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There are 19682 results for: content related to: TORC 2—a new player in genome stability

  1. You have full text access to this OnlineOpen article
    mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue

    EMBO Molecular Medicine

    Volume 8, Issue 3, March 2016, Pages: 232–246, Verena Albert, Kristoffer Svensson, Mitsugu Shimobayashi, Marco Colombi, Sergio Muñoz, Veronica Jimenez, Christoph Handschin, Fatima Bosch and Michael N Hall

    Article first published online : 15 JAN 2016, DOI: 10.15252/emmm.201505610

  2. You have free access to this content
    mTORC1- and mTORC2-interacting proteins keep their multifunctional partners focused

    IUBMB Life

    Volume 63, Issue 10, October 2011, Pages: 896–914, Ismael Bracho-Valdés, Paola Moreno-Alvarez, Israel Valencia-Martínez, Evelyn Robles-Molina, Lydia Chávez-Vargas and José Vázquez-Prado

    Article first published online : 9 SEP 2011, DOI: 10.1002/iub.558

  3. You have full text access to this OnlineOpen article
    Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

    Aging Cell

    Volume 14, Issue 2, April 2015, Pages: 265–273, Katherine H. Schreiber, Denise Ortiz, Emmeline C. Academia, Arieanna C. Anies, Chen-Yu Liao and Brian K. Kennedy

    Article first published online : 4 FEB 2015, DOI: 10.1111/acel.12313

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    Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitations

    British Journal of Pharmacology

    Volume 171, Issue 16, August 2014, Pages: 3801–3813, M Moschetta, A Reale, C Marasco, A Vacca and M R Carratù

    Article first published online : 25 JUL 2014, DOI: 10.1111/bph.12749

  5. You have free access to this content
    Regulation of TOR by small GTPases

    EMBO reports

    Volume 13, Issue 2, February 2012, Pages: 121–128, Raúl V Durán and Michael N Hall

    Article first published online : 13 JAN 2012, DOI: 10.1038/embor.2011.257

  6. You have full text access to this Open Access content
    Mechanistic / mammalian target protein of rapamycin signaling in hematopoietic stem cells and leukemia

    Cancer Science

    Volume 104, Issue 8, August 2013, Pages: 977–982, Atsushi Hirao and Takayuki Hoshii

    Article first published online : 9 JUN 2013, DOI: 10.1111/cas.12189

  7. You have full text access to this OnlineOpen article
    Antimicrobial peptides and gut microbiota in homeostasis and pathology

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1465–1483, Maureen J. Ostaff, Eduard Friedrich Stange and Jan Wehkamp

    Article first published online : 23 AUG 2013, DOI: 10.1002/emmm.201201773

  8. You have full text access to this OnlineOpen article
    Targeting the adaptive molecular landscape of castration-resistant prostate cancer

    EMBO Molecular Medicine

    Volume 7, Issue 7, July 2015, Pages: 878–894, Alexander W Wyatt and Martin E Gleave

    Article first published online : 20 APR 2015, DOI: 10.15252/emmm.201303701

  9. mTORC1 and mTORC2 have largely distinct functions in Purkinje cells

    European Journal of Neuroscience

    Volume 42, Issue 8, October 2015, Pages: 2595–2612, Nico Angliker, Michael Burri, Mariana Zaichuk, Jean-Marc Fritschy and Markus A. Rüegg

    Article first published online : 18 SEP 2015, DOI: 10.1111/ejn.13051

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    PI3K-p110-alpha-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2

    Journal of Neurochemistry

    Volume 130, Issue 2, July 2014, Pages: 255–267, Shalaka Dhanraj Wahane, Nicole Hellbach, Mirja Tamara Prentzell, Stefan Christopher Weise, Riccardo Vezzali, Clemens Kreutz, Jens Timmer, Kerstin Krieglstein, Kathrin Thedieck and Tanja Vogel

    Article first published online : 3 MAY 2014, DOI: 10.1111/jnc.12718

  11. You have full text access to this OnlineOpen article
    Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients

    EMBO Molecular Medicine

    Tina Gruosso, Virginie Mieulet, Melissa Cardon, Brigitte Bourachot, Yann Kieffer, Flavien Devun, Thierry Dubois, Marie Dutreix, Anne Vincent-Salomon, Kyle Malcolm Miller and Fatima Mechta-Grigoriou

    Article first published online : 22 MAR 2016, DOI: 10.15252/emmm.201505891

  12. mTOR signaling for biological control and cancer

    Journal of Cellular Physiology

    Volume 228, Issue 8, August 2013, Pages: 1658–1664, Anya Alayev and Marina K. Holz

    Article first published online : 18 APR 2013, DOI: 10.1002/jcp.24351

  13. You have full text access to this OnlineOpen article
    The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations

    EMBO Molecular Medicine

    Sven Diederichs, Lorenz Bartsch, Julia C Berkmann, Karin Fröse, Jana Heitmann, Caroline Hoppe, Deetje Iggena, Danny Jazmati, Philipp Karschnia, Miriam Linsenmeier, Thomas Maulhardt, Lino Möhrmann, Johannes Morstein, Stella V Paffenholz, Paula Röpenack, Timo Rückert, Ludger Sandig, Maximilian Schell, Anna Steinmann, Gjendine Voss, Jacqueline Wasmuth, Maria E Weinberger and Ramona Wullenkord

    Article first published online : 18 MAR 2016, DOI: 10.15252/emmm.201506055

  14. You have full text access to this OnlineOpen article
    Lost in translation: pluripotent stem cell-derived hematopoiesis

    EMBO Molecular Medicine

    Volume 7, Issue 11, November 2015, Pages: 1388–1402, Mania Ackermann, Steffi Liebhaber, Jan-Henning Klusmann and Nico Lachmann

    Article first published online : 14 JUL 2015, DOI: 10.15252/emmm.201505301

  15. You have full text access to this OnlineOpen article
    ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat

    EMBO Molecular Medicine

    Volume 7, Issue 6, June 2015, Pages: 831–847, Simone Meidhof, Simone Brabletz, Waltraut Lehmann, Bogdan-Tiberius Preca, Kerstin Mock, Manuel Ruh, Julia Schüler, Maria Berthold, Anika Weber, Ulrike Burk, Michael Lübbert, Martin Puhr, Zoran Culig, Ulrich Wellner, Tobias Keck, Peter Bronsert, Simon Küsters, Ulrich T Hopt, Marc P Stemmler and Thomas Brabletz

    Article first published online : 14 APR 2015, DOI: 10.15252/emmm.201404396

  16. You have full text access to this OnlineOpen article
    Defective autophagy is a key feature of cerebral cavernous malformations

    EMBO Molecular Medicine

    Volume 7, Issue 11, November 2015, Pages: 1403–1417, Saverio Marchi, Mariangela Corricelli, Eliana Trapani, Luca Bravi, Alessandra Pittaro, Simona Delle Monache, Letizia Ferroni, Simone Patergnani, Sonia Missiroli, Luca Goitre, Lorenza Trabalzini, Alessandro Rimessi, Carlotta Giorgi, Barbara Zavan, Paola Cassoni, Elisabetta Dejana, Saverio Francesco Retta and Paolo Pinton

    Article first published online : 28 SEP 2015, DOI: 10.15252/emmm.201505316

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    Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies

    British Journal of Haematology

    Volume 166, Issue 3, August 2014, Pages: 336–351, Toby A. Eyre, Graham P. Collins, Anthony H. Goldstone and Kate Cwynarski

    Article first published online : 19 MAY 2014, DOI: 10.1111/bjh.12945

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    Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells

    The Journal of Physiology

    Volume 591, Issue 3, February 2013, Pages: 609–625, Fredrick J. Rosario, Yoshikatsu Kanai, Theresa L. Powell and Thomas Jansson

    Article first published online : 11 JAN 2013, DOI: 10.1113/jphysiol.2012.238014

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    mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

    The EMBO Journal

    Volume 29, Issue 23, December 1, 2010, Pages: 3939–3951, Won Jun Oh, Chang -chih Wu, Sung Jin Kim, Valeria Facchinetti, Louis -André Julien, Monica Finlan, Philippe P Roux, Bing Su and Estela Jacinto

    Article first published online : 2 NOV 2010, DOI: 10.1038/emboj.2010.271

  20. Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: Assembly of a multiprotein signaling complex

    Journal of Cellular Biochemistry

    Volume 113, Issue 5, May 2012, Pages: 1488–1500, Uma K. Misra and Salvatore V. Pizzo

    Article first published online : 15 MAR 2012, DOI: 10.1002/jcb.24018