DOI: 10.1002/cmdc.201500028

  6. The molecular basis of antifolate resistance in Plasmodium falciparum: looking beyond point mutations

    Annals of the New York Academy of Sciences

    Volume 1342, Issue 1, April 2015, Pages: 10–18, Adina Heinberg and Laura Kirkman

    Version of Record online : 18 FEB 2015, DOI: 10.1111/nyas.12662

  7. MRP1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum

    FEBS Letters

    Volume 590, Issue 4, February 2016, Pages: 482–492, Sanna R. Rijpma, Maarten van der Velden, Albert Bilos, Robert S. Jansen, Sunny Mahakena, Frans G. M. Russel, Robert W. Sauerwein, Koen van de Wetering and Jan B. Koenderink

    Version of Record online : 17 FEB 2016, DOI: 10.1002/1873-3468.12079

  8. You have free access to this content
    The role of folate in malaria – implications for home fortification programmes among children aged 6–59 months

    Maternal & Child Nutrition

    Volume 11, Issue S4, December 2015, Pages: 1–15, Roland Kupka

    Version of Record online : 18 OCT 2013, DOI: 10.1111/mcn.12102

  9. Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance

    International Journal of Cancer

    Volume 138, Issue 7, 1 April 2016, Pages: 1645–1656, Anna Wojtuszkiewicz, Shachar Raz, Michal Stark, Yehuda G. Assaraf, Gerrit Jansen, Godefridus J. Peters, Edwin Sonneveld, Gertjan J. L. Kaspers and Jacqueline Cloos

    Version of Record online : 25 NOV 2015, DOI: 10.1002/ijc.29919

  10. The critical role of alpha-folate receptor in the resistance of melanoma to methotrexate

    Pigment Cell & Melanoma Research

    Volume 22, Issue 5, October 2009, Pages: 588–600, Luís Sánchez-del-Campo, María F. Montenegro, Juan Cabezas-Herrera and José Neptuno Rodríguez-López

    Version of Record online : 2 JUN 2009, DOI: 10.1111/j.1755-148X.2009.00586.x

  11. You have free access to this content
    Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum

    Molecular Microbiology

    Volume 88, Issue 4, May 2013, Pages: 702–712, Adina Heinberg, Edwin Siu, Chaya Stern, Elizabeth A. Lawrence, Michael T. Ferdig, Kirk W. Deitsch and Laura A. Kirkman

    Version of Record online : 24 APR 2013, DOI: 10.1111/mmi.12162

  12. You have free access to this content
    Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates

    International Journal of Cancer

    Volume 87, Issue 6, 15 September 2000, Pages: 771–778, H.H.J. Backus, H.M. Pinedo, D. Wouters, J.M. Padrón, N. Molders, C.L. van der Wilt, C.J. van Groeningen, G. Jansen and G.J. Peters

    Version of Record online : 18 AUG 2000, DOI: 10.1002/1097-0215(20000915)87:6<771::AID-IJC2>3.0.CO;2-V

  13. Malaria Chemotherapeutics Part I: History of Antimalarial Drug Development, Currently Used Therapeutics, and Drugs in Clinical Development


    Volume 2, Issue 7, July 9, 2007, Pages: 944–986, Martin Schlitzer

    Version of Record online : 25 MAY 2007, DOI: 10.1002/cmdc.200600240

  14. Mathematical Programming Assisted Drug Design for Nonclassical Antifolates

    Biotechnology Progress

    Volume 17, Issue 3, 2001, Pages: 412–418, Sanjeev Garg and Luke E. K. Achenie

    Version of Record online : 5 SEP 2008, DOI: 10.1021/bp010034q

  15. Antimalarial Agents

    Standard Article

    Burger's Medicinal Chemistry and Drug Discovery

    Dee Ann Casteel

    Published Online : 15 JAN 2003, DOI: 10.1002/0471266949.bmc091

  16. Colorectal Cancer

    Standard Article

    Wiley Handbook of Current and Emerging Drug Therapies

    Published Online : 15 SEP 2006, DOI: 10.1002/9780470041000.cedt009

  17. Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein II and folate receptor alpha that, upon folate repletion, confer drug resistance to CHL cells

    Journal of Experimental Therapeutics and Oncology

    Volume 2, Issue 5, September 2002, Pages: 264–277, Wei-Yong Zhu, M. Bunni, D. G. Priest, J. L. DiCapua, J. M. Dressler, Z. Chen and Peter W. Melera

    Version of Record online : 28 AUG 2002, DOI: 10.1046/j.1359-4117.2002.01049.x

  18. You have free access to this content
    Review of a promising new agent—pemetrexed disodium


    Volume 97, Issue S8, 15 April 2003, Pages: 2056–2063, Luis Paz-Ares, Susana Bezares, José M. Tabernero, Daniel Castellanos and Hernán Cortes-Funes

    Version of Record online : 1 APR 2003, DOI: 10.1002/cncr.11279

  19. You have free access to this content
    Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia


    Volume 100, Issue 4, 15 February 2004, Pages: 773–782, Yotam Kaufman, Stavit Drori, Peter D. Cole, Barton A. Kamen, Jenny Sirota, Ilan Ifergan, Myriam Weyl Ben Arush, Ronit Elhasid, Dvora Sahar, Gert Jan L. Kaspers, Gerrit Jansen, Larry H. Matherly, Gideon Rechavi, Amos Toren and Yehuda G. Assaraf

    Version of Record online : 23 DEC 2003, DOI: 10.1002/cncr.20018

  20. You have free access to this content
    Evidence for distinct DNA- and RNA-based mechanisms of 5-fluorouracil cytotoxicity in Saccharomyces cerevisiae


    Volume 24, Issue 10, October 2007, Pages: 861–870, Jason Hoskins and J. Scott Butler

    Version of Record online : 20 JUL 2007, DOI: 10.1002/yea.1516