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There are 11061 results for: content related to: Augmentation/Attenuation of the QRST Complexes and Their Effects on the QT/QTc: A Heretofore Overlooked Important Association

  1. The Thorough QT/QTc Study

    Integrated Cardiac Safety: Assessment Methodologies for Noncardiac Drugs in Discovery, Development, and Postmarketing Surveillance

    J. Rick Turner, Todd A. Durham, Pages: 135–191, 2008

    Published Online : 16 MAY 2008, DOI: 10.1002/9780470411292.ch7

  2. QT and QTc Interval With Standard and Supratherapeutic Doses of Darifenacin, a Muscarinic M3 Selective Receptor Antagonist for the Treatment of Overactive Bladder

    The Journal of Clinical Pharmacology

    Volume 45, Issue 9, September 2005, Pages: 1038–1047, Denise B. Serra, Melton B. Affrime, Martin P. Bedigian, Gerard Greig, Slavica Milosavljev, Andrej Skerjanec and Yibin Wang

    Article first published online : 19 MAR 2013, DOI: 10.1177/0091270005279010

  3. You have free access to this content
    Levofloxacin can be used effectively as a positive control in thorough QT/QTc studies in healthy volunteers

    British Journal of Clinical Pharmacology

    Volume 69, Issue 4, April 2010, Pages: 391–400, Jorg Taubel, Asif Naseem, Tomohiko Harada, Duolao Wang, Radivoj Arezina, Ulrike Lorch and A John Camm

    Article first published online : 24 NOV 2009, DOI: 10.1111/j.1365-2125.2009.03595.x

  4. Absence of Effect of Telbivudine on Cardiac Repolarization: Results of a Thorough QT/QTc Study in Healthy Participants

    The Journal of Clinical Pharmacology

    Volume 49, Issue 12, December 2009, Pages: 1436–1446, Dr Fred Poordad, Dr Gillian Zeldin, Dr Stuart I. Harris, Dr June Ke, Dr Limin Xu, Dr Douglas Mayers and Dr Xiao-Jian Zhou

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270009337943

  5. Sample Size, Power Calculations, and Their Implications for the Cost of Thorough Studies of Drug Induced QT Interval Prolongation

    Pacing and Clinical Electrophysiology

    Volume 27, Issue 12, December 2004, Pages: 1659–1669, MAREK MALIK, KATERINA HNATKOVA, VELISLAV BATCHVAROV, YI GANG, PETER SMETANA and A. JOHN CAMM

    Article first published online : 10 DEC 2004, DOI: 10.1111/j.1540-8159.2004.00701.x

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    The thorough QT/QTc study 4 years after the implementation of the ICH E14 guidance

    British Journal of Pharmacology

    Volume 159, Issue 1, January 2010, Pages: 49–57, B Darpo

    Article first published online : 18 NOV 2009, DOI: 10.1111/j.1476-5381.2009.00487.x

  7. Lack of Significant Effect of Bilastine Administered at Therapeutic and Supratherapeutic Doses and Concomitantly With Ketoconazole on Ventricular Repolarization: Results of a Thorough QT Study (TQTS) With QT-Concentration Analysis

    The Journal of Clinical Pharmacology

    Volume 52, Issue 6, June 2012, Pages: 893–903, Dr Benoît Tyl, Dr Meriam Kabbaj, Dr Sara Azzam, Dr Ander Sologuren, Dr Román Valiente, Dr Elizabeth Reinbolt, Dr Kathryn Roupe, Ms Nathalie Blanco and Dr William Wheeler

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270011407191

  8. REGULATORY UPDATES: ICH E14 draft consensus guideline on clinical evaluation of QT/QTc interval prolongation

    Pharmaceutical Statistics

    Volume 3, Issue 4, October/December 2004, Pages: 289–293, Scott D. Patterson

    Article first published online : 2 DEC 2004, DOI: 10.1002/pst.142

  9. Bupivacaine Extended Release Liposome Injection Does Not Prolong QTc Interval in a Thorough QT/QTc Study in Healthy Volunteers

    The Journal of Clinical Pharmacology

    Volume 52, Issue 9, September 2012, Pages: 1441–1447, Asif Naseem, Tomohiko Harada, Duolao Wang, Radivoj Arezina, Ulrike Lorch, Erol Onel, Alan John Camm and Jorg Taubel

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270011419853

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    Facts, fancies and follies of drug-induced QT/QTc interval shortening

    British Journal of Pharmacology

    Volume 159, Issue 1, January 2010, Pages: 70–76, Marek Malik

    Article first published online : 19 JAN 2010, DOI: 10.1111/j.1476-5381.2009.00554.x

  11. Comparison of Semiautomated and Fully Automated Methods for QT Measurement During a Thorough QT/QTc Study: Variability and Sample Size Considerations

    The Journal of Clinical Pharmacology

    Volume 49, Issue 8, August 2009, Pages: 905–915, Dr Benoît Tyl, Dr Meriam Kabbaj, Mr Basmah Fassi, Dr Patrick De Jode and Dr William Wheeler

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270009337944

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    Comparison of the effects of levofloxacin on QT/QTc interval assessed in both healthy Japanese and Caucasian subjects

    British Journal of Clinical Pharmacology

    Volume 73, Issue 3, March 2012, Pages: 455–459, Atsushi Sugiyama, Yuji Nakamura, Satomi Nishimura, Satomi Adachi-Akahane, Yuji Kumagai, Juleen Gayed, Asif Naseem, Georg Ferber, Jorg Taubel and John Camm

    Article first published online : 13 FEB 2012, DOI: 10.1111/j.1365-2125.2011.04110.x

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    Relationship of QT interval duration with carotid intima media thickness in a clinically healthy population undergoing cardiovascular risk screening

    Journal of Internal Medicine

    Volume 257, Issue 3, March 2005, Pages: 238–246, B. STROHMER, M. PICHLER, B. IGLSEDER and B. PAULWEBER

    Article first published online : 16 FEB 2005, DOI: 10.1111/j.1365-2796.2004.01436.x

  14. Thorough QT/QTc Study of Ritonavir-Boosted Saquinavir Following Multiple-Dose Administration of Therapeutic and Supratherapeutic Doses in Healthy Participants

    The Journal of Clinical Pharmacology

    Volume 52, Issue 4, April 2012, Pages: 520–529, Dr Xiaoping Zhang, Dr Paul Jordan, Ms Laura Cristea, Dr Miklos Salgo, Ms Rana Farha, Mr Stanley Kolis and Dr Lois S. Lee

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270011400071

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    Effect of the thrombin receptor antagonist (PAR-1) vorapaxar on QT/QTc interval in healthy volunteers: A randomized, placebo- and positive-controlled, parallel group trial

    Clinical Pharmacology in Drug Development

    Volume 3, Issue 1, January/February 2014, Pages: 18–24, Teddy Kosoglou, Thomas L. Hunt, Fengjuan Xuan, Bharath Kumar, Paul Statkevich, Mary E. Hanson and David L. Cutler

    Article first published online : 25 SEP 2013, DOI: 10.1002/cpdd.49

  16. Evaluation of Eslicarbazepine Acetate on Cardiac Repolarization in a Thorough QT/QTc Study

    The Journal of Clinical Pharmacology

    Volume 52, Issue 2, February 2012, Pages: 222–233, Dr Manuel Vaz-Da-Silva, Dr Teresa Nunes, Dr Luis Almeida, Dr Maria J. Gutierrez, Dr Jeffrey S. Litwin and Dr Patrício Soares-Da-Silva

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270010391789

  17. Positive Control in a “Thorough QT/QTc Study”

    The Journal of Clinical Pharmacology

    Volume 52, Issue 1, January 2012, Pages: 117–118, Qian Liu and Ying Jun Cao

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270010388940

  18. QT/QTc study conducted in Japanese adult healthy subjects: A novel xanthine oxidase inhibitor topiroxostat was not associated with QT prolongation

    The Journal of Clinical Pharmacology

    Volume 54, Issue 4, April 2014, Pages: 446–452, Atsushi Sugiyama, Hiroya Hashimoto, Yuji Nakamura, Tomoe Fujita and Yuji Kumagai

    Article first published online : 22 NOV 2013, DOI: 10.1002/jcph.226

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    No cardiac effects of therapeutic and supratherapeutic doses of rupatadine: results from a ‘thorough QT/QTc study’ performed according to ICH guidelines

    British Journal of Clinical Pharmacology

    Volume 69, Issue 4, April 2010, Pages: 401–410, Ester Donado, Iñaki Izquierdo, Iñaki Pérez, Olga García, Rosa Ma Antonijoan, Ignaci Gich, Anna Solans, Juana Peña, Joel Morganroth and Manuel J. Barbanoj

    Article first published online : 24 NOV 2009, DOI: 10.1111/j.1365-2125.2009.03599.x

  20. Lack of Electrocardiographic Effect of Dexlansoprazole MR, a Novel Modified-Release Formulation of the Proton Pump Inhibitor Dexlansoprazole, in Healthy Participants

    The Journal of Clinical Pharmacology

    Volume 49, Issue 12, December 2009, Pages: 1447–1455, Majid Vakily, Jingtao Wu and Stuart N. Atkinson

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270009339188