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There are 17536 results for: content related to: Crystal Structures of IL-2-inducible T cell Kinase Complexed with Inhibitors: Insights into Rational Drug Design and Activity Regulation

  1. You have free access to this content
    Allele-sensitive mutant, Itkas, reveals that Itk kinase activity is required for Th1, Th2, Th17, and iNKT-cell cytokine production

    European Journal of Immunology

    Volume 45, Issue 8, August 2015, Pages: 2276–2285, Arun Kannan, YongChan Lee, Qian Qi, Weishan Huang, Ah-Reum Jeong, Sarah Ohnigian and Avery August

    Version of Record online : 10 JUN 2015, DOI: 10.1002/eji.201445087

  2. Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk

    Immunological Reviews

    Volume 228, Issue 1, March 2009, Pages: 93–114, Julie A. Readinger, Kristen L. Mueller, Ana M. Venegas, Reiko Horai and Pamela L. Schwartzberg

    Version of Record online : 6 MAR 2009, DOI: 10.1111/j.1600-065X.2008.00757.x

  3. Tec kinases, actin, and cell adhesion

    Immunological Reviews

    Volume 218, Issue 1, August 2007, Pages: 45–64, Julio Gomez-Rodriguez, Julie A. Readinger, Irene C. Viorritto, Kristen L. Mueller, Richard A. Houghtling and Pamela L. Schwartzberg

    Version of Record online : 9 JUL 2007, DOI: 10.1111/j.1600-065X.2007.00534.x

  4. The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development

    Immunological Reviews

    Volume 228, Issue 1, March 2009, Pages: 115–131, Amanda L. Prince, Catherine C. Yin, Megan E. Enos, Martin Felices and Leslie J. Berg

    Version of Record online : 6 MAR 2009, DOI: 10.1111/j.1600-065X.2008.00746.x

  5. The role of Tec family kinases in T cell development and function

    Immunological Reviews

    Volume 191, Issue 1, February 2003, Pages: 119–138, Julie A. Lucas, Andrew T. Miller, Luana O. Atherly and Leslie J. Berg

    Version of Record online : 5 MAR 2003, DOI: 10.1034/j.1600-065X.2003.00029.x

  6. You have free access to this content
    Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec

    Protein Science

    Volume 21, Issue 9, September 2012, Pages: 1288–1297, Scott E. Boyken, D. Bruce Fulton and Amy H. Andreotti

    Version of Record online : 16 JUL 2012, DOI: 10.1002/pro.2114

  7. Conformational snapshots of Tec kinases during signaling

    Immunological Reviews

    Volume 228, Issue 1, March 2009, Pages: 74–92, Raji E. Joseph and Amy H. Andreotti

    Version of Record online : 6 MAR 2009, DOI: 10.1111/j.1600-065X.2008.00740.x

  8. You have free access to this content
    Impaired T-cell development in the absence of Vav1 and Itk

    European Journal of Immunology

    Volume 38, Issue 12, December 2008, Pages: 3530–3542, Julia Raberger, Nicole Boucheron, Shinya Sakaguchi, Josef M. Penninger and Wilfried Ellmeier

    Version of Record online : 13 NOV 2008, DOI: 10.1002/eji.200838388

  9. You have free access to this content
    Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells

    European Journal of Immunology

    Volume 39, Issue 9, September 2009, Pages: 2584–2595, Catarina Sacristán, Stefan A. Schattgen, Leslie J. Berg, Stephen C. Bunnell, Ananda L. Roy and Yvonne Rosenstein

    Version of Record online : 21 AUG 2009, DOI: 10.1002/eji.200839031

  10. You have free access to this content
    Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates

    The FEBS Journal

    Volume 278, Issue 12, June 2011, Pages: 1980–1989, Julio Gomez-Rodriguez, Zachary J. Kraus and Pamela L. Schwartzberg

    Version of Record online : 29 MAR 2011, DOI: 10.1111/j.1742-4658.2011.08072.x

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    The proline rich region of the Tec homology domain of ITK regulates its activity

    FEBS Letters

    Volume 525, Issue 1-3, August 14, 2002, Pages: 53–58, Shengli Hao and Avery August

    Version of Record online : 11 JUL 2002, DOI: 10.1016/S0014-5793(02)03066-1

  12. You have free access to this content
    A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor

    The EMBO Journal

    Volume 20, Issue 6, March 15, 2001, Pages: 1232–1244, Melody L. Woods, Wendy J. Kivens, Margaret A. Adelsman, Yun Qiu, Avery August and Yoji Shimizu

    Version of Record online : 15 MAR 2001, DOI: 10.1093/emboj/20.6.1232

  13. You have free access to this content
    A kinase independent function for Tec kinase ITK in regulating antigen receptor induced serum response factor activation

    FEBS Letters

    Volume 580, Issue 11, May 15, 2006, Pages: 2691–2697, Shengli Hao, Qian Qi, Jianfang Hu and Avery August

    Version of Record online : 19 APR 2006, DOI: 10.1016/j.febslet.2006.04.023

  14. You have free access to this content
    Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk

    European Journal of Immunology

    Volume 37, Issue 10, October 2007, Pages: 2892–2899, Jianfang Hu, Nisebita Sahu, Elizabeth Walsh and Avery August

    Version of Record online : 27 AUG 2007, DOI: 10.1002/eji.200737311

  15. You have free access to this content
    TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK

    The FEBS Journal

    Volume 278, Issue 12, June 2011, Pages: 2001–2010, Alamdar Hussain, Liang Yu, Rani Faryal, Dara K. Mohammad, Abdalla J. Mohamed and C. I. Edvard Smith

    Version of Record online : 18 MAY 2011, DOI: 10.1111/j.1742-4658.2011.08134.x

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    The Association of a Single-Nucleotide Polymorphism of the IL-2 Inducible T-cell Kinase Gene with Asthma

    Annals of Human Genetics

    Volume 75, Issue 3, May 2011, Pages: 359–369, Shin-Hwa Lee, Hun Soo Chang, An-Soo Jang, Sung-Woo Park, Jong Sook Park, Soo-Taek Uh, Yong Hoon Kim, Bermseok Oh, Jong-Keuk Lee, Byung-Lae Park, Hyung Doo Shin, Choon-Sik Park and Kuchan Kimm

    Version of Record online : 15 FEB 2011, DOI: 10.1111/j.1469-1809.2010.00637.x

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    Inhibitors of BTK and ITK: State of the New Drugs for Cancer, Autoimmunity and Inflammatory Diseases

    Scandinavian Journal of Immunology

    Volume 78, Issue 2, August 2013, Pages: 130–139, L. Vargas, A. Hamasy, B. F. Nore and C. I. E. Smith

    Version of Record online : 21 JUL 2013, DOI: 10.1111/sji.12069

  18. You have free access to this content
    Tec family kinases: Itk signaling and the development of NKT αβ and γδ T cells

    The FEBS Journal

    Volume 278, Issue 12, June 2011, Pages: 1970–1979, Qian Qi, Arun Kumar Kannan and Avery August

    Version of Record online : 29 MAR 2011, DOI: 10.1111/j.1742-4658.2011.08074.x

  19. Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: a new concept for the therapy of inflammatory skin diseases

    Experimental Dermatology

    Volume 20, Issue 1, January 2011, Pages: 41–47, Arne von Bonin, Alexandra Rausch, Anne Mengel, Marion Hitchcock, Martin Krüger, Oliver von Ahsen, Claudia Merz, Lars Röse, Christine Stock, Stefan F. Martin, Gabriele Leder, Wolf-Dietrich Döcke, Khusru Asadullah and Ulrich Zügel

    Version of Record online : 16 DEC 2010, DOI: 10.1111/j.1600-0625.2010.01198.x

  20. A Role for Hydration in Interleukin-2 Inducible T Cell Kinase (Itk) Selectivity

    Molecular Informatics

    Volume 30, Issue 11-12, December 2011, Pages: 950–959, Ronald M. A. Knegtel and Daniel D. Robinson

    Version of Record online : 30 NOV 2011, DOI: 10.1002/minf.201100086