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There are 6278 results for: content related to: Augmentation/Attenuation of the QRST Complexes and Their Effects on the QT/QTc: A Heretofore Overlooked Important Association

  1. QT and QTc Interval With Standard and Supratherapeutic Doses of Darifenacin, a Muscarinic M3 Selective Receptor Antagonist for the Treatment of Overactive Bladder

    The Journal of Clinical Pharmacology

    Volume 45, Issue 9, September 2005, Pages: 1038–1047, Denise B. Serra, Melton B. Affrime, Martin P. Bedigian, Gerard Greig, Slavica Milosavljev, Andrej Skerjanec and Yibin Wang

    Article first published online : 19 MAR 2013, DOI: 10.1177/0091270005279010

  2. You have full text access to this OnlineOpen article
    Levofloxacin can be used effectively as a positive control in thorough QT/QTc studies in healthy volunteers

    British Journal of Clinical Pharmacology

    Volume 69, Issue 4, April 2010, Pages: 391–400, Jorg Taubel, Asif Naseem, Tomohiko Harada, Duolao Wang, Radivoj Arezina, Ulrike Lorch and A John Camm

    Article first published online : 24 NOV 2009, DOI: 10.1111/j.1365-2125.2009.03595.x

  3. The Thorough QT/QTc Study

    Integrated Cardiac Safety: Assessment Methodologies for Noncardiac Drugs in Discovery, Development, and Postmarketing Surveillance

    J. Rick Turner, Todd A. Durham, Pages: 135–191, 2008

    Published Online : 16 MAY 2008, DOI: 10.1002/9780470411292.ch7

  4. Absence of Effect of Telbivudine on Cardiac Repolarization: Results of a Thorough QT/QTc Study in Healthy Participants

    The Journal of Clinical Pharmacology

    Volume 49, Issue 12, December 2009, Pages: 1436–1446, Dr Fred Poordad, Dr Gillian Zeldin, Dr Stuart I. Harris, Dr June Ke, Dr Limin Xu, Dr Douglas Mayers and Dr Xiao-Jian Zhou

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270009337943

  5. Chronic N-Methyl-d-Aspartate Receptor Activation Induces Cardiac Electrical Remodeling and Increases Susceptibility to Ventricular Arrhythmias

    Pacing and Clinical Electrophysiology

    SHAOBO SHI, TAO LIU, YAFENG LI, MU QIN, YANHONG TANG, JERRY Y. SHEN, JINJUN LIANG, BO YANG and CONGXIN HUANG

    Article first published online : 30 MAY 2014, DOI: 10.1111/pace.12430

  6. Sample Size, Power Calculations, and Their Implications for the Cost of Thorough Studies of Drug Induced QT Interval Prolongation

    Pacing and Clinical Electrophysiology

    Volume 27, Issue 12, December 2004, Pages: 1659–1669, MAREK MALIK, KATERINA HNATKOVA, VELISLAV BATCHVAROV, YI GANG, PETER SMETANA and A. JOHN CAMM

    Article first published online : 10 DEC 2004, DOI: 10.1111/j.1540-8159.2004.00701.x

  7. The Impact of Hemodialysis on the Dispersion of Ventricular Repolarization

    Pacing and Clinical Electrophysiology

    Volume 36, Issue 3, March 2013, Pages: 322–327, KALLIRROI KALANTZI, CHARA GOUVA, KONSTANTINOS P. LETSAS, APHRODITE VLACHOPANOU, VALERIOS FOULIDIS, ARIS BECHLIOULIS, KONSTANTINOS P. KATOPODIS, JOHN A. GOUDEVENOS and PANAGIOTIS KORANTZOPOULOS

    Article first published online : 10 JAN 2013, DOI: 10.1111/pace.12066

  8. Tpeak – Tend and Tpeak – Tend/QT Ratio as Markers of Ventricular Arrhythmia Risk in Cardiac Resynchronization Therapy Patients

    Pacing and Clinical Electrophysiology

    Volume 36, Issue 1, January 2013, Pages: 103–108, CHIRAG BARBHAIYA, JOSE RICARDO F. PO, SAM HANON and PAUL SCHWEITZER

    Article first published online : 27 OCT 2012, DOI: 10.1111/pace.12031

  9. You have full text access to this OnlineOpen article
    The thorough QT/QTc study 4 years after the implementation of the ICH E14 guidance

    British Journal of Pharmacology

    Volume 159, Issue 1, January 2010, Pages: 49–57, B Darpo

    Article first published online : 18 NOV 2009, DOI: 10.1111/j.1476-5381.2009.00487.x

  10. Lack of Significant Effect of Bilastine Administered at Therapeutic and Supratherapeutic Doses and Concomitantly With Ketoconazole on Ventricular Repolarization: Results of a Thorough QT Study (TQTS) With QT-Concentration Analysis

    The Journal of Clinical Pharmacology

    Volume 52, Issue 6, June 2012, Pages: 893–903, Dr Benoît Tyl, Dr Meriam Kabbaj, Dr Sara Azzam, Dr Ander Sologuren, Dr Román Valiente, Dr Elizabeth Reinbolt, Dr Kathryn Roupe, Ms Nathalie Blanco and Dr William Wheeler

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270011407191

  11. REGULATORY UPDATES: ICH E14 draft consensus guideline on clinical evaluation of QT/QTc interval prolongation

    Pharmaceutical Statistics

    Volume 3, Issue 4, October/December 2004, Pages: 289–293, Scott D. Patterson

    Article first published online : 2 DEC 2004, DOI: 10.1002/pst.142

  12. Comparison of Semiautomated and Fully Automated Methods for QT Measurement During a Thorough QT/QTc Study: Variability and Sample Size Considerations

    The Journal of Clinical Pharmacology

    Volume 49, Issue 8, August 2009, Pages: 905–915, Dr Benoît Tyl, Dr Meriam Kabbaj, Mr Basmah Fassi, Dr Patrick De Jode and Dr William Wheeler

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270009337944

  13. You have full text access to this OnlineOpen article
    Comparison of the effects of levofloxacin on QT/QTc interval assessed in both healthy Japanese and Caucasian subjects

    British Journal of Clinical Pharmacology

    Volume 73, Issue 3, March 2012, Pages: 455–459, Atsushi Sugiyama, Yuji Nakamura, Satomi Nishimura, Satomi Adachi-Akahane, Yuji Kumagai, Juleen Gayed, Asif Naseem, Georg Ferber, Jorg Taubel and John Camm

    Article first published online : 13 FEB 2012, DOI: 10.1111/j.1365-2125.2011.04110.x

  14. Bupivacaine Extended Release Liposome Injection Does Not Prolong QTc Interval in a Thorough QT/QTc Study in Healthy Volunteers

    The Journal of Clinical Pharmacology

    Volume 52, Issue 9, September 2012, Pages: 1441–1447, Asif Naseem, Tomohiko Harada, Duolao Wang, Radivoj Arezina, Ulrike Lorch, Erol Onel, Alan John Camm and Jorg Taubel

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270011419853

  15. You have free access to this content
    Effect of the thrombin receptor antagonist (PAR-1) vorapaxar on QT/QTc interval in healthy volunteers: A randomized, placebo- and positive-controlled, parallel group trial

    Clinical Pharmacology in Drug Development

    Volume 3, Issue 1, January/February 2014, Pages: 18–24, Teddy Kosoglou, Thomas L. Hunt, Fengjuan Xuan, Bharath Kumar, Paul Statkevich, Mary E. Hanson and David L. Cutler

    Article first published online : 25 SEP 2013, DOI: 10.1002/cpdd.49

  16. QT/QTc study conducted in Japanese adult healthy subjects: A novel xanthine oxidase inhibitor topiroxostat was not associated with QT prolongation

    The Journal of Clinical Pharmacology

    Volume 54, Issue 4, April 2014, Pages: 446–452, Atsushi Sugiyama, Hiroya Hashimoto, Yuji Nakamura, Tomoe Fujita and Yuji Kumagai

    Article first published online : 22 NOV 2013, DOI: 10.1002/jcph.226

  17. You have full text access to this OnlineOpen article
    Relationship of QT interval duration with carotid intima media thickness in a clinically healthy population undergoing cardiovascular risk screening

    Journal of Internal Medicine

    Volume 257, Issue 3, March 2005, Pages: 238–246, B. STROHMER, M. PICHLER, B. IGLSEDER and B. PAULWEBER

    Article first published online : 16 FEB 2005, DOI: 10.1111/j.1365-2796.2004.01436.x

  18. Thorough QT/QTc Study of Ritonavir-Boosted Saquinavir Following Multiple-Dose Administration of Therapeutic and Supratherapeutic Doses in Healthy Participants

    The Journal of Clinical Pharmacology

    Volume 52, Issue 4, April 2012, Pages: 520–529, Dr Xiaoping Zhang, Dr Paul Jordan, Ms Laura Cristea, Dr Miklos Salgo, Ms Rana Farha, Mr Stanley Kolis and Dr Lois S. Lee

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270011400071

  19. Evaluation of Eslicarbazepine Acetate on Cardiac Repolarization in a Thorough QT/QTc Study

    The Journal of Clinical Pharmacology

    Volume 52, Issue 2, February 2012, Pages: 222–233, Dr Manuel Vaz-Da-Silva, Dr Teresa Nunes, Dr Luis Almeida, Dr Maria J. Gutierrez, Dr Jeffrey S. Litwin and Dr Patrício Soares-Da-Silva

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270010391789

  20. Positive Control in a “Thorough QT/QTc Study”

    The Journal of Clinical Pharmacology

    Volume 52, Issue 1, January 2012, Pages: 117–118, Qian Liu and Ying Jun Cao

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270010388940