Search Results

There are 10778 results for: content related to: Targeting nascent soluble Aβ42 for potential Alzheimer drug development

  1. Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease


    Volume 38, Issue 2, February 2001, Pages: 120–134, M R D'Andrea, R G Nagele, H-Y Wang, P A Peterson and D H S Lee

    Article first published online : 21 DEC 2001, DOI: 10.1046/j.1365-2559.2001.01082.x

  2. You have full text access to this OnlineOpen article
    Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease

    EMBO Molecular Medicine

    Volume 4, Issue 4, April 2012, Pages: 344–352, Nobuto Kakuda, Mikio Shoji, Hiroyuki Arai, Katsutoshi Furukawa, Takeshi Ikeuchi, Kohei Akazawa, Mako Takami, Hiroyuki Hatsuta, Shigeo Murayama, Yasuhiro Hashimoto, Masakazu Miyajima, Hajime Arai, Yu Nagashima, Haruyasu Yamaguchi, Ryozo Kuwano, Kazuhiro Nagaike, Yasuo Ihara and the Japanese Alzheimer's Disease Neuroimaging Initiative

    Article first published online : 21 FEB 2012, DOI: 10.1002/emmm.201200214

  3. β-amyloid peptide is internalized into chick retinal neurons and alters the distribution of myosin Vb


    Volume 69, Issue 3, March 2012, Pages: 166–178, Leandro T. Oliveira, Priscila A. Matos, David William Provance Jr., Fernando G. de Mello, Leonardo R. Andrade, Martha M. Sorenson and Verônica P. Salerno

    Article first published online : 3 FEB 2012, DOI: 10.1002/cm.21007

  4. You have free access to this content
    Cross-seeding effects of amyloid β-protein and α-synuclein

    Journal of Neurochemistry

    Volume 122, Issue 5, September 2012, Pages: 883–890, Kenjiro Ono, Ryoichi Takahashi, Tokuhei Ikeda and Masahito Yamada

    Article first published online : 23 JUL 2012, DOI: 10.1111/j.1471-4159.2012.07847.x

  5. You have free access to this content
    Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils

    Journal of Neurochemistry

    Volume 126, Issue 3, August 2013, Pages: 305–311, Lei Gu and Zhefeng Guo

    Article first published online : 12 MAR 2013, DOI: 10.1111/jnc.12202

  6. You have free access to this content
    Amelioration of cognitive deficits in plaque-bearing Alzheimer's disease model mice through selective reduction of nascent soluble Aβ42 without affecting other Aβ pools

    Journal of Neurochemistry

    Volume 125, Issue 3, May 2013, Pages: 465–472, Yasuyuki Mitani, Junko Yarimizu, Hiroki Akashiba, Yoshitsugu Shitaka, Keni Ni and Nobuya Matsuoka

    Article first published online : 8 JAN 2013, DOI: 10.1111/jnc.12125

  7. Identification of Physiological and Toxic Conformations in Aβ42 Aggregates


    Volume 10, Issue 2, January 26, 2009, Pages: 287–295, Yuichi Masuda, Satoko Uemura, Ryutaro Ohashi, Azusa Nakanishi, K. Takegoshi, Takahiko Shimizu, Takuji Shirasawa and Kazuhiro Irie

    Article first published online : 29 DEC 2008, DOI: 10.1002/cbic.200800411

  8. Dual effects of familial Alzheimer's disease mutations (D7H, D7N, and H6R) on amyloid β peptide: Correlation dynamics and zinc binding

    Proteins: Structure, Function, and Bioinformatics

    Volume 82, Issue 12, December 2014, Pages: 3286–3297, Liang Xu, Yonggang Chen and Xiaojuan Wang

    Article first published online : 21 OCT 2014, DOI: 10.1002/prot.24669

  9. NF-κB pathway: a target for preventing β-amyloid (Aβ)-induced neuronal damage and Aβ42 production

    European Journal of Neuroscience

    Volume 23, Issue 7, April 2006, Pages: 1711–1720, Alessandra Valerio, Flora Boroni, Marina Benarese, Ilenia Sarnico, Valentina Ghisi, Laura Grazia Bresciani, Marina Ferrario, Giuseppe Borsani, PierFranco Spano and Marina Pizzi

    Article first published online : 5 APR 2006, DOI: 10.1111/j.1460-9568.2006.04722.x

  10. You have free access to this content
    Discovery of amyloid-beta aggregation inhibitors using an engineered assay for intracellular protein folding and solubility

    Protein Science

    Volume 18, Issue 2, February 2009, Pages: 277–286, Li Ling Lee, HyungHo Ha, Young-Tae Chang and Matthew P. DeLisa

    Article first published online : 15 DEC 2008, DOI: 10.1002/pro.33

  11. Extracellular amyloid beta 42 causes necrosis, inhibition of nuclear division, and mitotic disruption under both folate deficient and folate replete conditions as measured by the cytokinesis-block micronucleus cytome assay

    Environmental and Molecular Mutagenesis

    Volume 55, Issue 1, January 2014, Pages: 1–14, Sau Lai Lee, Philip Thomas and Michael Fenech

    Article first published online : 28 AUG 2013, DOI: 10.1002/em.21811

  12. Distance Measurement between Tyr10 and Met35 in Amyloid β by Site-Directed Spin-Labeling ESR Spectroscopy: Implications for the Stronger Neurotoxicity of Aβ42 than Aβ40


    Volume 8, Issue 18, December 17, 2007, Pages: 2308–2314, Kazuma Murakami, Hideyuki Hara, Yuichi Masuda, Hajime Ohigashi and Kazuhiro Irie

    Article first published online : 19 NOV 2007, DOI: 10.1002/cbic.200700240

  13. You have free access to this content
    Despite its role in assembly, methionine 35 is not necessary for amyloid β-protein toxicity

    Journal of Neurochemistry

    Volume 113, Issue 5, June 2010, Pages: 1252–1262, Panchanan Maiti, Aleksey Lomakin, George B. Benedek and Gal Bitan

    Article first published online : 20 MAR 2010, DOI: 10.1111/j.1471-4159.2010.06692.x

  14. You have full text access to this Open Access content
    Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers

    EMBO Molecular Medicine

    Volume 4, Issue 7, July 2012, Pages: 647–659, Daniela Kaden, Anja Harmeier, Christoph Weise, Lisa M. Munter, Veit Althoff, Benjamin R. Rost, Peter W. Hildebrand, Dietmar Schmitz, Michael Schaefer, Rudi Lurz, Sabine Skodda, Raina Yamamoto, Sönke Arlt, Ulrich Finckh and Gerd Multhaup

    Article first published online : 19 APR 2012, DOI: 10.1002/emmm.201200239

  15. You have free access to this content
    The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: The emerging role in the pathogenesis of Alzheimer's disease

    Geriatrics & Gerontology International

    Volume 10, Issue s1, July 2010, Pages: S169–S179, Kazuma Murakami, Yuichi Masuda, Takuji Shirasawa, Takahiko Shimizu and Kazuhiro Irie

    Article first published online : 2 JUN 2010, DOI: 10.1111/j.1447-0594.2010.00598.x

  16. You have free access to this content
    Co-incorporation of Aβ40 and Aβ42 to form mixed pre-fibrillar aggregates

    European Journal of Biochemistry

    Volume 270, Issue 4, February 2003, Pages: 654–663, David Frost, Paul M Gorman, Christopher M. Yip and Avijit Chakrabartty

    Article first published online : 24 JAN 2003, DOI: 10.1046/j.1432-1033.2003.03415.x

  17. High mobility group box protein-1 inhibits microglial Aβ clearance and enhances Aβ neurotoxicity

    Journal of Neuroscience Research

    Volume 78, Issue 6, 15 December 2004, Pages: 880–891, Kazuyuki Takata, Yoshihisa Kitamura, Daiju Tsuchiya, Toshiyuki Kawasaki, Takashi Taniguchi and Shun Shimohama

    Article first published online : 21 OCT 2004, DOI: 10.1002/jnr.20340

  18. You have free access to this content
    Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease

    British Journal of Pharmacology

    Volume 163, Issue 2, May 2011, Pages: 375–389, B Van Broeck, J-M Chen, G Tréton, M Desmidt, C Hopf, N Ramsden, E Karran, M Mercken and A Rowley

    Article first published online : 18 APR 2011, DOI: 10.1111/j.1476-5381.2011.01207.x

  19. Differential binding and activation of caspase-3 in cultured hippocampal neurons by assembly forms of Aβ1–42

    Journal of Neuroscience Research

    Volume 85, Issue 6, 1 May 2007, Pages: 1205–1214, Paul A. St. John

    Article first published online : 26 MAR 2007, DOI: 10.1002/jnr.21251

  20. You have free access to this content
    An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42

    Journal of Neurochemistry

    Volume 115, Issue 4, November 2010, Pages: 873–884, Ioannis Dafnis, Efstratios Stratikos, Athina Tzinia, Effie C. Tsilibary, Vassilis I. Zannis and Angeliki Chroni

    Article first published online : 20 APR 2010, DOI: 10.1111/j.1471-4159.2010.06756.x