Online ISBN: 9780470015902

DOI: 10.1002/047001590X

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  1. Biochemistry
  2. Bioethics & Philosophy
  3. Cell Biology
  4. Developmental Biology
  5. Ecology
  6. Evolution & Diversity of Life
  7. Genetics & Disease
    1. Bioinformatics and Genetic Disease
    2. Cancer Genetics
    3. Chromosomal Disorders
    4. Epigenetics and Disease
    5. Forensic Genetics
    6. Gene and Genome Structure and Organisation
    7. Gene Expression Profiling of Genetic Disease
    8. Gene Mapping by Disease Association
    9. Gene Therapy
    10. General Genetics and Disease
    11. Genetic Counseling
    12. Genetic Models
    13. Genetics of Intelligence and Cognition
    14. Genomic Disorders
    15. Inter-Individual Variation and Polymorphism
    16. Linkage Analysis
    17. Mitochondrial Diseases
    18. Model Organisms and Human Disease
    19. Molecular Genetics of Common and Complex Disease
    20. Mutational Mechanisms of Genetic Disease
    21. Pharmacogenetics and Pharmacogenomics
    22. Proteomic Studies of Genetic Disease
    23. Quantitative Genetics
    24. Specific Genetic Disorders
    25. Statistical Methodology in Genetics
    26. Techniques and Tools in Clinical Genetics
      1. Adeno-associated Viral Vectors in Gene Therapy
      2. Adenovirus Vectors in Gene Therapy
      3. Adoption Strategies
      4. Adoption Studies
      5. Advances in Next Generation Sequencing Technologies and Cancer Epigenomics
      6. Alignment: Statistical Significance
      7. Alkaline Blotting of DNA Gels
      8. Alternative Promoter Usage
      9. Antisense and Ribozymes
      10. Application of Chromosome Conformation Capture (3C) to the Study of Human Genetic Disease
      11. Application of Exome Sequencing to Mendelian Disorders and the Emergence of Personalised Medicine
      12. Artificial Chromosomes
      13. Artificial Chromosomes
      14. Ascertainment in Genetics Studies
      15. Assessing Genetic Variants of Uncertain Significance: The Example of Lynch Syndrome
      16. Autoimmune Diseases: Gene Therapy
      17. Autonomy and Responsibility in Reproductive Genetics
      18. Bacillus subtilis as a Model for Bacterial Systems Biology
      19. Behavioural Phenotypes: Goals and Methods
      20. Beyond Consent: Respect for Community in Genetic Research
      21. Bioethics of Genetic Testing
      22. Bioethics: ELSI
      23. You have free access to this content
      24. Biomolecular Sequence Analysis: Pattern Acquisition and Frequency Counts
      25. Blocks of Limited Haplotype Diversity
      26. Breast Cancer
      27. Calibration of a Transilluminator for UV Fixation of DNA to Nylon Filters
      28. Cancer Genome Anatomy Project
      29. Cancer Genome Sequencing
      30. Cancer: Chromosomal Abnormalities
      31. Capillary Blotting of RNA and DNA Gels
      32. Capillary Electrophoresis
      33. Cardiovascular Disease: Gene Therapy
      34. Carrier Screening for Inherited Hemoglobin Disorders in Cyprus and the United Kingdom
      35. Carrier Screening of Adolescents in Montreal
      36. Celera Genomics: The Race for the Human Genome Sequence
      37. Characterising Somatic Mutations in Cancer Genome by Means of Next-generation Sequencing
      38. Characterising Structural Variation by Means of Next-Generation Sequencing
      39. Children in Genetic Research
      40. Chromosome 22: Sequencing
      41. Chromosome Analysis and Identification
      42. Chromosome Preparation
      43. You have free access to this content
        Chromosome Preparation and Banding
      44. Chromosomes: Methods for Preparation
      45. Clinical Genetic Services in the United Kingdom
      46. Clinical Genetics and Genetic Counseling Professionals: Attitudes to Contentious Issues
      47. Clinical Molecular Cytogenetics
      48. Cloning of Animals in Genetic Research: Ethical and Religious Issues
      49. Comparative Genomic Hybridization
      50. Comparative Genomic Hybridization in the Study of Human Disease
      51. Computational Methods in SNP Analysis
      52. Conditional Lethal Mutations as Experimental Tools
      53. Contig Assembly
      54. Cot Analysis: Single-copy versus Repetitive DNA
      55. Cre–lox-Inducible Gene Targeting
      56. Cystic Fibrosis: Gene Therapy
      57. Cytogenetic and Physical Chromosomal Maps: Integration
      58. Databases in Genetics Clinics
      59. Deconstructing Gene Function through ENU Mutagenesis
      60. Denaturation of RNA Using Glyoxal
      61. Denaturing Formamide Polyacrylamide Gels for Separating RNA and DNA
      62. Denaturing Gel Electrophoresis of DNA in Alkaline Agarose Gels
      63. Denaturing Gel Electrophoresis of RNA and DNA Using Urea–Polyacrylamide Gels
      64. Development and Role of the Human Reference Sequence in Personal Genomics
      65. Diabetes Mellitus: Gene Therapy
      66. Dictyostelium as a Biomedical Model
      67. You have free access to this content
        Dideoxy Sequencing of DNA
      68. Digital Image Analysis
      69. Direct Sequencing of PCR Products
      70. Direct-to-Consumer Genetic Testing
      71. DNA Chip Revolution
      72. You have free access to this content
        DNA Chips and Microarrays
      73. DNA Damage Response: From Tumourigenesis to Therapy
      74. DNA Evidence: Inferring Identity
      75. DNA Fingerprinting, Paternity Testing and Relationship (Immigration) Analysis
      76. You have free access to this content
        DNA Profiling in Forensic Science
      77. DNA Technology: A Critical European Perspective
      78. DNA Viral Vectors in Gene Therapy
      79. DNA: Mechanical Breakage
      80. DNA: Methods for Preparation
      81. Dolly and Polly
      82. Drosophila as a Model for Human Diseases
      83. Dysmorphism: Syndromes
      84. Ectopic Transcription
      85. Electroblotting of Gels
      86. Electrophoresis of DNA and RNA in Non-denaturing Vertical Polyacrylamide Gels
      87. ELSI Research Programme of the NHGRI
      88. Environmental Mutagenesis
      89. Epidemiological Tools
      90. You have free access to this content
        Experimental Organisms Used in Genetics
      91. Expressed-sequence Tag (EST)
      92. Expression Analysis In Vivo
      93. Expression Analysis In vivo: Cell Systems
      94. Expression Studies
      95. Expression Targeting in Gene Therapy
      96. Familial Hypercholesterolemia: Gene Therapy
      97. FASTA Search Programs
      98. Fetal Diagnosis
      99. Flow-sorted Chromosomes
      100. Fluorescence in situ Hybridization
      101. Forensic Genetics
      102. Forensic Genetics: Mathematics
      103. Fragile Sites
      104. Framework Map
      105. Functional Complementation
      106. Gel Electrophoresis of RNA in Denaturing Formaldehyde Agarose Gels
      107. Gene Delivery by Viruses
      108. Gene Expression Databases
      109. Gene Expression Networks
      110. Gene Families
      111. Gene Feature Identification
      112. Gene Localization by in situ Hybridization: FISH
      113. Gene Mapping and Positional Cloning
      114. Gene Mapping: Comparative
      115. Gene Targeting by Homologous Recombination
      116. Gene Therapy
      117. Gene Therapy for Neurodevelopmental Disorders
      118. Gene Therapy: Delivery Targeting
      119. Gene Therapy: Technology
      120. Gene Transfer and Expression in Tissue Culture Cells
      121. Gene Transfer in Transplantation
      122. Genetic Age: A Vision
      123. Genetic Carrier Testing
      124. Genetic Databases
      125. Genetic Databases: Mining
      126. Genetic Disability and Legal Action: Wrongful Birth, Wrongful Life
      127. Genetic Disorders in History and Prehistory
      128. Genetic Engineering: Reporter Genes
      129. Genetic Enhancement
      130. Genetic Epidemiology of Complex Traits
      131. Genetic Information Access, a Legal Perspective: A Duty to Know or a Right Not to Know, and a Duty or Option to Warn?
      132. Genetic Information, Genetic Testing, and Employment
      133. Genetic Linkage Mapping
      134. Genetic Mapping: Comparison of Direct and Indirect Approaches
      135. Genetic Maps: Direct Meiotic Analysis
      136. Genetic Maps: Integration
      137. Genetic Screening and Testing
      138. Genetic Screening for Susceptibility to Disease
      139. Genetic Screening: Facilitating Informed Choices
      140. Genetic Testing of Children
      141. Genetic Testing of Children: Capacity of Children to Consent
      142. Genetic Testing of Children: Parental Requests
      143. Genetics in Contemporary Germany
      144. Genetics of Chromosome 22q11.2 Deletion Syndrome
      145. Genetics of Glaucoma
      146. Genetics of X-linked Mental Retardation
      147. Genome Inserts
      148. Genome Map
      149. Genome Map: Resolution
      150. Genome Mapping
      151. Genome Mapping
      152. Genome Organization of Vertebrates
      153. Genome Sequencing
      154. Genome-wide Association Studies
      155. Genome-wide Association Studies: The Success, Failure and Future
      156. Genomics, Pharmacogenetics and Proteomics: An Integration
      157. Gibbs Sampling and Bayesian Inference
      158. Haemophilias: Gene Therapy
      159. HAPPY Mapping
      160. Hematopoietic Stem Cells
      161. Herpes Simplex Viral Vectors in Gene Therapy
      162. High-throughput ‘On Chip’ Protein and Nucleic Acid Transfection
      163. High-Throughput Single Nucleotide Polymorphisms Genotyping Technologies
      164. hnRNP: Methods for Preparation
      165. Homogenization of Soft Tissues (Rat Liver) in Iso-osmotic Media
      166. Human Chromosome Evolution
      167. Human Chromosomes
      168. Human Cloning
      169. Human Cloning: Legal Aspects
      170. Human Gene Nomenclature
      171. You have free access to this content
        Human Gene Therapy
      172. Human Gene Therapy: Risks and Safety Considerations
      173. Human Genetics: Ethical Issues and Social Impact
      174. Human Genetics: Online Resources
      175. Human Genetics: Principles
      176. Human Genome Project as a Social Enterprise
      177. Human Genome Project: Importance in Clinical Genetics
      178. Human Genome: Draft Sequence
      179. Human Variation Databases
      180. Huntington Disease: Predictive Genetic Testing
      181. Hypertrophic Cardiomyopathy
      182. Identical Twins Reared Apart
      183. Identification of Disease Genes by CGH Microarrays
      184. Identifying Genes Underlying Human Inherited Disease
      185. Immunodeficiency Syndromes: Gene Therapy
      186. In Vitro Fertilization
      187. In Vitro Mutagenesis
      188. Infectious Diseases: Gene Therapy
      189. Infectomics: Study of Microbial Infections Using Omic Approaches
      190. Information Theories in Molecular Biology and Genomics
      191. You have free access to this content
        Informed Consent and Multiplex Genetic Screening
      192. Informed Consent in Human Genetic Research
      193. Inherited Muscle Disease: Gene Therapy
      194. Isolation of DNA from Agarose Gels using Agarase
      195. Isolation of DNA from Low Gelling Temperature Agarose
      196. Karyotype Analysis and Chromosome Banding
      197. Karyotype Interpretation
      198. Knockout and Knock-in Animals
      199. Lentiviral Vectors in Gene Therapy
      200. Linkage and Association Studies: Replication
      201. Long-range PCR
      202. Lysosomal Storage Disorders: Gene Therapy
      203. Mammalian Artificial Chromosomes (MACs)
      204. Manifold Dot or Slot Blotting of DNA on to Nitrocellulose or Uncharged Nylon Membrane
      205. Manual Dot Blotting
      206. Medical Genetics in Britain: Laying the Foundation (1940s–1960s)
      207. Method for the Concentration of RNA and DNA Samples
      208. Microarray Bioinformatics
      209. Microarrays and Expression Profiling in Cancer
      210. Microarrays and Single Nucleotide Polymorphism (SNP) Genotyping
      211. Microarrays in Disease Diagnosis and Prognosis
      212. Microarrays in Drug Discovery and Development
      213. Microarrays in Toxicological Research
      214. Microarrays: Use in Gene Identification
      215. Microarrays: Use in Mutation Detection
      216. You have free access to this content
        Microorganisms: Applications in Molecular Biology
      217. Migraine: Genetics
      218. Minisatellites
      219. Molecular Cytogenetic Analysis: Applications in Cancer
      220. Molecular Genetics of Crohn Disease
      221. Molecular Genetics of Galactosaemia
      222. Molecular Genetics of Metastasis
      223. Mouse as a Model for Human Diseases
      224. Mouse Knockouts: Modifying the Mouse Genome by using Embryonic Stem Cells
      225. Mouse N-ethyl-N-nitrosourea (ENU) Mutagenesis
      226. Mutation Databases
      227. Mutation Detection
      228. Mutation Nomenclature
      229. Naked DNA in Gene Therapy
      230. Neonatal Screening
      231. Neural Stem Cells
      232. Neurological Diseases: Gene Therapy
      233. New Vectors for Gene Delivery: Human and Mouse Artificial Chromosomes
      234. Newborn Screening Programmes
      235. Next Generation Sequencing Technologies and Their Applications
      236. Next-generation Sequencing in Clinical Molecular Diagnostics
      237. Nick Translation
      238. Nonsense Mutations Causing Inherited Diseases: Therapeutic Approaches
      239. Northern Blotting
      240. Northern Blotting and RNA Detection
      241. Nuclear Run-on Assays
      242. Nucleic Acid Backbone Structure Variations: Peptide Nucleic Acids
      243. Nucleic Acid Hybridization
      244. Nucleotide Sequence Databases
      245. Optical Mapping
      246. Ownership of Genetic Material and Information
      247. Patenting of Genes: A Personal View
      248. Patenting of Genes: Discoveries or Inventions?
      249. PCR-mediated Mutagenesis
      250. Pharmacogenetics and Pharmacogenomics
      251. Polygenic Inheritance and Genetic Susceptibility Screening
      252. You have free access to this content
        Polymerase Chain Reaction (PCR)
      253. Polymerase Chain Reaction (PCR)
      254. Polymerase Chain Reaction (PCR): Design and Optimization of Reactions
      255. You have free access to this content
        Population Genetics of Modern Human Evolution
      256. Population Stratification, Adjustment for
      257. Predictive Genetic Testing: Emotional and Behavioural Impact
      258. Predictive Genetic Testing: Psychological Impact
      259. Predictive Genetic Testing: The Huntington Disease Model
      260. Preimplantation Diagnosis
      261. Preimplantation Genetic Diagnosis: Ethical Aspects
      262. Prenatal Screening: Impact on Normal Pregnancies
      263. Presymptomatic Diagnosis
      264. Primer Walking
      265. Promoter Haplotypes and Gene Expression
      266. Prospects for Prenatal Gene Therapy
      267. Protein Interaction and Genetic Disease
      268. Proteomics: A Molecular Scanner in Medicine
      269. Pulsed-field Gel Electrophoresis of DNA
      270. Radiation Hybrid Mapping
      271. Radiolabelling Nucleic Acids: Generating DNA Probes by Random Priming
      272. Recombinant DNA
      273. Recovery of DNA from Polyacrylamide or Agarose by Electroelution
      274. Regulatable Gene Expression in Gene Therapy
      275. Representational Difference Analysis
      276. Reproductive Choice
      277. Reproductive Genetic Screening: A Public Health Perspective from the United Kingdom
      278. Research on Rare Variants for Complex Diseases
      279. Restriction Enzyme Digests of DNA in Agarose Plugs for Pulsed Field Gel Electrophoresis
      280. Restriction Enzymes
      281. Restriction Fragment Length Polymorphism (RFLP)
      282. Restriction Mapping
      283. Restriction Mapping of Cloned DNA
      284. Retroviral Vectors in Gene Therapy
      285. RNA Gene Prediction
      286. RNA Viral Vectors in Gene Therapy
      287. RNA-Seq and Human Complex Disease
      288. RNA: Methods for Preparation
      289. Robotics and Automation in Molecular Genetics
      290. Role of Bioinformatics in Genome-wide Association Studies
      291. Segregation Analysis Software
      292. Separation of RNA and DNA in Methylmercuric Hydroxide Denaturing Agarose Gels
      293. Sequence Accuracy and Verification
      294. Sequence Assembly
      295. Sequence Complexity and Composition
      296. Sequence-tagged Site (STS)
      297. You have free access to this content
        Sequencing the Human Genome: Novel Insights into its Structure and Function
      298. Shotgunning the Human Genome: A Personal View
      299. Similarity Search
      300. Simple Repeats
      301. Single Nucleotide Polymorphisms (SNPs): Identification and Scoring
      302. Site-directed Mutagenesis Using PCR
      303. Site-specific Recombination: Uses in Biotechnology
      304. Small Silencing RNAs and Gene Therapy
      305. Smith–Magenis Syndrome
      306. snRNPs: Methods for Purification
      307. Somatic Cell Genetics
      308. Southern Blotting and Related DNA Detection Techniques
      309. Southern Blotting for the Analysis of Human Disease
      310. Staining, Viewing and Photography of Gels and Estimation of Fragment Sizes
      311. Statistical Methods in Physical Mapping
      312. Studying Genomic Aberrations by Microarray Profiling
      313. Susceptibility Genes: Detection
      314. Synthetic Nucleic Acid Delivery Systems in Gene Therapy
      315. Systems Biology: Genomics Aspects
      316. Transcriptomics and Proteomics: Integration?
      317. Transfection of DNA into Mammalian Cells in Culture
      318. You have free access to this content
        Transgenic Mice
      319. Transgenic Mice Production
      320. Transgenic Xenopus Production
      321. Twin Studies
      322. Twinning
      323. Use of Personalized Genomic Information
      324. Variable Drug Response: Genetic Evaluation
      325. Whole Animal Cloning
      326. Whole Genome Resequencing and 1000 Genomes Project
      327. Whole-genome Amplification
      328. Xenopus as an Experimental Organism
      329. Yeast as a Model for Human Diseases
      330. Yeast as a Model Genetic Organism
      331. Zebrafish as a Model for Human Diseases
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