Signalling Networks in Cell Shape and Motility: Novartis Foundation Symposium 269

Signalling Networks in Cell Shape and Motility: Novartis Foundation Symposium 269

Editor(s): Gregory Bock, Jamie Goode

Published Online: 7 OCT 2008

Print ISBN: 9780470011904

Online ISBN: 9780470017661

DOI: 10.1002/047001766X

Series Editor(s): Novartis Foundation

About this Book

This book features contributions from experts in cell biology, genetics, neurobiology, immunology and structural biology.  The unifying element is that they all study processes of cell shape change and motility.  Several key questions in this field of research are discussed:

  • What are the organising principles behind cell shape change?
  • Are there 'master switches' present in every cell type?
  • How are extracellular signals interpreted by the cell in order to activate intracellular mechanisms?
  • What is the influence of the extracellular matrix on cell movement and internal signalling pathways?
  • How do pathogens subvert cellular systems in order to stimulate or block their uptake?

The book addresses all of these important questions.  Data are presented on the key proteins that regulate cell shape: the GTP binding proteins of the Rho family. There are also extensive discussions of the potential applications of the data to clinical problems, particularly that of cell motility in cancer.

Table of contents

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    2. Regulation of Microtubules by Rho GTPases in Migrating Cells (pages 106–126)

      Gregg G. Gundersen, Ying Wen, Christina H. Eng, Jan Schmoranzer, Noemi Cabrera-Poch, Edward J. S. Morris, Michael Chen and Edgar R. Gomes

    3. Integrin-Syndecan Cooperation Governs the Assembly of Signalling Complexes during Cell Spreading (pages 178–192)

      Martin J. Humphries, Zohreh Mostafavi-Pour, Mark R. Morgan, Nicholas O. Deakin, Anthea J. Messent and Mark D. Bass

    4. Formation of Multicellular Epithelial Structures (pages 193–205)

      Keith Mostov, Paul Brakeman, Anirban Datta, Ama Gassama, Leonid Katz, Minji Kim, Pascale Leroy, Max Levin, Kathleen Liu, Fernando Martin, Lucy E. O'Brien, Marcel Verges, Tao Su, Kitty Tang, Naoki Tanimizu, Toshiyuki Yamaji and Wei Yu

    5. Rho GTPase-Formin Pairs in Cytoskeletal Remodelling (pages 206–222)

      Kathryn M. Eisenmann, Jun Peng, Bradley J. Wallar and Arthur S. Alberts

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