Online ISBN: 9780470015902

DOI: 10.1002/047001590X

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  1. Biochemistry
  2. Bioethics & Philosophy
  3. Cell Biology
  4. Developmental Biology
  5. Ecology
  6. Evolution & Diversity of Life
  7. Genetics & Disease
    1. Bioinformatics and Genetic Disease
    2. Cancer Genetics
    3. Chromosomal Disorders
    4. Epigenetics and Disease
    5. Forensic Genetics
    6. Gene and Genome Structure and Organisation
    7. Gene Expression Profiling of Genetic Disease
    8. Gene Mapping by Disease Association
    9. Gene Therapy
    10. General Genetics and Disease
    11. Genetic Counseling
    12. Genetic Models
    13. Genetics of Intelligence and Cognition
    14. Genomic Disorders
    15. Inter-Individual Variation and Polymorphism
    16. Linkage Analysis
    17. Mitochondrial Diseases
    18. Model Organisms and Human Disease
    19. Molecular Genetics of Common and Complex Disease
    20. Mutational Mechanisms of Genetic Disease
    21. Pharmacogenetics and Pharmacogenomics
    22. Proteomic Studies of Genetic Disease
    23. Quantitative Genetics
    24. Specific Genetic Disorders
    25. Statistical Methodology in Genetics
    26. Techniques and Tools in Clinical Genetics
      1. Adeno-associated Viral Vectors in Gene Therapy
      2. Adenovirus Vectors in Gene Therapy
      3. Adoption Strategies
      4. Adoption Studies
      5. Advances in Next Generation Sequencing Technologies and Cancer Epigenomics
      6. Alignment: Statistical Significance
      7. Alkaline Blotting of DNA Gels
      8. Alternative Promoter Usage
      9. Antibody Microarrays
      10. Antisense and Ribozymes
      11. Application of Chromosome Conformation Capture (3C) to the Study of Human Genetic Disease
      12. Application of Exome Sequencing to Mendelian Disorders and the Emergence of Personalised Medicine
      13. Artificial Chromosomes
      14. Artificial Chromosomes
      15. Ascertainment in Genetics Studies
      16. Assessing Genetic Variants of Uncertain Significance: The Example of Lynch Syndrome
      17. Autoimmune Diseases: Gene Therapy
      18. Autonomy and Responsibility in Reproductive Genetics
      19. Bacillus subtilis as a Model for Bacterial Systems Biology
      20. Behavioural Phenotypes: Goals and Methods
      21. Beyond Consent: Respect for Community in Genetic Research
      22. Bioethics of Genetic Testing
      23. Bioethics: ELSI
      24. You have free access to this content
      25. Biomolecular Sequence Analysis: Pattern Acquisition and Frequency Counts
      26. Blocks of Limited Haplotype Diversity
      27. Breast Cancer
      28. Calibration of a Transilluminator for UV Fixation of DNA to Nylon Filters
      29. Cancer Genome Anatomy Project
      30. Cancer Genome Sequencing
      31. Cancer: Chromosomal Abnormalities
      32. Capillary Blotting of RNA and DNA Gels
      33. Capillary Electrophoresis
      34. Cardiovascular Disease: Gene Therapy
      35. Carrier Screening for Inherited Hemoglobin Disorders in Cyprus and the United Kingdom
      36. Carrier Screening of Adolescents in Montreal
      37. Celera Genomics: The Race for the Human Genome Sequence
      38. Characterising Somatic Mutations in Cancer Genome by Means of Next-generation Sequencing
      39. Characterising Structural Variation by Means of Next-Generation Sequencing
      40. Children in Genetic Research
      41. Chromosome 22: Sequencing
      42. Chromosome Analysis and Identification
      43. Chromosome Preparation
      44. You have free access to this content
        Chromosome Preparation and Banding
      45. Chromosomes: Methods for Preparation
      46. Clinical Genetic Services in the United Kingdom
      47. Clinical Genetics and Genetic Counseling Professionals: Attitudes to Contentious Issues
      48. Clinical Molecular Cytogenetics
      49. Cloning of Animals in Genetic Research: Ethical and Religious Issues
      50. Comparative Genomic Hybridization
      51. Comparative Genomic Hybridization in the Study of Human Disease
      52. Computational Methods in SNP Analysis
      53. Conditional Lethal Mutations as Experimental Tools
      54. Contig Assembly
      55. Cot Analysis: Single-copy versus Repetitive DNA
      56. Cre–lox-Inducible Gene Targeting
      57. Cystic Fibrosis: Gene Therapy
      58. Cytogenetic and Physical Chromosomal Maps: Integration
      59. Databases in Genetics Clinics
      60. Deconstructing Gene Function through ENU Mutagenesis
      61. Denaturation of RNA Using Glyoxal
      62. Denaturing Formamide Polyacrylamide Gels for Separating RNA and DNA
      63. Denaturing Gel Electrophoresis of DNA in Alkaline Agarose Gels
      64. Denaturing Gel Electrophoresis of RNA and DNA Using Urea–Polyacrylamide Gels
      65. Development and Role of the Human Reference Sequence in Personal Genomics
      66. Diabetes Mellitus: Gene Therapy
      67. Dictyostelium as a Biomedical Model
      68. You have free access to this content
        Dideoxy Sequencing of DNA
      69. Direct Sequencing of PCR Products
      70. Direct-to-Consumer Genetic Testing
      71. DNA Chip Revolution
      72. You have free access to this content
        DNA Chips and Microarrays
      73. DNA Damage Response: From Tumourigenesis to Therapy
      74. DNA Evidence: Inferring Identity
      75. DNA Fingerprinting, Paternity Testing and Relationship (Immigration) Analysis
      76. You have free access to this content
        DNA Profiling in Forensic Science
      77. DNA Technology: A Critical European Perspective
      78. DNA Viral Vectors in Gene Therapy
      79. DNA: Mechanical Breakage
      80. DNA: Methods for Preparation
      81. Dolly and Polly
      82. Drosophila as a Model for Human Diseases
      83. Dysmorphism: Syndromes
      84. Ectopic Transcription
      85. Electroblotting of Gels
      86. Electrophoresis of DNA and RNA in Non-denaturing Vertical Polyacrylamide Gels
      87. Environmental Mutagenesis
      88. Epidemiological Tools
      89. You have free access to this content
        Experimental Organisms Used in Genetics
      90. Expressed-sequence Tag (EST)
      91. Expression Analysis In Vivo
      92. Expression Analysis In vivo: Cell Systems
      93. Expression Studies
      94. Expression Targeting in Gene Therapy
      95. Familial Hypercholesterolemia: Gene Therapy
      96. FASTA Search Programs
      97. Fetal Diagnosis
      98. Flow-sorted Chromosomes
      99. Fluorescence in situ Hybridization
      100. Forensic Genetics
      101. Forensic Genetics: Mathematics
      102. Fragile Sites
      103. Framework Map
      104. Functional Complementation
      105. Gel Electrophoresis of RNA in Denaturing Formaldehyde Agarose Gels
      106. Gene Delivery by Viruses
      107. Gene Expression Databases
      108. Gene Expression Networks
      109. Gene Families
      110. Gene Feature Identification
      111. Gene Localization by in situ Hybridization: FISH
      112. Gene Mapping and Positional Cloning
      113. Gene Mapping: Comparative
      114. Gene Targeting by Homologous Recombination
      115. Gene Therapy
      116. Gene Therapy for Neurodevelopmental Disorders
      117. Gene Therapy: Delivery Targeting
      118. Gene Therapy: Technology
      119. Gene Transfer and Expression in Tissue Culture Cells
      120. Gene Transfer in Transplantation
      121. Genetic Age: A Vision
      122. Genetic Databases
      123. Genetic Databases: Mining
      124. Genetic Disability and Legal Action: Wrongful Birth, Wrongful Life
      125. Genetic Disorders in History and Prehistory
      126. Genetic Engineering: Reporter Genes
      127. Genetic Enhancement
      128. Genetic Epidemiology of Complex Traits
      129. Genetic Information, Genetic Testing, and Employment
      130. Genetic Linkage Mapping
      131. Genetic Mapping: Comparison of Direct and Indirect Approaches
      132. Genetic Maps: Direct Meiotic Analysis
      133. Genetic Maps: Integration
      134. Genetic Screening and Testing
      135. Genetic Screening for Susceptibility to Disease
      136. Genetic Screening: Facilitating Informed Choices
      137. Genetic Testing of Children
      138. Genetic Testing of Children: Capacity of Children to Consent
      139. Genetic Testing of Children: Parental Requests
      140. Genetics and Genomics Education of Primary Care Health Professionals in Britain
      141. Genetics of Chromosome 22q11.2 Deletion Syndrome
      142. Genetics of Glaucoma
      143. Genetics of Polycystic Ovary Syndrome
      144. Genetics of X-linked Mental Retardation
      145. Genome Inserts
      146. Genome Map
      147. Genome Map: Resolution
      148. Genome Mapping
      149. Genome Mapping
      150. Genome Organization of Vertebrates
      151. Genome Sequencing
      152. Genome-wide Association Studies
      153. Genome-wide Association Studies: The Success, Failure and Future
      154. Genomics, Pharmacogenetics and Proteomics: An Integration
      155. Gibbs Sampling and Bayesian Inference
      156. Haemophilias: Gene Therapy
      157. HAPPY Mapping
      158. Hematopoietic Stem Cells
      159. Herpes Simplex Viral Vectors in Gene Therapy
      160. High-throughput ‘On Chip’ Protein and Nucleic Acid Transfection
      161. High-Throughput Single Nucleotide Polymorphisms Genotyping Technologies
      162. hnRNP: Methods for Preparation
      163. Homogenization of Soft Tissues (Rat Liver) in Iso-osmotic Media
      164. Human Chromosome Evolution
      165. Human Chromosomes
      166. Human Cloning
      167. Human Cloning: Legal Aspects
      168. Human Gene Nomenclature
      169. You have free access to this content
        Human Gene Therapy
      170. Human Gene Therapy: Risks and Safety Considerations
      171. Human Genetics: Ethical Issues and Social Impact
      172. Human Genetics: Online Resources
      173. Human Genetics: Principles
      174. Human Genome Project: Importance in Clinical Genetics
      175. Human Genome: Draft Sequence
      176. Human Variation Databases
      177. Huntington Disease: Predictive Genetic Testing
      178. Hypertrophic Cardiomyopathy
      179. Identical Twins Reared Apart
      180. Identification of Disease Genes by CGH Microarrays
      181. Immunodeficiency Syndromes: Gene Therapy
      182. In Vitro Fertilization
      183. In Vitro Mutagenesis
      184. Infectious Diseases: Gene Therapy
      185. Infectomics: Study of Microbial Infections Using Omic Approaches
      186. Information Theories in Molecular Biology and Genomics
      187. You have free access to this content
        Informed Consent and Multiplex Genetic Screening
      188. Informed Consent in Human Genetic Research
      189. Inherited Muscle Disease: Gene Therapy
      190. Isolation of DNA from Agarose Gels using Agarase
      191. Isolation of DNA from Low Gelling Temperature Agarose
      192. Karyotype Analysis and Chromosome Banding
      193. Karyotype Interpretation
      194. Knockout and Knock-in Animals
      195. Lentiviral Vectors in Gene Therapy
      196. Linkage and Association Studies: Replication
      197. Long-range PCR
      198. Lysosomal Storage Disorders: Gene Therapy
      199. Mammalian Artificial Chromosomes (MACs)
      200. Management of Incidental Findings in Clinical Genomic Sequencing Studies
      201. Manifold Dot or Slot Blotting of DNA on to Nitrocellulose or Uncharged Nylon Membrane
      202. Manual Dot Blotting
      203. Medical Genetics in Britain: Laying the Foundation (1940s–1960s)
      204. Method for the Concentration of RNA and DNA Samples
      205. Microarray Bioinformatics
      206. Microarrays and Expression Profiling in Cancer
      207. Microarrays and Single Nucleotide Polymorphism (SNP) Genotyping
      208. Microarrays in Disease Diagnosis and Prognosis
      209. Microarrays in Drug Discovery and Development
      210. Microarrays in Toxicological Research
      211. Microarrays: Use in Gene Identification
      212. Microarrays: Use in Mutation Detection
      213. You have free access to this content
        Microorganisms: Applications in Molecular Biology
      214. Migraine: Genetics
      215. Minisatellites
      216. Molecular Cytogenetic Analysis: Applications in Cancer
      217. Molecular Genetics of Crohn Disease
      218. Molecular Genetics of Galactosaemia
      219. Molecular Genetics of Metastasis
      220. Mouse as a Model for Human Diseases
      221. Mouse Knockouts: Modifying the Mouse Genome by using Embryonic Stem Cells
      222. Mouse N-ethyl-N-nitrosourea (ENU) Mutagenesis
      223. Mutation Databases
      224. Mutation Detection
      225. Mutation Nomenclature
      226. Naked DNA in Gene Therapy
      227. Neonatal Screening
      228. Neural Stem Cells
      229. Neurological Diseases: Gene Therapy
      230. New Vectors for Gene Delivery: Human and Mouse Artificial Chromosomes
      231. Newborn Screening Programmes
      232. Next Generation Sequencing Technologies and Their Applications
      233. Next-generation Sequencing in Clinical Molecular Diagnostics
      234. Nick Translation
      235. Noninvasive Prenatal Testing for Chromosomal and Genetic Conditions
      236. Nonsense Mutations Causing Inherited Diseases: Therapeutic Approaches
      237. Northern Blotting
      238. Northern Blotting and RNA Detection
      239. Nuclear Run-on Assays
      240. You have free access to this content
        Nucleic Acid Backbone Structure Variations: Peptide Nucleic Acids
      241. Nucleic Acid Hybridization
      242. Nucleotide Sequence Databases
      243. Optical Mapping
      244. Ownership of Genetic Material and Information
      245. Patenting of Genes: A Personal View
      246. Patenting of Genes: Discoveries or Inventions?
      247. PCR-mediated Mutagenesis
      248. Pharmacogenetics and Pharmacogenomics
      249. Polygenic Inheritance and Genetic Susceptibility Screening
      250. You have free access to this content
        Polymerase Chain Reaction (PCR)
      251. Polymerase Chain Reaction (PCR)
      252. Polymerase Chain Reaction (PCR): Design and Optimization of Reactions
      253. You have free access to this content
        Population Genetics of Modern Human Evolution
      254. Population Stratification, Adjustment for
      255. Predictive Genetic Testing: Emotional and Behavioural Impact
      256. Predictive Genetic Testing: Psychological Impact
      257. Preimplantation Diagnosis
      258. Preimplantation Genetic Diagnosis: Ethical Aspects
      259. Prenatal Screening: Impact on Normal Pregnancies
      260. Presymptomatic Diagnosis
      261. Primer Walking
      262. Promoter Haplotypes and Gene Expression
      263. Prospects for Prenatal Gene Therapy
      264. Protein Interaction and Genetic Disease
      265. Proteomics: A Molecular Scanner in Medicine
      266. Pulsed-field Gel Electrophoresis of DNA
      267. Radiation Hybrid Mapping
      268. Radiolabelling Nucleic Acids: Generating DNA Probes by Random Priming
      269. Recombinant DNA
      270. Recovery of DNA from Polyacrylamide or Agarose by Electroelution
      271. Regulatable Gene Expression in Gene Therapy
      272. Representational Difference Analysis
      273. Reproductive Choice
      274. Reproductive Genetic Screening: A Public Health Perspective from the United Kingdom
      275. Research on Rare Variants for Complex Diseases
      276. Restriction Enzyme Digests of DNA in Agarose Plugs for Pulsed Field Gel Electrophoresis
      277. Restriction Enzymes
      278. Restriction Fragment Length Polymorphism (RFLP)
      279. Restriction Mapping
      280. Restriction Mapping of Cloned DNA
      281. Retroviral Vectors in Gene Therapy
      282. Risks for Relatives
      283. RNA Gene Prediction
      284. RNA Viral Vectors in Gene Therapy
      285. RNA-Seq and Human Complex Disease
      286. RNA: Methods for Preparation
      287. Robotics and Automation in Molecular Genetics
      288. Role of Bioinformatics in Genome-wide Association Studies
      289. Segregation Analysis Software
      290. Separation of RNA and DNA in Methylmercuric Hydroxide Denaturing Agarose Gels
      291. Sequence Accuracy and Verification
      292. Sequence Assembly
      293. Sequence Complexity and Composition
      294. Sequence-tagged Site (STS)
      295. Sequencing the Human Genome: Novel Insights into Its Structure and Function
      296. Shotgunning the Human Genome: A Personal View
      297. Similarity Search
      298. Single Nucleotide Polymorphisms (SNPs): Identification and Scoring
      299. Site-directed Mutagenesis Using PCR
      300. Site-specific Recombination: Uses in Biotechnology
      301. Small Silencing RNAs and Gene Therapy
      302. Smith–Magenis Syndrome
      303. snRNPs: Methods for Purification
      304. Somatic Cell Genetics
      305. Southern Blotting and Related DNA Detection Techniques
      306. Southern Blotting for the Analysis of Human Disease
      307. Staining, Viewing and Photography of Gels and Estimation of Fragment Sizes
      308. Statistical Methods in Physical Mapping
      309. Studying Genomic and Epigenetic Aberrations by Microarray Profiling
      310. Susceptibility Genes: Detection
      311. Synthetic Nucleic Acid Delivery Systems in Gene Therapy
      312. Systems Biology: Genomics Aspects
      313. Therapeutic Applications of RNA Interference
      314. Transcriptomics and Proteomics: Integration?
      315. Transfection of DNA into Mammalian Cells in Culture
      316. You have free access to this content
        Transgenic Mice
      317. Transgenic Mice Production
      318. Transgenic Xenopus Production
      319. Translational Readthrough of Premature Termination Codons in a Therapeutic Context
      320. Transposon-Based Cellular Reprogramming to Induced Pluripotency
      321. Twin Studies
      322. Twinning
      323. Use of Personalized Genomic Information
      324. Variable Drug Response: Genetic Evaluation
      325. Whole Animal Cloning
      326. Whole Genome Resequencing and 1000 Genomes Project
      327. Whole-genome Amplification
      328. Xenopus as an Experimental Organism
      329. Yeast as a Model for Human Diseases
      330. Yeast as a Model Genetic Organism
      331. Zebrafish as a Model for Human Diseases
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  14. Structural Biology
  15. Virology