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There are 76824 results for: content related to: Targeting nascent soluble Aβ42 for potential Alzheimer drug development

  1. You have free access to this content
    Amelioration of cognitive deficits in plaque-bearing Alzheimer's disease model mice through selective reduction of nascent soluble Aβ42 without affecting other Aβ pools

    Journal of Neurochemistry

    Volume 125, Issue 3, May 2013, Pages: 465–472, Yasuyuki Mitani, Junko Yarimizu, Hiroki Akashiba, Yoshitsugu Shitaka, Keni Ni and Nobuya Matsuoka

    Version of Record online : 8 JAN 2013, DOI: 10.1111/jnc.12125

  2. You have free access to this content
    Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils

    Journal of Neurochemistry

    Volume 126, Issue 3, August 2013, Pages: 305–311, Lei Gu and Zhefeng Guo

    Version of Record online : 12 MAR 2013, DOI: 10.1111/jnc.12202

  3. Identification of Physiological and Toxic Conformations in Aβ42 Aggregates

    ChemBioChem

    Volume 10, Issue 2, January 26, 2009, Pages: 287–295, Yuichi Masuda, Satoko Uemura, Ryutaro Ohashi, Azusa Nakanishi, K. Takegoshi, Takahiko Shimizu, Takuji Shirasawa and Kazuhiro Irie

    Version of Record online : 29 DEC 2008, DOI: 10.1002/cbic.200800411

  4. You have full text access to this OnlineOpen article
    Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease

    EMBO Molecular Medicine

    Volume 4, Issue 4, April 2012, Pages: 344–352, Nobuto Kakuda, Mikio Shoji, Hiroyuki Arai, Katsutoshi Furukawa, Takeshi Ikeuchi, Kohei Akazawa, Mako Takami, Hiroyuki Hatsuta, Shigeo Murayama, Yasuhiro Hashimoto, Masakazu Miyajima, Hajime Arai, Yu Nagashima, Haruyasu Yamaguchi, Ryozo Kuwano, Kazuhiro Nagaike, Yasuo Ihara and the Japanese Alzheimer's Disease Neuroimaging Initiative

    Version of Record online : 21 FEB 2012, DOI: 10.1002/emmm.201200214

  5. β-Amyloid Therapeutic Strategies for Alzheimer's Disease

    Standard Article

    Burger's Medicinal Chemistry and Drug Discovery

    Bruno P. Imbimbo and Francesca Speroni

    Published Online : 14 OCT 2005, DOI: 10.1002/0471266949.bmc112

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    Discovery of amyloid-beta aggregation inhibitors using an engineered assay for intracellular protein folding and solubility

    Protein Science

    Volume 18, Issue 2, February 2009, Pages: 277–286, Li Ling Lee, HyungHo Ha, Young-Tae Chang and Matthew P. DeLisa

    Version of Record online : 15 DEC 2008, DOI: 10.1002/pro.33

  7. Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

    Histopathology

    Volume 38, Issue 2, February 2001, Pages: 120–134, M R D'Andrea, R G Nagele, H-Y Wang, P A Peterson and D H S Lee

    Version of Record online : 21 DEC 2001, DOI: 10.1046/j.1365-2559.2001.01082.x

  8. β-amyloid peptide is internalized into chick retinal neurons and alters the distribution of myosin Vb

    Cytoskeleton

    Volume 69, Issue 3, March 2012, Pages: 166–178, Leandro T. Oliveira, Priscila A. Matos, David William Provance Jr., Fernando G. de Mello, Leonardo R. Andrade, Martha M. Sorenson and Verônica P. Salerno

    Version of Record online : 3 FEB 2012, DOI: 10.1002/cm.21007

  9. Distance Measurement between Tyr10 and Met35 in Amyloid β by Site-Directed Spin-Labeling ESR Spectroscopy: Implications for the Stronger Neurotoxicity of Aβ42 than Aβ40

    ChemBioChem

    Volume 8, Issue 18, December 17, 2007, Pages: 2308–2314, Kazuma Murakami, Hideyuki Hara, Yuichi Masuda, Hajime Ohigashi and Kazuhiro Irie

    Version of Record online : 19 NOV 2007, DOI: 10.1002/cbic.200700240

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    The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: The emerging role in the pathogenesis of Alzheimer's disease

    Geriatrics & Gerontology International

    Volume 10, Issue s1, July 2010, Pages: S169–S179, Kazuma Murakami, Yuichi Masuda, Takuji Shirasawa, Takahiko Shimizu and Kazuhiro Irie

    Version of Record online : 2 JUN 2010, DOI: 10.1111/j.1447-0594.2010.00598.x

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    Modulation of β-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures

    Journal of Neurochemistry

    Volume 88, Issue 2, January 2004, Pages: 337–348, Laura Gasparini, Laura Rusconi, Huaxi Xu, Piero Del Soldato and Ennio Ongini

    Version of Record online : 23 DEC 2003, DOI: 10.1111/j.1471-4159.2004.02154.x

  12. High mobility group box protein-1 inhibits microglial Aβ clearance and enhances Aβ neurotoxicity

    Journal of Neuroscience Research

    Volume 78, Issue 6, 15 December 2004, Pages: 880–891, Kazuyuki Takata, Yoshihisa Kitamura, Daiju Tsuchiya, Toshiyuki Kawasaki, Takashi Taniguchi and Shun Shimohama

    Version of Record online : 21 OCT 2004, DOI: 10.1002/jnr.20340

  13. Differential binding and activation of caspase-3 in cultured hippocampal neurons by assembly forms of Aβ1–42

    Journal of Neuroscience Research

    Volume 85, Issue 6, 1 May 2007, Pages: 1205–1214, Paul A. St. John

    Version of Record online : 26 MAR 2007, DOI: 10.1002/jnr.21251

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    An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42

    Journal of Neurochemistry

    Volume 115, Issue 4, November 2010, Pages: 873–884, Ioannis Dafnis, Efstratios Stratikos, Athina Tzinia, Effie C. Tsilibary, Vassilis I. Zannis and Angeliki Chroni

    Version of Record online : 20 APR 2010, DOI: 10.1111/j.1471-4159.2010.06756.x

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    The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway

    The FEBS Journal

    Volume 281, Issue 11, June 2014, Pages: 2674–2687, Yu-Jen Chang and Yun-Ru Chen

    Version of Record online : 6 MAY 2014, DOI: 10.1111/febs.12813

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    Inhibition of Alzheimer’s amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo

    Journal of Neurochemistry

    Volume 108, Issue 4, February 2009, Pages: 1097–1108, Hyun-Seok Hong, Sandeep Rana, Lydia Barrigan, Aibin Shi, Yi Zhang, Feimeng Zhou, Lee-Way Jin and Duy H. Hua

    Version of Record online : 25 DEC 2008, DOI: 10.1111/j.1471-4159.2008.05866.x

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    Cross-seeding effects of amyloid β-protein and α-synuclein

    Journal of Neurochemistry

    Volume 122, Issue 5, September 2012, Pages: 883–890, Kenjiro Ono, Ryoichi Takahashi, Tokuhei Ikeda and Masahito Yamada

    Version of Record online : 23 JUL 2012, DOI: 10.1111/j.1471-4159.2012.07847.x

  18. Critique of the use of fluorescence-based reporters in Escherichia coli as a screening tool for the identification of peptide inhibitors of Aβ42 aggregation

    Journal of Peptide Science

    Volume 19, Issue 2, February 2013, Pages: 74–83, Oliver Wright, Liao Zhang, Yun Liu, Tatsuya Yoshimi, Yizhi Zheng and Alan Tunnacliffe

    Version of Record online : 16 DEC 2012, DOI: 10.1002/psc.2474

  19. You have full text access to this Open Access content
    Insulin-activated Akt rescues Aβ oxidative stress-induced cell death by orchestrating molecular trafficking

    Aging Cell

    Volume 10, Issue 5, October 2011, Pages: 832–843, Pasquale Picone, Daniela Giacomazza, Valeria Vetri, Rita Carrotta, Valeria Militello, Pier L. San Biagio and Marta Di Carlo

    Version of Record online : 8 JUL 2011, DOI: 10.1111/j.1474-9726.2011.00724.x

  20. Dual effects of familial Alzheimer's disease mutations (D7H, D7N, and H6R) on amyloid β peptide: Correlation dynamics and zinc binding

    Proteins: Structure, Function, and Bioinformatics

    Volume 82, Issue 12, December 2014, Pages: 3286–3297, Liang Xu, Yonggang Chen and Xiaojuan Wang

    Version of Record online : 21 OCT 2014, DOI: 10.1002/prot.24669