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There are 460996 results for: content related to: Senescence-escape in melanoma

  1. You have free access to this content
    Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants

    The EMBO Journal

    Volume 35, Issue 2, 18 January 2016, Pages: 143–161, Martin Köhler, Michael Röring, Björn Schorch, Katharina Heilmann, Natalie Stickel, Gina J Fiala, Lisa C Schmitt, Sandra Braun, Sophia Ehrenfeld, Franziska M Uhl, Thorsten Kaltenbacher, Florian Weinberg, Sebastian Herzog, Robert Zeiser, Wolfgang W Schamel, Hassan Jumaa and Tilman Brummer

    Version of Record online : 10 DEC 2015, DOI: 10.15252/embj.201592097

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    Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling

    The EMBO Journal

    Volume 31, Issue 11, May 30, 2012, Pages: 2629–2647, Michael Röring, Ricarda Herr, Gina J Fiala, Katharina Heilmann, Sandra Braun, Anja E Eisenhardt, Sebastian Halbach, David Capper, Andreas von Deimling, Wolfgang W Schamel, Darren N Saunders and Tilman Brummer

    Version of Record online : 17 APR 2012, DOI: 10.1038/emboj.2012.100

  3. Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways

    Journal of Cellular Physiology

    Volume 226, Issue 11, November 2011, Pages: 2762–2781, James A. McCubrey, Linda S. Steelman, C. Ruth Kempf, William H. Chappell, Stephen L. Abrams, Franca Stivala, Graziella Malaponte, Ferdinando Nicoletti, Massimo Libra, Jörg Bäsecke, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Giuseppe Montalto, Melchiorre Cervello, Lucio Cocco and Alberto M. Martelli

    Version of Record online : 24 AUG 2011, DOI: 10.1002/jcp.22647

  4. You have free access to this content
    Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma

    International Journal of Cancer

    Volume 129, Issue 9, 1 November 2011, Pages: 2297–2303, Anja E. Eisenhardt, Heike Olbrich, Michael Röring, Wibke Janzarik, Ton Nu Van Anh, Huriye Cin, Marc Remke, Hendrik Witt, Andrey Korshunov, Stefan M. Pfister, Heymut Omran and Tilman Brummer

    Version of Record online : 25 JUL 2011, DOI: 10.1002/ijc.25893

  5. You have free access to this content
    Melanoma 2010 Congress

    Pigment Cell & Melanoma Research

    Volume 23, Issue 6, December 2010, Pages: 874–1004,

    Version of Record online : 13 OCT 2010, DOI: 10.1111/j.1755-148X.2010.00767.x

  6. Raf-1 and B-Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain

    European Journal of Neuroscience

    Volume 11, Issue 6, June 1999, Pages: 1995–2006, Cecile Morice, Fatiha Nothias, Sandra König, Philippe Vernier, Manuela Baccarini, Jean-Didier Vincent and Jean Vianney Barnier

    Version of Record online : 9 OCT 2008, DOI: 10.1046/j.1460-9568.1999.00609.x

  7. You have free access to this content
    Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601

    The EMBO Journal

    Volume 19, Issue 20, October 16, 2000, Pages: 5429–5439, Bao-Hong Zhang and Kun-Liang Guan

    Version of Record online : 16 OCT 2000, DOI: 10.1093/emboj/19.20.5429

  8. You have free access to this content
    Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

    The EMBO Journal

    Volume 21, Issue 21, November 1, 2002, Pages: 5611–5622, Tilman Brummer, Peter E. Shaw, Michael Reth and Yukiko Misawa

    Version of Record online : 1 NOV 2002, DOI: 10.1093/emboj/cdf588

  9. You have free access to this content
    Metastatic Melanoma: Insights Into the Evolution of the Treatments and Future Challenges

    Medicinal Research Reviews

    Volume 37, Issue 1, January 2017, Pages: 98–148, Antoine Millet, Anthony R. Martin, Cyril Ronco, Stéphane Rocchi and Rachid Benhida

    Version of Record online : 29 AUG 2016, DOI: 10.1002/med.21404

  10. You have free access to this content
    PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas

    Pigment Cell & Melanoma Research

    Volume 23, Issue 6, December 2010, Pages: 820–827, John T. Lee, Ling Li, Patricia A. Brafford, Marcia van den Eijnden, Molly B. Halloran, Katrin Sproesser, Nikolas K. Haass, Keiran S.M. Smalley, James Tsai, Gideon Bollag and Meenhard Herlyn

    Version of Record online : 13 OCT 2010, DOI: 10.1111/j.1755-148X.2010.00763.x

  11. Optimization of Diarylthiazole B-Raf Inhibitors: Identification of a Compound Endowed with High Oral Antitumor Activity, Mitigated hERG Inhibition, and Low Paradoxical Effect

    ChemMedChem

    Volume 10, Issue 2, February 2015, Pages: 276–295, Dr. Maurizio Pulici, Dr. Gabriella Traquandi, Dr. Chiara Marchionni, Dr. Michele Modugno, Dr. Rosita Lupi, Nadia Amboldi, Dr. Elena Casale, Dr. Nicoletta Colombo, Luca Corti, Dr. Marina Fasolini, Dr. Fabio Gasparri, Wilma Pastori, Dr. Alessandra Scolaro, Dr. Daniele Donati, Dr. Eduard Felder, Dr. Arturo Galvani, Dr. Antonella Isacchi, Dr. Enrico Pesenti and Dr. Marina Ciomei

    Version of Record online : 27 NOV 2014, DOI: 10.1002/cmdc.201402424

  12. You have free access to this content
    The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf

    The EMBO Journal

    Volume 25, Issue 15, August 9, 2006, Pages: 3556–3564, Kenta Terai and Michiyuki Matsuda

    Version of Record online : 20 JUL 2006, DOI: 10.1038/sj.emboj.7601241

  13. You have full text access to this OnlineOpen article
    “RAF” neighborhood: Protein–protein interaction in the Raf/Mek/Erk pathway

    FEBS Letters

    Volume 588, Issue 15, August 01, 2014, Pages: 2398–2406, Botond Cseh, Eszter Doma and Manuela Baccarini

    Version of Record online : 14 JUN 2014, DOI: 10.1016/j.febslet.2014.06.025

  14. You have free access to this content
    Raf-interactome in tuning the complexity and diversity of Raf function

    The FEBS Journal

    Volume 282, Issue 1, January 2015, Pages: 32–53, Su An, Yang Yang, Richard Ward, Ying Liu, Xiao-Xi Guo and Tian-Rui Xu

    Version of Record online : 21 NOV 2014, DOI: 10.1111/febs.13113

  15. You have free access to this content
    Regulation of Raf activity by dimerization

    Pigment Cell & Melanoma Research

    Volume 23, Issue 2, April 2010, Pages: 156–157, Hua Wei and Ming-Ming Zhou

    Version of Record online : 7 JAN 2010, DOI: 10.1111/j.1755-148X.2010.00672.x

  16. You have free access to this content
    B-Raf-mediated signaling pathway regulates T cell development

    European Journal of Immunology

    Volume 38, Issue 2, February 2008, Pages: 518–527, Hirotake Tsukamoto, Atsushi Irie, Satoru Senju, Antonis K. Hatzopoulos, Leszek Wojnowski and Yasuharu Nishimura

    Version of Record online : 28 JAN 2008, DOI: 10.1002/eji.200737430

  17. Identification and Characterization of Small-Molecule Inhibitors to Selectively Target the DFG-in over the DFG-out Conformation of the B-Raf Kinase V600E Mutant in Colorectal Cancer

    Archiv der Pharmazie

    Volume 349, Issue 10, October 2016, Pages: 808–815, Huixiang Yao, Qun Sun and Jinshui Zhu

    Version of Record online : 14 SEP 2016, DOI: 10.1002/ardp.201600184

  18. You have free access to this content
    Raf kinases: Oncogenesis and drug discovery

    International Journal of Cancer

    Volume 119, Issue 10, 15 November 2006, Pages: 2261–2271, Ralf Schreck and Ulf R. Rapp

    Version of Record online : 7 AUG 2006, DOI: 10.1002/ijc.22144

  19. You have free access to this content
    αB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells

    Pigment Cell & Melanoma Research

    Volume 23, Issue 2, April 2010, Pages: 201–209, Rong Hu and Andrew E. Aplin

    Version of Record online : 7 JAN 2010, DOI: 10.1111/j.1755-148X.2010.00668.x

  20. You have free access to this content
    Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib

    Hepatology

    Volume 56, Issue 6, December 2012, Pages: 2363–2374, Carlo Spirli, Carola M. Morell, Luigi Locatelli, Stefano Okolicsanyi, Cecilia Ferrero, Amy K. Kim, Luca Fabris, Romina Fiorotto and Mario Strazzabosco

    Version of Record online : 27 AUG 2012, DOI: 10.1002/hep.25872