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There are 155283 results for: content related to: Functional analysis and purification of a Pen-2 fusion protein for γ-secretase structural studies

  1. You have free access to this content
    Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production

    Journal of Neurochemistry

    Volume 133, Issue 3, May 2015, Pages: 409–421, Alexandre Matz, Blanka Halamoda-Kenzaoui, Romain Hamelin, Sebastien Mosser, Jean-René Alattia, Mitko Dimitrov, Marc Moniatte and Patrick C. Fraering

    Version of Record online : 24 FEB 2015, DOI: 10.1111/jnc.12996

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    Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment

    Journal of Neurochemistry

    Volume 123, Issue 5, December 2012, Pages: 837–844, Guozhang Mao, Mei-Zhen Cui, Tong Li, Yipeng Jin and Xuemin Xu

    Version of Record online : 11 OCT 2012, DOI: 10.1111/jnc.12016

  3. Nicastrin is required for amyloid precursor protein (APP) but not Notch processing, while anterior pharynx-defective 1 is dispensable for processing of both APP and Notch

    Journal of Neurochemistry

    Volume 136, Issue 6, March 2016, Pages: 1246–1258, Chen Hu, Linlin Zeng, Ting Li, Michael A. Meyer, Mei-Zhen Cui and Xuemin Xu

    Version of Record online : 17 JAN 2016, DOI: 10.1111/jnc.13518

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    Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase

    Journal of Neurochemistry

    Volume 125, Issue 1, April 2013, Pages: 144–156, Benedikt Kretner, Akio Fukumori, Peer-Hendrik Kuhn, Blanca Isabel Pérez-Revuelta, Stefan F. Lichtenthaler, Christian Haass and Harald Steiner

    Version of Record online : 15 JAN 2013, DOI: 10.1111/jnc.12124

  5. ADAM10 and BACE1 are localized to synaptic vesicles

    Journal of Neurochemistry

    Volume 135, Issue 3, November 2015, Pages: 606–615, Jolanta L. Lundgren, Saheeb Ahmed, Sophia Schedin-Weiss, Gunnar K. Gouras, Bengt Winblad, Lars O. Tjernberg and Susanne Frykman

    Version of Record online : 17 SEP 2015, DOI: 10.1111/jnc.13287

  6. You have full text access to this OnlineOpen article
    Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

    Journal of Neurochemistry

    Volume 129, Issue 5, June 2014, Pages: 756–769, Edgar Dawkins and David H. Small

    Version of Record online : 7 MAR 2014, DOI: 10.1111/jnc.12675

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    Substrate determinants in the C99 juxtamembrane domains differentially affect γ–secretase cleavage specificity and modulator pharmacology

    Journal of Neurochemistry

    Volume 125, Issue 4, May 2013, Pages: 610–619, Solenne Ousson, Arman Saric, Aurelie Baguet, Christophe Losberger, Stephane Genoud, Francis Vilbois, Bruno Permanne, Ishrut Hussain and Dirk Beher

    Version of Record online : 18 JAN 2013, DOI: 10.1111/jnc.12129

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    Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

    Journal of Neurochemistry

    Volume 130, Issue 1, July 2014, Pages: 4–28, Robert Vassar, Peer-Hendrik Kuhn, Christian Haass, Matthew E. Kennedy, Lawrence Rajendran, Philip C. Wong and Stefan F. Lichtenthaler

    Version of Record online : 19 APR 2014, DOI: 10.1111/jnc.12715

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    Degradation of gamma secretase activating protein by the ubiquitin–proteasome pathway

    Journal of Neurochemistry

    Volume 133, Issue 3, May 2015, Pages: 432–439, Jin Chu, Jian-Guo Li, Nicholas E. Hoffman, Muniswamy Madesh and Domenico Praticò

    Version of Record online : 13 FEB 2015, DOI: 10.1111/jnc.13011

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    Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production

    Journal of Neurochemistry

    Volume 128, Issue 2, January 2014, Pages: 330–339, Marc Suárez-Calvet, Olivia Belbin, Marta Pera, Nahuai Badiola, Jordi Magrané, Cristina Guardia-Laguarta, Laia Muñoz, Martí Colom-Cadena, Jordi Clarimón and Alberto Lleó

    Version of Record online : 24 OCT 2013, DOI: 10.1111/jnc.12466

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    Reconstitution of γ-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of γ-secretase complex

    Genes to Cells

    Volume 11, Issue 1, January 2006, Pages: 83–93, Hirohisa Shiraishi, Toshihiro Marutani, Hua-Qin Wang, Yasuhiro Maeda, Yukihisa Kurono, Akihiko Takashima, Wataru Araki, Masaki Nishimura, Katsuhiko Yanagisawa and Hiroto Komano

    Version of Record online : 22 NOV 2005, DOI: 10.1111/j.1365-2443.2005.00914.x

  12. Akt1 phosphorylates Nicastrin to regulate its protein stability and activity

    Journal of Neurochemistry

    Volume 134, Issue 5, September 2015, Pages: 799–810, Eun-Hye Jo, Ji-Seon Ahn, Jung-Soon Mo, Ji-Hye Yoon, Eun-Jung Ann, Hyeong-Jin Baek, Hye-Jin Lee, Seol-Hee Kim, Mi-Yeon Kim and Hee-Sae Park

    Version of Record online : 16 JUL 2015, DOI: 10.1111/jnc.13173

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    Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss

    Journal of Neurochemistry

    Volume 96, Issue 5, March 2006, Pages: 1423–1440, William A. Campbell, Hongwei Yang, Henrik Zetterberg, Stéphanie Baulac, Jacqueline A. Sears, Tianming Liu, Stephen T. C. Wong, Tao P. Zhong and Weiming Xia

    Version of Record online : 8 FEB 2006, DOI: 10.1111/j.1471-4159.2006.03648.x

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    Pre-synaptic localization of the γ-secretase-inhibiting protein p24α2 in the mammalian brain

    Journal of Neurochemistry

    Volume 133, Issue 3, May 2015, Pages: 422–431, Lei Liu, Kazunori Fujino and Masaki Nishimura

    Version of Record online : 26 JAN 2015, DOI: 10.1111/jnc.13000

  15. Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia

    Journal of Neurochemistry

    Volume 137, Issue 5, June 2016, Pages: 770–781, Sunmin Jung, Jihoon Nah, Jonghee Han, Seon-Guk Choi, Hyunjoo Kim, Jaesang Park, Ha-Kyung Pyo and Yong-Keun Jung

    Version of Record online : 17 MAR 2016, DOI: 10.1111/jnc.13597

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    From synaptic spines to nuclear signaling: nuclear and synaptic actions of the amyloid precursor protein

    Journal of Neurochemistry

    Volume 126, Issue 2, July 2013, Pages: 183–190, Jean-Noël Octave, Nathalie Pierrot, Susana Ferao Santos, Natalia N. Nalivaeva and Anthony J. Turner

    Version of Record online : 3 APR 2013, DOI: 10.1111/jnc.12239

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    Signaling pathways regulating neuron–glia interaction and their implications in Alzheimer's disease

    Journal of Neurochemistry

    Volume 136, Issue 3, February 2016, Pages: 475–491, Hong Lian and Hui Zheng

    Version of Record online : 30 NOV 2015, DOI: 10.1111/jnc.13424

  18. Functional reconstitution of γ-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2

    Journal of Neuroscience Research

    Volume 77, Issue 3, 1 August 2004, Pages: 309–322, Goran Periz and Mark E. Fortini

    Version of Record online : 14 JUN 2004, DOI: 10.1002/jnr.20203

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    The Aβ-clearance protein transthyretin, like neprilysin, is epigenetically regulated by the amyloid precursor protein intracellular domain

    Journal of Neurochemistry

    Volume 130, Issue 3, August 2014, Pages: 419–431, Caroline Kerridge, Nikolai D. Belyaev, Natalia N. Nalivaeva and Anthony J. Turner

    Version of Record online : 12 MAR 2014, DOI: 10.1111/jnc.12680

  20. The amyloid cascade hypothesis: are we poised for success or failure?

    Journal of Neurochemistry

    Eric Karran and Bart De Strooper

    Version of Record online : 3 JUN 2016, DOI: 10.1111/jnc.13632