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There are 2545 results for: content related to: Specifying protein kinase C functions in melanoma

  1. Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells

    Journal of Cellular Biochemistry

    Volume 112, Issue 6, June 2011, Pages: 1696–1707, Peter P. Ruvolo, Liran Zhou, Julie C. Watt, Vivian R. Ruvolo, Jared K. Burks, Tilahun Jiffar, Steven Kornblau, Marina Konopleva and Michael Andreeff

    Version of Record online : 18 APR 2011, DOI: 10.1002/jcb.23090

  2. Safety, Tolerability, QTc Evaluation, and Pharmacokinetics of Single and Multiple Doses of Enzastaurin HCl (LY317615), a Protein Kinase C-β Inhibitor, in Healthy Subjects

    The Journal of Clinical Pharmacology

    Volume 47, Issue 9, September 2007, Pages: 1138–1151, Pamela A. Welch, Vikram P. Sinha, Ann L. Cleverly, Christelle Darstein, Shawn D. Flanagan and Luna C. Musib

    Version of Record online : 23 APR 2013, DOI: 10.1177/0091270007304775

  3. You have free access to this content
    The serine-threonine kinase p90RSK is a new target of enzastaurin in follicular lymphoma cells

    British Journal of Pharmacology

    Volume 170, Issue 7, December 2013, Pages: 1374–1383, S Kheirallah, S Fruchon, L Ysebaert, A Blanc, F Capilla, A Marrot, T AlSaati, F X Frenois, K A Benhadji, J J Fournié, G Laurent and C Bezombes

    Version of Record online : 14 NOV 2013, DOI: 10.1111/bph.12351

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    Phase 2 randomized study of enzastaurin (LY317615) for lung cancer prevention in former smokers


    Volume 119, Issue 5, 1 March 2013, Pages: 1023–1032, Jhanelle E. Gray, Soner Altiok, Mark G. Alexandrow, Frank W. Walsh, Jian Chen, Michael J. Schell, Datchen Fritz Tai and Gerold Bepler

    Version of Record online : 12 OCT 2012, DOI: 10.1002/cncr.27836

  5. Antitumor activity of enzastaurin as radiation sensitizer in head and neck squamous cell carcinoma

    Head & Neck

    Volume 33, Issue 8, August 2011, Pages: 1106–1114, Xiaoying Yin, D. Neil Hayes and Carol G Shores

    Version of Record online : 21 OCT 2010, DOI: 10.1002/hed.21578

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    A double-blind, randomized, placebo-controlled, phase 2 study of maintenance enzastaurin with 5-fluorouracil/leucovorin plus bevacizumab after first-line therapy for metastatic colorectal cancer


    Volume 118, Issue 17, 1 September 2012, Pages: 4132–4138, Robert A. Wolff, Martin Fuchs, Maria Di Bartolomeo, Anwar M. Hossain, Clemens Stoffregen, Steven Nicol and Volker Heinemann

    Version of Record online : 27 DEC 2011, DOI: 10.1002/cncr.26692

  7. The potential of enzastaurin to enhance platelet aggregation and growth factor secretion: implications for cancer cell survival

    Journal of Thrombosis and Haemostasis

    Volume 13, Issue 8, August 2015, Pages: 1514–1520, G. Lesyk, T. Fong, P. P. Ruvolo and P. Jurasz

    Version of Record online : 17 JUN 2015, DOI: 10.1111/jth.13010

  8. Effect of complementary pathway blockade on efficacy of combination enzastaurin and rapamycin

    Head & Neck

    Volume 33, Issue 12, December 2011, Pages: 1774–1782, Jing Liu, Wen-Liang Kuo, Tanguy Y. Seiwert, Mark Lingen, Mark F. Ciaccio, Richard B. Jones, Marsha Rich Rosner and Ezra Eddy Wyssam Cohen

    Version of Record online : 24 MAR 2011, DOI: 10.1002/hed.21701

  9. Synergy between enzastaurin doxorubicin in inducing melanoma apoptosis

    Pigment Cell & Melanoma Research

    Volume 26, Issue 6, November 2013, Pages: 900–911, Simona Romano, Giovanna Nappo, Gaetano Calì, Samuel Y.-S. Wang, Stefania Staibano, Anna D'Angelillo, Gennaro Ilardi, Antonio Sorrentino, Anna Laura Di Pace, Maria Siano, Rita Bisogni and Maria Fiammetta Romano

    Version of Record online : 7 AUG 2013, DOI: 10.1111/pcmr.12144

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    Phase I dose escalation and pharmacokinetic study of oral enzastaurin (LY317615) in advanced solid tumors

    Cancer Science

    Volume 101, Issue 10, October 2010, Pages: 2193–2199, Toru Mukohara, Shunji Nagai, Minori Koshiji, Kenichi Yoshizawa and Hironobu Minami

    Version of Record online : 13 JUL 2010, DOI: 10.1111/j.1349-7006.2010.01677.x

  11. Inhibitors of protein kinase C sensitise multiple myeloma cells to common genotoxic drugs

    European Journal of Haematology

    Volume 80, Issue 1, January 2008, Pages: 37–45, Philipp Baumann, Jakob Armann, Sonja Mandl-Weber, Gabriel Grün, Fuat Oduncu and Ralf Schmidmaier

    Version of Record online : 4 OCT 2007, DOI: 10.1111/j.1600-0609.2007.00977.x

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    Effects of enzastaurin and its metabolites on the QT interval in cancer patients

    The Journal of Clinical Pharmacology

    Volume 56, Issue 1, January 2016, Pages: 101–108, Pamela A. Welch, Wee Teck Ng, Christelle L. Darstein, Luna Musib and Thierry Lesimple

    Version of Record online : 17 AUG 2015, DOI: 10.1002/jcph.573

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    Molecular targeting of the PKC-β inhibitor enzastaurin (LY317615) in multiple myeloma involves a coordinated downregulation of MYC and IRF4 expression

    Hematological Oncology

    Volume 27, Issue 1, March 2009, Pages: 23–30, Donata Verdelli, Lucia Nobili, Katia Todoerti, Daniela Intini, Maria Cosenza, Monica Civallero, Jessika Bertacchini, Giorgio Lambertenghi Deliliers, Stefano Sacchi, Luigia Lombardi and Antonino Neri

    Version of Record online : 1 SEP 2008, DOI: 10.1002/hon.875

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    The combination of bortezomib with enzastaurin or lenalidomide enhances cytotoxicity in follicular and mantle cell lymphoma cell lines

    Hematological Oncology

    Volume 33, Issue 4, December 2015, Pages: 166–175, Maria Cosenza, Monica Civallero, Samantha Pozzi, Luigi Marcheselli, Alessia Bari and Stefano Sacchi

    Version of Record online : 13 NOV 2014, DOI: 10.1002/hon.2179

    Corrected by:

    Erratum: Erratum

    Vol. 34, Issue 2, 117, Version of Record online: 18 MAR 2016

  15. Genomic profiling of enzastaurin-treated B cell lymphoma RL cells

    Hematological Oncology

    Volume 29, Issue 3, September 2011, Pages: 154–156, Monica Civallero, Maria Cosenza, Antonino Neri and Alessia Bari

    Version of Record online : 27 OCT 2010, DOI: 10.1002/hon.974

  16. PROX1 overexpression inhibits protein kinase C beta II transcription through promoter DNA methylation

    Genes, Chromosomes and Cancer

    Volume 51, Issue 11, November 2012, Pages: 1024–1036, Kazumi Hagiwara, Hiromi Ito, Takashi Murate, Yasuhiko Miyata, Haruhiko Ohashi and Hirokazu Nagai

    Version of Record online : 25 JUL 2012, DOI: 10.1002/gcc.21985

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    Protein Kinase Cβ Is Required for Lupus Development in Sle Mice

    Arthritis & Rheumatism

    Volume 65, Issue 4, April 2013, Pages: 1022–1031, David Oleksyn, Mary Pulvino, Jiyong Zhao, Ravi Misra, Aram Vosoughi, Scott Jenks, Christopher Tipton, Frances Lund, George Schwartz, Bruce Goldman, Chandra Mohan, Kamal Mehta, Madhu Mehta, Michael Leitgets, Ignacio Sanz and Luojing Chen

    Version of Record online : 28 MAR 2013, DOI: 10.1002/art.37825

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    Open-label, single-arm, phase II study of enzastaurin in patients with follicular lymphoma

    British Journal of Haematology

    Volume 166, Issue 1, July 2014, Pages: 91–97, Lee Schwartzberg, Robert Hermann, Ian Flinn, Douglas Flora, Eric D. Hsi, Oday Hamid, Peipei Shi, Boris K. Lin, Scott P. Myrand, Tuan S. Nguyen and Martin Dreyling

    Version of Record online : 27 MAR 2014, DOI: 10.1111/bjh.12853

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    A phase I safety study of enzastaurin plus bortezomib in the treatment of relapsed or refractory multiple myeloma

    American Journal of Hematology

    Volume 86, Issue 7, July 2011, Pages: 573–578, Irene M. Ghobrial, Nikhil C. Munshi, Brianna N. Harris, Peipei Shi, Nichole M. Porter, Robert L. Schlossman, Jacob P. Laubach, Kenneth C. Anderson, Durisala Desaiah, Scott P. Myrand, James E. Wooldridge, Paul G. Richardson and Rafat Abonour

    Version of Record online : 31 MAY 2011, DOI: 10.1002/ajh.22048

  20. Genomewide RNAi screen identifies protein kinase Cβ and new members of mitogen-activated protein kinase pathway as regulators of melanoma cell growth and metastasis

    Pigment Cell & Melanoma Research

    Volume 27, Issue 3, May 2014, Pages: 418–430, Madeleine Schönherr, Animesh Bhattacharya, Tina Kottek, Silke Szymczak, Margarethe Köberle, Claudia Wickenhauser, Udo Siebolts, Anja Saalbach, Dirk Koczan, Thomas M. Magin, Jan C. Simon and Manfred Kunz

    Version of Record online : 31 JAN 2014, DOI: 10.1111/pcmr.12216