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There are 3672 results for: content related to: Substrate determinants in the C99 juxtamembrane domains differentially affect γ–secretase cleavage specificity and modulator pharmacology

  1. You have free access to this content
    α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation

    Journal of Neurochemistry

    Volume 111, Issue 6, December 2009, Pages: 1369–1382, Sebastian Jäger, Stefanie Leuchtenberger, Anne Martin, Eva Czirr, Johanna Wesselowski, Marco Dieckmann, Elaine Waldron, Carsten Korth, Edward H. Koo, Michael Heneka, Sascha Weggen and Claus U. Pietrzik

    Version of Record online : 5 OCT 2009, DOI: 10.1111/j.1471-4159.2009.06420.x

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    Amyloid Precursor Protein and Notch Intracellular Domains are Generated after Transport of their Precursors to the Cell Surface


    Volume 7, Issue 4, April 2006, Pages: 408–415, Christoph Kaether, Stephanie Schmitt, Michael Willem and Christian Haass

    Version of Record online : 1 FEB 2006, DOI: 10.1111/j.1600-0854.2006.00396.x

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    Cholesterol as a co-solvent and a ligand for membrane proteins

    Protein Science

    Volume 23, Issue 1, January 2014, Pages: 1–22, Yuanli Song, Anne K. Kenworthy and Charles R. Sanders

    Version of Record online : 18 NOV 2013, DOI: 10.1002/pro.2385

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    Failure of the interaction between presenilin 1 and the substrate of γ-secretase to produce Aβ in insect cells

    Journal of Neurochemistry

    Volume 83, Issue 2, October 2002, Pages: 390–399, Didier Pitsi, Pascal Kienlen-Campard and Jean-Noël Octave

    Version of Record online : 2 OCT 2002, DOI: 10.1046/j.1471-4159.2002.01138.x

  5. Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping

    The EMBO Journal

    Akio Fukumori and Harald Steiner

    Version of Record online : 24 MAY 2016, DOI: 10.15252/embj.201694151

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    X11α impairs γ- but not β-cleavage of amyloid precursor protein

    Journal of Neurochemistry

    Volume 88, Issue 4, February 2004, Pages: 971–982, Gwendalyn D. King, Kay Cherian and R. Scott Turner

    Version of Record online : 20 JAN 2004, DOI: 10.1046/j.1471-4159.2003.02234.x

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    N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production

    Journal of Neurochemistry

    Volume 119, Issue 2, October 2011, Pages: 354–363, Megumi Asada-Utsugi, Kengo Uemura, Yasuha Noda, Akira Kuzuya, Masato Maesako, Koichi Ando, Masakazu Kubota, Kiwamu Watanabe, Makio Takahashi, Takeshi Kihara, Shun Shimohama, Ryosuke Takahashi, Oksana Berezovska and Ayae Kinoshita

    Version of Record online : 20 SEP 2011, DOI: 10.1111/j.1471-4159.2011.07364.x

  8. Inhibition of histone deacetylation enhances the neurotoxicity induced by the c-terminal fragments of amyloid precursor protein

    Journal of Neuroscience Research

    Volume 75, Issue 1, 1 January 2004, Pages: 117–124, Hye-Sun Kim, Eun-Mee Kim, Na-Jung Kim, Keun-A Chang, Yoori Choi, Kwang-Woo Ahn, Jun-Ho Lee, Seonghan Kim, Cheol Hyoung Park and Yoo-Hun Suh

    Version of Record online : 11 NOV 2003, DOI: 10.1002/jnr.10845

  9. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis

    European Journal of Neuroscience

    Volume 37, Issue 12, June 2013, Pages: 1962–1969, Yu Deng, Zhe Wang, Ruitao Wang, Xiaozhu Zhang, Shuting Zhang, Yili Wu, Matthias Staufenbiel, Fang Cai and Weihong Song

    Version of Record online : 16 JUN 2013, DOI: 10.1111/ejn.12235

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    Co-expressed presenilin 1 NTF and CTF form functional γ-secretase complexes in cells devoid of full-length protein

    Journal of Neurochemistry

    Volume 89, Issue 1, April 2004, Pages: 44–53, Hanna Laudon, Paul M. Mathews, Helena Karlström, Anna Bergman, Mark R. Farmery, Ralph A. Nixon, Bengt Winblad, Samuel E. Gandy, Urban Lendahl, Johan Lundkvist and Jan Näslund

    Version of Record online : 24 FEB 2004, DOI: 10.1046/j.1471-4159.2003.02298.x

  11. Nearby supernova rates from the Lick Observatory Supernova Search – III. The rate–size relation, and the rates as a function of galaxy Hubble type and colour

    Monthly Notices of the Royal Astronomical Society

    Volume 412, Issue 3, April 2011, Pages: 1473–1507, Weidong Li, Ryan Chornock, Jesse Leaman, Alexei V. Filippenko, Dovi Poznanski, Xiaofeng Wang, Mohan Ganeshalingam and Filippo Mannucci

    Version of Record online : 16 MAR 2011, DOI: 10.1111/j.1365-2966.2011.18162.x

  12. Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia

    Journal of Neurochemistry

    Volume 137, Issue 5, June 2016, Pages: 770–781, Sunmin Jung, Jihoon Nah, Jonghee Han, Seon-Guk Choi, Hyunjoo Kim, Jaesang Park, Ha-Kyung Pyo and Yong-Keun Jung

    Version of Record online : 17 MAR 2016, DOI: 10.1111/jnc.13597

  13. Tat acetylation regulates its actions on microtubule dynamics and apoptosis in T lymphocytes

    The Journal of Pathology

    Volume 223, Issue 1, January 2011, Pages: 28–36, Lihong Huo, Dengwen Li, Lei Sun, Min Liu, Xingjuan Shi, Xiaoou Sun, Jingyu Li, Bin Dong, Xin Dong and Jun Zhou

    Version of Record online : 6 SEP 2010, DOI: 10.1002/path.2768

  14. Caspases-2 and -8 are involved in the presenilin1/γ-secretase-dependent cleavage of amyloid precursor protein after the induction of apoptosis

    Journal of Neuroscience Research

    Volume 88, Issue 9, July 2010, Pages: 1926–1933, San Sook Chae, Chul Bae Yoo, Chulman Jo, Sang-Moon Yun, Sangmee Ahn Jo and Young Ho Koh

    Version of Record online : 8 FEB 2010, DOI: 10.1002/jnr.22356

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    ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

    The EMBO Journal

    Volume 29, Issue 17, September 1, 2010, Pages: 3020–3032, Peer-Hendrik Kuhn, Huanhuan Wang, Bastian Dislich, Alessio Colombo, Ulrike Zeitschel, Joachim W Ellwart, Elisabeth Kremmer, Steffen Roßner and Stefan F Lichtenthaler

    Version of Record online : 30 JUL 2010, DOI: 10.1038/emboj.2010.167

  16. Three-dimensional photoionization modelling of the planetary nebula NGC 3918

    Monthly Notices of the Royal Astronomical Society

    Volume 340, Issue 4, April 2003, Pages: 1153–1172, B. Ercolano, C. Morisset, M. J. Barlow, P. J. Storey and X.-W. Liu

    Version of Record online : 9 APR 2003, DOI: 10.1046/j.1365-8711.2003.06370.x

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    Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity

    Journal of Neurochemistry

    Volume 91, Issue 6, December 2004, Pages: 1312–1321, Izumi Maezawa, Lee-Way Jin, Randall L. Woltjer, Nobuyo Maeda, George M. Martin, Thomas J. Montine and Kathleen S. Montine

    Version of Record online : 4 NOV 2004, DOI: 10.1111/j.1471-4159.2004.02818.x

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    The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of Aβ precursors

    Journal of Neurochemistry

    Volume 96, Issue 4, February 2006, Pages: 1182–1188, Georgia Agiostratidou, Rosa Miñana Muros, Junichi Shioi, Philippe Marambaud and Nikolaos K. Robakis

    Version of Record online : 17 JAN 2006, DOI: 10.1111/j.1471-4159.2005.03616.x

  19. Two-component galaxy models: the effect of density profile at large radii on the phase-space consistency

    Monthly Notices of the Royal Astronomical Society

    Volume 393, Issue 1, February 2009, Pages: 179–191, Luca Ciotti and Lucia Morganti

    Version of Record online : 9 JAN 2009, DOI: 10.1111/j.1365-2966.2008.14187.x

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    Alterations in phosphatidylethanolamine levels affect the generation of Aβ

    Aging Cell

    Volume 11, Issue 1, February 2012, Pages: 63–72, Iva Nesic, Francesc X. Guix, Krist’l Vennekens, Vasiliki Michaki, Paul P. Van Veldhoven, Fabian Feiguin, Bart De Strooper, Carlos G. Dotti and Tina Wahle

    Version of Record online : 28 NOV 2011, DOI: 10.1111/j.1474-9726.2011.00760.x