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There are 5574 results for: content related to: Signalling by protein phosphatases and drug development: a systems-centred view

  1. You have free access to this content
    Small molecule tools for functional interrogation of protein tyrosine phosphatases

    The FEBS Journal

    Volume 280, Issue 2, January 2013, Pages: 731–750, Rongjun He, Li-Fan Zeng, Yantao He, Sheng Zhang and Zhong-Yin Zhang

    Version of Record online : 16 AUG 2012, DOI: 10.1111/j.1742-4658.2012.08718.x

  2. You have free access to this content
    Protein tyrosine phosphatases – from housekeeping enzymes to master regulators of signal transduction

    The FEBS Journal

    Volume 280, Issue 2, January 2013, Pages: 346–378, Nicholas K. Tonks

    Version of Record online : 17 JAN 2013, DOI: 10.1111/febs.12077

  3. Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo

    ChemMedChem

    Volume 10, Issue 5, May 2015, Pages: 815–826, Dr. Stefanie Grosskopf, Chris Eckert, Dr. Christoph Arkona, Dr. Silke Radetzki, Dr. Kerstin Böhm, Prof. Dr. Udo Heinemann, Prof. Dr. Gerhard Wolber, Dr. Jens-Peter von Kries, Prof. Dr. Walter Birchmeier and Prof. Dr. Jörg Rademann

    Version of Record online : 15 APR 2015, DOI: 10.1002/cmdc.201500015

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    Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2

    Developmental Neurobiology

    Volume 67, Issue 13, November 2007, Pages: 1789–1801, Xiaotao T. Zhao, Yueping K. Qian, Ariel W.S. Chan, Raghavan Madhavan and H. Benjamin Peng

    Version of Record online : 20 JUL 2007, DOI: 10.1002/dneu.20556

  5. You have full text access to this OnlineOpen article
    Functions of Shp2 in cancer

    Journal of Cellular and Molecular Medicine

    Volume 19, Issue 9, September 2015, Pages: 2075–2083, Jie Zhang, Fei Zhang and Ruifang Niu

    Version of Record online : 19 JUN 2015, DOI: 10.1111/jcmm.12618

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    Force-dependent integrin–cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2

    The EMBO Journal

    Volume 22, Issue 19, October 1, 2003, Pages: 5023–5035, Götz von Wichert, Beatrice Haimovich, Gen-Sheng Feng and Michael P. Sheetz

    Version of Record online : 1 OCT 2003, DOI: 10.1093/emboj/cdg492

  7. Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients

    Hepatology

    Volume 65, Issue 5, May 2017, Pages: 1566–1580, Daimin Xiang, Zhuo Cheng, Hui Liu, Xue Wang, Tao Han, Wen Sun, Xiaofeng Li, Wen Yang, Cheng Chen, Mingyang Xia, Na Liu, Shengyong Yin, Guangzhi Jin, Terence Lee, Liwei Dong, Heping Hu, Hongyang Wang and Jin Ding

    Version of Record online : 6 JAN 2017, DOI: 10.1002/hep.28919

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    Protein tyrosine phosphatase structure–function relationships in regulation and pathogenesis

    The FEBS Journal

    Volume 280, Issue 2, January 2013, Pages: 413–431, Frank Böhmer, Stefan Szedlacsek, Lydia Tabernero, Arne Östman and Jeroen den Hertog

    Version of Record online : 2 JUL 2012, DOI: 10.1111/j.1742-4658.2012.08655.x

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    The Transition from Stem Cell to Progenitor Spermatogonia and Male Fertility Requires the SHP2 Protein Tyrosine Phosphatase

    STEM CELLS

    Volume 32, Issue 3, March 2014, Pages: 741–753, Pawan Puri, Bart T. Phillips, Hitomi Suzuki, Kyle E. Orwig, Aleksandar Rajkovic, Philip E. Lapinski, Philip D. King, Gen-Sheng Feng and William H. Walker

    Version of Record online : 19 FEB 2014, DOI: 10.1002/stem.1572

  10. SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis

    Histopathology

    Volume 53, Issue 4, October 2008, Pages: 389–402, X Zhou, J Coad, B Ducatman and Y M Agazie

    Version of Record online : 16 JUL 2008, DOI: 10.1111/j.1365-2559.2008.03103.x

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    Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB

    FEBS Letters

    Volume 585, Issue 20, October 20, 2011, Pages: 3224–3228, Emi Kumamaru, Tadahiro Numakawa, Naoki Adachi and Hiroshi Kunugi

    Version of Record online : 19 SEP 2011, DOI: 10.1016/j.febslet.2011.09.010

  12. Development of a Plate-Based Assay Platform to Monitor Cellular SHP2 Phosphatase Activity During Erythroid Differentiation

    Journal of the Chinese Chemical Society

    Volume 59, Issue 3, March 2012, Pages: 297–304, Chi-Yuan Chu, Chun-Chen Kuo, Mei-Hsiao Chen, Kuan-Ju Chen, Lee-Chiang Lo and Jing-Jer Lin

    Version of Record online : 7 MAR 2012, DOI: 10.1002/jccs.201100725

  13. Protein tyrosine phosphatase SHP2 regulates TGF-β1 production in airway epithelia and asthmatic airway remodeling in mice

    Allergy

    Volume 67, Issue 12, December 2012, Pages: 1547–1556, X.-J. Qin, G.-S. Zhang, X. Zhang, Z.-W. Qiu, P.-L. Wang, Y.-W. Li, W. Li, Q.-M. Xie, Y.-H. Ke, J. J Lee and H.-H. Shen

    Version of Record online : 11 OCT 2012, DOI: 10.1111/all.12048

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    Protein tyrosine phosphatases in health and disease

    The FEBS Journal

    Volume 280, Issue 2, January 2013, Pages: 708–730, Wiljan J. A. J. Hendriks, Ari Elson, Sheila Harroch, Rafael Pulido, Andrew Stoker and Jeroen den Hertog

    Version of Record online : 1 OCT 2012, DOI: 10.1111/febs.12000

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    Tyrosine phosphatases Shp1 and Shp2 have unique and opposing roles in oligodendrocyte development

    Journal of Neurochemistry

    Volume 113, Issue 1, April 2010, Pages: 200–212, Emory Kuo, Daniel K. Park, Iva D. Tzvetanova, Cindy V. Leiton, Brian S. Cho and Holly Colognato

    Version of Record online : 2 FEB 2010, DOI: 10.1111/j.1471-4159.2010.06596.x

  16. Noonan syndrome–associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

    Human Mutation

    Volume 23, Issue 3, March 2004, Pages: 267–277, Alessandra Fragale, Marco Tartaglia, Jie Wu and Bruce D. Gelb

    Version of Record online : 9 FEB 2004, DOI: 10.1002/humu.20005

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    Alterations in insulin receptor signalling in the rat epitrochlearis muscle upon cessation of voluntary exercise

    The Journal of Physiology

    Volume 562, Issue 3, February 2005, Pages: 829–838, David S. Kump and Frank W. Booth

    Version of Record online : 20 JAN 2005, DOI: 10.1113/jphysiol.2004.073593

  18. Src homology phosphotyrosyl phosphatase-2 expression is an independent negative prognostic factor in human breast cancer

    Histopathology

    Volume 63, Issue 1, July 2013, Pages: 74–82, Simone Muenst, Ellen C Obermann, Feng Gao, Daniel Oertli, Carsten T Viehl, Walter P Weber, Timothy Fleming, William E Gillanders and Savas D Soysal

    Version of Record online : 15 MAY 2013, DOI: 10.1111/his.12140

  19. Direct Chemical Activation of a Rationally Engineered Signaling Enzyme

    ChemBioChem

    Volume 16, Issue 12, August 17, 2015, Pages: 1735–1739, Cynthia M. Chio, Karen W. Cheng and Prof. Anthony C. Bishop

    Version of Record online : 30 JUN 2015, DOI: 10.1002/cbic.201500245

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    Protein tyrosine phosphatases: functional inferences from mouse models and human diseases

    The FEBS Journal

    Volume 275, Issue 5, March 2008, Pages: 816–830, Wiljan J. A. J. Hendriks, Ari Elson, Sheila Harroch and Andrew W. Stoker

    Version of Record online : 8 FEB 2008, DOI: 10.1111/j.1742-4658.2008.06249.x