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There are 5089 results for: content related to: Inhibition of checkpoint kinase 2 ( CHK 2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine

  1. You have free access to this content
    Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

    The EMBO Journal

    Volume 29, Issue 20, October 20, 2010, Pages: 3558–3570, Hiroyuki Niida, Kazuhiro Murata, Midori Shimada, Kumiko Ogawa, Kumiko Ohta, Kyoko Suzuki, Hidetsugu Fujigaki, Aik Kia Khaw, Birendranath Banerjee, M Prakash Hande, Tomomi Miyamoto, Ichiro Miyoshi, Tomoyuki Shirai, Noboru Motoyama, Mireille Delhase, Ettore Appella and Makoto Nakanishi

    Version of Record online : 10 SEP 2010, DOI: 10.1038/emboj.2010.218

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    Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

    The EMBO Journal

    Volume 21, Issue 19, October 1, 2002, Pages: 5195–5205, Hiroyuki Takai, Kazuhito Naka, Yuki Okada, Miho Watanabe, Naoki Harada, Shin'ichi Saito, Carl W. Anderson, Ettore Appella, Makoto Nakanishi, Hiroshi Suzuki, Kazuo Nagashima, Hirofumi Sawa, Kyoji Ikeda and Noboru Motoyama

    Version of Record online : 1 OCT 2002, DOI: 10.1093/emboj/cdf506

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    Tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cells

    International Journal of Cancer

    Volume 131, Issue 2, 15 July 2012, Pages: 357–366, Byong Hoon Yoo, Alexander Berezkin, Yanfei Wang, Anna Zagryazhskaya and Kirill V. Rosen

    Version of Record online : 2 NOV 2011, DOI: 10.1002/ijc.26368

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    Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain

    EMBO reports

    Volume 4, Issue 8, August 2003, Pages: 787–792, Ashley Craig, Mary Scott, Lindsay Burch, Graeme Smith, Kathryn Ball and Ted Hupp

    Version of Record online : 1 AUG 2003, DOI: 10.1038/sj.embor.embor901

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    ATM–Chk2–p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency

    The EMBO Journal

    Volume 25, Issue 10, May 17, 2006, Pages: 2167–2177, Liu Cao, Sangsoo Kim, Cuiying Xiao, Rui-Hong Wang, Xavier Coumoul, Xiaoyan Wang, Wen Mei Li, Xiao Ling Xu, Joseph A De Soto, Hiroyuki Takai, Sabine Mai, Stephen J Elledge, Noboru Motoyama and Chu-Xia Deng

    Version of Record online : 4 MAY 2006, DOI: 10.1038/sj.emboj.7601115

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    Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors

    British Journal of Pharmacology

    Volume 159, Issue 6, March 2010, Pages: 1326–1338, IM Pires, TH Ward and C Dive

    Version of Record online : 28 JAN 2010, DOI: 10.1111/j.1476-5381.2009.00607.x

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    Role of Chk1 and Chk2 in Ara-C-induced differentiation of human leukemia K562 cells

    Genes to Cells

    Volume 10, Issue 2, February 2005, Pages: 97–106, Kazuchika Takagaki, Susumu Katsuma, Yoshinori Kaminishi, Tatsuya Horio, Teruo Tanaka, Tadaaki Ohgi and Junichi Yano

    Version of Record online : 25 JAN 2005, DOI: 10.1111/j.1365-2443.2005.00821.x

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    Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange

    The EMBO Journal

    Volume 25, Issue 13, July 12, 2006, Pages: 3179–3190, Antony W Oliver, Angela Paul, Katherine J Boxall, S Elaine Barrie, G Wynne Aherne, Michelle D Garrett, Sibylle Mittnacht and Laurence H Pearl

    Version of Record online : 22 JUN 2006, DOI: 10.1038/sj.emboj.7601209

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    Global dissociation of HuR–mRNA complexes promotes cell survival after ionizing radiation

    The EMBO Journal

    Volume 30, Issue 6, March 16, 2011, Pages: 1040–1053, Kiyoshi Masuda, Kotb Abdelmohsen, Mihee M Kim, Subramanya Srikantan, Eun Kyung Lee, Kumiko Tominaga, Roza Selimyan, Jennifer L Martindale, Xiaoling Yang, Elin Lehrmann, Yongqing Zhang, Kevin G Becker, Jian-Ying Wang, Hyeon Ho Kim and Myriam Gorospe

    Version of Record online : 11 FEB 2011, DOI: 10.1038/emboj.2011.24

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    Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair

    The EMBO Journal

    Volume 27, Issue 23, December 3, 2008, Pages: 3140–3150, Wen-Cheng Chou, Hui-Chun Wang, Fen-Hwa Wong, Shian-ling Ding, Pei-Ei Wu, Sheau-Yann Shieh and Chen-Yang Shen

    Version of Record online : 30 OCT 2008, DOI: 10.1038/emboj.2008.229

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    Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase

    Cytometry Part A

    Volume 73A, Issue 6, June 2008, Pages: 480–489, Hong Zhao, Frank Traganos and Zbigniew Darzynkiewicz

    Version of Record online : 5 MAY 2008, DOI: 10.1002/cyto.a.20574

  12. You have full text access to this OnlineOpen article
    Cyclo(phenylalanine-proline) induces DNA damage in mammalian cells via reactive oxygen species

    Journal of Cellular and Molecular Medicine

    Volume 19, Issue 12, December 2015, Pages: 2851–2864, Kwanghyun Lee, Jae Eun Jeong, In Hwang Kim, Kun-Soo Kim and Bong-Gun Ju

    Version of Record online : 28 SEP 2015, DOI: 10.1111/jcmm.12678

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    In vivo role of checkpoint kinase 2 in signaling telomere dysfunction

    Aging Cell

    Volume 13, Issue 5, October 2014, Pages: 810–816, María García-Beccaria, Paula Martínez, Juana M. Flores and Maria A. Blasco

    Version of Record online : 12 JUN 2014, DOI: 10.1111/acel.12237

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    DNA damage checkpoint kinase Chk2 triggers replicative senescence

    The EMBO Journal

    Volume 23, Issue 13, July 7, 2004, Pages: 2554–2563, Véronique Gire, Pierre Roux, David Wynford-Thomas, Jean-Marc Brondello and Vjekoslav Dulic

    Version of Record online : 10 JUN 2004, DOI: 10.1038/sj.emboj.7600259

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    Chk2/Cds1 protein kinase blocks apoptosis during early development of Xenopus laevis

    Developmental Dynamics

    Volume 233, Issue 4, August 2005, Pages: 1359–1365, Brian N. Wroble and Jill C. Sible

    Version of Record online : 3 JUN 2005, DOI: 10.1002/dvdy.20449

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    Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor

    Protein Science

    Volume 18, Issue 1, January 2009, Pages: 92–100, George T. Lountos, Joseph E. Tropea, Di Zhang, Andrew G. Jobson, Yves Pommier, Robert H. Shoemaker and David S. Waugh

    Version of Record online : 2 DEC 2008, DOI: 10.1002/pro.16

  17. ATR dependent activation of Chk2

    Journal of Cellular Physiology

    Volume 208, Issue 3, September 2006, Pages: 613–619, Xiao Qi Wang, J. Leslie Redpath, Sheung Tat Fan and Eric J. Stanbridge

    Version of Record online : 1 JUN 2006, DOI: 10.1002/jcp.20700

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    HDM2 negatively affects the Chk2-mediated phosphorylation of p53

    FEBS Letters

    Volume 579, Issue 12, May 09, 2005, Pages: 2604–2608, Marina Bjørling-Poulsen, David Meek and Olaf-Georg Issinger

    Version of Record online : 9 APR 2005, DOI: 10.1016/j.febslet.2005.03.081

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    Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells

    FEBS Letters

    Volume 505, Issue 1, September 07, 2001, Pages: 7–12, Qiang Yu, Ji Hyun La Rose, Hongliang Zhang and Yves Pommier

    Version of Record online : 6 SEP 2001, DOI: 10.1016/S0014-5793(01)02756-9

  20. Identification of protein phosphorylation sites within Ser/Thr-rich cluster domains using site-directed mutagenesis and hybrid linear quadrupole ion trap Fourier transform ion cyclotron resonance mass spectrometry

    Rapid Communications in Mass Spectrometry

    Volume 21, Issue 21, 15 November 2007, Pages: 3443–3451, Julie B. King, Julia Gross, Christine M. Lovly, Helen Piwnica-Worms and R. Reid Townsend

    Version of Record online : 4 OCT 2007, DOI: 10.1002/rcm.3223